Single cell type - PPP1R16B - The Human Protein Atlas

PPP1R16B

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PPP1R16B
Gene descriptionⁱ Full gene name according to HGNC.	Protein phosphatase 1 regulatory subunit 16B
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	NK-cells & T-cells - Immune system & Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Oligodendrocytes, Excitatory neurons, Dendritic cells, Oligodendrocyte precursor cells, Inhibitory neurons)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.81
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Committed oligodendrocyte precursor)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Excitatory neurons, Dendritic cells, Oligodendrocyte precursor cells, Inhibitory neurons)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Committed oligodendrocyte precursor)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

PPP1R16B is part of cluster 78 NK-cells & T-cells - Immune system & Transcription with confidenceⁱ 1
392 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CDK17	Cyclin dependent kinase 17	0.7838	7
ATP8A1	ATPase phospholipid transporting 8A1	0.6040	51
RALGAPA1	Ral GTPase activating protein catalytic subunit alpha 1	0.5795	78
NR3C1	Nuclear receptor subfamily 3 group C member 1	0.5687	28
RBM38	RNA binding motif protein 38	0.5259	78
ATF7IP	Activating transcription factor 7 interacting protein	0.5227	78
ARAP2	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	0.5216	78
MAPRE2	Microtubule associated protein RP/EB family member 2	0.5189	78
PIP4K2A	Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha	0.5184	51
PHTF2	Putative homeodomain transcription factor 2	0.5110	78
MSL2	MSL complex subunit 2	0.5098	78
IL21R	Interleukin 21 receptor	0.5098	78
EPC1	Enhancer of polycomb homolog 1	0.5061	78
FYN	FYN proto-oncogene, Src family tyrosine kinase	0.5034	78
ARHGEF7	Rho guanine nucleotide exchange factor 7	0.4990	48

IMMUNE CELLS

PPP1R16B is part of cluster 12 Non-specific - Mitochondrial translation with confidenceⁱ 0.75
566 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TAF1A	TATA-box binding protein associated factor, RNA polymerase I subunit A	1.0000	12
EMG1	EMG1 N1-specific pseudouridine methyltransferase	0.9524	12
DCK	Deoxycytidine kinase	0.9524	12
IQCB1	IQ motif containing B1	0.9524	12
FAM3C	FAM3 metabolism regulating signaling molecule C	0.9286	12
CD81	CD81 molecule	0.9286	12
NCOA5	Nuclear receptor coactivator 5	0.9286	12
SIRT5	Sirtuin 5	0.9286	12
MRPL40	Mitochondrial ribosomal protein L40	0.9286	12
ZMYM3	Zinc finger MYM-type containing 3	0.9286	12
CRACR2B	Calcium release activated channel regulator 2B	0.9286	12
FAM133B	Family with sequence similarity 133 member B	0.9048	12
STPG1	Sperm tail PG-rich repeat containing 1	0.9048	12
CLK2	CDC like kinase 2	0.9048	12
ZNF528	Zinc finger protein 528	0.9048	12

Adipocytes	28.1 nTPM
Adipose tissue	28.5 nTPM
Breast	27.8 nTPM

Alveolar cells type 1	0.2 nTPM
Lung	0.2 nTPM

Alveolar cells type 2	0.1 nTPM
Lung	0.1 nTPM

Astrocytes	1.2 nTPM
Brain	1.2 nTPM

B-cells	34.2 nTPM
Stomach	77.6 nTPM
Thymus	65.7 nTPM
Lymph node	61.8 nTPM
Salivary gland	44.2 nTPM
Spleen	44.1 nTPM
Esophagus	35.4 nTPM
Bone marrow	30.8 nTPM
Adipose tissue	27.2 nTPM
Lung	20.1 nTPM
Liver	14.5 nTPM
PBMC	10.8 nTPM
Kidney	10.4 nTPM
Skin	1.7 nTPM

Ciliated cells	1.1 nTPM
Bronchus	2.6 nTPM
Fallopian tube	0.9 nTPM
Lung	0.5 nTPM
Endometrium	0.2 nTPM

