Single cell type - ARSB - The Human Protein Atlas

ARSB

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ARSB
Gene descriptionⁱ Full gene name according to HGNC.	Arylsulfatase B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Oligodendrocyte precursor - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Oligodendrocyte precursor cells, Oligodendrocytes, Inhibitory neurons, Astrocytes, Microglial cells, Excitatory neurons)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.61
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enhanced (eosinophil)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Oligodendrocyte precursor cells, Oligodendrocytes, Inhibitory neurons, Astrocytes, Microglial cells, Excitatory neurons)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enhanced (eosinophil)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ARSB is part of cluster 76 Oligodendrocyte precursor - Unknown function with confidenceⁱ 1
210 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RIN2	Ras and Rab interactor 2	0.5658	76
SLC10A7	Solute carrier family 10 member 7	0.5309	76
CHST11	Carbohydrate sulfotransferase 11	0.5111	76
FCHSD2	FCH and double SH3 domains 2	0.4973	76
ZSWIM6	Zinc finger SWIM-type containing 6	0.4918	76
SGMS1	Sphingomyelin synthase 1	0.4827	76
SCN9A	Sodium voltage-gated channel alpha subunit 9	0.4756	58
ZNF710	Zinc finger protein 710	0.4748	28
PLPPR1	Phospholipid phosphatase related 1	0.4733	76
LGMN	Legumain	0.4678	58
KCNQ1	Potassium voltage-gated channel subfamily Q member 1	0.4631	16
USP24	Ubiquitin specific peptidase 24	0.4627	76
SCAF8	SR-related CTD associated factor 8	0.4512	69
NAV2	Neuron navigator 2	0.4446	76
ADCK1	AarF domain containing kinase 1	0.4415	51

IMMUNE CELLS

ARSB is part of cluster 10 Non-specific - Membrane trafficking with confidenceⁱ 0.97
408 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PHETA2	PH domain containing endocytic trafficking adaptor 2	1.0000	10
H1-0	H1.0 linker histone	0.9762	10
CAMTA1	Calmodulin binding transcription activator 1	0.9762	41
KIF5B	Kinesin family member 5B	0.9524	10
ENSG00000267740	Novel protein	0.9524	10
TEN1	TEN1 subunit of CST complex	0.9524	10
SETD4	SET domain containing 4	0.9524	10
COA5	Cytochrome c oxidase assembly factor 5	0.9524	10
NAA38	N-alpha-acetyltransferase 38, NatC auxiliary subunit	0.9524	10
CAPG	Capping actin protein, gelsolin like	0.9524	10
FAM234A	Family with sequence similarity 234 member A	0.9524	10
UQCRQ	Ubiquinol-cytochrome c reductase complex III subunit VII	0.9524	10
FMO5	Flavin containing dimethylaniline monoxygenase 5	0.9524	10
MTIF3	Mitochondrial translational initiation factor 3	0.9524	10
HSD17B4	Hydroxysteroid 17-beta dehydrogenase 4	0.9286	10

Adipocytes	3.8 nTPM
Adipose tissue	4.5 nTPM
Breast	3.0 nTPM

Alveolar cells type 1	2.7 nTPM
Lung	2.7 nTPM

Alveolar cells type 2	3.0 nTPM
Lung	3.0 nTPM

B-cells	5.3 nTPM
Skin	11.9 nTPM
Adipose tissue	7.4 nTPM
Lung	6.7 nTPM
Spleen	6.0 nTPM
Stomach	5.9 nTPM
Thymus	5.9 nTPM
Lymph node	5.7 nTPM
Bone marrow	5.7 nTPM
Kidney	5.2 nTPM
PBMC	4.6 nTPM
Salivary gland	4.4 nTPM
Liver	0.0 nTPM
Esophagus	0.0 nTPM

Basal keratinocytes	0.8 nTPM
Tongue	1.2 nTPM
Skin	0.4 nTPM

Ciliated cells	1.2 nTPM
Endometrium	1.5 nTPM
Lung	1.5 nTPM
Fallopian tube	1.1 nTPM
Bronchus	0.8 nTPM

Club cells	2.2 nTPM
Lung	3.1 nTPM
Prostate	1.8 nTPM
Bronchus	1.6 nTPM

Endothelial cells	5.6 nTPM
Lung	14.1 nTPM
Pancreas	10.3 nTPM
Liver	10.1 nTPM
Thymus	7.8 nTPM
Placenta	7.4 nTPM
Prostate	7.0 nTPM
Salivary gland	6.5 nTPM
Endometrium	5.9 nTPM
Vascular	4.5 nTPM
Skeletal muscle	4.0 nTPM
Tongue	3.9 nTPM
Skin	3.8 nTPM
Ovary	3.8 nTPM
Breast	3.5 nTPM
Fallopian tube	3.2 nTPM
Heart muscle	2.3 nTPM
Testis	1.5 nTPM
Esophagus	1.3 nTPM

