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The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.
The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".
Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.
Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.
& Survival analysisi
Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.
TIMP1 is not prognostic in Pancreatic Adenocarcinoma (TCGA)
Stage:
Survival analysis
Current cut offi
Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.
:
Best expression cut offi
Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .
When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.
Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.
Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.
: N/A
P scorei
Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.
N/A
5-year survival highi
5-year survival for patients with higher expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
5-year survival lowi
5-year survival for patients with lower expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
TCGA RNA samplesi
RNA-seq data is reported as average FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.
Average TPM
1614.0
Number of samples
176
Samples
Sample
Description
TPM
TCGA-2J-AABP-01A
0 years, female, white, stage:Stage IIB, alive, 463 days
7315.4
TCGA-LB-A8F3-01A
0 years, female, black or african american, stage:Stage IIA, alive, 379 days
4033.3
TCGA-HZ-A77Q-01A
0 years, female, white, stage:Stage IIB, alive, 33 days
3666.5
TCGA-IB-7888-01A
0 years, female, black or african american, stage:Stage IIA, dead, 1332 days
3654.1
TCGA-HZ-A49I-01A
0 years, male, white, stage:Stage IIB, dead, 308 days
3411.8
TCGA-XN-A8T5-01A
0 years, female, white, stage:Stage IB, alive, 720 days
3402.0
TCGA-HZ-8001-01A
0 years, male, white, stage:Stage III, alive, 706 days
3207.1
TCGA-Q3-AA2A-01A
0 years, female, white, stage:Stage IB, alive, 95 days
2981.4
TCGA-IB-7645-01A
0 years, female, stage:Stage IIB, dead, 1502 days
2906.9
TCGA-HZ-7920-01A
0 years, male, white, stage:Stage IB, dead, 236 days
2740.7
TCGA-FB-AAPZ-01A
0 years, male, white, stage:Stage IIB, alive, 716 days
2719.8
TCGA-2J-AAB6-01A
0 years, male, white, stage:Stage IIA, dead, 293 days
2685.0
TCGA-2J-AABH-01A
0 years, male, white, stage:Stage IIA, alive, 1287 days
2537.2
TCGA-IB-A5ST-01A
0 years, female, white, stage:Stage IIB, alive, 635 days
2523.5
TCGA-HZ-A4BH-01A
0 years, male, white, stage:Stage IIB, alive, 194 days
2478.8
TCGA-RL-AAAS-01A
0 years, female, white, stage:Stage IB, alive, 9 days
2470.0
TCGA-IB-A5SS-01A
0 years, female, white, stage:Stage IIB, dead, 460 days
2465.8
TCGA-HZ-7925-01A
0 years, male, white, stage:Stage IIB, dead, 614 days
2459.1
TCGA-FB-AAPS-01A
0 years, female, white, stage:Stage IIB, alive, 228 days
2430.7
TCGA-IB-7646-01A
0 years, male, white, stage:Stage IIB, dead, 145 days
2404.0
TCGA-3A-A9IB-01A
0 years, female, white, stage:Stage IIB, dead, 224 days
2403.9
TCGA-US-A77J-01A
0 years, female, white, stage:Stage IIB, dead, 568 days
2396.8
TCGA-2L-AAQJ-01A
0 years, female, white, stage:Stage III, dead, 394 days
2376.1
TCGA-IB-AAUS-01A
0 years, female, white, stage:Stage IIB, alive, 225 days
2375.5
TCGA-IB-A6UF-01A
0 years, male, white, stage:Stage IIB, alive, 666 days
2334.5
TCGA-IB-7652-01A
0 years, female, asian, stage:Stage IIB, alive, 1116 days
2330.3
TCGA-2J-AAB1-01A
0 years, male, white, stage:Stage IIB, dead, 66 days
