Single cell type - GPLD1 - The Human Protein Atlas

GPLD1

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GPLD1
Gene descriptionⁱ Full gene name according to HGNC.	Glycosylphosphatidylinositol specific phospholipase D1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Enzymes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Hepatocytes - Metabolism (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Hepatocytes, Inhibitory neurons, Excitatory neurons, Cone photoreceptor cells, Oligodendrocyte precursor cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.76
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data.	Protein predicted to be secreted

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Hepatocytes, Inhibitory neurons, Excitatory neurons, Cone photoreceptor cells, Oligodendrocyte precursor cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

GPLD1 is part of cluster 43 Hepatocytes - Metabolism with confidenceⁱ 0.99
200 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GYS2	Glycogen synthase 2	0.6903	62
ZNF385D	Zinc finger protein 385D	0.6471	8
ABAT	4-aminobutyrate aminotransferase	0.6466	62
GLS2	Glutaminase 2	0.6301	62
SYT3	Synaptotagmin 3	0.6265	69
KLKB1	Kallikrein B1	0.6125	62
AKAIN1	A-kinase anchor inhibitor 1	0.6104	8
ORM1	Orosomucoid 1	0.5937	43
CFHR5	Complement factor H related 5	0.5915	62
ALDH5A1	Aldehyde dehydrogenase 5 family member A1	0.5847	43
CA5A	Carbonic anhydrase 5A	0.5813	43
MAST1	Microtubule associated serine/threonine kinase 1	0.5807	69
CPEB3	Cytoplasmic polyadenylation element binding protein 3	0.5786	8
KNG1	Kininogen 1	0.5771	43
CYP2B6	Cytochrome P450 family 2 subfamily B member 6	0.5760	43

Adipocytes	0.2 nTPM
Breast	0.3 nTPM
Adipose tissue	0.2 nTPM

Alveolar cells type 1	1.0 nTPM
Lung	1.0 nTPM

Alveolar cells type 2	5.0 nTPM
Lung	5.0 nTPM

Astrocytes	23.5 nTPM
Brain	23.5 nTPM

B-cells	1.5 nTPM
Liver	4.8 nTPM
Bone marrow	3.2 nTPM
Lung	2.7 nTPM
Salivary gland	2.7 nTPM
Adipose tissue	2.1 nTPM
Thymus	1.5 nTPM
Spleen	1.0 nTPM
Stomach	0.8 nTPM
Lymph node	0.4 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM

Ciliated cells	1.7 nTPM
Lung	3.1 nTPM
Fallopian tube	1.9 nTPM
Bronchus	1.2 nTPM
Endometrium	0.5 nTPM

Club cells	1.9 nTPM
Prostate	2.9 nTPM
Lung	1.6 nTPM
Bronchus	1.2 nTPM

Endothelial cells	0.7 nTPM
Liver	3.8 nTPM
Testis	1.2 nTPM
Placenta	1.1 nTPM
Ovary	0.9 nTPM
Skeletal muscle	0.8 nTPM
Lung	0.8 nTPM
Vascular	0.7 nTPM
Tongue	0.6 nTPM
Fallopian tube	0.6 nTPM
Prostate	0.5 nTPM
Thymus	0.4 nTPM
Endometrium	0.3 nTPM
Salivary gland	0.2 nTPM
Heart muscle	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM
Breast	0.0 nTPM

Enteroendocrine cells	0.2 nTPM
Colon	0.5 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	1.5 nTPM
Heart muscle	6.8 nTPM
Breast	3.0 nTPM
Liver	2.4 nTPM
Salivary gland	1.6 nTPM
Vascular	1.6 nTPM
Skeletal muscle	1.5 nTPM
Fallopian tube	1.5 nTPM
Skin	1.4 nTPM
Adipose tissue	1.1 nTPM
Esophagus	0.7 nTPM
Thymus	0.7 nTPM
Lung	0.6 nTPM
Pancreas	0.4 nTPM
Placenta	0.0 nTPM
Stomach	0.0 nTPM
Prostate	0.0 nTPM

