Single cell type - CUL9 - The Human Protein Atlas

CUL9

Search result

Field

Term

Cluster

Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CUL9
Gene descriptionⁱ Full gene name according to HGNC.	Cullin 9
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Late spermatids - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enriched (Late spermatids)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.72
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enriched (Late spermatids)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

CUL9 is part of cluster 36 Late spermatids - Unknown function with confidenceⁱ 1
427 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PDYN	Prodynorphin	0.9537	36
ADAM21	ADAM metallopeptidase domain 21	0.9497	36
SPATA12	Spermatogenesis associated 12	0.9438	36
TMEM239	Transmembrane protein 239	0.9352	36
MSTO1	Misato mitochondrial distribution and morphology regulator 1	0.9277	36
MORN3	MORN repeat containing 3	0.9151	36
ENSG00000187186	Novel protein	0.9151	36
PSMF1	Proteasome inhibitor subunit 1	0.8894	36
TSPAN16	Tetraspanin 16	0.8843	36
PHF2	PHD finger protein 2	0.8820	36
NUPR2	Nuclear protein 2, transcriptional regulator	0.8701	36
TMEM210	Transmembrane protein 210	0.8673	36
SPATA20	Spermatogenesis associated 20	0.8668	36
CLPB	Caseinolytic mitochondrial matrix peptidase chaperone subunit B	0.8576	36
C16orf90	Chromosome 16 open reading frame 90	0.8569	36

IMMUNE CELLS

CUL9 is part of cluster 33 Non-specific - ATP binding with confidenceⁱ 0.91
757 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
DAP3	Death associated protein 3	1.0000	33
MPI	Mannose phosphate isomerase	1.0000	33
TECR	Trans-2,3-enoyl-CoA reductase	0.9762	33
ADSL	Adenylosuccinate lyase	0.9762	33
ACOT1	Acyl-CoA thioesterase 1	0.9762	33
NDUFAF2	NADH:ubiquinone oxidoreductase complex assembly factor 2	0.9762	33
THAP11	THAP domain containing 11	0.9762	33
PLK3	Polo like kinase 3	0.9524	33
COX11	Cytochrome c oxidase copper chaperone COX11	0.9524	12
NFS1	NFS1 cysteine desulfurase	0.9286	33
NCDN	Neurochondrin	0.9286	33
TECPR1	Tectonin beta-propeller repeat containing 1	0.9286	33
GLOD4	Glyoxalase domain containing 4	0.9286	12
RPUSD4	RNA pseudouridine synthase D4	0.9286	33
SEPTIN8	Septin 8	0.9286	33

Adipocytes	6.4 nTPM
Adipose tissue	7.9 nTPM
Breast	5.0 nTPM

Alveolar cells type 1	5.5 nTPM
Lung	5.5 nTPM

Alveolar cells type 2	6.0 nTPM
Lung	6.0 nTPM

Astrocytes	15.5 nTPM
Brain	15.5 nTPM

B-cells	8.6 nTPM
Esophagus	23.6 nTPM
Lung	13.4 nTPM
Bone marrow	12.5 nTPM
Kidney	10.4 nTPM
Stomach	10.1 nTPM
Salivary gland	9.1 nTPM
Thymus	9.1 nTPM
Lymph node	8.6 nTPM
Spleen	7.1 nTPM
Adipose tissue	4.9 nTPM
PBMC	3.1 nTPM
Liver	0.0 nTPM
Skin	0.0 nTPM

Ciliated cells	9.1 nTPM
Bronchus	12.9 nTPM
Lung	9.3 nTPM
Fallopian tube	8.2 nTPM
Endometrium	6.0 nTPM

Club cells	6.4 nTPM
Bronchus	7.5 nTPM
Prostate	6.3 nTPM
Lung	5.6 nTPM

Endothelial cells	6.5 nTPM
Liver	15.1 nTPM
Testis	9.8 nTPM
Esophagus	9.6 nTPM
Vascular	7.7 nTPM
Thymus	7.6 nTPM
Heart muscle	7.1 nTPM
Placenta	6.8 nTPM
Tongue	6.8 nTPM
Ovary	6.7 nTPM
Skeletal muscle	6.6 nTPM
Prostate	5.3 nTPM
Salivary gland	5.0 nTPM
Endometrium	4.7 nTPM
Lung	4.7 nTPM
Fallopian tube	4.6 nTPM
Skin	3.5 nTPM
Pancreas	2.6 nTPM
Breast	2.6 nTPM

Enteroendocrine cells	5.0 nTPM
Small intestine	6.9 nTPM
Rectum	5.0 nTPM
Colon	3.1 nTPM

