Single cell type - GNPAT - The Human Protein Atlas

GNPAT

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GNPAT
Gene descriptionⁱ Full gene name according to HGNC.	Glyceronephosphate O-acyltransferase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Late spermatids - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Late spermatids)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.34
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Late spermatids)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

GNPAT is part of cluster 36 Late spermatids - Unknown function with confidenceⁱ 1
427 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HIF1AN	Hypoxia inducible factor 1 subunit alpha inhibitor	0.6177	36
PTPMT1	Protein tyrosine phosphatase mitochondrial 1	0.5662	36
CPT1B	Carnitine palmitoyltransferase 1B	0.5157	36
CUL4A	Cullin 4A	0.4917	36
PSMF1	Proteasome inhibitor subunit 1	0.4883	36
FLAD1	Flavin adenine dinucleotide synthetase 1	0.4786	15
DUSP18	Dual specificity phosphatase 18	0.4765	36
DHX57	DExH-box helicase 57	0.4764	36
ELOF1	Elongation factor 1	0.4747	36
PTDSS2	Phosphatidylserine synthase 2	0.4736	36
FIBP	FGF1 intracellular binding protein	0.4696	15
OXA1L	OXA1L mitochondrial inner membrane protein	0.4681	39
DUS4L	Dihydrouridine synthase 4 like	0.4664	39
METTL22	Methyltransferase 22, Kin17 lysine	0.4653	36
TMEM102	Transmembrane protein 102	0.4632	45

IMMUNE CELLS

GNPAT is part of cluster 12 Non-specific - Mitochondrial translation with confidenceⁱ 0.61
566 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
AURKA	Aurora kinase A	0.9762	25
ARHGAP4	Rho GTPase activating protein 4	0.9762	25
DPP3	Dipeptidyl peptidase 3	0.9762	12
ATP13A1	ATPase 13A1	0.9524	25
MLH1	MutL homolog 1	0.9524	25
PDCL3	Phosducin like 3	0.9524	12
EEFSEC	Eukaryotic elongation factor, selenocysteine-tRNA specific	0.9524	25
EFCAB11	EF-hand calcium binding domain 11	0.9524	25
HAUS7	HAUS augmin like complex subunit 7	0.9524	25
NOC2L	NOC2 like nucleolar associated transcriptional repressor	0.9524	12
MEMO1	Mediator of cell motility 1	0.9524	25
PMVK	Phosphomevalonate kinase	0.9524	12
CHCHD4	Coiled-coil-helix-coiled-coil-helix domain containing 4	0.9524	12
SEPTIN9	Septin 9	0.9524	12
BOP1	BOP1 ribosomal biogenesis factor	0.9286	25

Adipocytes	17.0 nTPM
Breast	18.0 nTPM
Adipose tissue	16.0 nTPM

Alveolar cells type 1	29.8 nTPM
Lung	29.8 nTPM

Alveolar cells type 2	24.5 nTPM
Lung	24.5 nTPM

Astrocytes	18.9 nTPM
Brain	18.9 nTPM

B-cells	28.1 nTPM
Kidney	41.6 nTPM
PBMC	40.0 nTPM
Liver	38.6 nTPM
Bone marrow	34.9 nTPM
Lung	34.9 nTPM
Thymus	34.8 nTPM
Stomach	32.5 nTPM
Spleen	26.4 nTPM
Lymph node	24.7 nTPM
Salivary gland	23.1 nTPM
Adipose tissue	16.0 nTPM
Skin	11.9 nTPM
Esophagus	5.9 nTPM

Ciliated cells	26.2 nTPM
Lung	30.8 nTPM
Fallopian tube	28.9 nTPM
Bronchus	24.2 nTPM
Endometrium	20.8 nTPM

Club cells	22.3 nTPM
Bronchus	23.3 nTPM
Prostate	21.9 nTPM
Lung	21.7 nTPM

Endothelial cells	21.4 nTPM
Heart muscle	42.6 nTPM
Ovary	31.8 nTPM
Placenta	31.2 nTPM
Testis	30.2 nTPM
Pancreas	28.4 nTPM
Breast	21.1 nTPM
Lung	20.2 nTPM
Skeletal muscle	19.2 nTPM
Salivary gland	18.4 nTPM
Thymus	18.0 nTPM
Esophagus	17.7 nTPM
Vascular	17.3 nTPM
Tongue	17.2 nTPM
Endometrium	15.7 nTPM
Prostate	15.2 nTPM
Liver	15.1 nTPM
Fallopian tube	13.2 nTPM
Skin	13.0 nTPM

