Single cell type - VWF - The Human Protein Atlas

VWF

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	VWF
Gene descriptionⁱ Full gene name according to HGNC.	Von Willebrand factor
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Human disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Adipocytes & Endothelial cells - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (Adipocytes, Endothelial cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.79
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enriched (Endothelial cell)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data.	Protein predicted to be secreted

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Group enriched (Adipocytes, Endothelial cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enriched (Endothelial cell)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

VWF is part of cluster 41 Adipocytes & Endothelial cells - Mixed function with confidenceⁱ 1
325 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ARHGEF15	Rho guanine nucleotide exchange factor 15	0.9386	41
MMRN2	Multimerin 2	0.9367	41
CYYR1	Cysteine and tyrosine rich 1	0.9067	41
CLEC14A	C-type lectin domain containing 14A	0.9024	41
LCN6	Lipocalin 6	0.8881	41
ADGRL4	Adhesion G protein-coupled receptor L4	0.8540	41
SOX18	SRY-box transcription factor 18	0.8473	41
SEMA3G	Semaphorin 3G	0.8445	41
NOTCH4	Notch receptor 4	0.8252	41
SPAAR	Small regulatory polypeptide of amino acid response	0.8179	41
PECAM1	Platelet and endothelial cell adhesion molecule 1	0.8177	41
MEOX1	Mesenchyme homeobox 1	0.8113	41
CD34	CD34 molecule	0.8031	41
BTNL9	Butyrophilin like 9	0.8002	41
EMCN	Endomucin	0.7967	41

Adipocytes	917.4 nTPM
Adipose tissue	1194.6 nTPM
Breast	640.1 nTPM

Alveolar cells type 1	8.9 nTPM
Lung	8.9 nTPM

Alveolar cells type 2	5.8 nTPM
Lung	5.8 nTPM

Astrocytes	3.4 nTPM
Brain	3.4 nTPM

B-cells	4.1 nTPM
Kidney	31.2 nTPM
Thymus	17.2 nTPM
Salivary gland	1.9 nTPM
Lung	1.3 nTPM
Lymph node	1.0 nTPM
Spleen	0.1 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Stomach	0.0 nTPM

Ciliated cells	3.0 nTPM
Lung	6.0 nTPM
Fallopian tube	4.8 nTPM
Endometrium	1.1 nTPM
Bronchus	0.3 nTPM

Club cells	3.4 nTPM
Lung	5.2 nTPM
Prostate	4.2 nTPM
Bronchus	0.9 nTPM

Endothelial cells	827.6 nTPM
Testis	1561.2 nTPM
Heart muscle	1517.0 nTPM
Thymus	1458.5 nTPM
Vascular	1343.0 nTPM
Ovary	1215.8 nTPM
Lung	1128.1 nTPM
Skeletal muscle	1105.5 nTPM
Salivary gland	1019.7 nTPM
Fallopian tube	850.3 nTPM
Prostate	764.7 nTPM
Tongue	615.1 nTPM
Endometrium	593.7 nTPM
Placenta	440.5 nTPM
Esophagus	388.1 nTPM
Breast	365.6 nTPM
Liver	215.4 nTPM
Skin	193.8 nTPM
Pancreas	121.5 nTPM

Enteroendocrine cells	0.0 nTPM
Colon	0.1 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	17.2 nTPM
Stomach	70.6 nTPM
Heart muscle	61.5 nTPM
Liver	56.9 nTPM
Thymus	35.9 nTPM
Vascular	16.6 nTPM
Lung	11.1 nTPM
Prostate	5.9 nTPM
Breast	4.8 nTPM
Skeletal muscle	3.7 nTPM
Skin	2.3 nTPM
Esophagus	1.9 nTPM
Salivary gland	1.6 nTPM
Adipose tissue	0.9 nTPM
Fallopian tube	0.9 nTPM
Placenta	0.4 nTPM
Pancreas	0.0 nTPM

