Single cell type - CRYZ - The Human Protein Atlas

CRYZ

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CRYZ
Gene descriptionⁱ Full gene name according to HGNC.	Crystallin zeta
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Enzymes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Proximal tubular cells - Transmembrane transport (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Proximal tubular cells, Distal tubular cells, Hepatocytes, Oocytes, Collecting duct cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.59
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Choroid plexus epithelial cell)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Proximal tubular cells, Distal tubular cells, Hepatocytes, Oocytes, Collecting duct cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Choroid plexus epithelial cell)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

CRYZ is part of cluster 38 Proximal tubular cells - Transmembrane transport with confidenceⁱ 1
131 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CCDC198	Coiled-coil domain containing 198	0.8468	38
HOGA1	4-hydroxy-2-oxoglutarate aldolase 1	0.8414	38
CLTRN	Collectrin, amino acid transport regulator	0.8261	38
SLC17A3	Solute carrier family 17 member 3	0.8244	38
PRODH2	Proline dehydrogenase 2	0.8234	38
NAT8	N-acetyltransferase 8 (putative)	0.8213	38
SLC22A12	Solute carrier family 22 member 12	0.8161	38
SLC22A2	Solute carrier family 22 member 2	0.8161	38
CLEC18C	C-type lectin domain family 18 member C	0.8136	38
DNMT3L	DNA methyltransferase 3 like	0.8091	56
FXYD2	FXYD domain containing ion transport regulator 2	0.8078	38
SLC6A13	Solute carrier family 6 member 13	0.8077	56
SLC22A6	Solute carrier family 22 member 6	0.8074	38
UGT2B7	UDP glucuronosyltransferase family 2 member B7	0.8062	38
SLC13A1	Solute carrier family 13 member 1	0.8031	38

IMMUNE CELLS

CRYZ is part of cluster 16 Non-specific - Cell proliferation with confidenceⁱ 1
161 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HOXB7	Homeobox B7	1.0000	16
ENSG00000249240	Novel protein	0.9762	16
APOBEC3D	Apolipoprotein B mRNA editing enzyme catalytic subunit 3D	0.9762	16
DBT	Dihydrolipoamide branched chain transacylase E2	0.9762	24
MCM10	Minichromosome maintenance 10 replication initiation factor	0.9524	16
SMIM35	Small integral membrane protein 35	0.9524	16
EFCAB7	EF-hand calcium binding domain 7	0.9524	16
P2RY8	P2Y receptor family member 8	0.9524	24
RHEBL1	RHEB like 1	0.9524	16
ALDH18A1	Aldehyde dehydrogenase 18 family member A1	0.9524	24
DLGAP5	DLG associated protein 5	0.9286	16
TROAP	Trophinin associated protein	0.9286	16
CD70	CD70 molecule	0.9286	16
GTSF1L	Gametocyte specific factor 1 like	0.9286	16
POLE2	DNA polymerase epsilon 2, accessory subunit	0.9286	16

Adipocytes	6.7 nTPM
Breast	7.4 nTPM
Adipose tissue	5.9 nTPM

Alveolar cells type 1	13.3 nTPM
Lung	13.3 nTPM

Alveolar cells type 2	10.4 nTPM
Lung	10.4 nTPM

Astrocytes	4.6 nTPM
Brain	4.6 nTPM

B-cells	18.3 nTPM
Kidney	36.4 nTPM
Bone marrow	30.6 nTPM
Esophagus	29.5 nTPM
Spleen	27.5 nTPM
Liver	24.2 nTPM
Lymph node	21.3 nTPM
Stomach	18.1 nTPM
Skin	10.2 nTPM
PBMC	9.2 nTPM
Thymus	8.6 nTPM
Salivary gland	7.9 nTPM
Adipose tissue	7.0 nTPM
Lung	6.7 nTPM

Ciliated cells	32.7 nTPM
Fallopian tube	54.8 nTPM
Endometrium	51.8 nTPM
Bronchus	12.7 nTPM
Lung	11.5 nTPM

Club cells	10.1 nTPM
Bronchus	15.4 nTPM
Prostate	9.0 nTPM
Lung	5.8 nTPM

Endothelial cells	7.3 nTPM
Heart muscle	15.9 nTPM
Esophagus	12.5 nTPM
Ovary	11.0 nTPM
Testis	9.8 nTPM
Placenta	9.1 nTPM
Liver	8.8 nTPM
Breast	8.8 nTPM
Prostate	8.4 nTPM
Skin	7.8 nTPM
Fallopian tube	5.9 nTPM
Skeletal muscle	5.7 nTPM
Pancreas	5.2 nTPM
Endometrium	4.9 nTPM
Tongue	4.1 nTPM
Vascular	3.8 nTPM
Thymus	3.7 nTPM
Lung	3.0 nTPM
Salivary gland	3.0 nTPM