Granulocytes	0.5 nTPM
Lung	1.0 nTPM
Fallopian tube	0.6 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	0.3 nTPM
Rectum	0.9 nTPM
Small intestine	0.1 nTPM
Colon	0.0 nTPM

Lymphatic endothelial cells	0.2 nTPM
Fallopian tube	0.4 nTPM
Ovary	0.0 nTPM

Macrophages	0.1 nTPM
Skeletal muscle	0.4 nTPM
Thymus	0.4 nTPM
Lung	0.2 nTPM
Prostate	0.2 nTPM
Salivary gland	0.2 nTPM
Vascular	0.1 nTPM
Breast	0.1 nTPM
Testis	0.0 nTPM
Kidney	0.0 nTPM
Endometrium	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Tongue	0.0 nTPM
Fallopian tube	0.0 nTPM

Paneth cells	0.1 nTPM
Rectum	0.2 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Basal respiratory cells	3.5 nTPM
Bronchus	3.5 nTPM

Bipolar cells	19.1 nTPM
Eye	19.1 nTPM

Collecting duct cells	3.9 nTPM
Kidney	3.9 nTPM

Early spermatids	3.7 nTPM
Testis	3.7 nTPM

Plasma cells	3.5 nTPM
Liver	6.0 nTPM
Esophagus	5.2 nTPM
Fallopian tube	5.1 nTPM
Bone marrow	4.5 nTPM
Stomach	3.4 nTPM
Salivary gland	3.1 nTPM
Thymus	0.6 nTPM
Spleen	0.2 nTPM

Schwann cells	0.5 nTPM
Vascular	1.6 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	0.5 nTPM
Salivary gland	1.0 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	1.4 nTPM
Vascular	4.4 nTPM
Fallopian tube	2.3 nTPM
Skeletal muscle	2.1 nTPM
Adipose tissue	1.8 nTPM
Ovary	1.7 nTPM
Thymus	1.5 nTPM
Breast	1.4 nTPM
Liver	1.3 nTPM
Salivary gland	1.3 nTPM
Skin	1.2 nTPM
Prostate	1.2 nTPM
Endometrium	0.9 nTPM
Placenta	0.3 nTPM
Tongue	0.3 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM

T-cells	0.6 nTPM
PBMC	1.5 nTPM
Liver	1.4 nTPM
Salivary gland	1.3 nTPM
Skeletal muscle	1.1 nTPM
Fallopian tube	0.9 nTPM
Thymus	0.8 nTPM
Vascular	0.8 nTPM
Skin	0.7 nTPM
Spleen	0.5 nTPM
Lung	0.5 nTPM
Prostate	0.5 nTPM
Endometrium	0.4 nTPM
Adipose tissue	0.4 nTPM
Lymph node	0.3 nTPM
Bone marrow	0.3 nTPM
Tongue	0.3 nTPM
Breast	0.3 nTPM
Stomach	0.1 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Esophagus	0.0 nTPM

Undifferentiated cells	0.7 nTPM
Small intestine	0.9 nTPM
Rectum	0.8 nTPM
Colon	0.5 nTPM

Amygdala excitatory	64.5 nTPM
Thalamus	96.2 nTPM
Basal ganglia	66.6 nTPM
Amygdala	58.5 nTPM
Hippocampus	55.5 nTPM
Hypothalamus	55.5 nTPM
Cerebral cortex	54.8 nTPM

Astrocyte	43.3 nTPM
Cerebral cortex	49.1 nTPM
Basal ganglia	48.2 nTPM
Amygdala	48.0 nTPM
Midbrain	45.6 nTPM
Hippocampus	44.5 nTPM
Hypothalamus	43.3 nTPM
Thalamus	41.0 nTPM
Medulla oblongata	39.9 nTPM
Spinal cord	39.0 nTPM
Cerebellum	38.8 nTPM
Pons	38.8 nTPM

