Single cell type - PLPPR2 - The Human Protein Atlas

PLPPR2

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PLPPR2
Gene descriptionⁱ Full gene name according to HGNC.	Phospholipid phosphatase related 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Smooth muscle cells - Muscle contraction (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.43
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enriched (neutrophil)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enriched (neutrophil)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

PLPPR2 is part of cluster 32 Smooth muscle cells - Muscle contraction with confidenceⁱ 1
236 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TIMP1	TIMP metallopeptidase inhibitor 1	0.5088	29
PDLIM7	PDZ and LIM domain 7	0.4989	32
KCNS2	Potassium voltage-gated channel modifier subfamily S member 2	0.4971	9
EMILIN1	Elastin microfibril interfacer 1	0.4469	32
ZNF469	Zinc finger protein 469	0.4447	34
PRDM6	PR/SET domain 6	0.4398	32
SMARCD3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3	0.4398	32
BMERB1	BMERB domain containing 1	0.4380	36
MEIS3	Meis homeobox 3	0.4362	34
CTIF	Cap binding complex dependent translation initiation factor	0.4329	47
NRSN2	Neurensin 2	0.4277	10
RAB23	RAB23, member RAS oncogene family	0.4262	50
FGD1	FYVE, RhoGEF and PH domain containing 1	0.4218	9
TNC	Tenascin C	0.4209	32
SCRG1	Stimulator of chondrogenesis 1	0.4137	32

IMMUNE CELLS

PLPPR2 is part of cluster 21 Neutrophils - Unknown function with confidenceⁱ 1
492 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
OR52K2	Olfactory receptor family 52 subfamily K member 2	1.0000	21
CEACAM4	CEA cell adhesion molecule 4	1.0000	21
CHMP2A	Charged multivesicular body protein 2A	0.9762	21
NATD1	N-acetyltransferase domain containing 1	0.9762	21
ABAT	4-aminobutyrate aminotransferase	0.9762	21
ARHGEF40	Rho guanine nucleotide exchange factor 40	0.9762	21
FCGR2A	Fc gamma receptor IIa	0.9762	21
HERC3	HECT and RLD domain containing E3 ubiquitin protein ligase 3	0.9762	21
YIPF3	Yip1 domain family member 3	0.9762	21
PADI2	Peptidyl arginine deiminase 2	0.9524	21
CPQ	Carboxypeptidase Q	0.9524	7
MTMR3	Myotubularin related protein 3	0.9524	21
H3-3A	H3.3 histone A	0.9524	21
RFX2	Regulatory factor X2	0.9524	21
LRRC75A	Leucine rich repeat containing 75A	0.9524	21

Adipocytes	8.4 nTPM
Breast	9.8 nTPM
Adipose tissue	6.9 nTPM

Alveolar cells type 1	3.3 nTPM
Lung	3.3 nTPM

Alveolar cells type 2	9.1 nTPM
Lung	9.1 nTPM

Astrocytes	13.6 nTPM
Brain	13.6 nTPM

B-cells	0.9 nTPM
Liver	4.8 nTPM
Skin	1.7 nTPM
Thymus	1.5 nTPM
Lung	1.3 nTPM
Salivary gland	1.0 nTPM
Adipose tissue	0.8 nTPM
Stomach	0.4 nTPM
Lymph node	0.1 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Ciliated cells	2.9 nTPM
Bronchus	4.2 nTPM
Lung	2.9 nTPM
Fallopian tube	2.3 nTPM
Endometrium	2.1 nTPM

Club cells	6.2 nTPM
Bronchus	8.3 nTPM
Lung	6.1 nTPM
Prostate	4.2 nTPM

Endothelial cells	9.0 nTPM
Pancreas	15.5 nTPM
Breast	14.9 nTPM
Thymus	13.4 nTPM
Placenta	11.9 nTPM
Lung	11.4 nTPM
Testis	10.4 nTPM
Endometrium	9.7 nTPM
Esophagus	9.1 nTPM
Fallopian tube	9.1 nTPM
Ovary	8.2 nTPM
Vascular	8.0 nTPM
Prostate	7.5 nTPM
Skin	7.2 nTPM
Liver	6.3 nTPM
Tongue	5.8 nTPM
Heart muscle	4.9 nTPM
Skeletal muscle	4.8 nTPM
Salivary gland	4.6 nTPM

Enteroendocrine cells	15.1 nTPM
Rectum	30.2 nTPM
Small intestine	13.7 nTPM
Colon	1.3 nTPM

