Single cell type - MRPS2 - The Human Protein Atlas

MRPS2

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MRPS2
Gene descriptionⁱ Full gene name according to HGNC.	Mitochondrial ribosomal protein S2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes Plasma proteins Ribosomal proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Glandular & Luminal cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.30
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

MRPS2 is part of cluster 37 Glandular & Luminal cells - Unknown function with confidenceⁱ 1
334 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PAEP	Progestagen associated endometrial protein	0.7377	37
GABRQ	Gamma-aminobutyric acid type A receptor subunit theta	0.7260	37
C2CD4A	C2 calcium dependent domain containing 4A	0.6990	37
OLIG3	Oligodendrocyte transcription factor 3	0.6947	37
GADD45A	Growth arrest and DNA damage inducible alpha	0.6780	37
PAX8	Paired box 8	0.6673	37
SLC30A2	Solute carrier family 30 member 2	0.6649	37
HAP1	Huntingtin associated protein 1	0.6614	37
PCCA	Propionyl-CoA carboxylase subunit alpha	0.6494	37
RIMKLB	Ribosomal modification protein rimK like family member B	0.6485	37
LIMS4	LIM zinc finger domain containing 4	0.6438	37
RIPK4	Receptor interacting serine/threonine kinase 4	0.6230	37
POU5F1	POU class 5 homeobox 1	0.6214	37
TNFSF15	TNF superfamily member 15	0.6049	37
SLC25A35	Solute carrier family 25 member 35	0.5917	37

IMMUNE CELLS

MRPS2 is part of cluster 5 Non-specific - Cell proliferation with confidenceⁱ 1
689 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NIPAL3	NIPA like domain containing 3	0.9762	5
PIGU	Phosphatidylinositol glycan anchor biosynthesis class U	0.9762	5
ILKAP	ILK associated serine/threonine phosphatase	0.9762	5
ZNF526	Zinc finger protein 526	0.9524	5
DDX20	DEAD-box helicase 20	0.9286	9
MSI2	Musashi RNA binding protein 2	0.9286	5
PSMA5	Proteasome 20S subunit alpha 5	0.9286	5
INTS14	Integrator complex subunit 14	0.9286	5
PCYOX1	Prenylcysteine oxidase 1	0.9286	5
SLC41A3	Solute carrier family 41 member 3	0.9286	5
PPP3CB	Protein phosphatase 3 catalytic subunit beta	0.9286	5
FXYD5	FXYD domain containing ion transport regulator 5	0.9286	5
REXO2	RNA exonuclease 2	0.9286	9
AIP	Aryl hydrocarbon receptor interacting protein	0.9048	5
CLCN3	Chloride voltage-gated channel 3	0.9048	5

Adipocytes	24.0 nTPM
Breast	29.2 nTPM
Adipose tissue	18.8 nTPM

Alveolar cells type 1	23.8 nTPM
Lung	23.8 nTPM

Alveolar cells type 2	30.2 nTPM
Lung	30.2 nTPM

Astrocytes	4.6 nTPM
Brain	4.6 nTPM

B-cells	24.1 nTPM
Kidney	57.2 nTPM
Liver	33.8 nTPM
Bone marrow	26.8 nTPM
Thymus	25.2 nTPM
PBMC	24.6 nTPM
Lung	22.8 nTPM
Spleen	22.7 nTPM
Stomach	21.9 nTPM
Salivary gland	21.2 nTPM
Skin	16.9 nTPM
Lymph node	15.5 nTPM
Adipose tissue	13.2 nTPM
Esophagus	11.8 nTPM

Ciliated cells	24.8 nTPM
Fallopian tube	38.6 nTPM
Endometrium	28.5 nTPM
Lung	18.9 nTPM
Bronchus	13.5 nTPM

Club cells	25.8 nTPM
Bronchus	26.4 nTPM
Lung	25.8 nTPM
Prostate	25.1 nTPM

Endothelial cells	28.0 nTPM
Pancreas	75.0 nTPM
Fallopian tube	48.0 nTPM
Placenta	34.1 nTPM
Tongue	32.4 nTPM
Ovary	29.5 nTPM
Testis	29.0 nTPM
Endometrium	28.3 nTPM
Thymus	27.8 nTPM
Breast	27.2 nTPM
Skin	23.9 nTPM
Lung	22.1 nTPM
Esophagus	22.0 nTPM
Liver	20.2 nTPM
Skeletal muscle	19.9 nTPM
Prostate	19.3 nTPM
Vascular	17.1 nTPM
Salivary gland	15.1 nTPM
Heart muscle	14.0 nTPM