Enteroendocrine cells	2.7 nTPM
Small intestine	3.4 nTPM
Rectum	3.4 nTPM
Colon	1.2 nTPM

Fibroblasts	6.6 nTPM
Liver	23.7 nTPM
Heart muscle	10.3 nTPM
Pancreas	9.9 nTPM
Skin	7.9 nTPM
Vascular	7.3 nTPM
Thymus	6.4 nTPM
Stomach	5.8 nTPM
Esophagus	5.5 nTPM
Placenta	4.9 nTPM
Adipose tissue	4.8 nTPM
Skeletal muscle	4.5 nTPM
Salivary gland	4.4 nTPM
Fallopian tube	4.3 nTPM
Lung	4.1 nTPM
Breast	2.2 nTPM
Prostate	0.0 nTPM

Granulocytes	9.5 nTPM
Tongue	19.4 nTPM
Fallopian tube	5.4 nTPM
Lung	3.5 nTPM

Intestinal goblet cells	8.1 nTPM
Rectum	14.4 nTPM
Colon	8.6 nTPM
Small intestine	1.2 nTPM

Lymphatic endothelial cells	5.2 nTPM
Ovary	5.5 nTPM
Fallopian tube	4.9 nTPM

Macrophages	17.4 nTPM
Vascular	30.4 nTPM
Esophagus	25.7 nTPM
Adipose tissue	25.4 nTPM
Lung	22.3 nTPM
Thymus	21.8 nTPM
Skin	21.2 nTPM
Pancreas	20.6 nTPM
Testis	18.0 nTPM
Spleen	18.0 nTPM
Skeletal muscle	17.9 nTPM
Fallopian tube	17.2 nTPM
Tongue	16.9 nTPM
Salivary gland	15.1 nTPM
Kidney	13.3 nTPM
Bone marrow	12.2 nTPM
Prostate	10.9 nTPM
Endometrium	8.6 nTPM
Stomach	7.7 nTPM
Breast	6.7 nTPM

Paneth cells	3.0 nTPM
Rectum	5.6 nTPM
Small intestine	3.5 nTPM
Colon	0.0 nTPM

Astrocytes	38.7 nTPM
Brain	38.7 nTPM

Collecting duct cells	1.9 nTPM
Kidney	1.9 nTPM

Cytotrophoblasts	2.1 nTPM
Placenta	2.1 nTPM

Distal enterocytes	2.4 nTPM
Rectum	4.2 nTPM
Colon	0.5 nTPM

Plasma cells	11.1 nTPM
Thymus	17.0 nTPM
Spleen	13.5 nTPM
Fallopian tube	12.2 nTPM
Esophagus	10.4 nTPM
Salivary gland	10.3 nTPM
Liver	10.0 nTPM
Stomach	9.2 nTPM
Bone marrow	6.0 nTPM

Schwann cells	6.6 nTPM
Adipose tissue	18.3 nTPM
Vascular	1.6 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	3.0 nTPM
Salivary gland	5.9 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	4.9 nTPM
Placenta	15.2 nTPM
Vascular	8.6 nTPM
Thymus	8.3 nTPM
Endometrium	7.5 nTPM
Liver	5.5 nTPM
Tongue	5.1 nTPM
Skin	4.0 nTPM
Salivary gland	3.7 nTPM
Skeletal muscle	3.6 nTPM
Esophagus	3.6 nTPM
Fallopian tube	3.5 nTPM
Adipose tissue	3.1 nTPM
Ovary	1.9 nTPM
Prostate	1.8 nTPM
Breast	1.6 nTPM
Lung	1.2 nTPM

T-cells	3.4 nTPM
Thymus	6.0 nTPM
Skeletal muscle	5.7 nTPM
Tongue	4.9 nTPM
Stomach	4.3 nTPM
Lung	4.2 nTPM
Endometrium	4.1 nTPM
Adipose tissue	4.0 nTPM
Vascular	4.0 nTPM
Lymph node	3.8 nTPM
Prostate	3.8 nTPM
Fallopian tube	3.5 nTPM
Spleen	3.0 nTPM
Colon	2.9 nTPM
Bone marrow	2.8 nTPM
Skin	2.5 nTPM
PBMC	2.4 nTPM
Esophagus	2.4 nTPM
Salivary gland	2.1 nTPM
Kidney	1.8 nTPM
Liver	1.7 nTPM
Breast	1.7 nTPM

Undifferentiated cells	2.8 nTPM
Rectum	3.2 nTPM
Small intestine	2.8 nTPM
Colon	2.3 nTPM

