Single cell type - SLC17A5 - The Human Protein Atlas

SLC17A5

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SLC17A5
Gene descriptionⁱ Full gene name according to HGNC.	Solute carrier family 17 member 5
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes Metabolic proteins Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Intestinal goblet cells - Mucin production (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.33
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

SLC17A5 is part of cluster 16 Intestinal goblet cells - Mucin production with confidenceⁱ 1
268 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CD164	CD164 molecule	0.5527	58
RNF185	Ring finger protein 185	0.5157	16
LRRC26	Leucine rich repeat containing 26	0.5058	16
PLA2G15	Phospholipase A2 group XV	0.5028	58
ELAPOR1	Endosome-lysosome associated apoptosis and autophagy regulator 1	0.4781	75
SLC31A1	Solute carrier family 31 member 1	0.4779	58
SMCO4	Single-pass membrane protein with coiled-coil domains 4	0.4724	75
DOP1B	DOP1 leucine zipper like protein B	0.4683	16
ACP2	Acid phosphatase 2, lysosomal	0.4682	58
RBM47	RNA binding motif protein 47	0.4667	75
NCEH1	Neutral cholesterol ester hydrolase 1	0.4665	58
SOAT1	Sterol O-acyltransferase 1	0.4612	58
PRRC1	Proline rich coiled-coil 1	0.4589	77
FFAR4	Free fatty acid receptor 4	0.4546	16
CLDN8	Claudin 8	0.4362	17

IMMUNE CELLS

SLC17A5 is part of cluster 13 Non-specific - Mitochondria with confidenceⁱ 0.65
458 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GTF2H3	General transcription factor IIH subunit 3	0.9048	33
ZNF527	Zinc finger protein 527	0.8810	13
OLA1	Obg like ATPase 1	0.8810	13
HUS1	HUS1 checkpoint clamp component	0.8810	13
ANKHD1-EIF4EBP3	ANKHD1-EIF4EBP3 readthrough	0.8571	2
TMEM101	Transmembrane protein 101	0.8571	13
FKBP5	FKBP prolyl isomerase 5	0.8571	33
GYS1	Glycogen synthase 1	0.8571	13
DYNLRB2	Dynein light chain roadblock-type 2	0.8571	30
NONO	Non-POU domain containing octamer binding	0.8571	13
GMDS	GDP-mannose 4,6-dehydratase	0.8333	33
MAP2K5	Mitogen-activated protein kinase kinase 5	0.8333	33
SEC61A2	SEC61 translocon subunit alpha 2	0.8333	33
BRAT1	BRCA1 associated ATM activator 1	0.8333	33
PSMA1	Proteasome 20S subunit alpha 1	0.8095	13

Adipocytes	9.0 nTPM
Breast	9.5 nTPM
Adipose tissue	8.5 nTPM

Alveolar cells type 1	22.4 nTPM
Lung	22.4 nTPM

Alveolar cells type 2	20.6 nTPM
Lung	20.6 nTPM

Astrocytes	15.5 nTPM
Brain	15.5 nTPM

B-cells	8.8 nTPM
Lung	14.8 nTPM
Esophagus	11.8 nTPM
Spleen	11.2 nTPM
Kidney	10.4 nTPM
Lymph node	9.8 nTPM
Liver	9.7 nTPM
PBMC	9.2 nTPM
Salivary gland	8.7 nTPM
Adipose tissue	8.6 nTPM
Thymus	7.7 nTPM
Stomach	5.9 nTPM
Bone marrow	5.6 nTPM
Skin	1.7 nTPM

Ciliated cells	14.7 nTPM
Bronchus	22.6 nTPM
Lung	15.4 nTPM
Endometrium	15.0 nTPM
Fallopian tube	5.9 nTPM

Club cells	21.8 nTPM
Prostate	27.4 nTPM
Bronchus	24.1 nTPM
Lung	13.9 nTPM

Dendritic cells	15.5 nTPM
Adipose tissue	20.3 nTPM
PBMC	10.8 nTPM

Endothelial cells	11.3 nTPM
Liver	23.9 nTPM
Skin	14.4 nTPM
Lung	14.4 nTPM
Prostate	13.7 nTPM
Salivary gland	13.7 nTPM
Esophagus	13.4 nTPM
Thymus	12.6 nTPM
Vascular	11.3 nTPM
Skeletal muscle	11.1 nTPM
Testis	10.7 nTPM
Tongue	10.1 nTPM
Heart muscle	9.7 nTPM
Endometrium	9.5 nTPM
Placenta	9.1 nTPM
Fallopian tube	7.8 nTPM
Ovary	7.0 nTPM
Breast	6.2 nTPM
Pancreas	5.2 nTPM