Enteroendocrine cells	39.9 nTPM
Colon	63.7 nTPM
Rectum	31.9 nTPM
Small intestine	24.0 nTPM

Fibroblasts	27.8 nTPM
Pancreas	63.6 nTPM
Placenta	57.2 nTPM
Thymus	32.5 nTPM
Fallopian tube	29.6 nTPM
Breast	28.7 nTPM
Adipose tissue	27.6 nTPM
Lung	25.1 nTPM
Salivary gland	24.7 nTPM
Esophagus	24.0 nTPM
Stomach	23.1 nTPM
Skeletal muscle	22.0 nTPM
Vascular	21.8 nTPM
Skin	20.3 nTPM
Liver	19.0 nTPM
Prostate	16.5 nTPM
Heart muscle	9.3 nTPM

Granulocytes	16.0 nTPM
Fallopian tube	19.6 nTPM
Lung	18.7 nTPM
Tongue	9.7 nTPM

Intestinal goblet cells	30.2 nTPM
Rectum	39.9 nTPM
Colon	30.5 nTPM
Small intestine	20.1 nTPM

Lymphatic endothelial cells	28.6 nTPM
Fallopian tube	29.8 nTPM
Ovary	27.3 nTPM

Macrophages	17.7 nTPM
Pancreas	41.1 nTPM
Kidney	28.3 nTPM
Breast	22.3 nTPM
Lung	21.1 nTPM
Thymus	19.8 nTPM
Prostate	19.3 nTPM
Stomach	18.0 nTPM
Endometrium	17.8 nTPM
Spleen	17.0 nTPM
Testis	16.7 nTPM
Esophagus	16.7 nTPM
Tongue	15.4 nTPM
Bone marrow	13.2 nTPM
Skeletal muscle	12.9 nTPM
Adipose tissue	12.9 nTPM
Salivary gland	12.4 nTPM
Fallopian tube	12.1 nTPM
Vascular	11.5 nTPM
Skin	7.8 nTPM

Paneth cells	28.3 nTPM
Rectum	42.5 nTPM
Colon	21.7 nTPM
Small intestine	20.7 nTPM

Basal keratinocytes	43.2 nTPM
Skin	43.4 nTPM
Tongue	43.1 nTPM

Basal prostatic cells	26.5 nTPM
Prostate	26.5 nTPM

Basal respiratory cells	52.9 nTPM
Bronchus	52.9 nTPM

Basal squamous epithelial cells	41.0 nTPM
Esophagus	41.0 nTPM

Plasma cells	46.0 nTPM
Thymus	70.5 nTPM
Spleen	59.7 nTPM
Fallopian tube	58.5 nTPM
Bone marrow	54.4 nTPM
Liver	47.6 nTPM
Stomach	30.6 nTPM
Esophagus	26.0 nTPM
Salivary gland	20.6 nTPM

Schwann cells	15.8 nTPM
Adipose tissue	22.3 nTPM
Vascular	13.1 nTPM
Esophagus	12.0 nTPM

Serous glandular cells	22.8 nTPM
Tongue	26.5 nTPM
Salivary gland	19.1 nTPM

Smooth muscle cells	25.4 nTPM
Placenta	44.3 nTPM
Ovary	33.8 nTPM
Lung	32.9 nTPM
Breast	31.1 nTPM
Fallopian tube	30.8 nTPM
Endometrium	30.7 nTPM
Prostate	27.4 nTPM
Liver	25.0 nTPM
Thymus	23.6 nTPM
Skin	22.3 nTPM
Tongue	19.2 nTPM
Skeletal muscle	18.6 nTPM
Esophagus	18.0 nTPM
Adipose tissue	17.6 nTPM
Salivary gland	15.7 nTPM
Vascular	15.7 nTPM

Suprabasal keratinocytes	38.2 nTPM
Skin	44.2 nTPM
Tongue	32.2 nTPM

T-cells	19.5 nTPM
Kidney	28.4 nTPM
PBMC	27.5 nTPM
Liver	25.9 nTPM
Breast	23.4 nTPM
Thymus	22.9 nTPM
Lung	22.7 nTPM
Bone marrow	22.1 nTPM
Prostate	21.1 nTPM
Endometrium	20.2 nTPM
Salivary gland	19.5 nTPM
Fallopian tube	19.0 nTPM
Stomach	18.2 nTPM
Skin	17.9 nTPM
Skeletal muscle	17.8 nTPM
Lymph node	16.8 nTPM
Colon	16.6 nTPM
Adipose tissue	16.1 nTPM
Esophagus	14.6 nTPM
Tongue	13.8 nTPM
Spleen	13.4 nTPM
Vascular	11.7 nTPM

