Single cell type - MAPK10 - The Human Protein Atlas

MAPK10

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Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MAPK10
Gene descriptionⁱ Full gene name according to HGNC.	Mitogen-activated protein kinase 10
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Enzymes Human disease related genes Potential drug targets RAS pathway related proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	116

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Neurons - Neuronal signaling (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Excitatory neurons, Astrocytes, Inhibitory neurons, Oligodendrocyte precursor cells, Late spermatids, Oligodendrocytes, Early spermatids)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.69
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Excitatory neurons, Astrocytes, Inhibitory neurons, Oligodendrocyte precursor cells, Late spermatids, Oligodendrocytes, Early spermatids)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

MAPK10 is part of cluster 34 Neurons - Neuronal signaling with confidenceⁱ 1
518 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
FMN2	Formin 2	0.8318	34
NAV3	Neuron navigator 3	0.8231	34
TRPM3	Transient receptor potential cation channel subfamily M member 3	0.8167	34
OTOL1	Otolin 1	0.7726	34
OPRM1	Opioid receptor mu 1	0.7511	34
CALHM1	Calcium homeostasis modulator 1	0.7261	34
KIAA0319	KIAA0319	0.7232	34
AGBL4	AGBL carboxypeptidase 4	0.7175	34
OR1J2	Olfactory receptor family 1 subfamily J member 2	0.7061	34
DCHS2	Dachsous cadherin-related 2	0.7028	34
ELAVL4	ELAV like RNA binding protein 4	0.7022	34
EFNA5	Ephrin A5	0.6998	34
SH3GL2	SH3 domain containing GRB2 like 2, endophilin A1	0.6968	34
NALF1	NALCN channel auxiliary factor 1	0.6961	34
OR1Q1	Olfactory receptor family 1 subfamily Q member 1	0.6953	34

IMMUNE CELLS

MAPK10 is part of cluster 35 Neutrophils - Protein binding with confidenceⁱ 0.58
504 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CD55	CD55 molecule (Cromer blood group)	1.0000	35
PTPRN2	Protein tyrosine phosphatase receptor type N2	1.0000	35
CSAD	Cysteine sulfinic acid decarboxylase	0.9762	20
CD300LD	CD300 molecule like family member d	0.9762	35
EVI2B	Ecotropic viral integration site 2B	0.9762	35
SDR42E2	Short chain dehydrogenase/reductase family 42E, member 2	0.9762	35
RMI1	RecQ mediated genome instability 1	0.9762	35
TMEM145	Transmembrane protein 145	0.9762	35
CDK19	Cyclin dependent kinase 19	0.9762	20
SLC12A6	Solute carrier family 12 member 6	0.9762	35
MAP7	Microtubule associated protein 7	0.9762	35
OR7C1	Olfactory receptor family 7 subfamily C member 1	0.9762	20
FKBP9	FKBP prolyl isomerase 9	0.9762	35
DICER1	Dicer 1, ribonuclease III	0.9762	35
CYB5R4	Cytochrome b5 reductase 4	0.9762	35

Adipocytes	3.0 nTPM
Breast	4.4 nTPM
Adipose tissue	1.6 nTPM

Alveolar cells type 1	4.4 nTPM
Lung	4.4 nTPM

Alveolar cells type 2	22.9 nTPM
Lung	22.9 nTPM

B-cells	3.7 nTPM
Thymus	8.3 nTPM
Lung	6.7 nTPM
Adipose tissue	6.2 nTPM
Kidney	5.2 nTPM
Liver	4.8 nTPM
Salivary gland	3.8 nTPM
PBMC	3.1 nTPM
Spleen	2.9 nTPM
Lymph node	1.8 nTPM
Skin	1.7 nTPM
Stomach	1.7 nTPM
Bone marrow	1.4 nTPM
Esophagus	0.0 nTPM

Basal keratinocytes	2.5 nTPM
Tongue	3.7 nTPM
Skin	1.2 nTPM

Ciliated cells	94.1 nTPM
Lung	148.2 nTPM
Bronchus	104.9 nTPM
Fallopian tube	66.6 nTPM
Endometrium	56.9 nTPM

Club cells	32.4 nTPM
Prostate	56.5 nTPM
Bronchus	23.6 nTPM
Lung	17.0 nTPM

Endothelial cells	1.5 nTPM
Prostate	4.8 nTPM
Ovary	4.5 nTPM
Heart muscle	2.2 nTPM
Placenta	1.7 nTPM
Endometrium	1.7 nTPM
Tongue	1.7 nTPM
Liver	1.3 nTPM
Vascular	1.3 nTPM
Testis	1.2 nTPM
Skeletal muscle	1.2 nTPM
Lung	1.1 nTPM
Breast	0.9 nTPM
Fallopian tube	0.8 nTPM
Salivary gland	0.6 nTPM
Thymus	0.6 nTPM
Esophagus	0.5 nTPM
Skin	0.4 nTPM
Pancreas	0.0 nTPM