2277.1
TCGA-HZ-7923-01A
0 years, male, white, stage:Stage IIA, alive, 314 days
2265.4
TCGA-IB-7649-01A
0 years, female, stage:Stage IIB, dead, 467 days
2259.5
TCGA-IB-A5SQ-01A
0 years, female, white, stage:Stage IB, dead, 219 days
2233.1
TCGA-2J-AABR-01A
0 years, female, white, stage:Stage IIA, alive, 438 days
2232.5
TCGA-2J-AAB4-01A
0 years, male, white, stage:Stage IIB, alive, 729 days
2231.5
TCGA-FB-A5VM-01A
0 years, male, white, stage:Stage IB, dead, 498 days
2218.0
TCGA-3A-A9IH-01A
0 years, female, white, stage:Stage IA, alive, 1021 days
2201.5
TCGA-2J-AABF-01A
0 years, male, white, stage:Stage IIB, dead, 691 days
2199.5
TCGA-3E-AAAY-01A
0 years, male, white, stage:Stage IIB, alive, 2285 days
2193.9
TCGA-F2-7273-01A
0 years, male, black or african american, stage:Stage IIB, dead, 592 days
2172.2
TCGA-FB-A78T-01A
0 years, female, white, stage:Stage IIB, dead, 375 days
2158.3
TCGA-HZ-A4BK-01A
0 years, male, white, stage:Stage IIB, alive, 657 days
2130.8
TCGA-FB-A4P6-01A
0 years, male, white, stage:Stage IIB, alive, 767 days
2077.5
TCGA-HZ-7922-01A
0 years, female, white, stage:Stage IIB, alive, 4 days
2069.5
TCGA-IB-AAUQ-01A
0 years, male, white, stage:Stage IIB, dead, 183 days
2053.8
TCGA-S4-A8RO-01A
0 years, female, white, stage:Stage IIB, alive, 525 days
2037.2
TCGA-YB-A89D-01A
0 years, male, white, stage:Stage IIB, alive, 350 days
2031.8
TCGA-HV-A7OP-01A
0 years, male, asian, stage:Stage IIB, alive, 978 days
2029.4
TCGA-2L-AAQL-01A
0 years, male, white, stage:Stage IIB, dead, 292 days
2009.3
TCGA-XD-AAUG-01A
0 years, female, white, stage:Stage IV, alive, 420 days
1999.6
TCGA-HZ-8002-01A
0 years, male, white, stage:Stage IIB, dead, 366 days
1971.3
TCGA-HZ-8636-01A
0 years, female, white, stage:Stage IV, dead, 545 days
1960.9
TCGA-RB-A7B8-01A
0 years, female, white, stage:Stage IIB, dead, 466 days
1942.5
TCGA-IB-AAUR-01A
0 years, male, white, stage:Stage IIB, alive, 338 days
1942.4
TCGA-2J-AAB9-01A
0 years, female, white, stage:Stage IIB, dead, 627 days
1938.7
TCGA-XN-A8T3-01A
0 years, male, white, stage:Stage IB, alive, 951 days
1918.9
TCGA-IB-7893-01A
0 years, male, white, stage:Stage IIA, dead, 117 days
1869.4
TCGA-FB-AAQ3-01A
0 years, female, white, stage:Stage IIB, dead, 31 days
1865.5
TCGA-FB-AAPY-01A
0 years, male, white, stage:Stage IIB, dead, 1059 days
1852.0
TCGA-IB-7889-01A
0 years, female, white, stage:Stage IIB, dead, 481 days
1841.1
TCGA-H6-A45N-01A
0 years, female, white, stage:Stage IIB, dead, 397 days
1815.5
TCGA-XD-AAUI-01A
0 years, female, white, stage:Stage IIB, dead, 366 days
1811.2
TCGA-3A-A9J0-01A
0 years, male, white, stage:Stage IIB, alive, 743 days
1786.3
TCGA-2J-AABO-01A
0 years, male, white, stage:Stage IIB, alive, 440 days
1779.9
TCGA-US-A77E-01A
0 years, male, white, stage:Stage IIB, dead, 430 days
1774.6
TCGA-HZ-7919-01A
0 years, female, white, stage:Stage IIB, dead, 593 days
1766.7
TCGA-3A-A9IV-01A
0 years, female, white, stage:Stage IB, alive, 1103 days
1756.9
TCGA-S4-A8RP-01A
0 years, female, white, stage:Stage IIB, dead, 702 days
1751.8
TCGA-FB-AAQ1-01A
0 years, male, white, stage:Stage IIB, dead, 123 days
1751.3
TCGA-OE-A75W-01A
0 years, male, white, stage:Stage IIA, dead, 267 days
1732.9
TCGA-HV-A7OL-01A
0 years, male, asian, stage:Stage IIA, alive, 252 days
1710.7
TCGA-2J-AABA-01A
0 years, male, white, stage:Stage IIB, dead, 607 days
1707.9
TCGA-YY-A8LH-01A
0 years, female, white, stage:Stage IIB, alive, 2016 days
