Single cell type - FARSB - The Human Protein Atlas

FARSB

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FARSB
Gene descriptionⁱ Full gene name according to HGNC.	Phenylalanyl-tRNA synthetase subunit beta
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Oocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.33
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Oocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

FARSB is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
835 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
XPO5	Exportin 5	0.5152	31
PIGU	Phosphatidylinositol glycan anchor biosynthesis class U	0.5102	39
TOMM70	Translocase of outer mitochondrial membrane 70	0.4925	15
OLA1	Obg like ATPase 1	0.4745	15
NDC1	NDC1 transmembrane nucleoporin	0.4668	15
RAD50	RAD50 double strand break repair protein	0.4641	15
POP1	POP1 homolog, ribonuclease P/MRP subunit	0.4537	39
POLD2	DNA polymerase delta 2, accessory subunit	0.4517	39
TCERG1	Transcription elongation regulator 1	0.4350	39
MRPS22	Mitochondrial ribosomal protein S22	0.4328	39
C1QBP	Complement C1q binding protein	0.4239	39
SFXN4	Sideroflexin 4	0.4223	39
MRPL4	Mitochondrial ribosomal protein L4	0.4175	39
MRPL11	Mitochondrial ribosomal protein L11	0.4114	39
PLAA	Phospholipase A2 activating protein	0.4046	15

IMMUNE CELLS

FARSB is part of cluster 43 Non-specific - Transcription & Translation with confidenceⁱ 0.97
433 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
POLL	DNA polymerase lambda	0.9762	43
FCSK	Fucose kinase	0.9762	43
GEMIN5	Gem nuclear organelle associated protein 5	0.9524	43
TRAP1	TNF receptor associated protein 1	0.9524	33
GPATCH4	G-patch domain containing 4 (gene/pseudogene)	0.9524	43
CEP95	Centrosomal protein 95	0.9286	43
ZNF268	Zinc finger protein 268	0.9286	43
C19orf73	Chromosome 19 open reading frame 73	0.9286	43
ZSCAN22	Zinc finger and SCAN domain containing 22	0.9286	16
BBS1	Bardet-Biedl syndrome 1	0.9286	16
FBXO21	F-box protein 21	0.9286	33
GFOD2	Glucose-fructose oxidoreductase domain containing 2	0.9286	43
FBXL8	F-box and leucine rich repeat protein 8	0.9048	33
SMPD4	Sphingomyelin phosphodiesterase 4	0.9048	33
FKBP4	FKBP prolyl isomerase 4	0.9048	43

Adipocytes	10.5 nTPM
Breast	11.7 nTPM
Adipose tissue	9.3 nTPM

Alveolar cells type 1	38.5 nTPM
Lung	38.5 nTPM

Alveolar cells type 2	31.2 nTPM
Lung	31.2 nTPM

Astrocytes	20.1 nTPM
Brain	20.1 nTPM

B-cells	17.9 nTPM
Stomach	32.1 nTPM
Spleen	30.0 nTPM
Bone marrow	25.7 nTPM
Lymph node	23.0 nTPM
Kidney	20.8 nTPM
PBMC	20.0 nTPM
Liver	19.3 nTPM
Salivary gland	18.3 nTPM
Thymus	14.9 nTPM
Lung	12.1 nTPM
Skin	8.5 nTPM
Adipose tissue	8.2 nTPM
Esophagus	0.0 nTPM

Ciliated cells	14.5 nTPM
Endometrium	15.7 nTPM
Bronchus	15.0 nTPM
Fallopian tube	13.7 nTPM
Lung	13.6 nTPM

Club cells	17.0 nTPM
Bronchus	24.8 nTPM
Lung	17.2 nTPM
Prostate	9.1 nTPM

Dendritic cells	12.9 nTPM
PBMC	14.4 nTPM
Adipose tissue	11.4 nTPM

Endothelial cells	13.8 nTPM
Pancreas	28.4 nTPM
Fallopian tube	19.6 nTPM
Lung	18.9 nTPM
Tongue	16.4 nTPM
Placenta	15.9 nTPM
Ovary	15.5 nTPM
Thymus	14.6 nTPM
Esophagus	13.4 nTPM
Endometrium	13.1 nTPM
Breast	12.3 nTPM
Heart muscle	11.7 nTPM
Skin	11.2 nTPM
Testis	10.4 nTPM
Skeletal muscle	10.4 nTPM
Liver	10.1 nTPM
Vascular	9.0 nTPM
Salivary gland	8.9 nTPM
Prostate	7.9 nTPM