Granulocytes	3.7 nTPM
Lung	8.6 nTPM
Fallopian tube	2.5 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Lymphatic endothelial cells	119.0 nTPM
Ovary	218.2 nTPM
Fallopian tube	19.9 nTPM

Macrophages	7.2 nTPM
Thymus	66.9 nTPM
Vascular	20.8 nTPM
Skeletal muscle	15.0 nTPM
Esophagus	5.1 nTPM
Breast	4.5 nTPM
Salivary gland	3.9 nTPM
Lung	3.8 nTPM
Tongue	3.3 nTPM
Stomach	2.6 nTPM
Testis	2.5 nTPM
Skin	2.2 nTPM
Endometrium	1.8 nTPM
Prostate	1.5 nTPM
Fallopian tube	1.2 nTPM
Bone marrow	1.0 nTPM
Adipose tissue	0.8 nTPM
Kidney	0.0 nTPM
Pancreas	0.0 nTPM
Spleen	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Basal prostatic cells	15.4 nTPM
Prostate	15.4 nTPM

Collecting duct cells	7.8 nTPM
Kidney	7.8 nTPM

Excitatory neurons	2.8 nTPM
Brain	2.8 nTPM

Plasma cells	2.9 nTPM
Thymus	12.8 nTPM
Salivary gland	6.3 nTPM
Liver	2.5 nTPM
Stomach	1.7 nTPM
Fallopian tube	0.3 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Schwann cells	10.1 nTPM
Vascular	18.3 nTPM
Esophagus	12.0 nTPM
Adipose tissue	0.0 nTPM

Serous glandular cells	8.9 nTPM
Tongue	13.3 nTPM
Salivary gland	4.5 nTPM

Smooth muscle cells	65.2 nTPM
Liver	779.0 nTPM
Skeletal muscle	168.1 nTPM
Prostate	18.9 nTPM
Thymus	18.7 nTPM
Vascular	15.6 nTPM
Breast	10.5 nTPM
Fallopian tube	9.1 nTPM
Ovary	8.5 nTPM
Lung	4.7 nTPM
Tongue	4.5 nTPM
Endometrium	3.3 nTPM
Adipose tissue	1.6 nTPM
Skin	1.2 nTPM
Placenta	0.2 nTPM
Esophagus	0.0 nTPM
Salivary gland	0.0 nTPM

T-cells	2.0 nTPM
Vascular	12.1 nTPM
Breast	7.5 nTPM
Skin	4.6 nTPM
Prostate	4.3 nTPM
Tongue	4.1 nTPM
Endometrium	2.3 nTPM
Salivary gland	1.9 nTPM
Lung	1.6 nTPM
Liver	1.3 nTPM
Thymus	0.9 nTPM
Stomach	0.7 nTPM
Fallopian tube	0.7 nTPM
Lymph node	0.6 nTPM
Skeletal muscle	0.4 nTPM
Adipose tissue	0.1 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Undifferentiated cells	0.1 nTPM
Rectum	0.2 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Amygdala excitatory	1.4 nTPM
Cerebral cortex	1.8 nTPM
Thalamus	1.8 nTPM
Hippocampus	1.5 nTPM
Amygdala	1.4 nTPM
Basal ganglia	1.3 nTPM
Hypothalamus	0.8 nTPM

Astrocyte	2.9 nTPM
Spinal cord	5.0 nTPM
Hypothalamus	4.7 nTPM
Medulla oblongata	4.0 nTPM
Cerebellum	3.2 nTPM
Hippocampus	2.9 nTPM
Basal ganglia	2.7 nTPM
Midbrain	2.6 nTPM
Thalamus	2.4 nTPM
Pons	2.1 nTPM
Cerebral cortex	1.6 nTPM
Amygdala	1.1 nTPM

Bergmann glia	3.5 nTPM
Cerebellum	4.7 nTPM
Medulla oblongata	4.3 nTPM
Pons	1.4 nTPM