Enteroendocrine cells	11.8 nTPM
Colon	15.0 nTPM
Small intestine	10.3 nTPM
Rectum	10.1 nTPM

Fibroblasts	26.0 nTPM
Placenta	54.4 nTPM
Heart muscle	42.3 nTPM
Liver	35.6 nTPM
Skin	34.8 nTPM
Adipose tissue	30.3 nTPM
Esophagus	30.1 nTPM
Skeletal muscle	29.9 nTPM
Vascular	24.7 nTPM
Salivary gland	21.8 nTPM
Thymus	21.8 nTPM
Breast	21.8 nTPM
Stomach	21.6 nTPM
Lung	16.6 nTPM
Prostate	11.9 nTPM
Fallopian tube	10.4 nTPM
Pancreas	8.5 nTPM

Granulocytes	5.2 nTPM
Lung	11.1 nTPM
Fallopian tube	4.6 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	55.5 nTPM
Small intestine	79.3 nTPM
Rectum	54.1 nTPM
Colon	33.0 nTPM

Lymphatic endothelial cells	8.9 nTPM
Fallopian tube	12.4 nTPM
Ovary	5.5 nTPM

Macrophages	26.1 nTPM
Skin	57.9 nTPM
Lung	50.0 nTPM
Vascular	39.6 nTPM
Salivary gland	37.4 nTPM
Thymus	32.1 nTPM
Prostate	26.7 nTPM
Esophagus	25.7 nTPM
Pancreas	24.7 nTPM
Fallopian tube	24.7 nTPM
Testis	24.2 nTPM
Adipose tissue	22.0 nTPM
Spleen	21.1 nTPM
Kidney	20.4 nTPM
Skeletal muscle	19.4 nTPM
Tongue	18.2 nTPM
Stomach	18.0 nTPM
Bone marrow	14.2 nTPM
Breast	11.0 nTPM
Endometrium	9.2 nTPM

Basal keratinocytes	6.7 nTPM
Skin	8.1 nTPM
Tongue	5.3 nTPM

Basal prostatic cells	26.2 nTPM
Prostate	26.2 nTPM

Basal respiratory cells	13.1 nTPM
Bronchus	13.1 nTPM

Basal squamous epithelial cells	7.5 nTPM
Esophagus	7.5 nTPM

Paneth cells	10.8 nTPM
Rectum	18.2 nTPM
Colon	7.2 nTPM
Small intestine	6.9 nTPM

Plasma cells	19.8 nTPM
Stomach	38.1 nTPM
Salivary gland	25.1 nTPM
Fallopian tube	23.5 nTPM
Spleen	17.6 nTPM
Bone marrow	16.6 nTPM
Esophagus	15.6 nTPM
Thymus	12.9 nTPM
Liver	9.0 nTPM

Schwann cells	5.8 nTPM
Vascular	9.9 nTPM
Adipose tissue	7.4 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	49.7 nTPM
Salivary gland	77.4 nTPM
Tongue	22.1 nTPM

Smooth muscle cells	12.9 nTPM
Salivary gland	30.0 nTPM
Liver	20.8 nTPM
Lung	20.0 nTPM
Placenta	15.6 nTPM
Tongue	15.6 nTPM
Vascular	14.5 nTPM
Thymus	13.5 nTPM
Endometrium	10.3 nTPM
Prostate	10.3 nTPM
Adipose tissue	10.2 nTPM
Skeletal muscle	10.0 nTPM
Skin	9.6 nTPM
Breast	9.3 nTPM
Ovary	6.9 nTPM
Fallopian tube	6.0 nTPM
Esophagus	3.6 nTPM

Suprabasal keratinocytes	10.9 nTPM
Tongue	11.5 nTPM
Skin	10.3 nTPM

T-cells	11.0 nTPM
Skin	19.3 nTPM
Lymph node	14.7 nTPM
Spleen	14.2 nTPM
Kidney	13.3 nTPM
Bone marrow	12.3 nTPM
Stomach	12.2 nTPM
Thymus	12.1 nTPM
Vascular	11.7 nTPM
Liver	11.4 nTPM
Tongue	11.4 nTPM
Prostate	11.1 nTPM
Salivary gland	11.0 nTPM
Skeletal muscle	9.8 nTPM
Adipose tissue	9.8 nTPM
PBMC	9.7 nTPM
Esophagus	9.7 nTPM
Lung	8.4 nTPM
Breast	7.9 nTPM
Colon	7.8 nTPM
Fallopian tube	7.8 nTPM
Endometrium	6.0 nTPM