Club cells	4.1 nTPM
Bronchus	6.5 nTPM
Lung	5.6 nTPM
Prostate	0.4 nTPM

Dendritic cells	62.0 nTPM
Adipose tissue	109.5 nTPM
PBMC	14.4 nTPM

Endothelial cells	22.5 nTPM
Thymus	49.4 nTPM
Liver	41.6 nTPM
Salivary gland	40.2 nTPM
Vascular	34.2 nTPM
Skeletal muscle	32.9 nTPM
Heart muscle	28.6 nTPM
Fallopian tube	20.5 nTPM
Esophagus	19.8 nTPM
Ovary	19.1 nTPM
Placenta	18.7 nTPM
Breast	17.6 nTPM
Prostate	17.4 nTPM
Tongue	16.7 nTPM
Lung	13.1 nTPM
Endometrium	11.7 nTPM
Pancreas	10.3 nTPM
Testis	7.6 nTPM
Skin	5.9 nTPM

Enteroendocrine cells	0.1 nTPM
Colon	0.3 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	2.9 nTPM
Liver	33.2 nTPM
Stomach	5.8 nTPM
Thymus	2.1 nTPM
Heart muscle	1.7 nTPM
Skin	0.7 nTPM
Esophagus	0.6 nTPM
Salivary gland	0.6 nTPM
Breast	0.5 nTPM
Lung	0.3 nTPM
Vascular	0.3 nTPM
Fallopian tube	0.3 nTPM
Skeletal muscle	0.2 nTPM
Placenta	0.0 nTPM
Pancreas	0.0 nTPM
Adipose tissue	0.0 nTPM
Prostate	0.0 nTPM

Granulocytes	0.9 nTPM
Fallopian tube	2.7 nTPM
Lung	0.0 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	0.1 nTPM
Colon	0.2 nTPM
Rectum	0.1 nTPM
Small intestine	0.0 nTPM

Lymphatic endothelial cells	27.1 nTPM
Ovary	32.7 nTPM
Fallopian tube	21.5 nTPM

Macrophages	3.2 nTPM
Endometrium	10.5 nTPM
Skin	6.7 nTPM
Fallopian tube	5.4 nTPM
Bone marrow	5.1 nTPM
Thymus	5.1 nTPM
Tongue	4.7 nTPM
Adipose tissue	4.3 nTPM
Pancreas	4.1 nTPM
Breast	4.1 nTPM
Salivary gland	2.8 nTPM
Skeletal muscle	2.2 nTPM
Spleen	2.0 nTPM
Esophagus	1.3 nTPM
Kidney	0.9 nTPM
Prostate	0.9 nTPM
Lung	0.5 nTPM
Vascular	0.5 nTPM
Testis	0.0 nTPM
Stomach	0.0 nTPM

Basal respiratory cells	0.8 nTPM
Bronchus	0.8 nTPM

Cholangiocytes	1.9 nTPM
Liver	1.9 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Plasma cells	14.1 nTPM
Esophagus	31.2 nTPM
Stomach	23.5 nTPM
Fallopian tube	17.0 nTPM
Spleen	10.3 nTPM
Salivary gland	9.4 nTPM
Bone marrow	7.6 nTPM
Liver	7.0 nTPM
Thymus	6.8 nTPM

Schwann cells	2.1 nTPM
Adipose tissue	5.9 nTPM
Vascular	0.5 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	0.4 nTPM
Salivary gland	0.8 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	3.1 nTPM
Liver	36.5 nTPM
Skeletal muscle	5.7 nTPM
Thymus	2.7 nTPM
Breast	1.6 nTPM
Prostate	1.2 nTPM
Skin	0.7 nTPM
Salivary gland	0.5 nTPM
Fallopian tube	0.3 nTPM
Endometrium	0.2 nTPM
Vascular	0.2 nTPM
Ovary	0.2 nTPM
Placenta	0.1 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM
Tongue	0.0 nTPM

T-cells	36.3 nTPM
Adipose tissue	86.0 nTPM
Stomach	78.6 nTPM
Fallopian tube	77.8 nTPM
Spleen	51.7 nTPM
Colon	49.7 nTPM
Skin	46.3 nTPM
Esophagus	43.8 nTPM
Endometrium	40.4 nTPM
Skeletal muscle	38.6 nTPM
Lymph node	36.9 nTPM
Thymus	36.6 nTPM
Breast	30.3 nTPM
Tongue	27.2 nTPM
Lung	26.4 nTPM
Bone marrow	22.5 nTPM
Vascular	18.5 nTPM
Liver	14.6 nTPM
Prostate	13.0 nTPM
Salivary gland	12.6 nTPM
PBMC	7.0 nTPM
Kidney	3.5 nTPM