Enteroendocrine cells	16.0 nTPM
Small intestine	20.6 nTPM
Colon	14.1 nTPM
Rectum	13.4 nTPM

Fibroblasts	18.6 nTPM
Placenta	56.4 nTPM
Heart muscle	43.1 nTPM
Esophagus	28.7 nTPM
Stomach	25.9 nTPM
Skin	24.9 nTPM
Pancreas	17.2 nTPM
Adipose tissue	15.9 nTPM
Prostate	15.8 nTPM
Skeletal muscle	15.0 nTPM
Breast	13.3 nTPM
Fallopian tube	11.5 nTPM
Liver	9.5 nTPM
Thymus	7.1 nTPM
Salivary gland	4.5 nTPM
Lung	4.4 nTPM
Vascular	4.4 nTPM

Granulocytes	12.9 nTPM
Lung	15.1 nTPM
Fallopian tube	14.0 nTPM
Tongue	9.7 nTPM

Intestinal goblet cells	8.9 nTPM
Rectum	12.4 nTPM
Colon	7.6 nTPM
Small intestine	6.7 nTPM

Lymphatic endothelial cells	8.9 nTPM
Fallopian tube	12.3 nTPM
Ovary	5.5 nTPM

Macrophages	9.2 nTPM
Kidney	34.5 nTPM
Esophagus	15.4 nTPM
Bone marrow	13.2 nTPM
Skin	12.3 nTPM
Pancreas	10.3 nTPM
Spleen	10.0 nTPM
Endometrium	9.2 nTPM
Testis	8.1 nTPM
Stomach	7.7 nTPM
Vascular	6.9 nTPM
Breast	6.6 nTPM
Adipose tissue	6.1 nTPM
Fallopian tube	6.0 nTPM
Lung	5.6 nTPM
Prostate	5.3 nTPM
Thymus	5.1 nTPM
Salivary gland	4.5 nTPM
Tongue	4.0 nTPM
Skeletal muscle	3.2 nTPM

Paneth cells	18.1 nTPM
Small intestine	38.0 nTPM
Rectum	9.0 nTPM
Colon	7.2 nTPM

Basal prostatic cells	28.6 nTPM
Prostate	28.6 nTPM

Basal respiratory cells	29.4 nTPM
Bronchus	29.4 nTPM

Bipolar cells	4.3 nTPM
Eye	4.3 nTPM

Cholangiocytes	83.9 nTPM
Liver	83.9 nTPM

Plasma cells	15.4 nTPM
Spleen	26.9 nTPM
Stomach	23.9 nTPM
Esophagus	20.8 nTPM
Bone marrow	18.1 nTPM
Liver	15.5 nTPM
Fallopian tube	9.3 nTPM
Thymus	6.3 nTPM
Salivary gland	2.7 nTPM

Schwann cells	7.4 nTPM
Esophagus	12.0 nTPM
Vascular	5.2 nTPM
Adipose tissue	5.1 nTPM

Serous glandular cells	3.6 nTPM
Salivary gland	7.2 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	13.0 nTPM
Esophagus	20.4 nTPM
Fallopian tube	19.9 nTPM
Prostate	18.2 nTPM
Skin	17.9 nTPM
Placenta	17.6 nTPM
Ovary	15.2 nTPM
Liver	13.6 nTPM
Skeletal muscle	12.5 nTPM
Adipose tissue	12.5 nTPM
Breast	12.0 nTPM
Thymus	11.5 nTPM
Tongue	9.0 nTPM
Vascular	8.3 nTPM
Endometrium	7.0 nTPM
Salivary gland	6.4 nTPM
Lung	5.9 nTPM

Suprabasal keratinocytes	13.3 nTPM
Skin	21.4 nTPM
Tongue	5.1 nTPM

T-cells	14.4 nTPM
Kidney	40.8 nTPM
Esophagus	34.1 nTPM
Bone marrow	25.9 nTPM
Spleen	25.8 nTPM
Stomach	21.3 nTPM
Liver	18.5 nTPM
Lymph node	18.3 nTPM
Skin	17.2 nTPM
Prostate	14.8 nTPM
Endometrium	11.4 nTPM
Fallopian tube	11.0 nTPM
PBMC	9.9 nTPM
Colon	8.8 nTPM
Breast	7.9 nTPM
Skeletal muscle	7.2 nTPM
Adipose tissue	7.0 nTPM
Thymus	5.9 nTPM
Tongue	5.2 nTPM
Salivary gland	5.0 nTPM
Vascular	3.6 nTPM
Lung	3.1 nTPM