Fibroblasts	4.5 nTPM
Stomach	8.6 nTPM
Liver	7.1 nTPM
Esophagus	6.1 nTPM
Salivary gland	5.7 nTPM
Placenta	5.6 nTPM
Skeletal muscle	5.5 nTPM
Thymus	4.6 nTPM
Vascular	4.6 nTPM
Adipose tissue	3.6 nTPM
Breast	3.6 nTPM
Heart muscle	3.5 nTPM
Fallopian tube	3.2 nTPM
Skin	3.1 nTPM
Lung	2.9 nTPM
Prostate	2.6 nTPM
Pancreas	2.0 nTPM

Granulocytes	2.8 nTPM
Lung	5.5 nTPM
Fallopian tube	2.9 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	5.8 nTPM
Small intestine	8.4 nTPM
Rectum	5.8 nTPM
Colon	3.2 nTPM

Lymphatic endothelial cells	7.3 nTPM
Ovary	10.9 nTPM
Fallopian tube	3.8 nTPM

Macrophages	8.3 nTPM
Bone marrow	13.2 nTPM
Spleen	12.0 nTPM
Skin	11.1 nTPM
Breast	10.9 nTPM
Kidney	9.7 nTPM
Thymus	9.7 nTPM
Tongue	9.4 nTPM
Esophagus	9.0 nTPM
Pancreas	8.2 nTPM
Salivary gland	8.2 nTPM
Vascular	7.5 nTPM
Lung	7.0 nTPM
Prostate	7.0 nTPM
Testis	6.8 nTPM
Fallopian tube	6.4 nTPM
Skeletal muscle	6.1 nTPM
Adipose tissue	6.0 nTPM
Stomach	5.1 nTPM
Endometrium	3.7 nTPM

Paneth cells	3.1 nTPM
Rectum	5.8 nTPM
Colon	3.6 nTPM
Small intestine	0.0 nTPM

Basal prostatic cells	5.2 nTPM
Prostate	5.2 nTPM

Bipolar cells	8.9 nTPM
Eye	8.9 nTPM

Collecting duct cells	3.9 nTPM
Kidney	3.9 nTPM

Cytotrophoblasts	3.3 nTPM
Placenta	3.3 nTPM

Plasma cells	3.5 nTPM
Thymus	5.8 nTPM
Spleen	5.3 nTPM
Salivary gland	4.9 nTPM
Stomach	3.8 nTPM
Bone marrow	3.0 nTPM
Fallopian tube	2.9 nTPM
Liver	2.5 nTPM
Esophagus	0.0 nTPM

Schwann cells	3.9 nTPM
Vascular	7.3 nTPM
Adipose tissue	4.3 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	9.3 nTPM
Tongue	13.3 nTPM
Salivary gland	5.3 nTPM

Smooth muscle cells	4.7 nTPM
Liver	8.9 nTPM
Prostate	7.3 nTPM
Salivary gland	6.6 nTPM
Lung	5.9 nTPM
Adipose tissue	4.7 nTPM
Vascular	4.7 nTPM
Tongue	4.5 nTPM
Endometrium	4.4 nTPM
Skin	4.3 nTPM
Skeletal muscle	4.0 nTPM
Thymus	3.8 nTPM
Breast	3.8 nTPM
Fallopian tube	3.6 nTPM
Ovary	3.1 nTPM
Placenta	3.0 nTPM
Esophagus	2.4 nTPM

T-cells	7.5 nTPM
Skin	14.7 nTPM
Lymph node	12.7 nTPM
Esophagus	12.2 nTPM
Breast	10.3 nTPM
Salivary gland	10.1 nTPM
Thymus	9.9 nTPM
Skeletal muscle	9.5 nTPM
Spleen	8.8 nTPM
Tongue	8.5 nTPM
Bone marrow	8.1 nTPM
Vascular	7.6 nTPM
Lung	7.3 nTPM
Endometrium	6.7 nTPM
Adipose tissue	6.6 nTPM
Stomach	6.2 nTPM
PBMC	5.1 nTPM
Liver	4.7 nTPM
Prostate	4.5 nTPM
Fallopian tube	3.3 nTPM
Colon	1.0 nTPM
Kidney	0.0 nTPM

Undifferentiated cells	4.4 nTPM
Rectum	5.7 nTPM
Small intestine	4.6 nTPM
Colon	2.8 nTPM

Amygdala excitatory	21.9 nTPM
Amygdala	26.3 nTPM
Hypothalamus	25.3 nTPM
Basal ganglia	23.4 nTPM
Cerebral cortex	20.4 nTPM
Hippocampus	19.6 nTPM
Thalamus	16.3 nTPM