Enteroendocrine cells	2.2 nTPM
Rectum	6.7 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Fibroblasts	22.6 nTPM
Prostate	79.2 nTPM
Esophagus	49.6 nTPM
Vascular	36.5 nTPM
Stomach	33.1 nTPM
Heart muscle	32.3 nTPM
Thymus	26.9 nTPM
Fallopian tube	25.4 nTPM
Salivary gland	23.0 nTPM
Lung	20.4 nTPM
Adipose tissue	13.9 nTPM
Breast	11.6 nTPM
Skeletal muscle	5.7 nTPM
Pancreas	2.2 nTPM
Skin	1.9 nTPM
Placenta	0.4 nTPM
Liver	0.0 nTPM

Granulocytes	2.0 nTPM
Fallopian tube	5.4 nTPM
Lung	0.5 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	0.2 nTPM
Small intestine	0.7 nTPM
Rectum	0.1 nTPM
Colon	0.0 nTPM

Lymphatic endothelial cells	0.3 nTPM
Fallopian tube	0.6 nTPM
Ovary	0.0 nTPM

Macrophages	1.0 nTPM
Prostate	2.9 nTPM
Esophagus	2.6 nTPM
Vascular	2.0 nTPM
Kidney	1.8 nTPM
Fallopian tube	1.8 nTPM
Thymus	1.6 nTPM
Adipose tissue	1.4 nTPM
Salivary gland	1.3 nTPM
Breast	1.3 nTPM
Bone marrow	1.0 nTPM
Testis	0.6 nTPM
Skeletal muscle	0.5 nTPM
Lung	0.5 nTPM
Tongue	0.5 nTPM
Endometrium	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Astrocytes	855.5 nTPM
Brain	855.5 nTPM

Bipolar cells	57.0 nTPM
Eye	57.0 nTPM

Cholangiocytes	15.3 nTPM
Liver	15.3 nTPM

Collecting duct cells	21.4 nTPM
Kidney	21.4 nTPM

Plasma cells	0.5 nTPM
Fallopian tube	2.6 nTPM
Thymus	0.8 nTPM
Salivary gland	0.4 nTPM
Spleen	0.2 nTPM
Liver	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Stomach	0.0 nTPM

Schwann cells	4.3 nTPM
Vascular	12.0 nTPM
Adipose tissue	0.8 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	3.1 nTPM
Tongue	4.4 nTPM
Salivary gland	1.8 nTPM

Smooth muscle cells	18.6 nTPM
Adipose tissue	81.7 nTPM
Esophagus	26.4 nTPM
Lung	25.9 nTPM
Breast	22.2 nTPM
Prostate	20.7 nTPM
Vascular	20.4 nTPM
Thymus	17.5 nTPM
Ovary	17.2 nTPM
Fallopian tube	13.4 nTPM
Skeletal muscle	11.4 nTPM
Placenta	10.6 nTPM
Endometrium	10.1 nTPM
Salivary gland	8.1 nTPM
Tongue	7.5 nTPM
Skin	2.0 nTPM
Liver	1.7 nTPM

T-cells	1.0 nTPM
Vascular	3.6 nTPM
Salivary gland	3.4 nTPM
Endometrium	2.4 nTPM
Prostate	1.9 nTPM
Fallopian tube	1.5 nTPM
Stomach	1.2 nTPM
Tongue	1.2 nTPM
Colon	1.0 nTPM
Skin	0.7 nTPM
Breast	0.7 nTPM
PBMC	0.6 nTPM
Adipose tissue	0.4 nTPM
Bone marrow	0.4 nTPM
Thymus	0.4 nTPM
Liver	0.3 nTPM
Lymph node	0.3 nTPM
Spleen	0.3 nTPM
Kidney	0.0 nTPM
Skeletal muscle	0.0 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM

Undifferentiated cells	0.1 nTPM
Colon	0.2 nTPM
Small intestine	0.1 nTPM
Rectum	0.1 nTPM

Amygdala excitatory	1228.1 nTPM
Cerebral cortex	1451.9 nTPM
Hypothalamus	1346.0 nTPM
Hippocampus	1322.3 nTPM
Amygdala	1278.6 nTPM
Basal ganglia	1145.6 nTPM
Thalamus	824.4 nTPM