Enteroendocrine cells	23.4 nTPM
Colon	43.2 nTPM
Rectum	16.8 nTPM
Small intestine	10.3 nTPM

Fibroblasts	19.1 nTPM
Pancreas	40.4 nTPM
Placenta	36.4 nTPM
Lung	26.9 nTPM
Stomach	25.9 nTPM
Thymus	23.4 nTPM
Fallopian tube	19.9 nTPM
Salivary gland	15.9 nTPM
Vascular	15.8 nTPM
Adipose tissue	14.5 nTPM
Prostate	14.5 nTPM
Breast	14.1 nTPM
Esophagus	14.0 nTPM
Heart muscle	13.8 nTPM
Skeletal muscle	12.9 nTPM
Skin	12.8 nTPM
Liver	4.7 nTPM

Granulocytes	6.9 nTPM
Lung	11.6 nTPM
Fallopian tube	9.0 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	16.6 nTPM
Colon	22.9 nTPM
Rectum	20.9 nTPM
Small intestine	5.8 nTPM

Lymphatic endothelial cells	17.0 nTPM
Fallopian tube	17.6 nTPM
Ovary	16.4 nTPM

Macrophages	12.5 nTPM
Lung	28.5 nTPM
Pancreas	24.7 nTPM
Kidney	17.7 nTPM
Esophagus	12.8 nTPM
Fallopian tube	12.8 nTPM
Skeletal muscle	12.7 nTPM
Thymus	12.6 nTPM
Adipose tissue	11.7 nTPM
Vascular	11.2 nTPM
Prostate	10.4 nTPM
Bone marrow	10.1 nTPM
Tongue	10.1 nTPM
Salivary gland	9.9 nTPM
Breast	9.4 nTPM
Endometrium	9.2 nTPM
Spleen	9.0 nTPM
Skin	8.9 nTPM
Testis	8.1 nTPM
Stomach	7.7 nTPM

Basal prostatic cells	11.0 nTPM
Prostate	11.0 nTPM

Basal respiratory cells	30.7 nTPM
Bronchus	30.7 nTPM

Basal squamous epithelial cells	22.2 nTPM
Esophagus	22.2 nTPM

Cholangiocytes	5.7 nTPM
Liver	5.7 nTPM

Paneth cells	16.5 nTPM
Rectum	24.5 nTPM
Colon	18.1 nTPM
Small intestine	6.9 nTPM

Plasma cells	26.8 nTPM
Thymus	53.9 nTPM
Spleen	46.7 nTPM
Bone marrow	42.3 nTPM
Liver	24.5 nTPM
Stomach	23.0 nTPM
Fallopian tube	14.2 nTPM
Salivary gland	9.8 nTPM
Esophagus	0.0 nTPM

Schwann cells	17.0 nTPM
Esophagus	24.0 nTPM
Adipose tissue	14.1 nTPM
Vascular	13.1 nTPM

Serous glandular cells	13.9 nTPM
Salivary gland	14.5 nTPM
Tongue	13.3 nTPM

Smooth muscle cells	16.2 nTPM
Placenta	26.9 nTPM
Esophagus	26.4 nTPM
Thymus	23.1 nTPM
Fallopian tube	20.9 nTPM
Adipose tissue	17.8 nTPM
Lung	17.6 nTPM
Salivary gland	16.3 nTPM
Ovary	15.8 nTPM
Skin	15.6 nTPM
Prostate	14.6 nTPM
Skeletal muscle	14.1 nTPM
Vascular	12.0 nTPM
Tongue	11.7 nTPM
Breast	10.9 nTPM
Endometrium	8.6 nTPM
Liver	6.4 nTPM

Suprabasal keratinocytes	25.4 nTPM
Tongue	36.7 nTPM
Skin	14.0 nTPM

T-cells	15.2 nTPM
Bone marrow	28.1 nTPM
Spleen	25.4 nTPM
Lymph node	24.0 nTPM
Stomach	23.6 nTPM
Esophagus	19.5 nTPM
PBMC	19.2 nTPM
Liver	16.7 nTPM
Skin	14.4 nTPM
Kidney	14.2 nTPM
Thymus	14.2 nTPM
Salivary gland	13.2 nTPM
Vascular	12.5 nTPM
Fallopian tube	12.2 nTPM
Tongue	11.8 nTPM
Endometrium	11.1 nTPM
Prostate	10.4 nTPM
Adipose tissue	10.3 nTPM
Colon	9.7 nTPM
Breast	9.6 nTPM
Skeletal muscle	9.5 nTPM
Lung	9.0 nTPM