1705.3
TCGA-F2-7276-01A
0 years, male, white, stage:Stage IIB, dead, 216 days
1695.0
TCGA-2L-AAQM-01A
0 years, male, white, stage:Stage IIB, alive, 1383 days
1692.5
TCGA-FB-AAQ6-01A
0 years, male, white, stage:Stage IA, dead, 244 days
1689.4
TCGA-IB-AAUV-01A
0 years, male, white, stage:Stage IIB, alive, 404 days
1687.2
TCGA-FB-AAQ0-01A
0 years, male, white, stage:Stage IIA, dead, 473 days
1681.7
TCGA-HZ-7918-01A
0 years, male, white, stage:Stage IIB, alive, 969 days
1674.4
TCGA-IB-AAUP-01A
0 years, male, white, stage:Stage IIB, alive, 431 days
1671.1
TCGA-XD-AAUH-01A
0 years, female, white, stage:Stage IIB, alive, 395 days
1665.3
TCGA-HV-AA8V-01A
0 years, male, asian, stage:Stage IIB, alive, 920 days
1658.4
TCGA-FB-A4P5-01A
0 years, female, white, stage:Stage IIB, dead, 179 days
1649.5
TCGA-RB-AA9M-01A
0 years, male, white, stage:Stage IIB, alive, 286 days
1641.1
TCGA-3A-A9IX-01A
0 years, male, white, stage:Stage IA, alive, 1037 days
1640.0
TCGA-IB-7897-01A
0 years, female, white, stage:Stage IIB, dead, 486 days
1634.8
TCGA-FB-AAPQ-01A
0 years, male, white, stage:Stage IIB, dead, 1130 days
1628.1
TCGA-IB-7891-01A
0 years, female, white, stage:Stage IIB, dead, 913 days
1623.0
TCGA-HZ-7926-01A
0 years, male, black or african american, stage:Stage IIB, dead, 518 days
1614.2
TCGA-IB-A5SO-01A
0 years, male, white, stage:Stage IIB, dead, 365 days
1592.6
TCGA-IB-AAUU-01A
0 years, male, white, stage:Stage IIB, alive, 245 days
1586.5
TCGA-H8-A6C1-01A
0 years, male, white, stage:Stage IIA, alive, 671 days
1555.2
TCGA-M8-A5N4-01A
0 years, female, stage:Stage IIA, alive, 584 days
1549.4
TCGA-HV-A5A4-01A
0 years, female, asian, stage:Stage IIA, alive, 232 days
1511.4
TCGA-HZ-A49H-01A
0 years, female, white, stage:Stage IIB, alive, 491 days
1497.3
TCGA-HZ-A8P1-01A
0 years, male, white, stage:Stage IB, alive, 7 days
1493.2
TCGA-Q3-A5QY-01A
0 years, male, white, stage:Stage IIB, alive, 416 days
1461.8
TCGA-3A-A9I5-01A
0 years, male, white, stage:'--, alive, 1794 days
1451.7
TCGA-2J-AAB8-01A
0 years, male, white, stage:Stage IIB, alive, 80 days
1451.1
TCGA-XD-AAUL-01A
0 years, male, white, stage:Stage IIA, alive, 498 days
1442.3
TCGA-F2-6879-01A
0 years, male, white, stage:Stage IIB, dead, 334 days
1436.7
TCGA-HZ-A49G-01A
0 years, female, white, stage:Stage IIB, alive, 660 days
1436.6
TCGA-IB-7890-01A
0 years, male, stage:Stage IB, dead, 598 days
1429.4
TCGA-HV-A5A6-01A
0 years, female, asian, stage:Stage IIB, dead, 2036 days
1412.9
TCGA-3A-A9IZ-01A
0 years, male, white, stage:Stage IIB, dead, 308 days
1408.0
TCGA-HZ-8519-01A
0 years, male, white, stage:Stage IA, alive, 454 days
1405.4
TCGA-Z5-AAPL-01A
0 years, female, white, stage:Stage IIA, alive, 467 days
1403.7
TCGA-HV-A5A5-01A
0 years, female, asian, stage:Stage IIB, alive, 289 days
1403.2
TCGA-H6-8124-01A
0 years, female, white, stage:Stage IIB, alive, 392 days
1386.0
TCGA-US-A774-01A
0 years, female, white, stage:Stage IIB, dead, 695 days
1331.2
TCGA-2L-AAQE-01A
0 years, male, white, stage:Stage IIB, dead, 684 days
1322.3
TCGA-IB-AAUT-01A
0 years, male, white, stage:Stage IIB, alive, 287 days
1311.2
TCGA-3A-A9IC-01A
0 years, female, white, stage:Stage IIB, dead, 738 days
1283.5
TCGA-FB-A545-01A
0 years, female, white, stage:Stage IIB, dead, 732 days
1277.3
TCGA-2L-AAQA-01A
0 years, male, white, stage:Stage IIB, dead, 143 days
1272.2
TCGA-IB-7887-01A
0 years, female, white, stage:Stage IIB, dead, 110 days
1240.6
