Single cell type - CYTIP - The Human Protein Atlas

CYTIP

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CYTIP
Gene descriptionⁱ Full gene name according to HGNC.	Cytohesin 1 interacting protein
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Neutrophils - Innate immune cellular maintenance (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Neutrophils, Breast lactating cells, T-cells, Plasma cells, CDC, NK-cells, B-cells, Monocytes, Innate lymphoid cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.79
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enriched (Leukocyte)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nCPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. * Single nuclei Read more
Single cell type groups RNA single cell type group specificity: Cell type enhanced (Neutrophils, Secretory cells, T-cells, Plasma cells, Dendritic cells, NK-cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enriched (Leukocyte)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas HPA data, as well as data generated by Monaco et al and Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

CYTIP is part of cluster 29 Neutrophils - Innate immune cellular maintenance with confidenceⁱ 1
342 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CD53	CD53 molecule	0.6549	29
ZDHHC18	Zinc finger DHHC-type palmitoyltransferase 18	0.6346	29
CPD	Carboxypeptidase D	0.6316	29
LIMK2	LIM domain kinase 2	0.6307	29
ATG2A	Autophagy related 2A	0.6230	29
TREM1	Triggering receptor expressed on myeloid cells 1	0.6149	29
SMCHD1	Structural maintenance of chromosomes flexible hinge domain containing 1	0.6029	24
HECA	Hdc homolog, cell cycle regulator	0.5971	29
NAMPT	Nicotinamide phosphoribosyltransferase	0.5805	31
PLXNC1	Plexin C1	0.5802	31
STK4	Serine/threonine kinase 4	0.5758	82
GNG2	G protein subunit gamma 2	0.5601	29
ARID4B	AT-rich interaction domain 4B	0.5548	29
FMNL1	Formin like 1	0.5499	29
RAB8B	RAB8B, member RAS oncogene family	0.5455	29

IMMUNE CELLS

CYTIP is part of cluster 35 Neutrophils - Protein binding with confidenceⁱ 0.9
504 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CARD8	Caspase recruitment domain family member 8	0.9762	35
BICRAL	BICRA like chromatin remodeling complex associated protein	0.9762	35
PARP16	Poly(ADP-ribose) polymerase family member 16	0.9762	35
COQ10B	Coenzyme Q10B	0.9762	35
ERBIN	Erbb2 interacting protein	0.9524	35
C16orf54	Chromosome 16 open reading frame 54	0.9524	35
YOD1	YOD1 deubiquitinase	0.9524	35
ZBTB49	Zinc finger and BTB domain containing 49	0.9524	35
RAB8B	RAB8B, member RAS oncogene family	0.9524	35
ZER1	Zyg-11 related cell cycle regulator	0.9524	35
SEC24B	SEC24 homolog B, COPII coat complex component	0.9524	35
FGD3	FYVE, RhoGEF and PH domain containing 3	0.9524	35
RAB18	RAB18, member RAS oncogene family	0.9524	35
PDK3	Pyruvate dehydrogenase kinase 3	0.9524	35
UBR2	Ubiquitin protein ligase E3 component n-recognin 2	0.9524	35

	Lacrimal acinar cells	Salivary acinar cells	Pancreatic acinar cells
Eye	38.0
Salivary gland		31.2
Pancreas			8.2
Mean exp	38.0	31.2	8.2

	Adipocytes
Heart muscle	7.6
Skeletal muscle	0.0
Adipose tissue	5.0
Mean exp	4.2

	Adrenal cortex cells	Adrenal medulla cells
Adrenal gland	1.8	0.0
Mean exp	1.8	0.0

	Alveolar cells type 1	Alveolar cells type 2	Transitional alveolar cells
Lung	0.3	0.4	0.8
Mean exp	0.3	0.4	0.8

	Esophageal apical cells
Esophagus	0.2
Mean exp	0.2

	B-cells
Brain	348.5
Eye	751.5
Lung	479.5
Salivary gland	466.7
Esophagus	628.6
Stomach	577.2
Liver	219.9
Kidney	261.1
Urinary bladder	452.2
Breast	142.1
Endometrium	364.4
Adipose tissue	124.9
Blood	249.8
Bone marrow	377.5
Lymph node	541.6
Spleen	380.0
Thymus	344.4
Mean exp	394.7

