Single cell type - TFG - The Human Protein Atlas

TFG

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TFG
Gene descriptionⁱ Full gene name according to HGNC.	Trafficking from ER to golgi regulator
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	27

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Plasma cells - Protein processing (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.24
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

TFG is part of cluster 77 Plasma cells - Protein processing with confidenceⁱ 1
324 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RRAGA	Ras related GTP binding A	0.5502	3
PGM3	Phosphoglucomutase 3	0.5195	77
TMED9	Transmembrane p24 trafficking protein 9	0.5188	77
RTCB	RNA 2',3'-cyclic phosphate and 5'-OH ligase	0.5185	22
SEC13	SEC13 homolog, nuclear pore and COPII coat complex component	0.5049	77
RNF121	Ring finger protein 121	0.5034	39
COPB2	COPI coat complex subunit beta 2	0.4913	77
TMEM115	Transmembrane protein 115	0.4739	50
ALG2	ALG2 alpha-1,3/1,6-mannosyltransferase	0.4659	77
LRRC41	Leucine rich repeat containing 41	0.4559	37
MKRN2OS	MKRN2 opposite strand	0.4530	22
YIPF5	Yip1 domain family member 5	0.4529	77
COPZ1	COPI coat complex subunit zeta 1	0.4503	77
KDELR2	KDEL endoplasmic reticulum protein retention receptor 2	0.4493	77
ABCF3	ATP binding cassette subfamily F member 3	0.4479	3

IMMUNE CELLS

TFG is part of cluster 42 Non-specific - Vesicular transport with confidenceⁱ 0.69
519 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
COPS7A	COP9 signalosome subunit 7A	1.0000	42
M6PR	Mannose-6-phosphate receptor, cation dependent	1.0000	42
CHP1	Calcineurin like EF-hand protein 1	0.9762	42
JKAMP	JNK1/MAPK8 associated membrane protein	0.9762	42
RUSC1	RUN and SH3 domain containing 1	0.9762	42
DHX8	DEAH-box helicase 8	0.9524	42
MCOLN1	Mucolipin TRP cation channel 1	0.9524	42
PRKAG1	Protein kinase AMP-activated non-catalytic subunit gamma 1	0.9524	10
COPS6	COP9 signalosome subunit 6	0.9524	42
GTF3C2	General transcription factor IIIC subunit 2	0.9524	10
EMC7	ER membrane protein complex subunit 7	0.9524	10
CERS5	Ceramide synthase 5	0.9524	42
TMCO1	Transmembrane and coiled-coil domains 1	0.9524	42
PPP1R7	Protein phosphatase 1 regulatory subunit 7	0.9286	42
SUCLG1	Succinate-CoA ligase GDP/ADP-forming subunit alpha	0.9286	42

Adipocytes	71.0 nTPM
Adipose tissue	83.4 nTPM
Breast	58.5 nTPM

Alveolar cells type 1	85.3 nTPM
Lung	85.3 nTPM

Alveolar cells type 2	80.8 nTPM
Lung	80.8 nTPM

Astrocytes	44.0 nTPM
Brain	44.0 nTPM

B-cells	41.6 nTPM
Skin	76.2 nTPM
Adipose tissue	64.6 nTPM
Lymph node	47.1 nTPM
Salivary gland	44.8 nTPM
Stomach	41.8 nTPM
PBMC	41.6 nTPM
Thymus	40.1 nTPM
Lung	38.9 nTPM
Spleen	38.6 nTPM
Bone marrow	38.4 nTPM
Esophagus	29.5 nTPM
Liver	24.2 nTPM
Kidney	15.6 nTPM

Ciliated cells	77.1 nTPM
Bronchus	84.2 nTPM
Endometrium	77.2 nTPM
Fallopian tube	74.4 nTPM
Lung	72.5 nTPM

Club cells	86.1 nTPM
Bronchus	127.1 nTPM
Lung	80.8 nTPM
Prostate	50.4 nTPM

Dendritic cells	59.7 nTPM
Adipose tissue	76.3 nTPM
PBMC	43.2 nTPM

Endothelial cells	69.3 nTPM
Pancreas	106.0 nTPM
Skin	90.4 nTPM
Fallopian tube	82.8 nTPM
Lung	78.0 nTPM
Skeletal muscle	77.4 nTPM
Placenta	73.2 nTPM
Tongue	70.4 nTPM
Thymus	69.6 nTPM
Breast	69.4 nTPM
Prostate	64.8 nTPM
Endometrium	63.4 nTPM
Testis	61.4 nTPM
Liver	60.5 nTPM
Salivary gland	60.2 nTPM
Vascular	56.1 nTPM
Esophagus	56.0 nTPM
Ovary	55.4 nTPM
Heart muscle	51.6 nTPM