TCGA-2J-AABU-01A
0 years, male, white, stage:Stage IIB, dead, 277 days
1238.1
TCGA-IB-8127-01A
0 years, male, white, stage:Stage IIB, alive, 522 days
1222.1
TCGA-3A-A9IU-01A
0 years, male, white, stage:Stage IIB, dead, 458 days
1211.0
TCGA-PZ-A5RE-01A
0 years, female, white, stage:Stage IIB, dead, 470 days
1207.4
TCGA-2J-AABT-01A
0 years, female, white, stage:Stage IIB, alive, 319 days
1198.8
TCGA-F2-A44G-01A
0 years, female, white, stage:Stage IIB, dead, 233 days
1189.5
TCGA-FB-A7DR-01A
0 years, male, asian, stage:Stage IIA, dead, 353 days
1188.7
TCGA-2L-AAQI-01A
0 years, male, white, stage:Stage IIB, dead, 103 days
1182.5
TCGA-IB-AAUW-01A
0 years, female, white, stage:Stage IIB, dead, 230 days
1174.1
TCGA-IB-AAUO-01A
0 years, female, white, stage:Stage IIB, dead, 239 days
1160.9
TCGA-F2-A7TX-01A
0 years, male, white, stage:Stage IIB, dead, 95 days
1153.1
TCGA-IB-7885-01A
0 years, female, white, stage:Stage IIB, alive, 1257 days
1152.9
TCGA-2J-AABE-01A
0 years, male, white, stage:Stage IIA, alive, 676 days
1144.6
TCGA-US-A776-01A
0 years, male, white, stage:Stage IIA, alive, 1216 days
1144.1
TCGA-YH-A8SY-01A
0 years, female, white, stage:'--, alive, 388 days
1127.0
TCGA-IB-A5SP-01A
0 years, male, white, stage:Stage IIA, alive, 482 days
1125.9
TCGA-F2-A44H-01A
0 years, male, white, stage:Stage IIA, alive, 586 days
1120.4
TCGA-FB-AAPU-01A
0 years, female, asian, stage:Stage IIA, dead, 381 days
1116.7
TCGA-F2-A8YN-01A
0 years, male, white, stage:Stage IIA, alive, 517 days
1104.0
TCGA-HZ-A77O-01A
0 years, female, white, stage:Stage IIB, dead, 160 days
1100.6
TCGA-2J-AABI-01A
0 years, female, white, stage:Stage IIA, alive, 969 days
1090.9
TCGA-IB-AAUN-01A
0 years, female, white, stage:Stage IB, dead, 144 days
1082.4
TCGA-HZ-8637-01A
0 years, female, white, stage:Stage IIB, dead, 517 days
1076.7
TCGA-HZ-A77P-01A
0 years, male, white, stage:Stage IIB, alive, 330 days
1075.7
TCGA-3A-A9I9-01A
0 years, male, white, stage:Stage IIA, dead, 634 days
1061.4
TCGA-HZ-8315-01A
0 years, female, white, stage:Stage IIA, dead, 299 days
1036.8
TCGA-HZ-A9TJ-01A
0 years, male, white, stage:Stage IV, alive, 603 days
1036.8
TCGA-FB-AAQ2-01A
0 years, female, white, stage:Stage IIB, dead, 153 days
1030.5
TCGA-US-A779-01A
0 years, female, white, stage:Stage IIB, dead, 511 days
1028.0
TCGA-HV-A5A3-01A
0 years, male, asian, stage:Stage IIA, dead, 128 days
1011.2
TCGA-IB-7886-01A
0 years, male, white, stage:Stage IIB, dead, 123 days
1001.1
TCGA-IB-7651-01A
0 years, female, white, stage:Stage IIB, dead, 603 days
988.3
TCGA-HV-AA8X-01A
0 years, female, asian, stage:Stage IIB, dead, 532 days
950.8
TCGA-3A-A9IN-01A
0 years, female, white, stage:Stage IB, alive, 2084 days
876.4
TCGA-2J-AABK-01A
0 years, male, white, stage:Stage IIB, alive, 484 days
875.1
TCGA-FB-AAPP-01A
0 years, male, white, stage:Stage IIB, dead, 485 days
859.8
TCGA-L1-A7W4-01A
0 years, female, white, stage:Stage IIB, dead, 278 days
850.2
TCGA-HZ-8317-01A
0 years, female, white, stage:Stage IIB, dead, 378 days
844.1
TCGA-LB-A9Q5-01A
0 years, female, white, stage:Stage IIB, dead, 313 days
840.4
TCGA-US-A77G-01A
0 years, male, white, stage:Stage IIB, dead, 12 days
832.3
TCGA-3A-A9I7-01A
0 years, male, black or african american, stage:Stage IIB, alive, 1323 days
774.3
TCGA-3A-A9IL-01A
0 years, female, white, stage:Stage I, alive, 2741 days
764.9
TCGA-HZ-8638-01A
0 years, female, white, stage:Stage IA, dead, 151 days
732.6
TCGA-S4-A8RM-01A