Undifferentiated cells	14.4 nTPM
Small intestine	16.0 nTPM
Colon	13.7 nTPM
Rectum	13.6 nTPM

Amygdala excitatory	74.3 nTPM
Cerebral cortex	90.1 nTPM
Hypothalamus	84.7 nTPM
Amygdala	83.5 nTPM
Hippocampus	78.0 nTPM
Basal ganglia	67.1 nTPM
Thalamus	42.2 nTPM

Astrocyte	37.5 nTPM
Hypothalamus	70.9 nTPM
Thalamus	40.9 nTPM
Medulla oblongata	37.2 nTPM
Midbrain	36.6 nTPM
Basal ganglia	36.0 nTPM
Cerebellum	33.1 nTPM
Cerebral cortex	33.1 nTPM
Pons	32.5 nTPM
Hippocampus	32.1 nTPM
Amygdala	31.8 nTPM
Spinal cord	28.2 nTPM

Bergmann glia	58.9 nTPM
Medulla oblongata	87.4 nTPM
Cerebellum	51.9 nTPM
Pons	37.4 nTPM

Central nervous system macrophage	62.6 nTPM
Amygdala	69.9 nTPM
Cerebellum	66.5 nTPM
Spinal cord	64.5 nTPM
Midbrain	63.3 nTPM
Thalamus	63.1 nTPM
Cerebral cortex	62.5 nTPM
Basal ganglia	61.9 nTPM
Pons	61.9 nTPM
Hippocampus	61.2 nTPM
Hypothalamus	59.8 nTPM
Medulla oblongata	53.6 nTPM

Cerebellar inhibitory	59.8 nTPM
Pons	69.1 nTPM
Cerebellum	62.3 nTPM
Medulla oblongata	61.1 nTPM
Midbrain	54.1 nTPM
Spinal cord	52.2 nTPM

Cge interneuron	48.6 nTPM
Hypothalamus	57.7 nTPM
Cerebral cortex	51.9 nTPM
Amygdala	51.1 nTPM
Hippocampus	49.3 nTPM
Basal ganglia	47.8 nTPM
Thalamus	42.2 nTPM
Midbrain	40.4 nTPM

Choroid plexus epithelial cell	20.4 nTPM
Basal ganglia	36.8 nTPM
Medulla oblongata	20.0 nTPM
Hippocampus	16.6 nTPM
Thalamus	8.2 nTPM

Committed oligodendrocyte precursor	33.2 nTPM
Midbrain	46.2 nTPM
Amygdala	41.7 nTPM
Thalamus	41.4 nTPM
Hippocampus	36.5 nTPM
Cerebellum	31.7 nTPM
Cerebral cortex	31.7 nTPM
Medulla oblongata	31.0 nTPM
Hypothalamus	30.7 nTPM
Pons	28.3 nTPM
Basal ganglia	27.4 nTPM
Spinal cord	18.4 nTPM

Deep-layer corticothalamic and 6b	54.4 nTPM
Hippocampus	64.3 nTPM
Hypothalamus	61.8 nTPM
Cerebral cortex	57.3 nTPM
Basal ganglia	52.7 nTPM
Amygdala	51.7 nTPM
Midbrain	38.8 nTPM

Deep-layer intratelencephalic	54.4 nTPM
Amygdala	62.7 nTPM
Cerebral cortex	55.8 nTPM
Hypothalamus	55.4 nTPM
Basal ganglia	49.6 nTPM
Hippocampus	48.6 nTPM

Deep-layer near-projecting	66.4 nTPM
Cerebral cortex	72.1 nTPM
Amygdala	69.6 nTPM
Hypothalamus	67.0 nTPM
Hippocampus	61.8 nTPM
Basal ganglia	61.7 nTPM

Eccentric medium spiny neuron	59.3 nTPM
Amygdala	61.6 nTPM
Basal ganglia	60.7 nTPM
Cerebral cortex	60.4 nTPM
Hypothalamus	60.0 nTPM
Thalamus	58.1 nTPM
Hippocampus	54.7 nTPM