Single cell type - NMU - The Human Protein Atlas

NMU

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NMU
Gene descriptionⁱ Full gene name according to HGNC.	Neuromedin U
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Squamous epithelial cells - Keratinization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Suprabasal keratinocytes, Squamous epithelial cells, Basal keratinocytes, Basal squamous epithelial cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.84
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Group enriched (MGE interneuron, Thalamic excitatory, Splatter)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (MAIT T-cell, memory CD4 T-cell)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data.	Protein predicted to be secreted

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Suprabasal keratinocytes, Squamous epithelial cells, Basal keratinocytes, Basal squamous epithelial cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Group enriched (MGE interneuron, Thalamic excitatory, Splatter)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Group enriched (MAIT T-cell, memory CD4 T-cell)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

NMU is part of cluster 12 Squamous epithelial cells - Keratinization with confidenceⁱ 1
309 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CALML3	Calmodulin like 3	0.8929	59
DSG3	Desmoglein 3	0.8867	12
LGALS7	Galectin 7	0.8513	12
FABP5	Fatty acid binding protein 5	0.8347	12
ZNF750	Zinc finger protein 750	0.8254	12
PITX1	Paired like homeodomain 1	0.8162	59
ADH7	Alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	0.8156	12
FOXN1	Forkhead box N1	0.8096	12
TMPRSS11A	Transmembrane serine protease 11A	0.8077	59
TRIM29	Tripartite motif containing 29	0.7856	12
CAPNS2	Calpain small subunit 2	0.7751	12
PGLYRP3	Peptidoglycan recognition protein 3	0.7681	12
LY6D	Lymphocyte antigen 6 family member D	0.7655	12
ALDH3A1	Aldehyde dehydrogenase 3 family member A1	0.7642	12
CLCA2	Chloride channel accessory 2	0.7600	12

IMMUNE CELLS

NMU is part of cluster 43 Non-specific - Transcription & Translation with confidenceⁱ 0.95
433 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SH2D3A	SH2 domain containing 3A	1.0000	43
RRP1B	Ribosomal RNA processing 1B	1.0000	43
TMEM25	Transmembrane protein 25	1.0000	43
ATIC	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	1.0000	43
CLEC2D	C-type lectin domain family 2 member D	1.0000	43
CLIP3	CAP-Gly domain containing linker protein 3	0.9762	43
RPS12	Ribosomal protein S12	0.9762	43
RPS25	Ribosomal protein S25	0.9762	43
RPL21	Ribosomal protein L21	0.9762	43
PARD6B	Par-6 family cell polarity regulator beta	0.9762	43
MTA3	Metastasis associated 1 family member 3	0.9762	43
CCR7	C-C motif chemokine receptor 7	0.9762	43
SAMD10	Sterile alpha motif domain containing 10	0.9762	43
RAB25	RAB25, member RAS oncogene family	0.9762	43
GYPC	Glycophorin C (Gerbich blood group)	0.9762	43

Adipocytes	0.0 nTPM
Breast	0.1 nTPM
Adipose tissue	0.0 nTPM

Alveolar cells type 1	12.2 nTPM
Lung	12.2 nTPM

Alveolar cells type 2	22.7 nTPM
Lung	22.7 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	0.5 nTPM
Esophagus	5.9 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM

Ciliated cells	4.1 nTPM
Bronchus	10.9 nTPM
Endometrium	3.3 nTPM
Lung	1.8 nTPM
Fallopian tube	0.4 nTPM

Club cells	8.3 nTPM
Bronchus	14.0 nTPM
Lung	7.5 nTPM
Prostate	3.5 nTPM

Endothelial cells	4.1 nTPM
Tongue	67.6 nTPM
Endometrium	1.8 nTPM
Skin	1.1 nTPM
Lung	1.0 nTPM
Esophagus	0.8 nTPM
Testis	0.6 nTPM
Placenta	0.6 nTPM
Heart muscle	0.3 nTPM
Liver	0.0 nTPM
Pancreas	0.0 nTPM
Skeletal muscle	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Vascular	0.0 nTPM
Breast	0.0 nTPM
Fallopian tube	0.0 nTPM
Ovary	0.0 nTPM