0 years, male, white, stage:Stage IIB, alive, 737 days
707.3
TCGA-IB-7654-01A
0 years, male, white, stage:Stage IIB, dead, 476 days
706.3
TCGA-3A-A9IO-01A
0 years, male, white, stage:'--, alive, 1942 days
699.2
TCGA-IB-A7M4-01A
0 years, male, white, stage:Stage IIB, alive, 483 days
677.8
TCGA-HZ-7289-01A
0 years, male, white, stage:Stage IIB, dead, 661 days
671.3
TCGA-IB-7644-01A
0 years, female, white, stage:Stage IV, dead, 394 days
658.3
TCGA-HZ-8005-01A
0 years, male, white, stage:Stage IIB, dead, 120 days
652.8
TCGA-HZ-8003-01A
0 years, female, white, stage:Stage IIB, dead, 596 days
642.5
TCGA-3E-AAAZ-01A
0 years, male, white, stage:Stage IIA, dead, 2182 days
633.8
TCGA-3A-A9IJ-01A
0 years, male, white, stage:Stage IB, alive, 1854 days
573.0
TCGA-IB-A7LX-01A
0 years, male, white, stage:Stage IIB, dead, 250 days
570.5
TCGA-LB-A7SX-01A
0 years, female, black or african american, stage:Stage IIB, dead, 393 days
568.6
TCGA-IB-8126-01A
0 years, female, white, stage:Stage III, alive, 462 days
552.6
TCGA-IB-A6UG-01A
0 years, male, white, stage:Stage IIB, dead, 41 days
551.0
TCGA-IB-AAUM-01A
0 years, male, white, stage:Stage IIB, alive, 8 days
506.7
TCGA-HZ-7924-01A
0 years, female, white, stage:Stage IIA, alive, 840 days
482.4
TCGA-2J-AABV-01A
0 years, male, white, stage:Stage IIB, dead, 652 days
365.6
TCGA-3A-A9IR-01A
0 years, female, white, stage:Stage IB, alive, 1542 days
108.1
TCGA-3A-A9IS-01A
0 years, male, white, stage:Stage IB, alive, 998 days
74.4
TCGA-F2-6880-01A
0 years, male, white, stage:Stage IIB, alive, 295 days
The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.
The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".
Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.
Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.
& Survival analysisi
Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.
TIMP1 is not prognostic in Pancreatic Adenocarcinoma (validation)
Stage:
Survival analysis
Current cut offi
Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.
:
Best expression cut offi
Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .
When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.
Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.
Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.
: N/A
P scorei
Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.
N/A
5-year survival highi
5-year survival for patients with higher expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
5-year survival lowi
5-year survival for patients with lower expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
TCGA RNA samplesi
RNA-seq data is reported as average FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.
Average TPM
307.8
Number of samples
80
Samples
Sample
Description
TPM
DO34728
0 years, female, NA, stage:, alive, 508 days
873.6
DO33128
0 years, male, NA, stage:, dead, 423 days
738.3
DO49079
0 years, male, NA, stage:, dead, 332 days
713.8
DO32860
0 years, male, NA, stage:, dead, 1259 days
651.3
DO49080
0 years, male, NA, stage:, alive, 83 days
643.5
DO34240
0 years, male, NA, stage:, dead, 236 days
574.3
DO33168
0 years, female, NA, stage:, dead, 8 days
535.0
DO34264
0 years, female, NA, stage:, dead, 1144 days
503.7
DO49137
0 years, female, NA, stage:, alive, 232 days
493.8
DO49166
0 years, female, NA, stage:, alive, 222 days
484.8
DO34680
0 years, male, NA, stage:, dead, 99 days
461.1
DO32863
0 years, male, NA, stage:, dead, 715 days