Astrocyte	2093.4 nTPM
Amygdala	3027.7 nTPM
Hypothalamus	2212.5 nTPM
Basal ganglia	2131.3 nTPM
Midbrain	2086.8 nTPM
Thalamus	2083.6 nTPM
Hippocampus	2068.6 nTPM
Cerebellum	2029.3 nTPM
Pons	1977.8 nTPM
Cerebral cortex	1960.0 nTPM
Spinal cord	1810.6 nTPM
Medulla oblongata	1638.8 nTPM

Bergmann glia	1811.6 nTPM
Pons	1900.3 nTPM
Cerebellum	1863.6 nTPM
Medulla oblongata	1670.8 nTPM

Central nervous system macrophage	68.5 nTPM
Hypothalamus	117.9 nTPM
Thalamus	96.5 nTPM
Amygdala	82.8 nTPM
Cerebral cortex	74.7 nTPM
Basal ganglia	72.7 nTPM
Medulla oblongata	68.7 nTPM
Hippocampus	58.8 nTPM
Midbrain	50.7 nTPM
Pons	50.7 nTPM
Spinal cord	40.0 nTPM
Cerebellum	39.6 nTPM

Cerebellar inhibitory	751.5 nTPM
Spinal cord	879.9 nTPM
Medulla oblongata	737.3 nTPM
Pons	736.9 nTPM
Cerebellum	721.7 nTPM
Midbrain	681.5 nTPM

Cge interneuron	731.3 nTPM
Hypothalamus	820.2 nTPM
Amygdala	814.2 nTPM
Thalamus	780.9 nTPM
Midbrain	711.3 nTPM
Hippocampus	705.8 nTPM
Cerebral cortex	656.2 nTPM
Basal ganglia	630.3 nTPM

Choroid plexus epithelial cell	1860.7 nTPM
Basal ganglia	2663.1 nTPM
Medulla oblongata	1696.7 nTPM
Thalamus	1693.5 nTPM
Hippocampus	1389.4 nTPM

Committed oligodendrocyte precursor	433.6 nTPM
Medulla oblongata	586.1 nTPM
Amygdala	479.3 nTPM
Thalamus	472.8 nTPM
Basal ganglia	449.5 nTPM
Hippocampus	445.5 nTPM
Cerebellum	413.8 nTPM
Spinal cord	408.4 nTPM
Cerebral cortex	401.5 nTPM
Hypothalamus	385.8 nTPM
Pons	370.1 nTPM
Midbrain	357.0 nTPM

Deep-layer corticothalamic and 6b	1235.9 nTPM
Amygdala	1461.4 nTPM
Cerebral cortex	1360.4 nTPM
Hypothalamus	1216.4 nTPM
Midbrain	1157.1 nTPM
Hippocampus	1131.3 nTPM
Basal ganglia	1088.6 nTPM

Deep-layer intratelencephalic	1350.3 nTPM
Hypothalamus	1566.2 nTPM
Amygdala	1418.0 nTPM
Hippocampus	1329.9 nTPM
Cerebral cortex	1306.0 nTPM
Basal ganglia	1131.2 nTPM

Deep-layer near-projecting	1567.1 nTPM
Cerebral cortex	1911.3 nTPM
Amygdala	1839.6 nTPM
Hypothalamus	1624.5 nTPM
Hippocampus	1355.9 nTPM
Basal ganglia	1104.4 nTPM

Eccentric medium spiny neuron	849.1 nTPM
Amygdala	1048.3 nTPM
Hippocampus	883.3 nTPM
Thalamus	851.7 nTPM
Cerebral cortex	816.7 nTPM
Hypothalamus	750.5 nTPM
Basal ganglia	744.0 nTPM

Endothelial cell	47.0 nTPM
Hippocampus	88.8 nTPM
Hypothalamus	84.4 nTPM
Amygdala	71.5 nTPM
Cerebral cortex	49.9 nTPM
Basal ganglia	45.7 nTPM
Thalamus	38.4 nTPM
Cerebellum	31.7 nTPM
Spinal cord	27.6 nTPM
Pons	27.5 nTPM
Medulla oblongata	25.6 nTPM
Midbrain	25.5 nTPM

Ependymal cell	2624.9 nTPM
Hypothalamus	3340.0 nTPM
Amygdala	3068.8 nTPM
Basal ganglia	3024.8 nTPM
Thalamus	2627.3 nTPM
Hippocampus	2567.8 nTPM
Midbrain	2529.5 nTPM
Pons	2324.1 nTPM
Medulla oblongata	2091.3 nTPM
Spinal cord	2050.7 nTPM