Single cell type - ACVR2B - The Human Protein Atlas

ACVR2B

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ACVR2B
Gene descriptionⁱ Full gene name according to HGNC.	Activin A receptor type 2B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Disease related genes Enzymes Human disease related genes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Neurons - Neuronal signaling (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.44
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ACVR2B is part of cluster 69 Neurons - Neuronal signaling with confidenceⁱ 1
331 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
AMIGO1	Adhesion molecule with Ig like domain 1	0.4106	71
TAC3	Tachykinin precursor 3	0.4103	69
USP13	Ubiquitin specific peptidase 13	0.4094	68
ZNF33B	Zinc finger protein 33B	0.4094	37
ZNF608	Zinc finger protein 608	0.3999	69
ELFN1	Extracellular leucine rich repeat and fibronectin type III domain containing 1	0.3968	69
TMEM200C	Transmembrane protein 200C	0.3902	69
TMEM245	Transmembrane protein 245	0.3866	72
GLP1R	Glucagon like peptide 1 receptor	0.3828	68
PARP2	Poly(ADP-ribose) polymerase 2	0.3821	15
PLSCR5	Phospholipid scramblase family member 5	0.3805	69
THSD7A	Thrombospondin type 1 domain containing 7A	0.3779	69
B3GALNT1	Beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)	0.3762	68
DNMT3B	DNA methyltransferase 3 beta	0.3751	24
B4GAT1	Beta-1,4-glucuronyltransferase 1	0.3745	24

Adipocytes	6.4 nTPM
Breast	8.3 nTPM
Adipose tissue	4.5 nTPM

Alveolar cells type 1	4.5 nTPM
Lung	4.5 nTPM

Alveolar cells type 2	6.4 nTPM
Lung	6.4 nTPM

Astrocytes	9.0 nTPM
Brain	9.0 nTPM

B-cells	2.1 nTPM
Skin	8.5 nTPM
Thymus	5.7 nTPM
Kidney	5.2 nTPM
Salivary gland	3.4 nTPM
Lung	2.7 nTPM
Adipose tissue	0.8 nTPM
Bone marrow	0.7 nTPM
Stomach	0.4 nTPM
Lymph node	0.1 nTPM
Spleen	0.1 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Esophagus	0.0 nTPM

Ciliated cells	9.5 nTPM
Lung	11.9 nTPM
Fallopian tube	11.5 nTPM
Endometrium	8.5 nTPM
Bronchus	5.9 nTPM

Club cells	6.6 nTPM
Prostate	11.6 nTPM
Lung	5.7 nTPM
Bronchus	2.4 nTPM

Endothelial cells	6.5 nTPM
Endometrium	11.5 nTPM
Salivary gland	11.5 nTPM
Prostate	9.7 nTPM
Placenta	8.5 nTPM
Vascular	8.0 nTPM
Tongue	7.9 nTPM
Ovary	7.5 nTPM
Testis	7.0 nTPM
Skin	6.3 nTPM
Skeletal muscle	6.3 nTPM
Liver	5.0 nTPM
Heart muscle	4.8 nTPM
Lung	4.8 nTPM
Breast	4.4 nTPM
Thymus	3.6 nTPM
Esophagus	3.4 nTPM
Fallopian tube	3.3 nTPM
Pancreas	2.6 nTPM

Enteroendocrine cells	4.2 nTPM
Rectum	6.7 nTPM
Small intestine	3.4 nTPM
Colon	2.5 nTPM

Fibroblasts	4.6 nTPM
Placenta	17.2 nTPM
Salivary gland	8.3 nTPM
Prostate	7.3 nTPM
Breast	5.9 nTPM
Skeletal muscle	4.4 nTPM
Vascular	4.2 nTPM
Adipose tissue	3.8 nTPM
Liver	3.6 nTPM
Esophagus	3.4 nTPM
Skin	3.0 nTPM
Fallopian tube	2.9 nTPM
Heart muscle	2.7 nTPM
Thymus	2.7 nTPM
Lung	2.0 nTPM
Stomach	1.4 nTPM
Pancreas	1.2 nTPM