430.9
DO49185
0 years, male, NA, stage:, alive, 179 days
425.4
DO32900
0 years, male, NA, stage:, dead, 768 days
418.8
DO49164
0 years, male, NA, stage:, alive, 272 days
417.6
DO49138
0 years, male, NA, stage:, dead, 230 days
416.8
DO49133
0 years, female, NA, stage:, alive, 188 days
410.9
DO33408
0 years, female, NA, stage:, alive, 909 days
396.4
DO33488
0 years, male, NA, stage:, alive, 844 days
395.4
DO49113
0 years, female, NA, stage:, alive, 413 days
388.6
DO49078
0 years, male, NA, stage:, dead, 465 days
384.7
DO49204
0 years, male, NA, stage:, dead, 156 days
379.6
DO34793
0 years, male, NA, stage:, dead, 427 days
361.7
DO33984
0 years, male, NA, stage:, alive, 847 days
359.7
DO33368
0 years, male, NA, stage:, dead, 98 days
351.3
DO49135
0 years, male, NA, stage:, alive, 270 days
350.8
DO34785
0 years, female, NA, stage:, alive, 721 days
345.2
DO32878
0 years, female, NA, stage:, dead, 260 days
338.2
DO49129
0 years, male, NA, stage:, alive, 337 days
338.0
DO32875
0 years, male, NA, stage:, dead, 348 days
337.6
DO49168
0 years, male, NA, stage:, alive, 149 days
325.6
DO49127
0 years, female, NA, stage:, alive, 392 days
320.1
DO49170
0 years, male, NA, stage:, alive, 197 days
319.8
DO49178
0 years, male, NA, stage:, dead, 27 days
316.7
DO49076
0 years, male, NA, stage:, dead, 480 days
315.5
DO34288
0 years, female, NA, stage:, dead, 220 days
314.4
DO34696
0 years, male, NA, stage:, alive, 689 days
313.5
DO34504
0 years, male, NA, stage:, dead, 257 days
310.0
DO49184
0 years, male, NA, stage:, dead, 455 days
305.0
DO34720
0 years, male, NA, stage:, alive, 555 days
300.1
DO33480
0 years, male, NA, stage:, alive, 1054 days
297.4
DO34432
0 years, female, NA, stage:, dead, 400 days
296.6
DO34656
0 years, female, NA, stage:, alive, 834 days
296.1
DO33552
0 years, female, NA, stage:, alive, 873 days
296.0
DO49193
0 years, male, NA, stage:, dead, 1 days
295.4
DO33376
0 years, female, NA, stage:, alive, 909 days
294.7
DO34448
0 years, female, NA, stage:, dead, 719 days
292.8
DO33392
0 years, male, NA, stage:, alive, 1014 days
279.2
DO33344
0 years, male, NA, stage:, dead, 361 days
258.4
DO34817
0 years, female, NA, stage:, alive, 540 days
234.6
DO34616
0 years, female, NA, stage:, alive, 666 days
228.8
DO34961
0 years, male, NA, stage:, dead, 632 days
227.2
DO34608
0 years, female, NA, stage:, dead, 709 days
224.9
DO49172
0 years, female, NA, stage:, dead, 1021 days
221.8
DO49130
0 years, female, NA, stage:, alive, 351 days
218.4
DO49183
0 years, female, NA, stage:, dead, 429 days
217.8
DO34849
0 years, female, NA, stage:, dead, 272 days
217.8
DO32829
0 years, female, NA, stage:T2N0MX, dead, 1874 days
205.3
DO33600
0 years, female, NA, stage:, alive, 854 days
203.8
DO33472
0 years, female, NA, stage:, dead, 388 days
201.1
DO34368
0 years, female, NA, stage:, dead, 537 days
198.9
DO34600
0 years, male, NA, stage:, dead, 537 days
197.6
DO34736
0 years, female, NA, stage:, dead, 203 days
184.4
DO34640
0 years, female, NA, stage:, dead, 287 days
181.0
DO33400
0 years, female, NA, stage:, alive, 1043 days
177.1
DO49181
0 years, male, NA, stage:, dead, 1534 days
175.1
DO34801
0 years, male, NA, stage:, alive, 626 days
152.6
DO33544
0 years, female, NA, stage:, dead, 412 days
152.1
DO33512
female, NA, stage:, dead, 499 days
149.0
DO49090
0 years, female, NA, stage:, dead, 152 days
143.5
DO34312
0 years, female, NA, stage:, dead, 226 days
140.0
DO49199