Amygdala excitatory	65.5 nTPM
Hypothalamus	115.4 nTPM
Amygdala	65.9 nTPM
Basal ganglia	64.3 nTPM
Thalamus	55.4 nTPM
Cerebral cortex	48.4 nTPM
Hippocampus	43.4 nTPM

Astrocyte	76.9 nTPM
Hypothalamus	101.4 nTPM
Amygdala	92.1 nTPM
Hippocampus	79.8 nTPM
Thalamus	79.6 nTPM
Midbrain	77.8 nTPM
Basal ganglia	72.2 nTPM
Cerebellum	71.6 nTPM
Spinal cord	71.4 nTPM
Pons	68.6 nTPM
Cerebral cortex	66.7 nTPM
Medulla oblongata	65.2 nTPM

Bergmann glia	73.5 nTPM
Medulla oblongata	81.0 nTPM
Cerebellum	79.1 nTPM
Pons	60.4 nTPM

Central nervous system macrophage	196.5 nTPM
Amygdala	285.2 nTPM
Hypothalamus	237.7 nTPM
Midbrain	207.1 nTPM
Hippocampus	197.5 nTPM
Thalamus	197.5 nTPM
Cerebellum	192.1 nTPM
Basal ganglia	177.4 nTPM
Pons	176.6 nTPM
Cerebral cortex	174.5 nTPM
Spinal cord	163.4 nTPM
Medulla oblongata	153.0 nTPM

Cerebellar inhibitory	42.6 nTPM
Cerebellum	49.1 nTPM
Midbrain	46.7 nTPM
Pons	45.1 nTPM
Medulla oblongata	41.8 nTPM
Spinal cord	30.2 nTPM

Cge interneuron	72.8 nTPM
Hypothalamus	96.1 nTPM
Amygdala	82.5 nTPM
Basal ganglia	71.6 nTPM
Midbrain	69.7 nTPM
Thalamus	65.8 nTPM
Cerebral cortex	62.7 nTPM
Hippocampus	61.6 nTPM

Choroid plexus epithelial cell	54.8 nTPM
Basal ganglia	96.4 nTPM
Hippocampus	41.6 nTPM
Thalamus	41.1 nTPM
Medulla oblongata	39.9 nTPM

Committed oligodendrocyte precursor	129.9 nTPM
Amygdala	187.8 nTPM
Cerebral cortex	163.4 nTPM
Hippocampus	161.4 nTPM
Spinal cord	150.8 nTPM
Hypothalamus	148.8 nTPM
Thalamus	131.0 nTPM
Basal ganglia	123.7 nTPM
Midbrain	111.7 nTPM
Cerebellum	92.0 nTPM
Pons	85.9 nTPM
Medulla oblongata	72.3 nTPM

Deep-layer corticothalamic and 6b	60.9 nTPM
Hippocampus	75.1 nTPM
Amygdala	74.8 nTPM
Hypothalamus	64.3 nTPM
Midbrain	61.0 nTPM
Cerebral cortex	48.5 nTPM
Basal ganglia	41.9 nTPM

Deep-layer intratelencephalic	61.0 nTPM
Hypothalamus	77.3 nTPM
Amygdala	72.3 nTPM
Basal ganglia	53.3 nTPM
Cerebral cortex	51.0 nTPM
Hippocampus	50.8 nTPM

Deep-layer near-projecting	84.1 nTPM
Amygdala	102.4 nTPM
Hypothalamus	95.7 nTPM
Cerebral cortex	82.7 nTPM
Basal ganglia	73.3 nTPM
Hippocampus	66.7 nTPM

Eccentric medium spiny neuron	59.9 nTPM
Hippocampus	66.3 nTPM
Hypothalamus	60.5 nTPM
Thalamus	59.5 nTPM
Cerebral cortex	58.2 nTPM
Amygdala	58.0 nTPM
Basal ganglia	56.9 nTPM

Endothelial cell	55.4 nTPM
Basal ganglia	83.9 nTPM
Spinal cord	77.7 nTPM
Thalamus	55.9 nTPM
Hippocampus	54.8 nTPM
Midbrain	52.0 nTPM
Cerebellum	51.9 nTPM
Amygdala	51.4 nTPM
Cerebral cortex	51.1 nTPM
Hypothalamus	47.1 nTPM
Pons	44.3 nTPM
Medulla oblongata	39.0 nTPM

Ependymal cell	35.8 nTPM
Amygdala	44.4 nTPM
Midbrain	44.4 nTPM
Basal ganglia	43.7 nTPM
Hippocampus	36.3 nTPM
Hypothalamus	35.7 nTPM
Pons	34.6 nTPM
Thalamus	31.2 nTPM
Medulla oblongata	27.4 nTPM
Spinal cord	24.9 nTPM