Granulocytes	5.9 nTPM
Tongue	14.6 nTPM
Lung	2.0 nTPM
Fallopian tube	1.3 nTPM

Intestinal goblet cells	3.9 nTPM
Small intestine	6.0 nTPM
Rectum	3.3 nTPM
Colon	2.5 nTPM

Lymphatic endothelial cells	1.5 nTPM
Fallopian tube	3.0 nTPM
Ovary	0.0 nTPM

Macrophages	3.0 nTPM
Prostate	8.9 nTPM
Salivary gland	8.8 nTPM
Testis	5.6 nTPM
Vascular	4.7 nTPM
Tongue	4.5 nTPM
Lung	4.4 nTPM
Esophagus	3.9 nTPM
Breast	3.9 nTPM
Thymus	3.1 nTPM
Adipose tissue	2.5 nTPM
Skeletal muscle	2.4 nTPM
Fallopian tube	2.4 nTPM
Skin	2.2 nTPM
Endometrium	0.6 nTPM
Kidney	0.0 nTPM
Pancreas	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	3.2 nTPM
Colon	3.6 nTPM
Small intestine	3.5 nTPM
Rectum	2.7 nTPM

Basal prostatic cells	8.7 nTPM
Prostate	8.7 nTPM

Basal respiratory cells	2.3 nTPM
Bronchus	2.3 nTPM

Cone photoreceptor cells	17.0 nTPM
Eye	17.0 nTPM

Early spermatids	5.8 nTPM
Testis	5.8 nTPM

Plasma cells	2.8 nTPM
Salivary gland	10.3 nTPM
Fallopian tube	5.1 nTPM
Thymus	2.7 nTPM
Bone marrow	1.5 nTPM
Spleen	1.2 nTPM
Liver	1.0 nTPM
Stomach	0.8 nTPM
Esophagus	0.0 nTPM

Schwann cells	8.6 nTPM
Esophagus	12.0 nTPM
Vascular	9.9 nTPM
Adipose tissue	3.9 nTPM

Serous glandular cells	9.5 nTPM
Salivary gland	10.2 nTPM
Tongue	8.8 nTPM

Smooth muscle cells	7.2 nTPM
Lung	11.8 nTPM
Salivary gland	11.0 nTPM
Tongue	9.6 nTPM
Adipose tissue	9.1 nTPM
Skeletal muscle	8.8 nTPM
Endometrium	8.6 nTPM
Liver	7.6 nTPM
Ovary	7.6 nTPM
Breast	7.5 nTPM
Vascular	6.2 nTPM
Esophagus	6.0 nTPM
Prostate	4.9 nTPM
Fallopian tube	4.7 nTPM
Skin	4.6 nTPM
Placenta	4.0 nTPM
Thymus	3.5 nTPM

T-cells	3.6 nTPM
Thymus	8.7 nTPM
Salivary gland	8.0 nTPM
Vascular	7.6 nTPM
Prostate	6.1 nTPM
Skeletal muscle	4.9 nTPM
Tongue	4.9 nTPM
Adipose tissue	4.6 nTPM
Lung	4.5 nTPM
Fallopian tube	4.2 nTPM
Skin	3.9 nTPM
PBMC	2.7 nTPM
Breast	2.7 nTPM
Lymph node	2.6 nTPM
Endometrium	2.5 nTPM
Esophagus	2.4 nTPM
Liver	1.7 nTPM
Bone marrow	1.2 nTPM
Kidney	0.9 nTPM
Spleen	0.9 nTPM
Stomach	0.4 nTPM
Colon	0.0 nTPM

Undifferentiated cells	5.5 nTPM
Rectum	6.0 nTPM
Small intestine	5.9 nTPM
Colon	4.6 nTPM

Amygdala excitatory	28.8 nTPM
Hypothalamus	33.1 nTPM
Amygdala	32.3 nTPM
Thalamus	29.9 nTPM
Basal ganglia	26.7 nTPM
Hippocampus	26.7 nTPM
Cerebral cortex	24.3 nTPM

Astrocyte	22.4 nTPM
Amygdala	32.0 nTPM
Hypothalamus	25.6 nTPM
Hippocampus	24.5 nTPM
Cerebral cortex	23.6 nTPM
Midbrain	22.0 nTPM
Basal ganglia	21.6 nTPM
Cerebellum	21.1 nTPM
Thalamus	20.7 nTPM
Pons	20.5 nTPM
Medulla oblongata	18.9 nTPM
Spinal cord	15.6 nTPM

