Single cell type - CACNG7 - The Human Protein Atlas

CACNG7

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CACNG7
Gene descriptionⁱ Full gene name according to HGNC.	Calcium voltage-gated channel auxiliary subunit gamma 7
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	FDA approved drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Horizontal & Bipolar cells - Neuronal signaling (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Horizontal cells, Inhibitory neurons, Excitatory neurons, Oligodendrocyte precursor cells, Oligodendrocytes, Astrocytes, Bipolar cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.92
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Horizontal cells, Inhibitory neurons, Excitatory neurons, Oligodendrocyte precursor cells, Oligodendrocytes, Astrocytes, Bipolar cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

CACNG7 is part of cluster 71 Horizontal & Bipolar cells - Neuronal signaling with confidenceⁱ 0.99
205 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CAMK2N2	Calcium/calmodulin dependent protein kinase II inhibitor 2	0.8173	71
CLEC2L	C-type lectin domain family 2 member L	0.8119	8
SLC6A17	Solute carrier family 6 member 17	0.8033	69
SV2A	Synaptic vesicle glycoprotein 2A	0.8015	71
SPTBN4	Spectrin beta, non-erythrocytic 4	0.8014	8
GRM4	Glutamate metabotropic receptor 4	0.7979	69
STX1B	Syntaxin 1B	0.7496	71
KCNC1	Potassium voltage-gated channel subfamily C member 1	0.7454	71
PAK5	P21 (RAC1) activated kinase 5	0.7428	8
LRP8	LDL receptor related protein 8	0.7423	8
PCLO	Piccolo presynaptic cytomatrix protein	0.7392	69
ZNF385D	Zinc finger protein 385D	0.7390	8
CACNA1A	Calcium voltage-gated channel subunit alpha1 A	0.7356	71
SULT4A1	Sulfotransferase family 4A member 1	0.7318	71
BEND6	BEN domain containing 6	0.7277	8

Adipocytes	0.1 nTPM
Breast	0.2 nTPM
Adipose tissue	0.0 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	0.0 nTPM
Lung	0.0 nTPM

B-cells	0.0 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM

Basal keratinocytes	0.0 nTPM
Skin	0.0 nTPM
Tongue	0.0 nTPM

Ciliated cells	0.0 nTPM
Endometrium	0.1 nTPM
Bronchus	0.0 nTPM
Lung	0.0 nTPM
Fallopian tube	0.0 nTPM

Club cells	0.0 nTPM
Bronchus	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM

Endothelial cells	0.0 nTPM
Skeletal muscle	0.2 nTPM
Endometrium	0.1 nTPM
Thymus	0.1 nTPM
Testis	0.0 nTPM
Heart muscle	0.0 nTPM
Liver	0.0 nTPM
Placenta	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM
Tongue	0.0 nTPM
Vascular	0.0 nTPM
Breast	0.0 nTPM
Fallopian tube	0.0 nTPM
Ovary	0.0 nTPM

Enteroendocrine cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	0.1 nTPM
Skeletal muscle	0.3 nTPM
Esophagus	0.3 nTPM
Breast	0.2 nTPM
Pancreas	0.1 nTPM
Skin	0.1 nTPM
Thymus	0.1 nTPM
Heart muscle	0.0 nTPM
Liver	0.0 nTPM
Placenta	0.0 nTPM
Adipose tissue	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM
Vascular	0.0 nTPM
Fallopian tube	0.0 nTPM

Granulocytes	0.0 nTPM
Lung	0.0 nTPM
Tongue	0.0 nTPM
Fallopian tube	0.0 nTPM

Intestinal goblet cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Lymphatic endothelial cells	0.0 nTPM
Fallopian tube	0.1 nTPM
Ovary	0.0 nTPM

Macrophages	0.0 nTPM
Skeletal muscle	0.2 nTPM
Breast	0.2 nTPM
Salivary gland	0.1 nTPM
Testis	0.0 nTPM
Kidney	0.0 nTPM
Endometrium	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Thymus	0.0 nTPM
Tongue	0.0 nTPM
Vascular	0.0 nTPM
Fallopian tube	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Astrocytes	11.8 nTPM
Brain	11.8 nTPM

Plasma cells	0.0 nTPM
Liver	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Fallopian tube	0.0 nTPM

Schwann cells	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Vascular	0.0 nTPM

Serous glandular cells	0.0 nTPM
Salivary gland	0.0 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	0.0 nTPM
Skeletal muscle	0.4 nTPM
Endometrium	0.2 nTPM
Breast	0.2 nTPM
Liver	0.0 nTPM
Placenta	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Tongue	0.0 nTPM
Vascular	0.0 nTPM
Fallopian tube	0.0 nTPM
Ovary	0.0 nTPM

T-cells	0.0 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
Endometrium	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Tongue	0.0 nTPM
Vascular	0.0 nTPM
Breast	0.0 nTPM
Fallopian tube	0.0 nTPM

