Single cell type - MYL9 - The Human Protein Atlas

MYL9

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MYL9
Gene descriptionⁱ Full gene name according to HGNC.	Myosin light chain 9
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Smooth muscle cells - Muscle contraction (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Smooth muscle cells, Peritubular cells, Sertoli cells, Breast myoepithelial cells, Alveolar cells type 1, Cardiomyocytes, Pancreatic endocrine cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.58
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enriched (Vascular associated smooth muscle cell)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enhanced (eosinophil, neutrophil)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Smooth muscle cells, Peritubular cells, Sertoli cells, Breast myoepithelial cells, Alveolar cells type 1, Cardiomyocytes, Pancreatic endocrine cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enriched (Vascular associated smooth muscle cell)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enhanced (eosinophil, neutrophil)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

MYL9 is part of cluster 32 Smooth muscle cells - Muscle contraction with confidenceⁱ 1
236 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ACTA2	Actin alpha 2, smooth muscle	0.9514	32
TAGLN	Transgelin	0.9459	32
PPP1R14A	Protein phosphatase 1 regulatory inhibitor subunit 14A	0.8704	32
TPM2	Tropomyosin 2	0.8684	32
MYLK	Myosin light chain kinase	0.8653	32
MYH11	Myosin heavy chain 11	0.8638	32
KCNMB1	Potassium calcium-activated channel subfamily M regulatory beta subunit 1	0.8618	32
CSRP1	Cysteine and glycine rich protein 1	0.8600	32
LMOD1	Leiomodin 1	0.8525	32
ACTG2	Actin gamma 2, smooth muscle	0.8496	32
RASL12	RAS like family 12	0.8495	32
TGFB1I1	Transforming growth factor beta 1 induced transcript 1	0.8329	32
FLNA	Filamin A	0.8137	32
CALD1	Caldesmon 1	0.8083	32
IRAG1	Inositol 1,4,5-triphosphate receptor associated 1	0.7987	32

IMMUNE CELLS

MYL9 is part of cluster 21 Neutrophils - Unknown function with confidenceⁱ 0.99
492 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MBLAC1	Metallo-beta-lactamase domain containing 1	1.0000	21
CERS4	Ceramide synthase 4	0.9762	21
ABHD13	Abhydrolase domain containing 13	0.9524	21
CRK	CRK proto-oncogene, adaptor protein	0.9524	21
ABCG1	ATP binding cassette subfamily G member 1	0.9524	21
PNPT1	Polyribonucleotide nucleotidyltransferase 1	0.9524	21
HELZ2	Helicase with zinc finger 2	0.9524	21
METTL4	Methyltransferase 4, N6-adenosine	0.9286	21
ZNF169	Zinc finger protein 169	0.9286	21
FOXO4	Forkhead box O4	0.9286	21
LCOR	Ligand dependent nuclear receptor corepressor	0.9286	21
STARD10	StAR related lipid transfer domain containing 10	0.9286	21
TTC9	Tetratricopeptide repeat domain 9	0.9048	21
CCNI	Cyclin I	0.9048	21
CEACAM1	CEA cell adhesion molecule 1	0.9048	21

Adipocytes	317.9 nTPM
Breast	404.0 nTPM
Adipose tissue	231.7 nTPM

Alveolar cells type 1	988.5 nTPM
Lung	988.5 nTPM

Alveolar cells type 2	95.8 nTPM
Lung	95.8 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	13.1 nTPM
Thymus	46.1 nTPM
Skin	35.6 nTPM
Esophagus	23.6 nTPM
Liver	14.5 nTPM
Kidney	10.4 nTPM
Adipose tissue	8.2 nTPM
Salivary gland	6.2 nTPM
Lymph node	5.9 nTPM
Bone marrow	5.1 nTPM
Stomach	5.1 nTPM
Lung	4.0 nTPM
Spleen	3.9 nTPM
PBMC	1.5 nTPM

Ciliated cells	73.2 nTPM
Fallopian tube	203.4 nTPM
Bronchus	41.5 nTPM
Lung	33.1 nTPM
Endometrium	14.6 nTPM

Club cells	35.0 nTPM
Bronchus	47.7 nTPM
Lung	36.9 nTPM
Prostate	20.3 nTPM

Endothelial cells	144.3 nTPM
Ovary	355.4 nTPM
Fallopian tube	300.3 nTPM
Testis	245.7 nTPM
Skeletal muscle	239.2 nTPM
Vascular	196.7 nTPM
Thymus	188.9 nTPM
Lung	182.1 nTPM
Skin	124.5 nTPM
Heart muscle	122.3 nTPM
Placenta	104.5 nTPM
Pancreas	103.4 nTPM
Tongue	95.0 nTPM
Prostate	77.7 nTPM
Salivary gland	66.0 nTPM
Esophagus	64.7 nTPM
Endometrium	55.8 nTPM
Breast	40.4 nTPM
Liver	34.0 nTPM

