Single cell type - KLHL24 - The Human Protein Atlas

KLHL24

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KLHL24
Gene descriptionⁱ Full gene name according to HGNC.	Kelch like family member 24
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	11

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	NK-cells & T-cells - Immune system & Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Cardiomyocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.31
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Cardiomyocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

KLHL24 is part of cluster 78 NK-cells & T-cells - Immune system & Transcription with confidenceⁱ 0.5
392 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CREBRF	CREB3 regulatory factor	0.5828	78
TRA2A	Transformer 2 alpha homolog	0.5264	78
PAPOLG	Poly(A) polymerase gamma	0.4981	29
PLEKHA2	Pleckstrin homology domain containing A2	0.4832	78
UBXN7	UBX domain protein 7	0.4786	55
ELF2	E74 like ETS transcription factor 2	0.4712	55
PDE7A	Phosphodiesterase 7A	0.4551	78
FOXN3	Forkhead box N3	0.4495	55
WASHC4	WASH complex subunit 4	0.4472	73
KBTBD8	Kelch repeat and BTB domain containing 8	0.4383	28
PRDM2	PR/SET domain 2	0.4368	73
KDM3B	Lysine demethylase 3B	0.4322	55
FAM53B	Family with sequence similarity 53 member B	0.4316	28
CHD2	Chromodomain helicase DNA binding protein 2	0.4311	80
PIKFYVE	Phosphoinositide kinase, FYVE-type zinc finger containing	0.4309	73

IMMUNE CELLS

KLHL24 is part of cluster 32 Basophils - Transcription with confidenceⁱ 0.63
291 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ECT2	Epithelial cell transforming 2	1.0000	32
CSNK2B	Casein kinase 2 beta	0.9762	32
HEXIM1	HEXIM P-TEFb complex subunit 1	0.9762	32
SPDYE1	Speedy/RINGO cell cycle regulator family member E1	0.9524	32
LMOD3	Leiomodin 3	0.9524	32
ZFPL1	Zinc finger protein like 1	0.9524	32
RACGAP1	Rac GTPase activating protein 1	0.9524	32
INO80C	INO80 complex subunit C	0.9524	32
UPF2	UPF2 regulator of nonsense mediated mRNA decay	0.9524	20
SNX12	Sorting nexin 12	0.9524	42
USP8	Ubiquitin specific peptidase 8	0.9524	32
PYGM	Glycogen phosphorylase, muscle associated	0.9524	32
MTERF1	Mitochondrial transcription termination factor 1	0.9524	32
EPS15L1	Epidermal growth factor receptor pathway substrate 15 like 1	0.9524	32
KCNJ13	Potassium inwardly rectifying channel subfamily J member 13	0.9524	32

Adipocytes	40.5 nTPM
Adipose tissue	50.0 nTPM
Breast	31.0 nTPM

Alveolar cells type 1	23.4 nTPM
Lung	23.4 nTPM

Alveolar cells type 2	72.2 nTPM
Lung	72.2 nTPM

Astrocytes	84.2 nTPM
Brain	84.2 nTPM

B-cells	75.3 nTPM
Adipose tissue	151.0 nTPM
Esophagus	100.3 nTPM
Lymph node	98.6 nTPM
Stomach	92.4 nTPM
Salivary gland	90.5 nTPM
Thymus	89.9 nTPM
Lung	73.8 nTPM
Bone marrow	65.9 nTPM
Spleen	64.2 nTPM
PBMC	50.8 nTPM
Skin	40.7 nTPM
Kidney	36.4 nTPM
Liver	24.2 nTPM

Ciliated cells	30.8 nTPM
Lung	39.6 nTPM
Endometrium	34.4 nTPM
Bronchus	34.0 nTPM
Fallopian tube	15.1 nTPM

Club cells	46.8 nTPM
Lung	55.1 nTPM
Prostate	47.4 nTPM
Bronchus	37.8 nTPM

Dendritic cells	77.4 nTPM
Adipose tissue	122.5 nTPM
PBMC	32.4 nTPM

Endothelial cells	35.4 nTPM
Prostate	64.6 nTPM
Heart muscle	60.6 nTPM
Salivary gland	57.3 nTPM
Endometrium	52.1 nTPM
Esophagus	47.9 nTPM
Skeletal muscle	45.0 nTPM
Tongue	39.0 nTPM
Vascular	38.1 nTPM
Pancreas	33.6 nTPM
Breast	31.6 nTPM
Ovary	26.7 nTPM
Testis	26.6 nTPM
Skin	24.0 nTPM
Liver	23.9 nTPM
Thymus	23.4 nTPM
Placenta	16.5 nTPM
Lung	16.2 nTPM
Fallopian tube	11.0 nTPM