Undifferentiated cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Amygdala excitatory	51.0 nTPM
Hypothalamus	63.3 nTPM
Amygdala	55.6 nTPM
Thalamus	53.5 nTPM
Basal ganglia	46.3 nTPM
Cerebral cortex	44.1 nTPM
Hippocampus	43.0 nTPM

Astrocyte	28.3 nTPM
Hippocampus	34.4 nTPM
Cerebral cortex	33.2 nTPM
Cerebellum	30.8 nTPM
Spinal cord	28.9 nTPM
Amygdala	28.3 nTPM
Basal ganglia	27.9 nTPM
Thalamus	27.8 nTPM
Midbrain	27.3 nTPM
Hypothalamus	25.7 nTPM
Pons	24.2 nTPM
Medulla oblongata	22.3 nTPM

Bergmann glia	31.7 nTPM
Cerebellum	43.5 nTPM
Pons	30.2 nTPM
Medulla oblongata	21.3 nTPM

Central nervous system macrophage	1.4 nTPM
Cerebral cortex	2.8 nTPM
Hypothalamus	2.1 nTPM
Thalamus	2.0 nTPM
Spinal cord	1.5 nTPM
Hippocampus	1.4 nTPM
Amygdala	1.3 nTPM
Basal ganglia	1.0 nTPM
Midbrain	0.8 nTPM
Pons	0.8 nTPM
Cerebellum	0.7 nTPM
Medulla oblongata	0.7 nTPM

Cerebellar inhibitory	54.2 nTPM
Cerebellum	67.7 nTPM
Spinal cord	52.2 nTPM
Pons	51.1 nTPM
Midbrain	50.4 nTPM
Medulla oblongata	49.5 nTPM

Cge interneuron	68.2 nTPM
Hypothalamus	87.2 nTPM
Amygdala	74.2 nTPM
Hippocampus	70.5 nTPM
Cerebral cortex	70.2 nTPM
Basal ganglia	61.0 nTPM
Midbrain	58.9 nTPM
Thalamus	55.5 nTPM

Choroid plexus epithelial cell	1.0 nTPM
Thalamus	2.7 nTPM
Medulla oblongata	0.9 nTPM
Basal ganglia	0.5 nTPM
Hippocampus	0.0 nTPM

Committed oligodendrocyte precursor	45.2 nTPM
Spinal cord	69.9 nTPM
Cerebellum	60.3 nTPM
Hippocampus	56.9 nTPM
Cerebral cortex	52.6 nTPM
Amygdala	51.3 nTPM
Midbrain	45.4 nTPM
Pons	39.8 nTPM
Hypothalamus	37.6 nTPM
Thalamus	37.1 nTPM
Basal ganglia	27.4 nTPM
Medulla oblongata	19.4 nTPM

Deep-layer corticothalamic and 6b	51.8 nTPM
Hypothalamus	65.7 nTPM
Hippocampus	56.4 nTPM
Cerebral cortex	55.2 nTPM
Basal ganglia	50.6 nTPM
Amygdala	49.7 nTPM
Midbrain	33.3 nTPM

Deep-layer intratelencephalic	54.3 nTPM
Hypothalamus	75.6 nTPM
Cerebral cortex	55.5 nTPM
Amygdala	47.8 nTPM
Hippocampus	47.2 nTPM
Basal ganglia	45.0 nTPM

Deep-layer near-projecting	61.5 nTPM
Cerebral cortex	73.2 nTPM
Amygdala	70.8 nTPM
Hypothalamus	70.4 nTPM
Basal ganglia	49.6 nTPM
Hippocampus	43.6 nTPM

Eccentric medium spiny neuron	46.5 nTPM
Amygdala	54.6 nTPM
Cerebral cortex	53.6 nTPM
Thalamus	50.1 nTPM
Hypothalamus	44.2 nTPM
Basal ganglia	42.0 nTPM
Hippocampus	34.8 nTPM

Endothelial cell	1.6 nTPM
Cerebral cortex	2.6 nTPM
Hypothalamus	2.5 nTPM
Amygdala	2.2 nTPM
Hippocampus	2.2 nTPM
Medulla oblongata	2.1 nTPM
Basal ganglia	1.9 nTPM
Pons	1.2 nTPM
Thalamus	1.1 nTPM
Midbrain	0.9 nTPM
Cerebellum	0.8 nTPM
Spinal cord	0.0 nTPM

Ependymal cell	1.6 nTPM
Midbrain	3.8 nTPM
Amygdala	2.3 nTPM
Hypothalamus	1.8 nTPM
Hippocampus	1.7 nTPM
Thalamus	1.6 nTPM
Basal ganglia	1.4 nTPM
Medulla oblongata	1.1 nTPM
Pons	0.4 nTPM
Spinal cord	0.0 nTPM