Undifferentiated cells	0.0 nTPM
Colon	0.1 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Amygdala excitatory	127.7 nTPM
Hippocampus	168.3 nTPM
Cerebral cortex	154.5 nTPM
Amygdala	150.8 nTPM
Hypothalamus	133.6 nTPM
Basal ganglia	106.4 nTPM
Thalamus	52.6 nTPM

Astrocyte	3.6 nTPM
Basal ganglia	5.4 nTPM
Spinal cord	4.9 nTPM
Cerebellum	4.7 nTPM
Hypothalamus	3.9 nTPM
Amygdala	3.7 nTPM
Hippocampus	3.6 nTPM
Midbrain	3.6 nTPM
Cerebral cortex	3.3 nTPM
Thalamus	2.5 nTPM
Medulla oblongata	1.8 nTPM
Pons	1.8 nTPM

Bergmann glia	1.4 nTPM
Cerebellum	2.1 nTPM
Medulla oblongata	2.1 nTPM
Pons	0.0 nTPM

Central nervous system macrophage	4.1 nTPM
Spinal cord	8.8 nTPM
Cerebral cortex	5.4 nTPM
Cerebellum	4.5 nTPM
Midbrain	4.4 nTPM
Hippocampus	4.3 nTPM
Thalamus	3.8 nTPM
Amygdala	3.3 nTPM
Basal ganglia	3.2 nTPM
Pons	3.1 nTPM
Medulla oblongata	2.0 nTPM
Hypothalamus	1.9 nTPM

Cerebellar inhibitory	32.3 nTPM
Medulla oblongata	40.0 nTPM
Spinal cord	35.7 nTPM
Cerebellum	30.8 nTPM
Midbrain	30.2 nTPM
Pons	25.0 nTPM

Cge interneuron	67.7 nTPM
Hypothalamus	89.6 nTPM
Cerebral cortex	75.2 nTPM
Amygdala	71.1 nTPM
Midbrain	63.3 nTPM
Basal ganglia	61.7 nTPM
Hippocampus	57.4 nTPM
Thalamus	55.4 nTPM

Choroid plexus epithelial cell	7.9 nTPM
Thalamus	24.7 nTPM
Medulla oblongata	5.2 nTPM
Basal ganglia	1.6 nTPM
Hippocampus	0.0 nTPM

Committed oligodendrocyte precursor	626.3 nTPM
Hippocampus	946.8 nTPM
Cerebral cortex	895.5 nTPM
Cerebellum	759.5 nTPM
Amygdala	734.7 nTPM
Hypothalamus	660.3 nTPM
Midbrain	659.4 nTPM
Spinal cord	640.2 nTPM
Basal ganglia	526.2 nTPM
Pons	448.0 nTPM
Thalamus	359.3 nTPM
Medulla oblongata	259.5 nTPM

Deep-layer corticothalamic and 6b	168.6 nTPM
Hypothalamus	235.6 nTPM
Cerebral cortex	189.3 nTPM
Amygdala	153.0 nTPM
Midbrain	148.7 nTPM
Basal ganglia	146.9 nTPM
Hippocampus	138.1 nTPM

Deep-layer intratelencephalic	157.0 nTPM
Hypothalamus	233.2 nTPM
Cerebral cortex	153.7 nTPM
Hippocampus	150.3 nTPM
Amygdala	128.5 nTPM
Basal ganglia	119.4 nTPM

Deep-layer near-projecting	104.3 nTPM
Hypothalamus	148.5 nTPM
Amygdala	113.7 nTPM
Basal ganglia	95.1 nTPM
Cerebral cortex	89.6 nTPM
Hippocampus	74.5 nTPM

Eccentric medium spiny neuron	175.7 nTPM
Hypothalamus	207.4 nTPM
Basal ganglia	206.0 nTPM
Thalamus	197.4 nTPM
Cerebral cortex	166.9 nTPM
Hippocampus	138.4 nTPM
Amygdala	138.1 nTPM

Endothelial cell	180.3 nTPM
Basal ganglia	275.9 nTPM
Hypothalamus	228.3 nTPM
Hippocampus	197.8 nTPM
Amygdala	187.8 nTPM
Midbrain	175.8 nTPM
Cerebral cortex	166.9 nTPM
Spinal cord	165.7 nTPM
Pons	156.0 nTPM
Cerebellum	152.5 nTPM
Thalamus	145.7 nTPM
Medulla oblongata	131.3 nTPM