Undifferentiated cells	16.3 nTPM
Small intestine	25.7 nTPM
Colon	12.1 nTPM
Rectum	11.1 nTPM

Amygdala excitatory	8.2 nTPM
Hypothalamus	10.9 nTPM
Amygdala	10.5 nTPM
Basal ganglia	10.2 nTPM
Thalamus	6.8 nTPM
Hippocampus	5.8 nTPM
Cerebral cortex	4.8 nTPM

Astrocyte	11.0 nTPM
Amygdala	14.2 nTPM
Basal ganglia	11.9 nTPM
Hypothalamus	11.5 nTPM
Hippocampus	11.4 nTPM
Thalamus	11.0 nTPM
Midbrain	10.9 nTPM
Spinal cord	10.9 nTPM
Cerebral cortex	10.6 nTPM
Pons	9.9 nTPM
Cerebellum	9.4 nTPM
Medulla oblongata	9.3 nTPM

Bergmann glia	13.3 nTPM
Pons	18.7 nTPM
Cerebellum	14.9 nTPM
Medulla oblongata	6.4 nTPM

Central nervous system macrophage	16.0 nTPM
Basal ganglia	18.3 nTPM
Amygdala	18.0 nTPM
Spinal cord	18.0 nTPM
Pons	17.3 nTPM
Midbrain	16.8 nTPM
Thalamus	16.2 nTPM
Hypothalamus	16.1 nTPM
Cerebellum	14.9 nTPM
Hippocampus	14.7 nTPM
Cerebral cortex	12.9 nTPM
Medulla oblongata	12.8 nTPM

Cerebellar inhibitory	3.1 nTPM
Pons	4.6 nTPM
Medulla oblongata	3.3 nTPM
Spinal cord	2.7 nTPM
Cerebellum	2.5 nTPM
Midbrain	2.2 nTPM

Cge interneuron	4.6 nTPM
Hippocampus	5.1 nTPM
Hypothalamus	4.9 nTPM
Amygdala	4.6 nTPM
Basal ganglia	4.6 nTPM
Thalamus	4.5 nTPM
Midbrain	4.2 nTPM
Cerebral cortex	4.1 nTPM

Choroid plexus epithelial cell	77.0 nTPM
Thalamus	79.5 nTPM
Hippocampus	77.7 nTPM
Medulla oblongata	77.2 nTPM
Basal ganglia	73.8 nTPM

Committed oligodendrocyte precursor	10.2 nTPM
Medulla oblongata	19.4 nTPM
Pons	14.2 nTPM
Cerebral cortex	12.0 nTPM
Spinal cord	11.0 nTPM
Hippocampus	9.6 nTPM
Cerebellum	9.5 nTPM
Hypothalamus	8.9 nTPM
Midbrain	8.4 nTPM
Thalamus	8.3 nTPM
Basal ganglia	6.6 nTPM
Amygdala	4.5 nTPM

Deep-layer corticothalamic and 6b	10.0 nTPM
Hypothalamus	17.4 nTPM
Amygdala	13.1 nTPM
Basal ganglia	10.1 nTPM
Midbrain	6.7 nTPM
Cerebral cortex	6.4 nTPM
Hippocampus	6.3 nTPM

Deep-layer intratelencephalic	8.6 nTPM
Hypothalamus	10.7 nTPM
Basal ganglia	9.5 nTPM
Hippocampus	8.9 nTPM
Amygdala	7.7 nTPM
Cerebral cortex	6.0 nTPM

Deep-layer near-projecting	5.7 nTPM
Basal ganglia	8.4 nTPM
Hypothalamus	8.1 nTPM
Cerebral cortex	4.5 nTPM
Amygdala	3.7 nTPM
Hippocampus	3.6 nTPM

Eccentric medium spiny neuron	2.4 nTPM
Hippocampus	4.6 nTPM
Amygdala	3.5 nTPM
Thalamus	1.8 nTPM
Cerebral cortex	1.7 nTPM
Hypothalamus	1.7 nTPM
Basal ganglia	1.1 nTPM

Endothelial cell	13.0 nTPM
Cerebellum	18.6 nTPM
Spinal cord	17.3 nTPM
Midbrain	17.0 nTPM
Thalamus	14.7 nTPM
Basal ganglia	14.0 nTPM
Hippocampus	12.5 nTPM
Medulla oblongata	12.3 nTPM
Pons	11.9 nTPM
Amygdala	11.2 nTPM
Hypothalamus	7.4 nTPM
Cerebral cortex	6.4 nTPM