Central nervous system macrophage	2.3 nTPM
Hypothalamus	4.1 nTPM
Spinal cord	3.5 nTPM
Basal ganglia	2.7 nTPM
Cerebellum	2.4 nTPM
Medulla oblongata	2.2 nTPM
Hippocampus	2.1 nTPM
Midbrain	2.0 nTPM
Pons	2.0 nTPM
Thalamus	1.7 nTPM
Cerebral cortex	1.6 nTPM
Amygdala	1.2 nTPM

Cerebellar inhibitory	2.3 nTPM
Medulla oblongata	3.9 nTPM
Spinal cord	2.7 nTPM
Cerebellum	2.1 nTPM
Pons	1.6 nTPM
Midbrain	1.2 nTPM

Cge interneuron	1.0 nTPM
Cerebral cortex	1.2 nTPM
Hippocampus	1.1 nTPM
Midbrain	1.1 nTPM
Thalamus	1.1 nTPM
Amygdala	1.0 nTPM
Basal ganglia	0.9 nTPM
Hypothalamus	0.6 nTPM

Choroid plexus epithelial cell	0.5 nTPM
Medulla oblongata	1.0 nTPM
Basal ganglia	0.9 nTPM
Hippocampus	0.0 nTPM
Thalamus	0.0 nTPM

Committed oligodendrocyte precursor	6.0 nTPM
Spinal cord	14.7 nTPM
Amygdala	10.1 nTPM
Midbrain	6.7 nTPM
Medulla oblongata	6.5 nTPM
Cerebral cortex	5.1 nTPM
Basal ganglia	4.9 nTPM
Cerebellum	4.8 nTPM
Hippocampus	4.4 nTPM
Thalamus	4.3 nTPM
Hypothalamus	2.7 nTPM
Pons	1.8 nTPM

Deep-layer corticothalamic and 6b	1.2 nTPM
Basal ganglia	1.5 nTPM
Cerebral cortex	1.5 nTPM
Hippocampus	1.3 nTPM
Amygdala	1.2 nTPM
Midbrain	1.1 nTPM
Hypothalamus	0.9 nTPM

Deep-layer intratelencephalic	1.2 nTPM
Basal ganglia	1.6 nTPM
Cerebral cortex	1.5 nTPM
Hippocampus	1.3 nTPM
Amygdala	1.1 nTPM
Hypothalamus	0.7 nTPM

Deep-layer near-projecting	1.5 nTPM
Amygdala	2.3 nTPM
Hippocampus	2.0 nTPM
Basal ganglia	1.2 nTPM
Cerebral cortex	1.2 nTPM
Hypothalamus	1.1 nTPM

Eccentric medium spiny neuron	1.3 nTPM
Hippocampus	2.1 nTPM
Cerebral cortex	1.5 nTPM
Hypothalamus	1.3 nTPM
Amygdala	1.2 nTPM
Basal ganglia	1.1 nTPM
Thalamus	0.9 nTPM

Endothelial cell	1181.2 nTPM
Basal ganglia	2576.3 nTPM
Hypothalamus	1325.0 nTPM
Amygdala	1270.9 nTPM
Midbrain	1111.4 nTPM
Cerebral cortex	1094.5 nTPM
Hippocampus	1049.9 nTPM
Thalamus	1022.3 nTPM
Medulla oblongata	1008.1 nTPM
Cerebellum	986.5 nTPM
Pons	832.0 nTPM
Spinal cord	716.3 nTPM

Ependymal cell	2.6 nTPM
Spinal cord	5.7 nTPM
Hippocampus	3.7 nTPM
Pons	2.7 nTPM
Medulla oblongata	2.4 nTPM
Thalamus	2.4 nTPM
Basal ganglia	1.8 nTPM
Hypothalamus	1.8 nTPM
Amygdala	1.7 nTPM
Midbrain	1.3 nTPM