Enteroendocrine cells	0.6 nTPM
Colon	1.7 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	0.2 nTPM
Lung	1.8 nTPM
Esophagus	0.5 nTPM
Placenta	0.2 nTPM
Skin	0.2 nTPM
Vascular	0.1 nTPM
Heart muscle	0.0 nTPM
Liver	0.0 nTPM
Pancreas	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Stomach	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Breast	0.0 nTPM
Fallopian tube	0.0 nTPM

Granulocytes	6.6 nTPM
Tongue	19.4 nTPM
Lung	0.5 nTPM
Fallopian tube	0.0 nTPM

Intestinal goblet cells	0.6 nTPM
Rectum	1.0 nTPM
Colon	0.7 nTPM
Small intestine	0.1 nTPM

Lymphatic endothelial cells	0.0 nTPM
Fallopian tube	0.0 nTPM
Ovary	0.0 nTPM

Macrophages	2.0 nTPM
Tongue	35.3 nTPM
Esophagus	1.3 nTPM
Endometrium	1.2 nTPM
Lung	0.2 nTPM
Salivary gland	0.1 nTPM
Breast	0.1 nTPM
Testis	0.0 nTPM
Kidney	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Prostate	0.0 nTPM
Thymus	0.0 nTPM
Vascular	0.0 nTPM
Fallopian tube	0.0 nTPM

Paneth cells	0.2 nTPM
Rectum	0.7 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Cytotrophoblasts	1.9 nTPM
Placenta	1.9 nTPM

Plasma cells	0.6 nTPM
Esophagus	5.2 nTPM
Liver	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Fallopian tube	0.0 nTPM

Schwann cells	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Vascular	0.0 nTPM

Serous glandular cells	8.8 nTPM
Tongue	17.7 nTPM
Salivary gland	0.0 nTPM

Smooth muscle cells	1.5 nTPM
Tongue	14.4 nTPM
Endometrium	4.8 nTPM
Esophagus	2.4 nTPM
Skin	0.8 nTPM
Breast	0.8 nTPM
Ovary	0.4 nTPM
Placenta	0.1 nTPM
Vascular	0.1 nTPM
Liver	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Fallopian tube	0.0 nTPM

Suprabasal keratinocytes	240.2 nTPM
Tongue	413.0 nTPM
Skin	67.4 nTPM

T-cells	1.4 nTPM
Tongue	21.1 nTPM
Liver	3.4 nTPM
Endometrium	1.3 nTPM
Skeletal muscle	0.8 nTPM
Breast	0.6 nTPM
Adipose tissue	0.3 nTPM
Lymph node	0.3 nTPM
Fallopian tube	0.3 nTPM
PBMC	0.2 nTPM
Spleen	0.2 nTPM
Prostate	0.2 nTPM
Bone marrow	0.1 nTPM
Stomach	0.1 nTPM
Thymus	0.1 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM
Salivary gland	0.0 nTPM
Vascular	0.0 nTPM

Undifferentiated cells	8.9 nTPM
Colon	21.0 nTPM
Rectum	4.5 nTPM
Small intestine	1.1 nTPM

Amygdala excitatory	0.5 nTPM
Thalamus	1.4 nTPM
Basal ganglia	0.9 nTPM
Hypothalamus	0.4 nTPM
Cerebral cortex	0.3 nTPM
Amygdala	0.2 nTPM
Hippocampus	0.2 nTPM

