Single cell type - PLAU - The Human Protein Atlas

PLAU

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PLAU
Gene descriptionⁱ Full gene name according to HGNC.	Plasminogen activator, urokinase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Disease related genes Enzymes Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Secreted, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Basal respiratory cells, Ionocytes, Collecting duct cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.68
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Group enriched (Fibroblast, Central nervous system macrophage, Vascular associated smooth muscle cell, Pericyte)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (neutrophil, plasmacytoid DC, myeloid DC)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data.	Protein predicted to be secreted

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Basal respiratory cells, Ionocytes, Collecting duct cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Group enriched (Fibroblast, Central nervous system macrophage, Vascular associated smooth muscle cell, Pericyte)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Group enriched (neutrophil, plasmacytoid DC, myeloid DC)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

PLAU is part of cluster 45 Non-specific - Mixed function with confidenceⁱ 1
349 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ANXA2	Annexin A2	0.8228	45
LAMB3	Laminin subunit beta 3	0.8179	45
GJB4	Gap junction protein beta 4	0.8179	45
F3	Coagulation factor III, tissue factor	0.8059	45
LAMC2	Laminin subunit gamma 2	0.7849	45
LCN2	Lipocalin 2	0.7490	45
MYEOV	Myeloma overexpressed	0.7410	45
LAMA3	Laminin subunit alpha 3	0.7376	45
ENSG00000284969	Novel protein	0.7329	45
PRSS22	Serine protease 22	0.7323	45
SERPINB7	Serpin family B member 7	0.7220	45
ITGA2	Integrin subunit alpha 2	0.7119	45
DUOX2	Dual oxidase 2	0.7028	45
ITGB6	Integrin subunit beta 6	0.6985	45
TNFRSF12A	TNF receptor superfamily member 12A	0.6843	45

IMMUNE CELLS

PLAU is part of cluster 38 Monocytes & Neutrophils - Degranulation with confidenceⁱ 0.97
501 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SAP25	Sin3A associated protein 25	0.9762	38
UBR4	Ubiquitin protein ligase E3 component n-recognin 4	0.9524	38
CLEC9A	C-type lectin domain containing 9A	0.9524	38
CACNB4	Calcium voltage-gated channel auxiliary subunit beta 4	0.9524	38
OLR1	Oxidized low density lipoprotein receptor 1	0.9524	38
CEP170	Centrosomal protein 170	0.9524	38
FURIN	Furin, paired basic amino acid cleaving enzyme	0.9524	38
TRIM6	Tripartite motif containing 6	0.9524	38
PLEKHG6	Pleckstrin homology and RhoGEF domain containing G6	0.9286	35
TLR6	Toll like receptor 6	0.9286	38
FFAR4	Free fatty acid receptor 4	0.9286	38
CDHR4	Cadherin related family member 4	0.9286	38
PLIN3	Perilipin 3	0.9048	38
RPGRIP1	RPGR interacting protein 1	0.9048	21
WDR47	WD repeat domain 47	0.9048	38

Adipocytes	24.2 nTPM
Breast	33.3 nTPM
Adipose tissue	15.0 nTPM

Alveolar cells type 1	0.4 nTPM
Lung	0.4 nTPM

Alveolar cells type 2	0.4 nTPM
Lung	0.4 nTPM

Astrocytes	0.3 nTPM
Brain	0.3 nTPM

B-cells	0.9 nTPM
Skin	6.8 nTPM
Lung	1.3 nTPM
Adipose tissue	1.2 nTPM
Thymus	1.2 nTPM
Stomach	0.4 nTPM
Lymph node	0.2 nTPM
Spleen	0.1 nTPM
Salivary gland	0.1 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Ciliated cells	33.5 nTPM
Bronchus	69.9 nTPM
Endometrium	58.5 nTPM
Fallopian tube	3.2 nTPM
Lung	2.4 nTPM

Club cells	70.6 nTPM
Bronchus	184.5 nTPM
Lung	18.7 nTPM
Prostate	8.4 nTPM

Endothelial cells	19.0 nTPM
Pancreas	126.7 nTPM
Heart muscle	53.0 nTPM
Skeletal muscle	38.1 nTPM
Tongue	18.3 nTPM
Salivary gland	16.4 nTPM
Esophagus	15.9 nTPM
Lung	14.7 nTPM
Placenta	12.5 nTPM
Vascular	10.1 nTPM
Prostate	9.7 nTPM
Thymus	8.1 nTPM
Skin	6.4 nTPM
Endometrium	4.0 nTPM
Fallopian tube	3.8 nTPM
Liver	1.3 nTPM
Ovary	1.3 nTPM
Testis	1.2 nTPM
Breast	0.9 nTPM