	Ocular epithelial cells	Mesothelial cells	Urothelial cells	Epicardial cells	Prostatic hillock cells
Eye	3.2
Urinary bladder			0.9
Prostate					1.3
Heart muscle				2.3
Adipose tissue		1.8
Thymus		6.9
Mean exp	3.2	4.4	0.9	2.3	1.3

	Respiratory basal cells	Esophageal basal cells	Salivary basal cells	Basal keratinocytes	Epididymal basal cells	Basal prostatic cells
Lung	1.2
Tongue				0.5
Salivary gland			0.1
Esophagus		0.2
Epididymis					0.6
Prostate						0.0
Skin				2.2
Mean exp	1.2	0.2	0.1	1.4	0.6	0.0

	Ependymal cells	Choroid plexus epithelial cells	Respiratory ciliated cells	Respiratory deuterosomal cells	Epididymal efferent duct ciliated cells	Fallopian tube ciliated cells	Endometrial ciliated cells
Brain	0.3	0.2
Lung			1.6	0.0
Epididymis					0.0
Fallopian tube						0.8
Endometrium							1.0
Mean exp	0.3	0.2	1.6	0.0	0.0	0.8	1.0

	Cdc	Pdcs
Lung		72.8
Breast	217.4	134.4
Endometrium		151.0
Adipose tissue	324.0
Skin	982.5
Blood		57.1
Lymph node	446.3
Mean exp	492.5	103.8

	Salivary duct cells	Cholangiocytes	Pancreatic duct cells	Renal collecting duct intercalated cells	Renal collecting duct principal cells	Renal connecting tubule cells	Epididymal efferent duct absorptive cells
Salivary gland	0.5
Liver		0.0
Pancreas			1.7
Kidney				53.9	1.0	2.5
Epididymis							2.7
Mean exp	0.5	0.0	1.7	53.9	1.0	2.5	2.7

	Vascular endothelial cells	Lymphatic endothelial cells
Brain	0.3
Eye	5.8	3.4
Pituitary gland	1.4
Lung	4.3	7.8
Tongue	3.6	1.9
Salivary gland	1.3	2.0
Esophagus	0.0	0.0
Stomach	8.9
Liver	1.6
Pancreas	0.4
Kidney	1.0	5.0
Urinary bladder	1.8	0.0
Testis	0.2	4.8
Epididymis	1.1
Prostate	0.0	0.0
Breast	2.1	2.6
Ovary	0.3	0.0
Fallopian tube	1.4	1.3
Endometrium	1.2	0.0
Placenta	0.0
Heart muscle	4.2
Skeletal muscle	0.0
Vasculature	0.1	2.8
Adipose tissue	4.2	2.2
Skin	5.4	2.3
Lymph node	22.5	22.6
Spleen		2.1
Thymus	2.5	1.8
Mean exp	2.8	3.3

	Enterocytes	Colonocytes
Small intestine	1.3
Colon		1.3
Rectum		0.9
Mean exp	1.3	1.1

	Neuroendocrine cells
Stomach	5.6
Small intestine	0.0
Colon	0.0
Rectum	0.0
Mean exp	1.4

	Erythrocyte progenitors	Erythrocytes
Blood		4.6
Bone marrow	1.3	8.9
Spleen		2.8
Mean exp	1.3	5.4

	Foveolar cells	Mucous neck cells	Parietal cells	Gastric chief cells
Stomach	35.0	65.3	31.8	68.8
Mean exp	35.0	65.3	31.8	68.8

	Megakaryocyte progenitors	Megakaryocyte-erythroid progenitors	Megakaryocytes
Bone marrow	5.5	11.2	6.2
Mean exp	5.5	11.2	6.2

	Fibro-adipogenic progenitors
Skeletal muscle	0.5
Adipose tissue	2.5
Mean exp	1.5

	Fibroblasts
Brain	0.4
Eye	6.6
Lung	1.4
Tongue	0.8
Salivary gland	2.5
Esophagus	1.6
Stomach	6.4
Pancreas	0.7
Kidney	1.7
Urinary bladder	2.4
Epididymis	0.0
Prostate	0.3
Breast	3.7
Fallopian tube	1.5
Placenta	0.3
Heart muscle	2.3
Vasculature	0.1
Skin	5.8
Lymph node	10.2
Thymus	0.6
Mean exp	2.5