0 years, male, NA, stage:, dead, 1095 days
128.2
DO49087
0 years, female, NA, stage:, dead, 260 days
127.9
DO34905
0 years, male, NA, stage:, alive, 1142 days
120.1
DO33336
0 years, female, NA, stage:, dead, 451 days
89.1
DO49074
0 years, male, NA, stage:, dead, 168 days
79.6
DO34809
0 years, female, NA, stage:, dead, 297 days
79.4
DO49198
0 years, female, NA, stage:, dead, 251 days
55.2
DO49175
0 years, male, NA, stage:, dead, 414 days
24.5
DO34336
0 years, female, NA, stage:, alive, 743 days
0.5
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PANCREATIC DUCTAL ADENOCARCINOMA - Protein relative expression (CPTAC)
Number of samples
235
Samples
Sample ID
Sample type
nRPX
CPT0011520003
Tumor
1.3
CPT0238610009
Tumor
1.2
CPT0081260004
Tumor
1.1
CPT0174700004
Tumor
1.0
CPT0247040003
Tumor
1.0
CPT0238530005
Tumor
0.9
CPT0109010004
Tumor
0.8
CPT0094940004
Tumor
0.8
CPT0000250017
Tumor
0.8
CPT0108930003
Tumor
0.7
CPT0087890004
Tumor
0.7
CPT0014040003
Tumor
0.7
CPT0264150003
Tumor
0.7
CPT0209640005
Tumor
0.7
CPT0207980005
Tumor
0.6
CPT0236780005
Tumor
0.6
CPT0170240004
Tumor
0.6
CPT0124360003
Tumor
0.6
CPT0081470004
Tumor
0.6
CPT0083270003
Tumor
0.6
CPT0238820005
Tumor
0.6
CPT0246940003
Tumor
0.6
CPT0089720003
Tumor
0.6
CPT0108400003
Tumor
0.6
CPT0019410004
Tumor
0.6
CPT0094130004
Tumor
0.5
CPT0064110003
Normal
0.5
CPT0093980004
Tumor
0.5
CPT0078000003
Tumor
0.5
CPT0078030003
Normal
0.5
CPT0183450005
Tumor
0.5
CPT0236340004
Tumor
0.5
CPT0237270005
Tumor
0.5
CPT0246720003
Tumor
0.5
CPT0209310004
Tumor
0.4
CPT0224460004
Tumor
0.4
CPT0183750005
Tumor
0.4
CPT0078160004
Tumor
0.4
CPT0001730017
Tumor
0.4
CPT0203850004
Tumor
0.4
CPT0248410004
Tumor
0.4
CPT0123750003
Tumor
0.4
CPT0208690004
Tumor
0.4
WU-PDA1
Tumor
0.4
CPT0127270003
Tumor
0.4
CPT0187550004
Tumor
0.4
CPT0124410004
Tumor
0.4
CPT0246210004
Tumor
0.3
CPT0008750003
Tumor
0.3
CPT0092630003
Tumor
0.3
CPT0063970004
Tumor
0.3
CPT0237910004
Tumor
0.3
CPT0064570003
Normal
0.3
CPT0017040004
Tumor
0.3
CPT0093860003
Tumor
0.3
CPT0226760004
Tumor
0.3
CPT0174800003
Normal
0.3
CPT0226600004
Tumor
0.3
CPT0065640003
Tumor
0.3
CPT0197420004
Tumor
0.3
CPT0239100009
Tumor
0.3
CPT0088260004
Tumor
0.3
CPT0246840003
Tumor
0.2
CPT0065570003
Tumor
0.2
CPT0123440003
Tumor
0.2
CPT0355180003
Normal
0.2
CPT0109200004
Tumor
0.2
CPT0161990005
Tumor
0.2
CPT0001750003
Normal
0.2
CPT0094630004
Tumor
0.2
CPT0077880003
Normal
0.2
CPT0066020003
Normal
0.2
CPT0238440005
Tumor
0.2
CPT0077790004
Tumor
0.2
CPT0226650004
Tumor
0.2
CPT0123990003
Tumor
0.2
CPT0185920004
Tumor
0.2
CPT0019300004
Tumor
0.2
CPT0238710004
Tumor
0.2
CPT0094230004
Tumor
0.2
CPT0161770004
Tumor
0.2
CPT0025750003
Tumor
0.2
CPT0109300004
Tumor
0.1
CPT0093880003
Normal
0.1
CPT0126160004
Tumor
0.1
CPT0186040004
Tumor
0.1
CPT0226490004
Tumor
0.1
CPT0124500004
Tumor
0.1
CPT0162660004
Tumor
0.1
CPT0236560004
Tumor
0.1
CPT0008800003
Tumor
0.1
CPT0081060004
Tumor
0.1
CPT0276010003
Tumor
0.1
CPT0208550005
Tumor
0.1
CPT0198700005
Tumor
0.1
CPT0064090003
Tumor
0.1
CPT0081360004
Tumor
0.0
CPT0246950003
Normal
0.0
CPT0207780004
Tumor
0.0
CPT0235230004
Tumor
0.0
CPT0123650003
Tumor
0.0
CPT0227930004
Tumor
0.0
CPT0078250003
Tumor
0.0
CPT0162670004
Normal
0.0
CPT0094180003
Tumor
0.0
C3L-00401-04
Normal
0.0
CPT0139000004
Tumor
0.0
CPT0086190004
Tumor
0.0
CPT0226530004
Tumor
0.0
CPT0123860003
Tumor
0.0
CPT0108960003
Normal
0.0
CPT0197440004
Normal
0.0
KoreanReference3
Tumor
0.0
CPT0077930004
Tumor
0.0