Undifferentiated cells	70.7 nTPM
Colon	96.9 nTPM
Small intestine	58.1 nTPM
Rectum	57.1 nTPM

Amygdala excitatory	5.5 nTPM
Basal ganglia	7.6 nTPM
Thalamus	5.4 nTPM
Hippocampus	5.3 nTPM
Amygdala	5.0 nTPM
Cerebral cortex	5.0 nTPM
Hypothalamus	4.4 nTPM

Astrocyte	9.6 nTPM
Cerebellum	12.0 nTPM
Cerebral cortex	11.6 nTPM
Medulla oblongata	10.9 nTPM
Midbrain	10.9 nTPM
Pons	10.8 nTPM
Thalamus	10.1 nTPM
Hippocampus	10.0 nTPM
Spinal cord	9.4 nTPM
Basal ganglia	8.7 nTPM
Hypothalamus	5.8 nTPM
Amygdala	5.2 nTPM

Bergmann glia	9.2 nTPM
Medulla oblongata	10.7 nTPM
Cerebellum	9.8 nTPM
Pons	7.2 nTPM

Central nervous system macrophage	5.3 nTPM
Spinal cord	7.1 nTPM
Medulla oblongata	6.8 nTPM
Cerebral cortex	6.0 nTPM
Hippocampus	5.7 nTPM
Thalamus	5.6 nTPM
Basal ganglia	5.4 nTPM
Midbrain	5.1 nTPM
Pons	5.0 nTPM
Cerebellum	4.4 nTPM
Hypothalamus	4.2 nTPM
Amygdala	3.1 nTPM

Cerebellar inhibitory	13.5 nTPM
Midbrain	16.5 nTPM
Cerebellum	15.1 nTPM
Pons	13.3 nTPM
Medulla oblongata	11.8 nTPM
Spinal cord	11.0 nTPM

Cge interneuron	10.2 nTPM
Midbrain	12.9 nTPM
Thalamus	11.3 nTPM
Basal ganglia	10.6 nTPM
Cerebral cortex	10.5 nTPM
Hippocampus	9.4 nTPM
Amygdala	8.5 nTPM
Hypothalamus	8.3 nTPM

Choroid plexus epithelial cell	9.4 nTPM
Hippocampus	11.1 nTPM
Thalamus	11.0 nTPM
Medulla oblongata	8.7 nTPM
Basal ganglia	6.9 nTPM

Committed oligodendrocyte precursor	10.3 nTPM
Spinal cord	22.1 nTPM
Pons	15.1 nTPM
Midbrain	13.4 nTPM
Hippocampus	9.8 nTPM
Medulla oblongata	9.0 nTPM
Cerebral cortex	8.2 nTPM
Cerebellum	7.9 nTPM
Thalamus	7.4 nTPM
Amygdala	7.3 nTPM
Basal ganglia	6.6 nTPM
Hypothalamus	6.1 nTPM

Deep-layer corticothalamic and 6b	7.2 nTPM
Midbrain	11.1 nTPM
Basal ganglia	7.5 nTPM
Hippocampus	6.4 nTPM
Cerebral cortex	6.3 nTPM
Amygdala	5.9 nTPM
Hypothalamus	5.9 nTPM

Deep-layer intratelencephalic	6.1 nTPM
Cerebral cortex	7.1 nTPM
Basal ganglia	6.7 nTPM
Hypothalamus	5.9 nTPM
Hippocampus	5.6 nTPM
Amygdala	5.2 nTPM

Deep-layer near-projecting	8.7 nTPM
Cerebral cortex	9.8 nTPM
Amygdala	9.5 nTPM
Hippocampus	9.1 nTPM
Basal ganglia	8.4 nTPM
Hypothalamus	6.6 nTPM

Eccentric medium spiny neuron	7.7 nTPM
Hypothalamus	9.1 nTPM
Basal ganglia	8.2 nTPM
Cerebral cortex	7.7 nTPM
Thalamus	7.6 nTPM
Hippocampus	7.5 nTPM
Amygdala	5.9 nTPM

Endothelial cell	10.5 nTPM
Medulla oblongata	21.5 nTPM
Midbrain	14.2 nTPM
Cerebellum	13.9 nTPM
Cerebral cortex	12.8 nTPM
Hippocampus	11.9 nTPM
Pons	11.9 nTPM
Thalamus	10.2 nTPM
Amygdala	6.7 nTPM
Hypothalamus	6.2 nTPM
Spinal cord	3.5 nTPM
Basal ganglia	2.8 nTPM