Enteroendocrine cells	26.0 nTPM
Colon	28.8 nTPM
Rectum	28.5 nTPM
Small intestine	20.6 nTPM

Fibroblasts	19.0 nTPM
Pancreas	34.5 nTPM
Placenta	26.5 nTPM
Heart muscle	26.3 nTPM
Liver	20.2 nTPM
Vascular	19.9 nTPM
Prostate	19.8 nTPM
Thymus	18.2 nTPM
Lung	18.1 nTPM
Adipose tissue	17.4 nTPM
Stomach	17.3 nTPM
Skeletal muscle	16.1 nTPM
Salivary gland	16.0 nTPM
Esophagus	15.8 nTPM
Skin	14.4 nTPM
Breast	13.4 nTPM
Fallopian tube	10.8 nTPM

Granulocytes	13.4 nTPM
Lung	23.2 nTPM
Fallopian tube	12.3 nTPM
Tongue	4.9 nTPM

Intestinal goblet cells	22.6 nTPM
Small intestine	27.7 nTPM
Rectum	21.4 nTPM
Colon	18.7 nTPM

Lymphatic endothelial cells	34.6 nTPM
Ovary	49.1 nTPM
Fallopian tube	20.1 nTPM

Macrophages	21.2 nTPM
Testis	47.1 nTPM
Kidney	32.7 nTPM
Spleen	31.1 nTPM
Lung	27.3 nTPM
Vascular	23.1 nTPM
Pancreas	22.6 nTPM
Thymus	22.0 nTPM
Salivary gland	19.8 nTPM
Prostate	18.3 nTPM
Bone marrow	18.2 nTPM
Skeletal muscle	17.8 nTPM
Tongue	17.3 nTPM
Skin	16.7 nTPM
Endometrium	15.4 nTPM
Stomach	15.4 nTPM
Adipose tissue	15.2 nTPM
Fallopian tube	14.7 nTPM
Esophagus	14.1 nTPM
Breast	14.1 nTPM

Paneth cells	37.9 nTPM
Rectum	43.2 nTPM
Small intestine	38.0 nTPM
Colon	32.6 nTPM

Basal keratinocytes	15.3 nTPM
Tongue	19.1 nTPM
Skin	11.6 nTPM

Basal prostatic cells	14.9 nTPM
Prostate	14.9 nTPM

Basal respiratory cells	22.2 nTPM
Bronchus	22.2 nTPM

Basal squamous epithelial cells	16.2 nTPM
Esophagus	16.2 nTPM

Plasma cells	27.7 nTPM
Bone marrow	42.3 nTPM
Thymus	32.9 nTPM
Stomach	30.6 nTPM
Liver	30.0 nTPM
Spleen	29.8 nTPM
Esophagus	26.0 nTPM
Salivary gland	15.2 nTPM
Fallopian tube	14.5 nTPM

Schwann cells	15.5 nTPM
Vascular	29.8 nTPM
Adipose tissue	16.8 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	18.6 nTPM
Salivary gland	28.4 nTPM
Tongue	8.8 nTPM

Smooth muscle cells	20.9 nTPM
Ovary	27.7 nTPM
Placenta	26.9 nTPM
Vascular	25.7 nTPM
Thymus	25.3 nTPM
Salivary gland	21.7 nTPM
Liver	21.2 nTPM
Lung	21.2 nTPM
Adipose tissue	20.7 nTPM
Skin	20.6 nTPM
Skeletal muscle	20.3 nTPM
Esophagus	19.2 nTPM
Tongue	18.6 nTPM
Fallopian tube	18.6 nTPM
Breast	17.1 nTPM
Endometrium	15.5 nTPM
Prostate	14.0 nTPM

Suprabasal keratinocytes	18.8 nTPM
Tongue	22.8 nTPM
Skin	14.8 nTPM

T-cells	23.0 nTPM
PBMC	34.7 nTPM
Lung	33.9 nTPM
Liver	33.4 nTPM
Kidney	30.1 nTPM
Bone marrow	29.9 nTPM
Thymus	28.9 nTPM
Spleen	25.2 nTPM
Stomach	25.1 nTPM
Skin	23.5 nTPM
Tongue	22.0 nTPM
Prostate	21.8 nTPM
Colon	19.5 nTPM
Lymph node	19.4 nTPM
Skeletal muscle	19.3 nTPM
Adipose tissue	19.0 nTPM
Vascular	18.9 nTPM
Salivary gland	18.1 nTPM
Breast	15.6 nTPM
Endometrium	15.4 nTPM
Fallopian tube	14.7 nTPM
Esophagus	14.6 nTPM