Enteroendocrine cells	0.3 nTPM
Colon	0.8 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	69.7 nTPM
Skeletal muscle	395.8 nTPM
Pancreas	266.6 nTPM
Stomach	161.4 nTPM
Fallopian tube	53.3 nTPM
Adipose tissue	46.6 nTPM
Breast	36.8 nTPM
Thymus	32.8 nTPM
Esophagus	30.5 nTPM
Salivary gland	29.5 nTPM
Vascular	13.8 nTPM
Heart muscle	13.2 nTPM
Skin	12.8 nTPM
Lung	12.0 nTPM
Liver	3.6 nTPM
Placenta	3.4 nTPM
Prostate	2.6 nTPM

Granulocytes	41.4 nTPM
Tongue	53.4 nTPM
Fallopian tube	45.2 nTPM
Lung	25.7 nTPM

Intestinal goblet cells	0.1 nTPM
Rectum	0.2 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Lymphatic endothelial cells	0.4 nTPM
Fallopian tube	0.9 nTPM
Ovary	0.0 nTPM

Macrophages	64.3 nTPM
Endometrium	182.0 nTPM
Breast	160.9 nTPM
Skin	154.9 nTPM
Tongue	114.1 nTPM
Fallopian tube	92.6 nTPM
Pancreas	92.5 nTPM
Esophagus	89.9 nTPM
Vascular	66.7 nTPM
Salivary gland	62.1 nTPM
Adipose tissue	51.9 nTPM
Lung	47.2 nTPM
Prostate	32.0 nTPM
Kidney	17.7 nTPM
Stomach	15.4 nTPM
Testis	13.6 nTPM
Skeletal muscle	13.2 nTPM
Spleen	7.0 nTPM
Thymus	5.4 nTPM
Bone marrow	2.0 nTPM

Paneth cells	0.4 nTPM
Rectum	1.2 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Basal keratinocytes	41.1 nTPM
Skin	46.4 nTPM
Tongue	35.7 nTPM

Basal squamous epithelial cells	59.6 nTPM
Esophagus	59.6 nTPM

Cytotrophoblasts	29.4 nTPM
Placenta	29.4 nTPM

Distal tubular cells	12.3 nTPM
Kidney	12.3 nTPM

Plasma cells	3.2 nTPM
Esophagus	10.4 nTPM
Salivary gland	8.1 nTPM
Fallopian tube	6.4 nTPM
Stomach	0.4 nTPM
Thymus	0.4 nTPM
Liver	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Schwann cells	0.2 nTPM
Vascular	0.5 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	8.3 nTPM
Tongue	13.3 nTPM
Salivary gland	3.3 nTPM

Smooth muscle cells	27.2 nTPM
Skeletal muscle	138.2 nTPM
Thymus	48.6 nTPM
Placenta	45.6 nTPM
Adipose tissue	37.2 nTPM
Breast	27.4 nTPM
Skin	26.9 nTPM
Tongue	20.1 nTPM
Esophagus	19.2 nTPM
Vascular	18.2 nTPM
Salivary gland	14.3 nTPM
Endometrium	11.7 nTPM
Fallopian tube	9.9 nTPM
Prostate	6.1 nTPM
Lung	5.9 nTPM
Liver	3.0 nTPM
Ovary	2.7 nTPM

Suprabasal keratinocytes	22.3 nTPM
Skin	33.5 nTPM
Tongue	11.1 nTPM

T-cells	2.1 nTPM
Endometrium	11.0 nTPM
Skin	7.0 nTPM
Colon	6.8 nTPM
Tongue	6.8 nTPM
Vascular	5.2 nTPM
Skeletal muscle	2.6 nTPM
Breast	2.1 nTPM
Fallopian tube	1.5 nTPM
Kidney	0.9 nTPM
Prostate	0.5 nTPM
Adipose tissue	0.3 nTPM
Lymph node	0.2 nTPM
Bone marrow	0.2 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Esophagus	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM

Undifferentiated cells	2.6 nTPM
Colon	4.4 nTPM
Small intestine	2.8 nTPM
Rectum	0.5 nTPM