	Submucosal glandular cells	Prostatic glandular cells	Prostatic club cells	Endometrial glandular cells
Lung	16.5
Esophagus	0.0
Prostate		0.4	2.3
Endometrium				1.3
Mean exp	8.3	0.4	2.3	1.3

	Astrocytes	Bergmann glia	Müller glia	Pituicytes/fscs	Oligodendrocyte progenitor cells	Oligodendrocytes	Schwann cells	Microglia
Brain	0.6	1.3			0.2	0.3		40.2
Eye			0.3				0.0
Pituitary gland				2.2
Tongue							0.0
Urinary bladder							2.0
Vasculature							0.3
Mean exp	0.6	1.3	0.3	2.2	0.2	0.3	0.6	40.2

	Conjunctival goblet cells	Goblet cells
Eye	19.4
Small intestine		25.4
Colon		5.0
Rectum		5.5
Mean exp	19.4	12.0

	Innate lymphoid cells
Lung	428.3
Salivary gland	162.9
Urinary bladder	334.4
Breast	183.0
Fallopian tube	319.2
Endometrium	171.9
Lymph node	333.3
Spleen	269.7
Thymus	206.5
Mean exp	267.7

	Respiratory ionocytes	Salivary ionocytes
Lung	5.1
Salivary gland		0.4
Mean exp	5.1	0.4

	Breast hormone-responsive cells	Endometrial luminal cells
Breast	5.2
Endometrium		1.1
Mean exp	5.2	1.1

	Mast cells
Eye	38.7
Lung	7.0
Tongue	43.1
Salivary gland	13.9
Stomach	27.4
Pancreas	7.2
Urinary bladder	12.6
Epididymis	6.0
Fallopian tube	10.3
Vasculature	10.8
Adipose tissue	7.5
Lymph node	8.0
Mean exp	16.0

	Monocyte progenitors	Monocytes	Macrophages	Kupffer cells	Hofbauer cells
Brain		544.2	13.1
Eye		474.9	158.2
Pituitary gland			147.7
Lung		405.5	146.9
Tongue		237.7	297.4
Salivary gland		264.6	78.7
Esophagus			248.5
Stomach		382.9	92.8
Liver		261.5	202.3	174.2
Pancreas		246.2	180.7
Kidney			37.4
Urinary bladder		186.7	80.4
Testis			330.2
Prostate		179.8	149.3
Breast		653.9	45.3
Ovary			133.4
Fallopian tube		417.2	255.5
Endometrium			119.5
Placenta					24.4
Heart muscle			37.1
Skeletal muscle			23.3
Vasculature		247.5	78.8
Adipose tissue			18.4
Skin			303.1
Blood		314.0
Bone marrow	168.3	439.4	255.1
Lymph node		361.8	222.4
Spleen		479.4	256.2
Thymus		272.4	103.7
Mean exp	168.3	353.9	148.7	174.2	24.4