Enteroendocrine cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	396.0 nTPM
Pancreas	1720.0 nTPM
Fallopian tube	652.4 nTPM
Lung	543.9 nTPM
Stomach	475.5 nTPM
Vascular	458.6 nTPM
Thymus	371.5 nTPM
Esophagus	355.7 nTPM
Adipose tissue	336.6 nTPM
Breast	293.6 nTPM
Salivary gland	255.6 nTPM
Skeletal muscle	239.7 nTPM
Heart muscle	201.9 nTPM
Skin	178.6 nTPM
Prostate	110.2 nTPM
Placenta	108.7 nTPM
Liver	33.2 nTPM

Granulocytes	34.7 nTPM
Fallopian tube	76.7 nTPM
Lung	17.6 nTPM
Tongue	9.7 nTPM

Intestinal goblet cells	1.4 nTPM
Small intestine	4.0 nTPM
Colon	0.2 nTPM
Rectum	0.1 nTPM

Lymphatic endothelial cells	68.6 nTPM
Ovary	92.7 nTPM
Fallopian tube	44.6 nTPM

Macrophages	28.8 nTPM
Vascular	161.4 nTPM
Thymus	89.6 nTPM
Skin	54.6 nTPM
Fallopian tube	34.2 nTPM
Pancreas	30.8 nTPM
Breast	28.0 nTPM
Esophagus	25.7 nTPM
Endometrium	23.4 nTPM
Skeletal muscle	21.9 nTPM
Testis	21.7 nTPM
Salivary gland	16.5 nTPM
Tongue	14.1 nTPM
Prostate	10.8 nTPM
Lung	5.5 nTPM
Adipose tissue	3.3 nTPM
Kidney	2.7 nTPM
Bone marrow	2.0 nTPM
Spleen	2.0 nTPM
Stomach	0.0 nTPM

Paneth cells	1.2 nTPM
Small intestine	3.5 nTPM
Colon	0.0 nTPM
Rectum	0.0 nTPM

Basal keratinocytes	28.5 nTPM
Tongue	29.6 nTPM
Skin	27.5 nTPM

Basal prostatic cells	67.4 nTPM
Prostate	67.4 nTPM

Basal respiratory cells	160.2 nTPM
Bronchus	160.2 nTPM

Basal squamous epithelial cells	12.2 nTPM
Esophagus	12.2 nTPM

Plasma cells	23.9 nTPM
Fallopian tube	110.0 nTPM
Thymus	26.1 nTPM
Esophagus	20.8 nTPM
Salivary gland	17.9 nTPM
Liver	8.0 nTPM
Stomach	7.5 nTPM
Spleen	0.5 nTPM
Bone marrow	0.0 nTPM

Schwann cells	113.7 nTPM
Vascular	208.4 nTPM
Esophagus	131.8 nTPM
Adipose tissue	0.8 nTPM

Serous glandular cells	23.1 nTPM
Salivary gland	28.5 nTPM
Tongue	17.7 nTPM

Smooth muscle cells	3240.6 nTPM
Thymus	7714.4 nTPM
Fallopian tube	6614.7 nTPM
Vascular	5611.8 nTPM
Esophagus	4524.0 nTPM
Breast	4113.4 nTPM
Prostate	3376.1 nTPM
Salivary gland	3252.5 nTPM
Ovary	3198.6 nTPM
Skin	3180.9 nTPM
Lung	2388.9 nTPM
Skeletal muscle	2074.5 nTPM
Adipose tissue	1972.8 nTPM
Placenta	1538.3 nTPM
Tongue	1088.5 nTPM
Endometrium	1033.0 nTPM
Liver	166.8 nTPM

T-cells	17.2 nTPM
Vascular	145.9 nTPM
Skin	67.6 nTPM
Endometrium	28.4 nTPM
Fallopian tube	25.2 nTPM
Esophagus	14.6 nTPM
Breast	12.4 nTPM
Prostate	11.2 nTPM
Skeletal muscle	10.6 nTPM
Lung	6.7 nTPM
PBMC	6.4 nTPM
Kidney	6.2 nTPM
Liver	5.6 nTPM
Tongue	4.3 nTPM
Salivary gland	4.2 nTPM
Colon	3.9 nTPM
Thymus	3.5 nTPM
Stomach	2.8 nTPM
Bone marrow	0.8 nTPM
Spleen	0.5 nTPM
Adipose tissue	0.3 nTPM
Lymph node	0.3 nTPM

Undifferentiated cells	4.1 nTPM
Colon	9.7 nTPM
Small intestine	2.1 nTPM
Rectum	0.5 nTPM