Enteroendocrine cells	28.8 nTPM
Rectum	35.2 nTPM
Colon	27.1 nTPM
Small intestine	24.0 nTPM

Fibroblasts	41.1 nTPM
Heart muscle	88.5 nTPM
Esophagus	69.5 nTPM
Salivary gland	67.4 nTPM
Adipose tissue	54.3 nTPM
Prostate	54.1 nTPM
Skin	45.1 nTPM
Liver	42.7 nTPM
Vascular	41.0 nTPM
Stomach	37.5 nTPM
Skeletal muscle	31.5 nTPM
Breast	30.0 nTPM
Thymus	26.3 nTPM
Fallopian tube	20.9 nTPM
Placenta	19.3 nTPM
Lung	19.3 nTPM
Pancreas	10.8 nTPM

Granulocytes	26.3 nTPM
Lung	33.8 nTPM
Fallopian tube	25.9 nTPM
Tongue	19.4 nTPM

Intestinal goblet cells	35.2 nTPM
Small intestine	43.9 nTPM
Rectum	37.5 nTPM
Colon	24.1 nTPM

Lymphatic endothelial cells	33.0 nTPM
Ovary	38.2 nTPM
Fallopian tube	27.7 nTPM

Macrophages	47.1 nTPM
Adipose tissue	140.0 nTPM
Prostate	90.9 nTPM
Salivary gland	86.5 nTPM
Esophagus	64.2 nTPM
Fallopian tube	61.6 nTPM
Vascular	54.6 nTPM
Tongue	42.3 nTPM
Spleen	42.1 nTPM
Thymus	36.9 nTPM
Bone marrow	36.5 nTPM
Skeletal muscle	35.8 nTPM
Testis	32.9 nTPM
Skin	31.2 nTPM
Lung	30.8 nTPM
Breast	30.5 nTPM
Stomach	25.7 nTPM
Kidney	23.9 nTPM
Endometrium	17.2 nTPM
Pancreas	10.3 nTPM

Basal keratinocytes	38.3 nTPM
Skin	46.0 nTPM
Tongue	30.6 nTPM

Basal prostatic cells	52.8 nTPM
Prostate	52.8 nTPM

Basal respiratory cells	21.0 nTPM
Bronchus	21.0 nTPM

Basal squamous epithelial cells	62.5 nTPM
Esophagus	62.5 nTPM

Paneth cells	30.2 nTPM
Rectum	34.0 nTPM
Colon	32.6 nTPM
Small intestine	24.2 nTPM

Plasma cells	38.1 nTPM
Salivary gland	77.9 nTPM
Stomach	58.6 nTPM
Fallopian tube	55.6 nTPM
Esophagus	36.4 nTPM
Thymus	27.8 nTPM
Spleen	19.5 nTPM
Bone marrow	15.1 nTPM
Liver	14.0 nTPM

Schwann cells	75.6 nTPM
Adipose tissue	115.2 nTPM
Esophagus	71.9 nTPM
Vascular	39.7 nTPM

Serous glandular cells	41.5 nTPM
Salivary gland	56.5 nTPM
Tongue	26.5 nTPM

Smooth muscle cells	38.5 nTPM
Esophagus	73.3 nTPM
Prostate	60.8 nTPM
Endometrium	54.3 nTPM
Salivary gland	54.1 nTPM
Tongue	53.0 nTPM
Adipose tissue	51.0 nTPM
Skeletal muscle	41.5 nTPM
Vascular	37.6 nTPM
Skin	30.7 nTPM
Ovary	29.1 nTPM
Breast	28.9 nTPM
Liver	25.0 nTPM
Lung	23.5 nTPM
Thymus	19.4 nTPM
Placenta	17.0 nTPM
Fallopian tube	16.7 nTPM

Suprabasal keratinocytes	32.7 nTPM
Skin	46.3 nTPM
Tongue	19.1 nTPM

T-cells	54.3 nTPM
Adipose tissue	111.0 nTPM
Salivary gland	81.0 nTPM
Prostate	74.2 nTPM
Lymph node	70.7 nTPM
Tongue	63.6 nTPM
Skeletal muscle	60.9 nTPM
Colon	60.4 nTPM
Esophagus	58.4 nTPM
Fallopian tube	58.0 nTPM
Thymus	54.4 nTPM
Vascular	52.7 nTPM
Skin	49.4 nTPM
PBMC	45.2 nTPM
Lung	44.3 nTPM
Breast	44.2 nTPM
Endometrium	43.9 nTPM
Spleen	39.6 nTPM
Liver	36.2 nTPM
Stomach	31.8 nTPM
Kidney	30.1 nTPM
Bone marrow	29.1 nTPM