Enteroendocrine cells	69.9 nTPM
Colon	111.2 nTPM
Small intestine	51.5 nTPM
Rectum	47.0 nTPM

Fibroblasts	92.6 nTPM
Pancreas	191.8 nTPM
Placenta	127.4 nTPM
Skeletal muscle	118.0 nTPM
Adipose tissue	105.3 nTPM
Lung	103.9 nTPM
Skin	103.2 nTPM
Fallopian tube	96.4 nTPM
Stomach	86.5 nTPM
Thymus	78.6 nTPM
Vascular	76.3 nTPM
Breast	75.1 nTPM
Prostate	68.6 nTPM
Salivary gland	68.2 nTPM
Heart muscle	67.0 nTPM
Esophagus	66.2 nTPM
Liver	48.6 nTPM

Granulocytes	109.6 nTPM
Fallopian tube	166.2 nTPM
Tongue	82.5 nTPM
Lung	80.2 nTPM

Intestinal goblet cells	117.3 nTPM
Colon	150.1 nTPM
Small intestine	109.6 nTPM
Rectum	92.3 nTPM

Lymphatic endothelial cells	86.5 nTPM
Fallopian tube	107.5 nTPM
Ovary	65.5 nTPM

Macrophages	49.1 nTPM
Adipose tissue	76.9 nTPM
Pancreas	76.1 nTPM
Lung	75.8 nTPM
Fallopian tube	63.0 nTPM
Tongue	57.8 nTPM
Vascular	55.3 nTPM
Thymus	55.0 nTPM
Breast	50.5 nTPM
Testis	49.0 nTPM
Skin	47.9 nTPM
Prostate	47.3 nTPM
Endometrium	46.1 nTPM
Skeletal muscle	45.9 nTPM
Salivary gland	40.8 nTPM
Kidney	33.6 nTPM
Spleen	33.1 nTPM
Esophagus	30.8 nTPM
Bone marrow	29.4 nTPM
Stomach	18.0 nTPM

Basal keratinocytes	123.3 nTPM
Skin	143.3 nTPM
Tongue	103.3 nTPM

Basal prostatic cells	100.2 nTPM
Prostate	100.2 nTPM

Basal respiratory cells	176.9 nTPM
Bronchus	176.9 nTPM

Basal squamous epithelial cells	66.7 nTPM
Esophagus	66.7 nTPM

Paneth cells	93.8 nTPM
Small intestine	114.0 nTPM
Rectum	87.9 nTPM
Colon	79.6 nTPM

Plasma cells	82.3 nTPM
Fallopian tube	115.8 nTPM
Stomach	105.5 nTPM
Salivary gland	87.3 nTPM
Esophagus	83.2 nTPM
Spleen	83.2 nTPM
Thymus	79.5 nTPM
Liver	55.6 nTPM
Bone marrow	48.3 nTPM

Schwann cells	68.6 nTPM
Esophagus	83.9 nTPM
Adipose tissue	76.5 nTPM
Vascular	45.4 nTPM

Serous glandular cells	69.8 nTPM
Salivary gland	86.5 nTPM
Tongue	53.0 nTPM

Smooth muscle cells	73.7 nTPM
Placenta	163.8 nTPM
Fallopian tube	88.0 nTPM
Skin	80.6 nTPM
Skeletal muscle	78.9 nTPM
Prostate	74.8 nTPM
Lung	74.1 nTPM
Tongue	71.0 nTPM
Adipose tissue	70.8 nTPM
Thymus	67.0 nTPM
Endometrium	66.5 nTPM
Breast	63.3 nTPM
Ovary	63.2 nTPM
Vascular	58.2 nTPM
Liver	53.9 nTPM
Esophagus	52.9 nTPM
Salivary gland	51.6 nTPM

Suprabasal keratinocytes	136.2 nTPM
Tongue	147.1 nTPM
Skin	125.3 nTPM

T-cells	46.0 nTPM
Adipose tissue	66.8 nTPM
Fallopian tube	58.2 nTPM
Breast	55.5 nTPM
Prostate	54.5 nTPM
Tongue	52.8 nTPM
Endometrium	51.7 nTPM
Skin	50.8 nTPM
Colon	49.7 nTPM
Skeletal muscle	48.8 nTPM
Lymph node	48.1 nTPM
Vascular	46.2 nTPM
Salivary gland	44.1 nTPM
Kidney	42.6 nTPM
Lung	42.1 nTPM
Thymus	41.1 nTPM
Stomach	40.7 nTPM
Spleen	40.6 nTPM
PBMC	35.9 nTPM
Liver	32.9 nTPM
Esophagus	31.6 nTPM
Bone marrow	31.2 nTPM