Astrocyte	27.2 nTPM
Cerebellum	36.9 nTPM
Pons	30.9 nTPM
Midbrain	28.4 nTPM
Hippocampus	28.0 nTPM
Spinal cord	27.4 nTPM
Thalamus	27.1 nTPM
Cerebral cortex	26.0 nTPM
Amygdala	24.5 nTPM
Basal ganglia	24.4 nTPM
Medulla oblongata	23.2 nTPM
Hypothalamus	22.3 nTPM

Bergmann glia	20.8 nTPM
Medulla oblongata	38.4 nTPM
Cerebellum	18.2 nTPM
Pons	5.8 nTPM

Central nervous system macrophage	25.9 nTPM
Amygdala	31.4 nTPM
Hippocampus	28.0 nTPM
Cerebral cortex	27.6 nTPM
Pons	26.5 nTPM
Midbrain	26.2 nTPM
Spinal cord	25.9 nTPM
Cerebellum	24.9 nTPM
Thalamus	23.8 nTPM
Basal ganglia	23.7 nTPM
Medulla oblongata	23.5 nTPM
Hypothalamus	23.4 nTPM

Cerebellar inhibitory	17.6 nTPM
Midbrain	23.6 nTPM
Cerebellum	17.2 nTPM
Medulla oblongata	17.1 nTPM
Spinal cord	16.5 nTPM
Pons	13.8 nTPM

Cge interneuron	17.5 nTPM
Hypothalamus	24.6 nTPM
Amygdala	18.7 nTPM
Cerebral cortex	16.9 nTPM
Thalamus	16.3 nTPM
Hippocampus	15.6 nTPM
Basal ganglia	15.5 nTPM
Midbrain	15.1 nTPM

Choroid plexus epithelial cell	22.3 nTPM
Basal ganglia	33.1 nTPM
Thalamus	24.7 nTPM
Medulla oblongata	17.7 nTPM
Hippocampus	13.9 nTPM

Committed oligodendrocyte precursor	24.0 nTPM
Cerebellum	33.3 nTPM
Basal ganglia	27.4 nTPM
Hippocampus	26.1 nTPM
Cerebral cortex	26.0 nTPM
Amygdala	25.4 nTPM
Thalamus	25.4 nTPM
Hypothalamus	25.3 nTPM
Pons	22.1 nTPM
Medulla oblongata	19.4 nTPM
Midbrain	18.5 nTPM
Spinal cord	14.7 nTPM

Deep-layer corticothalamic and 6b	20.7 nTPM
Hypothalamus	23.1 nTPM
Cerebral cortex	22.9 nTPM
Amygdala	22.3 nTPM
Basal ganglia	21.0 nTPM
Hippocampus	19.2 nTPM
Midbrain	15.5 nTPM

Deep-layer intratelencephalic	22.9 nTPM
Hypothalamus	31.3 nTPM
Cerebral cortex	22.8 nTPM
Basal ganglia	21.8 nTPM
Amygdala	19.9 nTPM
Hippocampus	18.7 nTPM

Deep-layer near-projecting	20.8 nTPM
Amygdala	25.2 nTPM
Hypothalamus	25.0 nTPM
Cerebral cortex	22.4 nTPM
Basal ganglia	16.9 nTPM
Hippocampus	14.6 nTPM

Eccentric medium spiny neuron	20.6 nTPM
Thalamus	22.2 nTPM
Amygdala	21.2 nTPM
Cerebral cortex	21.2 nTPM
Hippocampus	20.3 nTPM
Hypothalamus	20.0 nTPM
Basal ganglia	18.7 nTPM

Endothelial cell	16.5 nTPM
Hypothalamus	23.6 nTPM
Basal ganglia	19.6 nTPM
Medulla oblongata	19.5 nTPM
Pons	18.1 nTPM
Amygdala	17.9 nTPM
Hippocampus	16.7 nTPM
Spinal cord	15.5 nTPM
Midbrain	15.1 nTPM
Thalamus	13.6 nTPM
Cerebellum	11.6 nTPM
Cerebral cortex	10.9 nTPM

Ependymal cell	17.8 nTPM
Spinal cord	21.1 nTPM
Basal ganglia	20.6 nTPM
Hippocampus	20.0 nTPM
Amygdala	19.9 nTPM
Midbrain	17.1 nTPM
Thalamus	16.6 nTPM
Pons	15.7 nTPM
Medulla oblongata	14.9 nTPM
Hypothalamus	14.3 nTPM