Astrocyte	0.6 nTPM
Thalamus	1.4 nTPM
Hypothalamus	1.0 nTPM
Midbrain	0.9 nTPM
Cerebral cortex	0.5 nTPM
Spinal cord	0.5 nTPM
Basal ganglia	0.4 nTPM
Pons	0.4 nTPM
Cerebellum	0.3 nTPM
Hippocampus	0.3 nTPM
Amygdala	0.2 nTPM
Medulla oblongata	0.2 nTPM

Bergmann glia	0.0 nTPM
Cerebellum	0.1 nTPM
Medulla oblongata	0.0 nTPM
Pons	0.0 nTPM

Central nervous system macrophage	0.6 nTPM
Thalamus	2.2 nTPM
Spinal cord	1.5 nTPM
Cerebral cortex	1.1 nTPM
Hypothalamus	0.7 nTPM
Cerebellum	0.3 nTPM
Midbrain	0.3 nTPM
Basal ganglia	0.2 nTPM
Hippocampus	0.2 nTPM
Pons	0.2 nTPM
Amygdala	0.1 nTPM
Medulla oblongata	0.0 nTPM

Cerebellar inhibitory	3.4 nTPM
Pons	8.2 nTPM
Midbrain	3.4 nTPM
Medulla oblongata	3.1 nTPM
Cerebellum	2.3 nTPM
Spinal cord	0.0 nTPM

Cge interneuron	0.6 nTPM
Hippocampus	0.9 nTPM
Cerebral cortex	0.8 nTPM
Basal ganglia	0.7 nTPM
Midbrain	0.5 nTPM
Amygdala	0.4 nTPM
Hypothalamus	0.3 nTPM
Thalamus	0.3 nTPM

Choroid plexus epithelial cell	0.0 nTPM
Basal ganglia	0.1 nTPM
Hippocampus	0.0 nTPM
Medulla oblongata	0.0 nTPM
Thalamus	0.0 nTPM

Committed oligodendrocyte precursor	0.8 nTPM
Thalamus	2.0 nTPM
Hypothalamus	2.0 nTPM
Cerebral cortex	1.3 nTPM
Medulla oblongata	1.3 nTPM
Pons	0.9 nTPM
Midbrain	0.8 nTPM
Basal ganglia	0.5 nTPM
Amygdala	0.0 nTPM
Cerebellum	0.0 nTPM
Hippocampus	0.0 nTPM
Spinal cord	0.0 nTPM

Deep-layer corticothalamic and 6b	0.4 nTPM
Basal ganglia	0.7 nTPM
Hippocampus	0.7 nTPM
Cerebral cortex	0.4 nTPM
Amygdala	0.3 nTPM
Hypothalamus	0.2 nTPM
Midbrain	0.0 nTPM

Deep-layer intratelencephalic	0.3 nTPM
Basal ganglia	0.4 nTPM
Cerebral cortex	0.3 nTPM
Hypothalamus	0.3 nTPM
Amygdala	0.2 nTPM
Hippocampus	0.2 nTPM

Deep-layer near-projecting	2.7 nTPM
Basal ganglia	4.8 nTPM
Hippocampus	2.9 nTPM
Amygdala	2.1 nTPM
Hypothalamus	1.9 nTPM
Cerebral cortex	1.5 nTPM

Eccentric medium spiny neuron	0.3 nTPM
Hippocampus	0.4 nTPM
Amygdala	0.3 nTPM
Thalamus	0.3 nTPM
Basal ganglia	0.2 nTPM
Cerebral cortex	0.2 nTPM
Hypothalamus	0.2 nTPM

Endothelial cell	0.5 nTPM
Thalamus	2.8 nTPM
Hypothalamus	2.5 nTPM
Hippocampus	0.6 nTPM
Amygdala	0.0 nTPM
Basal ganglia	0.0 nTPM
Cerebellum	0.0 nTPM
Cerebral cortex	0.0 nTPM
Medulla oblongata	0.0 nTPM
Midbrain	0.0 nTPM
Pons	0.0 nTPM
Spinal cord	0.0 nTPM