Undifferentiated cells	51.1 nTPM
Colon	61.0 nTPM
Small intestine	46.7 nTPM
Rectum	45.6 nTPM

Amygdala excitatory	85.4 nTPM
Thalamus	98.9 nTPM
Cerebral cortex	86.8 nTPM
Basal ganglia	83.8 nTPM
Hypothalamus	81.8 nTPM
Amygdala	81.7 nTPM
Hippocampus	79.2 nTPM

Astrocyte	42.9 nTPM
Amygdala	54.1 nTPM
Basal ganglia	44.6 nTPM
Pons	44.5 nTPM
Hypothalamus	43.4 nTPM
Hippocampus	42.9 nTPM
Cerebral cortex	42.6 nTPM
Spinal cord	42.6 nTPM
Thalamus	42.5 nTPM
Midbrain	42.3 nTPM
Medulla oblongata	39.5 nTPM
Cerebellum	33.0 nTPM

Bergmann glia	35.6 nTPM
Cerebellum	47.3 nTPM
Pons	40.3 nTPM
Medulla oblongata	19.2 nTPM

Central nervous system macrophage	53.9 nTPM
Amygdala	67.4 nTPM
Hypothalamus	60.0 nTPM
Pons	55.4 nTPM
Spinal cord	55.3 nTPM
Thalamus	54.6 nTPM
Basal ganglia	53.5 nTPM
Cerebellum	51.2 nTPM
Hippocampus	50.9 nTPM
Midbrain	49.7 nTPM
Cerebral cortex	48.1 nTPM
Medulla oblongata	47.0 nTPM

Cerebellar inhibitory	87.5 nTPM
Spinal cord	107.2 nTPM
Medulla oblongata	89.7 nTPM
Midbrain	84.9 nTPM
Pons	78.1 nTPM
Cerebellum	77.4 nTPM

Cge interneuron	85.7 nTPM
Amygdala	89.4 nTPM
Hypothalamus	89.4 nTPM
Midbrain	86.1 nTPM
Thalamus	84.3 nTPM
Hippocampus	84.2 nTPM
Cerebral cortex	83.3 nTPM
Basal ganglia	83.1 nTPM

Choroid plexus epithelial cell	39.8 nTPM
Basal ganglia	51.5 nTPM
Medulla oblongata	44.4 nTPM
Hippocampus	33.3 nTPM
Thalamus	30.1 nTPM

Committed oligodendrocyte precursor	61.9 nTPM
Cerebellum	76.1 nTPM
Hypothalamus	70.3 nTPM
Cerebral cortex	69.0 nTPM
Midbrain	66.4 nTPM
Spinal cord	66.2 nTPM
Hippocampus	65.7 nTPM
Amygdala	65.4 nTPM
Thalamus	57.9 nTPM
Basal ganglia	50.4 nTPM
Medulla oblongata	47.8 nTPM
Pons	46.0 nTPM

Deep-layer corticothalamic and 6b	81.0 nTPM
Midbrain	85.4 nTPM
Basal ganglia	84.4 nTPM
Amygdala	83.9 nTPM
Cerebral cortex	81.8 nTPM
Hippocampus	79.2 nTPM
Hypothalamus	71.2 nTPM

Deep-layer intratelencephalic	87.2 nTPM
Basal ganglia	94.0 nTPM
Amygdala	90.8 nTPM
Hippocampus	87.5 nTPM
Cerebral cortex	84.9 nTPM
Hypothalamus	78.9 nTPM

Deep-layer near-projecting	92.4 nTPM
Hippocampus	99.5 nTPM
Cerebral cortex	95.2 nTPM
Basal ganglia	93.7 nTPM
Amygdala	90.1 nTPM
Hypothalamus	83.3 nTPM

Eccentric medium spiny neuron	82.9 nTPM
Hypothalamus	88.0 nTPM
Amygdala	86.3 nTPM
Basal ganglia	83.7 nTPM
Cerebral cortex	81.4 nTPM
Thalamus	81.1 nTPM
Hippocampus	76.7 nTPM