Acinar cells - 38.0 nCPM

Adipocytes - 4.2 nCPM

Adrenal endocrine cells - 1.8 nCPM

Alveolar cells - 0.8 nCPM

Apical squamous epithelial cells - 0.2 nCPM

B-cells - 394.7 nCPM

Barrier epithelial cells - 4.4 nCPM

Basal cells - 1.4 nCPM

Ciliated cells - 1.6 nCPM

Dendritic cells - 492.5 nCPM

Ductal cells - 53.9 nCPM

Endothelial cells - 3.3 nCPM

Enterocytes - 1.3 nCPM

Enteroendocrine cells - 1.4 nCPM

Erythrocytes - 5.4 nCPM

Fibro-adipogenic progenitors - 1.5 nCPM

Fibroblasts - 2.5 nCPM

Gastric glandular cells - 68.8 nCPM

Glandular cells - 8.3 nCPM

Glial cells - 40.2 nCPM

Goblet cells - 19.4 nCPM

Hepatocytes - 0.8 nCPM

Innate lymphoid cells - 267.7 nCPM

Ionocytes - 5.1 nCPM

Leydig cells - 0.5 nCPM

Luminal cells - 5.2 nCPM

Mast cells - 16.0 nCPM

Megakaryocytes - 11.2 nCPM

Mononuclear phagocytes - 353.9 nCPM

Mural cells - 12.9 nCPM

Myocytes - 2.8 nCPM

Neuronal cells - 0.4 nCPM

Neutrophils - 1793.3 nCPM

Nk-cells - 459.5 nCPM

Oocytes - 0.0 nCPM

Pancreatic islet cells - 3.6 nCPM

Pigment cells - 13.3 nCPM

Pituitary endocrine cells - 1.1 nCPM

Plasma cells - 515.3 nCPM

Platelets - 21.1 nCPM

Proliferating cells - 2.6 nCPM

Renal nephron cells - 34.3 nCPM

Reproductive supporting cells - 24.5 nCPM

Secretory cells - 657.5 nCPM

Secretory gland support - 7.1 nCPM

Smooth muscle cells - 0.8 nCPM

Spermatogenic cell types - 3.2 nCPM

Stellate cells - 0.0 nCPM

Stem cells - 50.9 nCPM

Stromal cells - 4.1 nCPM

Suprabasal cells - 1.8 nCPM

T-cells - 578.5 nCPM

Trophoblast cells - 24.1 nCPM

	Pericytes	Vascular smooth muscle cells
Brain	1.8	64.8
Eye	13.0	12.9
Pituitary gland	7.1
Lung	6.7	1.9
Tongue	2.5	13.1
Salivary gland	0.0	1.7
Stomach	0.0	9.2
Pancreas	0.6
Kidney	2.9	9.3
Urinary bladder	1.1	18.4
Testis	4.2
Epididymis	0.0	1.0
Prostate	0.0	35.6
Breast	2.5	12.5
Ovary	0.0	0.5
Fallopian tube	0.0	1.8
Placenta	0.0
Heart muscle	1.5	0.0
Skeletal muscle	0.0	44.8
Vasculature	0.6	0.1
Adipose tissue	5.9	7.1
Skin	7.5	8.1
Thymus	1.3	2.5
Mean exp	2.6	12.9

	Cardiomyocytes	Myonuclei
Heart muscle	2.8
Skeletal muscle		0.6
Mean exp	2.8	0.6

	Brain excitatory neurons	Brain inhibitory neurons	Retinal amacrine cells	Retinal horizontal cells	Retinal ganglion cells	Retinal bipolar cells	Rod photoreceptor cells	Cone photoreceptor cells	Other brain neurons
Brain	0.3	0.4							0.2
Eye			0.0	0.0	0.0	0.4	0.2	0.0
Mean exp	0.3	0.4	0.0	0.0	0.0	0.4	0.2	0.0	0.2

	Neutrophil progenitors	Neutrophils
Eye		1154.0
Lung		1259.4
Salivary gland		1453.6
Urinary bladder		1076.4
Prostate		1434.2
Vasculature		1651.2
Blood	154.7	2698.7
Bone marrow	30.8	1157.7
Lymph node		1922.0
Spleen	221.4	3803.6
Thymus	172.2	2115.9
Mean exp	144.8	1793.3

	Nk-cells
Brain	406.0
Eye	682.2
Lung	512.9
Salivary gland	509.1
Stomach	441.6
Colon	714.2
Liver	259.4
Kidney	287.3
Urinary bladder	554.2
Prostate	485.5
Fallopian tube	602.2
Endometrium	223.1
Vasculature	348.0
Blood	372.0
Bone marrow	473.9
Lymph node	495.9
Spleen	596.2
Thymus	307.0
Mean exp	459.5

	Melanocytes	Retinal pigment epithelial cells
Eye	6.3	0.0
Skin	20.3
Mean exp	13.3	0.0

	Corticotrophs	Gonadotrophs	Lactotrophs	Somatotrophs	Thyrotrophs
Pituitary gland	0.5	0.5	0.6	0.2	1.1
Mean exp	0.5	0.5	0.6	0.2	1.1

	Plasma cells
Eye	632.6
Lung	389.0
Salivary gland	493.0
Stomach	480.6
Liver	249.0
Urinary bladder	1158.8
Breast	253.0
Fallopian tube	738.7
Blood	340.8
Bone marrow	424.7
Lymph node	562.6
Thymus	519.7
Spleen	455.9
Mean exp	515.3

	Gastric progenitor cells	Enteric transient amplifying cells
Stomach	1.3
Small intestine		4.0
Colon		0.4
Rectum		3.5
Mean exp	1.3	2.6

	Podocytes	Proximal tubule cells	Loop of henle epithelial cells	Papillary tip epithelial cells	Distal convoluted tubule cells
Kidney	4.1	1.8	8.1	0.7	34.3
Mean exp	4.1	1.8	8.1	0.7	34.3