Fibroblasts	14.4 nTPM
Pancreas	31.4 nTPM
Thymus	28.4 nTPM
Breast	19.3 nTPM
Skin	18.8 nTPM
Vascular	17.4 nTPM
Fallopian tube	17.0 nTPM
Adipose tissue	16.4 nTPM
Stomach	15.9 nTPM
Esophagus	14.4 nTPM
Lung	13.7 nTPM
Skeletal muscle	12.8 nTPM
Salivary gland	12.3 nTPM
Placenta	4.2 nTPM
Prostate	4.0 nTPM
Liver	3.6 nTPM
Heart muscle	1.5 nTPM

Granulocytes	2.7 nTPM
Tongue	4.9 nTPM
Fallopian tube	1.9 nTPM
Lung	1.5 nTPM

Intestinal goblet cells	1.6 nTPM
Rectum	2.2 nTPM
Small intestine	2.0 nTPM
Colon	0.5 nTPM

Lymphatic endothelial cells	14.5 nTPM
Ovary	21.8 nTPM
Fallopian tube	7.2 nTPM

Macrophages	7.7 nTPM
Skeletal muscle	15.8 nTPM
Pancreas	14.4 nTPM
Fallopian tube	14.3 nTPM
Spleen	12.0 nTPM
Thymus	10.5 nTPM
Stomach	10.3 nTPM
Adipose tissue	9.8 nTPM
Testis	9.3 nTPM
Bone marrow	7.1 nTPM
Salivary gland	5.8 nTPM
Vascular	5.5 nTPM
Esophagus	5.1 nTPM
Endometrium	4.9 nTPM
Skin	4.5 nTPM
Lung	3.9 nTPM
Tongue	3.5 nTPM
Breast	3.5 nTPM
Prostate	3.2 nTPM
Kidney	2.7 nTPM

Paneth cells	0.4 nTPM
Rectum	1.2 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Basal prostatic cells	2.4 nTPM
Prostate	2.4 nTPM

Basal respiratory cells	4.3 nTPM
Bronchus	4.3 nTPM

Basal squamous epithelial cells	5.3 nTPM
Esophagus	5.3 nTPM

Bipolar cells	4.3 nTPM
Eye	4.3 nTPM

Plasma cells	2.0 nTPM
Salivary gland	5.8 nTPM
Stomach	3.8 nTPM
Liver	2.5 nTPM
Fallopian tube	2.3 nTPM
Thymus	1.5 nTPM
Spleen	0.2 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Schwann cells	3.1 nTPM
Vascular	8.9 nTPM
Adipose tissue	0.4 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	7.4 nTPM
Salivary gland	10.4 nTPM
Tongue	4.4 nTPM

Smooth muscle cells	16.4 nTPM
Thymus	31.1 nTPM
Placenta	23.1 nTPM
Vascular	21.1 nTPM
Skin	19.2 nTPM
Esophagus	19.2 nTPM
Liver	19.1 nTPM
Lung	18.8 nTPM
Breast	16.0 nTPM
Fallopian tube	15.7 nTPM
Adipose tissue	14.7 nTPM
Tongue	14.1 nTPM
Skeletal muscle	10.7 nTPM
Endometrium	10.5 nTPM
Salivary gland	9.9 nTPM
Prostate	9.7 nTPM
Ovary	9.0 nTPM

T-cells	1.8 nTPM
Skin	5.3 nTPM
Esophagus	4.9 nTPM
Vascular	2.8 nTPM
Breast	2.8 nTPM
Endometrium	2.4 nTPM
Lung	2.4 nTPM
Liver	1.7 nTPM
Tongue	1.5 nTPM
PBMC	1.4 nTPM
Adipose tissue	1.3 nTPM
Thymus	1.3 nTPM
Fallopian tube	1.2 nTPM
Skeletal muscle	1.1 nTPM
Salivary gland	1.1 nTPM
Colon	1.0 nTPM
Bone marrow	1.0 nTPM
Spleen	1.0 nTPM
Kidney	0.9 nTPM
Prostate	0.8 nTPM
Stomach	0.7 nTPM
Lymph node	0.6 nTPM

Undifferentiated cells	1.3 nTPM
Colon	1.9 nTPM
Rectum	1.3 nTPM
Small intestine	0.7 nTPM

Amygdala excitatory	43.2 nTPM
Hippocampus	50.9 nTPM
Thalamus	42.7 nTPM
Hypothalamus	42.4 nTPM
Amygdala	42.3 nTPM
Basal ganglia	42.1 nTPM
Cerebral cortex	38.8 nTPM