Amygdala excitatory	0.2 nTPM
Thalamus	0.9 nTPM
Amygdala	0.1 nTPM
Cerebral cortex	0.1 nTPM
Hypothalamus	0.1 nTPM
Basal ganglia	0.0 nTPM
Hippocampus	0.0 nTPM

Astrocyte	1.1 nTPM
Medulla oblongata	3.0 nTPM
Hypothalamus	1.5 nTPM
Basal ganglia	1.3 nTPM
Midbrain	1.2 nTPM
Spinal cord	1.0 nTPM
Thalamus	1.0 nTPM
Pons	0.9 nTPM
Cerebellum	0.7 nTPM
Hippocampus	0.6 nTPM
Cerebral cortex	0.5 nTPM
Amygdala	0.3 nTPM

Bergmann glia	3.5 nTPM
Medulla oblongata	6.4 nTPM
Pons	2.9 nTPM
Cerebellum	1.4 nTPM

Central nervous system macrophage	2.2 nTPM
Medulla oblongata	8.4 nTPM
Hypothalamus	2.7 nTPM
Thalamus	2.5 nTPM
Cerebral cortex	2.4 nTPM
Basal ganglia	1.9 nTPM
Pons	1.7 nTPM
Midbrain	1.4 nTPM
Hippocampus	1.2 nTPM
Amygdala	0.7 nTPM
Cerebellum	0.6 nTPM
Spinal cord	0.6 nTPM

Cerebellar inhibitory	0.6 nTPM
Medulla oblongata	1.3 nTPM
Midbrain	0.9 nTPM
Pons	0.6 nTPM
Cerebellum	0.2 nTPM
Spinal cord	0.0 nTPM

Cge interneuron	0.2 nTPM
Thalamus	0.3 nTPM
Basal ganglia	0.2 nTPM
Hippocampus	0.2 nTPM
Midbrain	0.2 nTPM
Amygdala	0.1 nTPM
Cerebral cortex	0.1 nTPM
Hypothalamus	0.1 nTPM

Choroid plexus epithelial cell	15.9 nTPM
Hippocampus	22.2 nTPM
Medulla oblongata	22.0 nTPM
Thalamus	11.0 nTPM
Basal ganglia	8.6 nTPM

Committed oligodendrocyte precursor	3.3 nTPM
Medulla oblongata	16.8 nTPM
Spinal cord	11.0 nTPM
Pons	2.7 nTPM
Hippocampus	2.1 nTPM
Thalamus	2.0 nTPM
Basal ganglia	1.1 nTPM
Midbrain	0.8 nTPM
Amygdala	0.0 nTPM
Cerebellum	0.0 nTPM
Cerebral cortex	0.0 nTPM
Hypothalamus	0.0 nTPM

Deep-layer corticothalamic and 6b	0.1 nTPM
Basal ganglia	0.2 nTPM
Cerebral cortex	0.1 nTPM
Hippocampus	0.1 nTPM
Amygdala	0.0 nTPM
Hypothalamus	0.0 nTPM
Midbrain	0.0 nTPM

Deep-layer intratelencephalic	0.3 nTPM
Basal ganglia	0.7 nTPM
Cerebral cortex	0.2 nTPM
Hippocampus	0.2 nTPM
Hypothalamus	0.2 nTPM
Amygdala	0.1 nTPM

Deep-layer near-projecting	0.3 nTPM
Hippocampus	0.7 nTPM
Amygdala	0.4 nTPM
Basal ganglia	0.3 nTPM
Cerebral cortex	0.1 nTPM
Hypothalamus	0.0 nTPM

Eccentric medium spiny neuron	0.1 nTPM
Thalamus	0.2 nTPM
Amygdala	0.1 nTPM
Basal ganglia	0.1 nTPM
Cerebral cortex	0.0 nTPM
Hippocampus	0.0 nTPM
Hypothalamus	0.0 nTPM

Endothelial cell	28.7 nTPM
Medulla oblongata	79.0 nTPM
Hypothalamus	53.3 nTPM
Midbrain	33.1 nTPM
Pons	30.0 nTPM
Thalamus	28.8 nTPM
Cerebral cortex	26.2 nTPM
Spinal cord	17.3 nTPM
Basal ganglia	14.0 nTPM
Amygdala	12.3 nTPM
Cerebellum	10.8 nTPM
Hippocampus	10.6 nTPM

Ependymal cell	5.7 nTPM
Thalamus	12.6 nTPM
Medulla oblongata	7.9 nTPM
Spinal cord	7.7 nTPM
Pons	6.7 nTPM
Basal ganglia	5.0 nTPM
Midbrain	3.8 nTPM
Hypothalamus	3.6 nTPM
Hippocampus	2.5 nTPM
Amygdala	1.7 nTPM