CPT0124530003
Normal
0.0
CPT0238040005
Tumor
0.0
KoreanReference1
Tumor
0.0
CPT0241320005
Tumor
0.0
CPT0091660003
Tumor
-0.1
CPT0064520004
Tumor
-0.1
CPT0063570003
Tumor
-0.1
CPT0125130003
Tumor
-0.1
CPT0086210003
Normal
-0.1
CPT0248620003
Normal
-0.1
CPT0187930005
Tumor
-0.1
CPT0138990003
Normal
-0.1
CPT0237840004
Tumor
-0.1
CPT0218200004
Tumor
-0.1
CPT0077860003
Tumor
-0.1
CPT0221470005
Tumor
-0.1
CPT0078090004
Tumor
-0.1
KoreanReference2
Tumor
-0.1
CPT0226610004
Normal
-0.1
CPT0226570004
Tumor
-0.1
CPT0207990004
Normal
-0.1
CPT0093930004
Tumor
-0.1
CPT0246220004
Normal
-0.1
CPT0123770003
Normal
-0.2
CPT0239910004
Tumor
-0.2
CPT0248590004
Tumor
-0.2
CPT0198420004
Tumor
-0.2
CPT0125090003
Tumor
-0.2
CPT0088320003
Tumor
-0.2
CPT0236700005
Tumor
-0.2
CPT0236360004
Normal
-0.2
CPT0011540003
Normal
-0.2
CPT0124980004
Tumor
-0.3
CPT0091680003
Normal
-0.3
CPT0123460003
Normal
-0.3
CPT0247090003
Tumor
-0.3
CPT0125010003
Normal
-0.3
CPT0094030003
Tumor
-0.3
CPT0247000003
Normal
-0.3
CPT0241510004
Normal
-0.3
CPT0246990003
Tumor
-0.3
CPT0088180004
Tumor
-0.3
CPT0162760003
Tumor
-0.3
C3L-03632-04
Normal
-0.3
C3N-00709-06
Normal
-0.3
CPT0077950003
Normal
-0.3
CPT0254680003
Tumor
-0.4
CPT0183770004
Normal
-0.4
CPT0123890003
Normal
-0.4
CPT0123670003
Normal
-0.4
CPT0246260004
Tumor
-0.4
CPT0238640004
Normal
-0.4
CPT0208840004
Tumor
-0.4
C3N-02573-03
Normal
-0.4
CPT0078180003
Normal
-0.4
CPT0017130003
Normal
-0.4
CPT0217700004
Tumor
-0.5
CPT0241500004
Tumor
-0.5
CPT0124610004
Tumor
-0.5
CPT0089750004
Normal
-0.5
CPT0246810003
Tumor
-0.5
CPT0094740004
Tumor
-0.5
CPT0187540004
Normal
-0.5
CPT0276030003
Normal
-0.6
CPT0226680005
Tumor
-0.6
CPT0248440003
Normal
-0.6
CPT0124000003
Normal
-0.6
CPT0221240004
Tumor
-0.6
CPT0221250004
Normal
-0.6
CPT0239140004
Normal
-0.6
CPT0209650004
Normal
-0.6
CPT0237850004
Normal
-0.6
CPT0166760004
Tumor
-0.6
CPT0127290003
Normal
-0.6
CPT0198440004
Normal
-0.7
CPT0170260004
Normal
-0.7
CPT0025760003
Normal
-0.7
C3L-00189-04
Normal
-0.7
CPT0208850004
Normal
-0.7
CPT0236710004
Normal
-0.7
CPT0347790002
Normal
-0.7
CPT0166780004
Normal
-0.7
CPT0198910005
Tumor
-0.7
CPT0238740004
Normal
-0.8
CPT0063580003
Normal
-0.8
CPT0347850002
Normal
-0.8
CPT0218220004
Normal
-0.8
CPT0238920004
Tumor
-0.8
CPT0198930003
Normal
-0.8
CPT0355200003
Normal
-0.8
CPT0077810003
Normal
-0.8
CPT0236800004
Normal
-0.9
CPT0347820002
Normal
-0.9
CPT0238940004
Normal
-0.9
CPT0347760002
Normal
-1.0
CPT0162780004
Normal
-1.0
CPT0239920004
Normal
-1.0
CPT0347880002
Normal
-1.1
CPT0355190003
Normal
-1.2
CPT0208710004
Normal
-1.2
CPT0237920004
Normal
-1.3
CPT0247050003
Normal
N/A
CPT0108410003
Normal
N/A
CPT0248320003
Normal
N/A
CPT0166650006
Tumor
N/A
CPT0224470004
Normal
N/A
C3L-01687-04
Normal
N/A
CPT0138890003
Normal
N/A
CPT0109110004
Tumor
N/A
WU-pooled sample
Tumor
N/A
CPT0014060003
Normal
N/A
CPT0109130003
Normal
N/A
CPT0138900004
Tumor
N/A
CPT0166680004
Normal
N/A
CPT0094760003
Normal
N/A
CPT0186050004
Normal
N/A
CPT0237290004
Normal
N/A
CPT0264180003
Normal
N/A
CPT0063990003
Normal
N/A
CPT0126200003
Normal
N/A
CPT0198730004
Normal
N/A
Show allShow less
PANCREATIC CANCER - Protein expressioni
A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here.
Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
Antibody stainingi
Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells.
Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.
The Human Protein Atlas project is funded