Astrocyte	31.0 nTPM
Pons	38.8 nTPM
Hippocampus	38.3 nTPM
Spinal cord	36.2 nTPM
Midbrain	34.1 nTPM
Cerebellum	31.8 nTPM
Cerebral cortex	31.8 nTPM
Medulla oblongata	30.3 nTPM
Thalamus	30.3 nTPM
Basal ganglia	24.4 nTPM
Amygdala	22.5 nTPM
Hypothalamus	22.1 nTPM

Bergmann glia	17.8 nTPM
Cerebellum	22.0 nTPM
Medulla oblongata	17.0 nTPM
Pons	14.4 nTPM

Central nervous system macrophage	11.4 nTPM
Hippocampus	17.9 nTPM
Spinal cord	14.4 nTPM
Cerebral cortex	11.3 nTPM
Midbrain	10.9 nTPM
Medulla oblongata	10.6 nTPM
Basal ganglia	10.3 nTPM
Pons	10.1 nTPM
Thalamus	10.1 nTPM
Amygdala	10.0 nTPM
Hypothalamus	9.8 nTPM
Cerebellum	9.5 nTPM

Cerebellar inhibitory	29.6 nTPM
Midbrain	36.4 nTPM
Cerebellum	34.7 nTPM
Pons	26.7 nTPM
Medulla oblongata	25.2 nTPM
Spinal cord	24.7 nTPM

Cge interneuron	47.4 nTPM
Basal ganglia	52.1 nTPM
Amygdala	49.2 nTPM
Hypothalamus	48.5 nTPM
Midbrain	48.2 nTPM
Hippocampus	47.7 nTPM
Thalamus	43.6 nTPM
Cerebral cortex	43.0 nTPM

Choroid plexus epithelial cell	11.1 nTPM
Thalamus	16.4 nTPM
Hippocampus	11.1 nTPM
Medulla oblongata	8.7 nTPM
Basal ganglia	8.3 nTPM

Committed oligodendrocyte precursor	39.8 nTPM
Spinal cord	66.2 nTPM
Hippocampus	49.2 nTPM
Cerebellum	47.6 nTPM
Pons	45.2 nTPM
Cerebral cortex	43.7 nTPM
Midbrain	41.2 nTPM
Amygdala	32.7 nTPM
Medulla oblongata	32.3 nTPM
Basal ganglia	31.2 nTPM
Hypothalamus	25.3 nTPM
Thalamus	23.4 nTPM

Deep-layer corticothalamic and 6b	33.7 nTPM
Hypothalamus	41.8 nTPM
Amygdala	38.7 nTPM
Hippocampus	35.9 nTPM
Basal ganglia	33.7 nTPM
Cerebral cortex	32.2 nTPM
Midbrain	20.0 nTPM

Deep-layer intratelencephalic	30.9 nTPM
Hypothalamus	34.8 nTPM
Hippocampus	34.4 nTPM
Amygdala	32.7 nTPM
Basal ganglia	27.0 nTPM
Cerebral cortex	25.6 nTPM

Deep-layer near-projecting	34.7 nTPM
Hypothalamus	44.3 nTPM
Basal ganglia	34.8 nTPM
Amygdala	33.5 nTPM
Hippocampus	31.5 nTPM
Cerebral cortex	29.3 nTPM

Eccentric medium spiny neuron	48.2 nTPM
Hippocampus	56.4 nTPM
Amygdala	53.2 nTPM
Hypothalamus	50.7 nTPM
Cerebral cortex	46.0 nTPM
Thalamus	44.4 nTPM
Basal ganglia	38.2 nTPM

Endothelial cell	14.6 nTPM
Hippocampus	23.4 nTPM
Cerebellum	22.5 nTPM
Cerebral cortex	17.9 nTPM
Amygdala	16.8 nTPM
Basal ganglia	16.8 nTPM
Pons	15.0 nTPM
Spinal cord	13.8 nTPM
Medulla oblongata	9.2 nTPM
Hypothalamus	8.7 nTPM
Midbrain	8.5 nTPM
Thalamus	8.5 nTPM

Ependymal cell	15.4 nTPM
Amygdala	20.5 nTPM
Midbrain	19.7 nTPM
Hippocampus	16.4 nTPM
Pons	15.7 nTPM
Hypothalamus	14.3 nTPM
Thalamus	13.8 nTPM
Spinal cord	13.4 nTPM
Medulla oblongata	13.2 nTPM
Basal ganglia	11.6 nTPM