Amygdala excitatory	0.1 nTPM
Thalamus	0.5 nTPM
Amygdala	0.1 nTPM
Cerebral cortex	0.1 nTPM
Basal ganglia	0.0 nTPM
Hippocampus	0.0 nTPM
Hypothalamus	0.0 nTPM

Astrocyte	0.5 nTPM
Cerebral cortex	1.9 nTPM
Hippocampus	0.9 nTPM
Amygdala	0.6 nTPM
Basal ganglia	0.6 nTPM
Hypothalamus	0.4 nTPM
Midbrain	0.2 nTPM
Pons	0.2 nTPM
Thalamus	0.2 nTPM
Cerebellum	0.1 nTPM
Medulla oblongata	0.1 nTPM
Spinal cord	0.0 nTPM

Bergmann glia	0.1 nTPM
Cerebellum	0.2 nTPM
Medulla oblongata	0.0 nTPM
Pons	0.0 nTPM

Central nervous system macrophage	13.3 nTPM
Spinal cord	34.1 nTPM
Hypothalamus	19.5 nTPM
Pons	14.8 nTPM
Medulla oblongata	13.2 nTPM
Cerebellum	12.6 nTPM
Basal ganglia	10.3 nTPM
Thalamus	10.0 nTPM
Hippocampus	8.3 nTPM
Cerebral cortex	8.2 nTPM
Midbrain	8.2 nTPM
Amygdala	6.7 nTPM

Cerebellar inhibitory	0.9 nTPM
Midbrain	1.6 nTPM
Medulla oblongata	1.3 nTPM
Pons	1.0 nTPM
Cerebellum	0.6 nTPM
Spinal cord	0.0 nTPM

Cge interneuron	0.2 nTPM
Cerebral cortex	0.3 nTPM
Hippocampus	0.3 nTPM
Hypothalamus	0.2 nTPM
Midbrain	0.2 nTPM
Thalamus	0.2 nTPM
Amygdala	0.1 nTPM
Basal ganglia	0.1 nTPM

Choroid plexus epithelial cell	0.0 nTPM
Basal ganglia	0.1 nTPM
Hippocampus	0.0 nTPM
Medulla oblongata	0.0 nTPM
Thalamus	0.0 nTPM

Committed oligodendrocyte precursor	0.1 nTPM
Cerebellum	1.6 nTPM
Amygdala	0.0 nTPM
Basal ganglia	0.0 nTPM
Cerebral cortex	0.0 nTPM
Hippocampus	0.0 nTPM
Hypothalamus	0.0 nTPM
Medulla oblongata	0.0 nTPM
Midbrain	0.0 nTPM
Pons	0.0 nTPM
Spinal cord	0.0 nTPM
Thalamus	0.0 nTPM

Deep-layer corticothalamic and 6b	0.0 nTPM
Amygdala	0.1 nTPM
Hippocampus	0.1 nTPM
Basal ganglia	0.0 nTPM
Cerebral cortex	0.0 nTPM
Hypothalamus	0.0 nTPM
Midbrain	0.0 nTPM

Deep-layer intratelencephalic	0.0 nTPM
Amygdala	0.1 nTPM
Cerebral cortex	0.1 nTPM
Basal ganglia	0.0 nTPM
Hippocampus	0.0 nTPM
Hypothalamus	0.0 nTPM

Deep-layer near-projecting	0.4 nTPM
Basal ganglia	0.8 nTPM
Cerebral cortex	0.7 nTPM
Amygdala	0.4 nTPM
Hippocampus	0.3 nTPM
Hypothalamus	0.0 nTPM

Eccentric medium spiny neuron	0.0 nTPM
Amygdala	0.1 nTPM
Basal ganglia	0.1 nTPM
Thalamus	0.1 nTPM
Cerebral cortex	0.0 nTPM
Hippocampus	0.0 nTPM
Hypothalamus	0.0 nTPM

Endothelial cell	1.8 nTPM
Basal ganglia	6.5 nTPM
Medulla oblongata	4.1 nTPM
Pons	1.9 nTPM
Thalamus	1.7 nTPM
Cerebral cortex	1.3 nTPM
Amygdala	1.1 nTPM
Hippocampus	1.0 nTPM
Midbrain	0.9 nTPM
Cerebellum	0.8 nTPM
Hypothalamus	0.0 nTPM
Spinal cord	0.0 nTPM