Undifferentiated cells	26.4 nTPM
Rectum	35.2 nTPM
Small intestine	30.7 nTPM
Colon	13.5 nTPM

Amygdala excitatory	122.2 nTPM
Hypothalamus	150.8 nTPM
Amygdala	121.6 nTPM
Thalamus	120.7 nTPM
Hippocampus	117.2 nTPM
Basal ganglia	114.1 nTPM
Cerebral cortex	108.6 nTPM

Astrocyte	167.5 nTPM
Basal ganglia	185.1 nTPM
Amygdala	184.8 nTPM
Thalamus	181.1 nTPM
Midbrain	178.8 nTPM
Cerebellum	175.8 nTPM
Cerebral cortex	170.1 nTPM
Hippocampus	167.1 nTPM
Pons	167.0 nTPM
Hypothalamus	153.0 nTPM
Spinal cord	152.8 nTPM
Medulla oblongata	126.7 nTPM

Bergmann glia	130.5 nTPM
Cerebellum	143.5 nTPM
Medulla oblongata	130.0 nTPM
Pons	118.0 nTPM

Central nervous system macrophage	140.9 nTPM
Hypothalamus	159.3 nTPM
Amygdala	157.4 nTPM
Spinal cord	148.1 nTPM
Basal ganglia	144.7 nTPM
Midbrain	142.9 nTPM
Hippocampus	142.8 nTPM
Thalamus	140.1 nTPM
Pons	134.1 nTPM
Cerebellum	133.5 nTPM
Cerebral cortex	126.4 nTPM
Medulla oblongata	120.3 nTPM

Cerebellar inhibitory	120.0 nTPM
Midbrain	132.8 nTPM
Pons	128.1 nTPM
Cerebellum	115.3 nTPM
Medulla oblongata	113.6 nTPM
Spinal cord	110.0 nTPM

Cge interneuron	125.6 nTPM
Hypothalamus	145.6 nTPM
Thalamus	132.5 nTPM
Amygdala	127.3 nTPM
Midbrain	122.1 nTPM
Cerebral cortex	119.3 nTPM
Hippocampus	119.3 nTPM
Basal ganglia	112.9 nTPM

Choroid plexus epithelial cell	193.0 nTPM
Basal ganglia	277.0 nTPM
Hippocampus	171.9 nTPM
Medulla oblongata	166.9 nTPM
Thalamus	156.2 nTPM

Committed oligodendrocyte precursor	169.0 nTPM
Thalamus	247.4 nTPM
Hypothalamus	225.3 nTPM
Amygdala	214.3 nTPM
Basal ganglia	169.2 nTPM
Hippocampus	163.8 nTPM
Spinal cord	161.9 nTPM
Cerebral cortex	150.1 nTPM
Midbrain	148.7 nTPM
Cerebellum	136.4 nTPM
Pons	134.6 nTPM
Medulla oblongata	107.2 nTPM

Deep-layer corticothalamic and 6b	119.5 nTPM
Hypothalamus	129.1 nTPM
Cerebral cortex	124.2 nTPM
Hippocampus	119.9 nTPM
Basal ganglia	117.8 nTPM
Amygdala	113.8 nTPM
Midbrain	112.0 nTPM

Deep-layer intratelencephalic	116.1 nTPM
Hypothalamus	138.5 nTPM
Cerebral cortex	117.7 nTPM
Amygdala	113.4 nTPM
Hippocampus	108.0 nTPM
Basal ganglia	103.0 nTPM

Deep-layer near-projecting	130.9 nTPM
Hypothalamus	161.6 nTPM
Cerebral cortex	136.4 nTPM
Amygdala	132.4 nTPM
Hippocampus	112.2 nTPM
Basal ganglia	111.9 nTPM

Eccentric medium spiny neuron	85.4 nTPM
Amygdala	93.2 nTPM
Thalamus	89.1 nTPM
Cerebral cortex	84.4 nTPM
Hippocampus	83.7 nTPM
Basal ganglia	81.3 nTPM
Hypothalamus	80.7 nTPM