Undifferentiated cells	92.0 nTPM
Small intestine	102.2 nTPM
Colon	99.2 nTPM
Rectum	74.8 nTPM

Amygdala excitatory	71.3 nTPM
Thalamus	76.7 nTPM
Hippocampus	75.3 nTPM
Cerebral cortex	73.4 nTPM
Hypothalamus	71.6 nTPM
Amygdala	67.9 nTPM
Basal ganglia	63.0 nTPM

Astrocyte	76.8 nTPM
Amygdala	96.1 nTPM
Spinal cord	92.2 nTPM
Hypothalamus	82.2 nTPM
Basal ganglia	77.0 nTPM
Hippocampus	74.6 nTPM
Cerebral cortex	72.8 nTPM
Thalamus	72.0 nTPM
Midbrain	70.6 nTPM
Pons	70.2 nTPM
Cerebellum	69.9 nTPM
Medulla oblongata	67.0 nTPM

Bergmann glia	76.0 nTPM
Pons	89.2 nTPM
Cerebellum	79.2 nTPM
Medulla oblongata	59.7 nTPM

Central nervous system macrophage	80.9 nTPM
Amygdala	109.5 nTPM
Hypothalamus	87.6 nTPM
Spinal cord	83.3 nTPM
Hippocampus	83.0 nTPM
Midbrain	82.7 nTPM
Basal ganglia	78.4 nTPM
Pons	78.4 nTPM
Thalamus	78.4 nTPM
Cerebellum	77.0 nTPM
Cerebral cortex	68.8 nTPM
Medulla oblongata	63.2 nTPM

Cerebellar inhibitory	99.5 nTPM
Spinal cord	104.5 nTPM
Cerebellum	102.2 nTPM
Midbrain	97.7 nTPM
Medulla oblongata	96.7 nTPM
Pons	96.6 nTPM

Cge interneuron	66.5 nTPM
Thalamus	73.6 nTPM
Midbrain	72.9 nTPM
Hypothalamus	68.3 nTPM
Amygdala	66.0 nTPM
Basal ganglia	62.1 nTPM
Cerebral cortex	61.8 nTPM
Hippocampus	61.1 nTPM

Choroid plexus epithelial cell	112.5 nTPM
Basal ganglia	156.5 nTPM
Medulla oblongata	108.7 nTPM
Hippocampus	99.8 nTPM
Thalamus	85.0 nTPM

Committed oligodendrocyte precursor	73.4 nTPM
Pons	93.0 nTPM
Cerebral cortex	77.9 nTPM
Hypothalamus	77.2 nTPM
Cerebellum	74.5 nTPM
Midbrain	73.9 nTPM
Spinal cord	73.6 nTPM
Hippocampus	73.0 nTPM
Amygdala	72.7 nTPM
Thalamus	68.9 nTPM
Medulla oblongata	65.8 nTPM
Basal ganglia	56.9 nTPM

Deep-layer corticothalamic and 6b	68.1 nTPM
Midbrain	76.5 nTPM
Amygdala	72.7 nTPM
Hippocampus	70.5 nTPM
Cerebral cortex	65.8 nTPM
Basal ganglia	61.6 nTPM
Hypothalamus	61.5 nTPM

Deep-layer intratelencephalic	64.7 nTPM
Amygdala	71.0 nTPM
Hippocampus	67.4 nTPM
Cerebral cortex	63.4 nTPM
Hypothalamus	62.6 nTPM
Basal ganglia	59.1 nTPM

Deep-layer near-projecting	61.8 nTPM
Cerebral cortex	65.2 nTPM
Basal ganglia	64.8 nTPM
Hypothalamus	62.3 nTPM
Amygdala	60.8 nTPM
Hippocampus	55.6 nTPM

Eccentric medium spiny neuron	69.2 nTPM
Basal ganglia	71.9 nTPM
Amygdala	71.3 nTPM
Hypothalamus	71.0 nTPM
Thalamus	68.9 nTPM
Hippocampus	67.6 nTPM
Cerebral cortex	64.8 nTPM