Bergmann glia	26.4 nTPM
Medulla oblongata	27.7 nTPM
Cerebellum	27.0 nTPM
Pons	24.5 nTPM

Central nervous system macrophage	4.0 nTPM
Amygdala	5.8 nTPM
Thalamus	5.7 nTPM
Cerebral cortex	4.9 nTPM
Hypothalamus	4.9 nTPM
Pons	4.6 nTPM
Cerebellum	4.0 nTPM
Hippocampus	3.1 nTPM
Midbrain	3.0 nTPM
Basal ganglia	2.9 nTPM
Medulla oblongata	2.7 nTPM
Spinal cord	2.6 nTPM

Cerebellar inhibitory	84.3 nTPM
Cerebellum	98.9 nTPM
Midbrain	90.2 nTPM
Medulla oblongata	84.7 nTPM
Pons	84.3 nTPM
Spinal cord	63.2 nTPM

Cge interneuron	85.9 nTPM
Cerebral cortex	98.9 nTPM
Basal ganglia	89.8 nTPM
Amygdala	85.3 nTPM
Midbrain	85.0 nTPM
Hypothalamus	84.8 nTPM
Hippocampus	83.3 nTPM
Thalamus	74.0 nTPM

Choroid plexus epithelial cell	14.5 nTPM
Medulla oblongata	18.5 nTPM
Basal ganglia	17.4 nTPM
Hippocampus	11.1 nTPM
Thalamus	11.0 nTPM

Committed oligodendrocyte precursor	24.5 nTPM
Midbrain	38.6 nTPM
Spinal cord	29.4 nTPM
Cerebral cortex	29.1 nTPM
Pons	26.6 nTPM
Cerebellum	25.4 nTPM
Basal ganglia	24.1 nTPM
Hippocampus	23.0 nTPM
Medulla oblongata	20.7 nTPM
Amygdala	19.2 nTPM
Thalamus	18.7 nTPM
Hypothalamus	15.0 nTPM

Deep-layer corticothalamic and 6b	79.4 nTPM
Midbrain	105.4 nTPM
Cerebral cortex	82.0 nTPM
Basal ganglia	77.0 nTPM
Hippocampus	74.6 nTPM
Amygdala	70.3 nTPM
Hypothalamus	67.3 nTPM

Deep-layer intratelencephalic	70.1 nTPM
Hippocampus	82.4 nTPM
Cerebral cortex	77.9 nTPM
Basal ganglia	67.1 nTPM
Hypothalamus	66.1 nTPM
Amygdala	56.6 nTPM

Deep-layer near-projecting	67.9 nTPM
Cerebral cortex	86.9 nTPM
Basal ganglia	71.9 nTPM
Amygdala	61.9 nTPM
Hypothalamus	59.5 nTPM
Hippocampus	59.2 nTPM

Eccentric medium spiny neuron	58.9 nTPM
Basal ganglia	60.5 nTPM
Hypothalamus	60.2 nTPM
Thalamus	59.8 nTPM
Cerebral cortex	59.1 nTPM
Amygdala	58.0 nTPM
Hippocampus	56.0 nTPM

Endothelial cell	8.9 nTPM
Medulla oblongata	15.4 nTPM
Cerebral cortex	14.1 nTPM
Thalamus	14.1 nTPM
Hippocampus	9.6 nTPM
Cerebellum	9.3 nTPM
Midbrain	8.5 nTPM
Hypothalamus	7.4 nTPM
Pons	6.9 nTPM
Amygdala	6.7 nTPM
Spinal cord	3.5 nTPM
Basal ganglia	2.8 nTPM

Ependymal cell	36.8 nTPM
Amygdala	48.3 nTPM
Basal ganglia	43.4 nTPM
Hypothalamus	42.8 nTPM
Hippocampus	37.1 nTPM
Thalamus	36.4 nTPM
Spinal cord	34.5 nTPM
Medulla oblongata	30.7 nTPM
Pons	29.9 nTPM
Midbrain	27.9 nTPM