Undifferentiated cells	33.1 nTPM
Small intestine	39.2 nTPM
Rectum	30.4 nTPM
Colon	29.8 nTPM

Amygdala excitatory	23.9 nTPM
Hippocampus	29.0 nTPM
Cerebral cortex	25.8 nTPM
Amygdala	25.1 nTPM
Basal ganglia	23.3 nTPM
Hypothalamus	21.5 nTPM
Thalamus	19.1 nTPM

Astrocyte	34.5 nTPM
Hippocampus	40.1 nTPM
Amygdala	39.2 nTPM
Cerebral cortex	37.2 nTPM
Midbrain	36.4 nTPM
Thalamus	34.9 nTPM
Basal ganglia	33.6 nTPM
Pons	33.0 nTPM
Medulla oblongata	31.9 nTPM
Cerebellum	31.8 nTPM
Hypothalamus	30.7 nTPM
Spinal cord	30.7 nTPM

Bergmann glia	38.3 nTPM
Cerebellum	44.3 nTPM
Medulla oblongata	36.2 nTPM
Pons	34.5 nTPM

Central nervous system macrophage	59.6 nTPM
Amygdala	73.6 nTPM
Hippocampus	63.1 nTPM
Midbrain	62.8 nTPM
Cerebellum	61.7 nTPM
Cerebral cortex	61.3 nTPM
Pons	58.8 nTPM
Thalamus	58.3 nTPM
Basal ganglia	56.8 nTPM
Spinal cord	53.9 nTPM
Medulla oblongata	53.2 nTPM
Hypothalamus	51.8 nTPM

Cerebellar inhibitory	28.7 nTPM
Spinal cord	33.0 nTPM
Cerebellum	28.9 nTPM
Midbrain	28.9 nTPM
Pons	27.3 nTPM
Medulla oblongata	25.4 nTPM

Cge interneuron	26.3 nTPM
Midbrain	28.2 nTPM
Thalamus	28.1 nTPM
Basal ganglia	27.2 nTPM
Cerebral cortex	27.2 nTPM
Amygdala	26.6 nTPM
Hippocampus	25.4 nTPM
Hypothalamus	21.7 nTPM

Choroid plexus epithelial cell	43.5 nTPM
Basal ganglia	58.3 nTPM
Thalamus	52.1 nTPM
Medulla oblongata	38.7 nTPM
Hippocampus	25.0 nTPM

Committed oligodendrocyte precursor	38.1 nTPM
Hippocampus	54.6 nTPM
Cerebral cortex	53.8 nTPM
Midbrain	46.2 nTPM
Thalamus	40.5 nTPM
Cerebellum	39.6 nTPM
Hypothalamus	38.9 nTPM
Basal ganglia	34.5 nTPM
Amygdala	31.6 nTPM
Spinal cord	29.4 nTPM
Pons	29.2 nTPM
Medulla oblongata	20.7 nTPM

Deep-layer corticothalamic and 6b	27.9 nTPM
Midbrain	39.9 nTPM
Cerebral cortex	29.0 nTPM
Hippocampus	28.5 nTPM
Basal ganglia	27.0 nTPM
Amygdala	24.2 nTPM
Hypothalamus	19.0 nTPM

Deep-layer intratelencephalic	22.9 nTPM
Cerebral cortex	26.2 nTPM
Hippocampus	25.0 nTPM
Basal ganglia	24.3 nTPM
Amygdala	22.8 nTPM
Hypothalamus	16.5 nTPM

Deep-layer near-projecting	26.5 nTPM
Cerebral cortex	31.0 nTPM
Basal ganglia	30.4 nTPM
Amygdala	28.2 nTPM
Hypothalamus	22.3 nTPM
Hippocampus	20.8 nTPM

Eccentric medium spiny neuron	24.5 nTPM
Hippocampus	28.2 nTPM
Thalamus	26.9 nTPM
Hypothalamus	24.1 nTPM
Basal ganglia	23.2 nTPM
Amygdala	22.3 nTPM
Cerebral cortex	22.3 nTPM

Endothelial cell	49.1 nTPM
Amygdala	73.8 nTPM
Cerebral cortex	72.9 nTPM
Midbrain	56.7 nTPM
Hippocampus	53.5 nTPM
Basal ganglia	50.3 nTPM
Thalamus	48.6 nTPM
Spinal cord	46.6 nTPM
Cerebellum	42.6 nTPM
Medulla oblongata	39.0 nTPM
Pons	31.8 nTPM
Hypothalamus	24.8 nTPM