Bergmann glia	29.0 nTPM
Pons	36.0 nTPM
Cerebellum	29.8 nTPM
Medulla oblongata	21.3 nTPM

Central nervous system macrophage	23.9 nTPM
Amygdala	30.2 nTPM
Hypothalamus	27.9 nTPM
Thalamus	26.5 nTPM
Hippocampus	26.2 nTPM
Midbrain	26.0 nTPM
Cerebellum	23.5 nTPM
Basal ganglia	22.6 nTPM
Medulla oblongata	22.6 nTPM
Cerebral cortex	22.2 nTPM
Pons	21.8 nTPM
Spinal cord	13.8 nTPM

Cerebellar inhibitory	17.0 nTPM
Spinal cord	19.2 nTPM
Cerebellum	17.4 nTPM
Midbrain	17.4 nTPM
Medulla oblongata	16.6 nTPM
Pons	14.5 nTPM

Cge interneuron	30.8 nTPM
Hypothalamus	43.5 nTPM
Amygdala	36.1 nTPM
Basal ganglia	31.8 nTPM
Hippocampus	30.4 nTPM
Cerebral cortex	28.6 nTPM
Midbrain	24.3 nTPM
Thalamus	21.0 nTPM

Choroid plexus epithelial cell	13.8 nTPM
Basal ganglia	25.5 nTPM
Medulla oblongata	13.2 nTPM
Hippocampus	8.3 nTPM
Thalamus	8.2 nTPM

Committed oligodendrocyte precursor	25.7 nTPM
Hypothalamus	38.9 nTPM
Amygdala	38.3 nTPM
Thalamus	29.9 nTPM
Hippocampus	27.4 nTPM
Midbrain	26.9 nTPM
Cerebral cortex	24.1 nTPM
Pons	22.1 nTPM
Spinal cord	22.1 nTPM
Cerebellum	20.6 nTPM
Basal ganglia	17.0 nTPM
Medulla oblongata	15.5 nTPM

Deep-layer corticothalamic and 6b	21.4 nTPM
Midbrain	25.5 nTPM
Amygdala	23.1 nTPM
Hypothalamus	21.6 nTPM
Basal ganglia	20.3 nTPM
Cerebral cortex	20.2 nTPM
Hippocampus	18.0 nTPM

Deep-layer intratelencephalic	27.2 nTPM
Hypothalamus	37.7 nTPM
Amygdala	28.5 nTPM
Hippocampus	23.9 nTPM
Basal ganglia	23.8 nTPM
Cerebral cortex	21.9 nTPM

Deep-layer near-projecting	17.1 nTPM
Hypothalamus	23.8 nTPM
Amygdala	17.8 nTPM
Basal ganglia	16.5 nTPM
Cerebral cortex	16.0 nTPM
Hippocampus	11.4 nTPM

Eccentric medium spiny neuron	24.5 nTPM
Amygdala	27.6 nTPM
Hippocampus	26.1 nTPM
Hypothalamus	25.4 nTPM
Thalamus	25.2 nTPM
Cerebral cortex	23.9 nTPM
Basal ganglia	19.1 nTPM

Endothelial cell	17.9 nTPM
Basal ganglia	24.2 nTPM
Hypothalamus	23.6 nTPM
Pons	22.5 nTPM
Thalamus	20.3 nTPM
Cerebral cortex	19.8 nTPM
Hippocampus	18.3 nTPM
Amygdala	16.8 nTPM
Spinal cord	15.5 nTPM
Midbrain	15.1 nTPM
Medulla oblongata	10.3 nTPM
Cerebellum	10.1 nTPM

Ependymal cell	15.6 nTPM
Amygdala	22.8 nTPM
Midbrain	19.0 nTPM
Basal ganglia	18.1 nTPM
Hypothalamus	17.0 nTPM
Hippocampus	16.6 nTPM
Thalamus	16.2 nTPM
Medulla oblongata	12.1 nTPM
Spinal cord	9.6 nTPM
Pons	9.0 nTPM