Single cell type - GRAP2 - The Human Protein Atlas

GRAP2

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Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GRAP2
Gene descriptionⁱ Full gene name according to HGNC.	GRB2 related adaptor protein 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Platelets - Hemostasis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Granulocytes, T-cells, NK-cells, Erythroid cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.86
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enriched (Leukocyte)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (naive CD8 T-cell, memory CD8 T-cell, gdT-cell, MAIT T-cell, memory CD4 T-cell, T-reg, naive CD4 T-cell)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Granulocytes, T-cells, NK-cells, Erythroid cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enriched (Leukocyte)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Group enriched (naive CD8 T-cell, memory CD8 T-cell, gdT-cell, MAIT T-cell, memory CD4 T-cell, T-reg, naive CD4 T-cell)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

GRAP2 is part of cluster 57 Platelets - Hemostasis with confidenceⁱ 1
173 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
AQP10	Aquaporin 10	0.9045	57
ENSG00000225528	Novel protein similar to translation machinery associated 7 homolog (S. cerevisiae) TMA7	0.8766	57
LGALS12	Galectin 12	0.8713	57
MPIG6B	Megakaryocyte and platelet inhibitory receptor G6b	0.8697	57
LY6G6F	Lymphocyte antigen 6 family member G6F	0.8427	57
H3C10	H3 clustered histone 10	0.8421	57
GP9	Glycoprotein IX platelet	0.8414	57
PF4	Platelet factor 4	0.8407	57
GP1BA	Glycoprotein Ib platelet subunit alpha	0.8382	57
PPBP	Pro-platelet basic protein	0.8376	57
TUBB1	Tubulin beta 1 class VI	0.8373	57
SCGB1C1	Secretoglobin family 1C member 1	0.8339	57
TREML1	Triggering receptor expressed on myeloid cells like 1	0.8324	57
ITGA2B	Integrin subunit alpha 2b	0.8323	57
PF4V1	Platelet factor 4 variant 1	0.8266	57

IMMUNE CELLS

GRAP2 is part of cluster 11 T-cells - Unknown function with confidenceⁱ 1
119 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CD8A	CD8a molecule	1.0000	11
IGHJ2	Immunoglobulin heavy joining 2	1.0000	11
GIMAP5	GTPase, IMAP family member 5	1.0000	11
BEX5	Brain expressed X-linked 5	1.0000	11
KCNA3	Potassium voltage-gated channel subfamily A member 3	1.0000	11
RFESD	Rieske Fe-S domain containing	1.0000	11
FAM241B	Family with sequence similarity 241 member B	1.0000	11
NSG1	Neuronal vesicle trafficking associated 1	1.0000	11
ACSL6	Acyl-CoA synthetase long chain family member 6	1.0000	11
HTR6	5-hydroxytryptamine receptor 6	1.0000	11
MID2	Midline 2	1.0000	11
FAM171A1	Family with sequence similarity 171 member A1	1.0000	11
SUSD4	Sushi domain containing 4	1.0000	11
SKAP1	Src kinase associated phosphoprotein 1	1.0000	11
CCDC65	Coiled-coil domain containing 65	1.0000	11

Adipocytes	1.1 nTPM
Breast	1.2 nTPM
Adipose tissue	1.0 nTPM

Alveolar cells type 1	0.2 nTPM
Lung	0.2 nTPM

Alveolar cells type 2	0.1 nTPM
Lung	0.1 nTPM

Astrocytes	0.3 nTPM
Brain	0.3 nTPM

B-cells	7.6 nTPM
PBMC	27.7 nTPM
Bone marrow	12.6 nTPM
Kidney	10.4 nTPM
Liver	9.7 nTPM
Skin	8.5 nTPM
Adipose tissue	6.2 nTPM
Spleen	5.5 nTPM
Salivary gland	5.2 nTPM
Stomach	4.6 nTPM
Thymus	3.6 nTPM
Lymph node	3.3 nTPM
Lung	1.3 nTPM
Esophagus	0.0 nTPM

Ciliated cells	0.5 nTPM
Fallopian tube	1.3 nTPM
Lung	0.4 nTPM
Endometrium	0.1 nTPM
Bronchus	0.0 nTPM

Club cells	0.2 nTPM
Prostate	0.5 nTPM
Bronchus	0.1 nTPM
Lung	0.1 nTPM

Endothelial cells	0.7 nTPM
Skin	2.4 nTPM
Heart muscle	2.1 nTPM
Prostate	1.4 nTPM
Tongue	1.2 nTPM
Vascular	0.9 nTPM
Esophagus	0.8 nTPM
Salivary gland	0.8 nTPM
Thymus	0.8 nTPM
Lung	0.5 nTPM
Skeletal muscle	0.3 nTPM
Fallopian tube	0.3 nTPM
Ovary	0.3 nTPM
Endometrium	0.1 nTPM
Testis	0.0 nTPM
Liver	0.0 nTPM
Placenta	0.0 nTPM
Pancreas	0.0 nTPM
Breast	0.0 nTPM

Enteroendocrine cells	0.6 nTPM
Rectum	1.7 nTPM
Colon	0.3 nTPM
Small intestine	0.0 nTPM

Fibroblasts	0.4 nTPM
Liver	1.2 nTPM
Heart muscle	1.0 nTPM
Skin	0.8 nTPM
Prostate	0.7 nTPM
Breast	0.6 nTPM
Salivary gland	0.5 nTPM
Vascular	0.4 nTPM
Lung	0.3 nTPM
Fallopian tube	0.3 nTPM
Thymus	0.2 nTPM
Skeletal muscle	0.1 nTPM
Placenta	0.0 nTPM
Pancreas	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Stomach	0.0 nTPM

Granulocytes	117.6 nTPM
Lung	182.0 nTPM
Fallopian tube	93.2 nTPM
Tongue	77.6 nTPM

Intestinal goblet cells	0.2 nTPM
Colon	0.5 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Lymphatic endothelial cells	0.2 nTPM
Fallopian tube	0.4 nTPM
Ovary	0.0 nTPM

Macrophages	1.4 nTPM
Salivary gland	7.8 nTPM
Skin	4.5 nTPM
Tongue	2.3 nTPM
Bone marrow	2.0 nTPM
Fallopian tube	1.9 nTPM
Kidney	1.8 nTPM
Thymus	1.6 nTPM
Breast	1.6 nTPM
Spleen	1.0 nTPM
Lung	0.7 nTPM
Endometrium	0.6 nTPM
Adipose tissue	0.5 nTPM
Skeletal muscle	0.4 nTPM
Prostate	0.3 nTPM
Vascular	0.2 nTPM
Testis	0.0 nTPM
Pancreas	0.0 nTPM
Esophagus	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	0.3 nTPM
Rectum	1.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Cholangiocytes	3.8 nTPM
Liver	3.8 nTPM

Plasma cells	1.3 nTPM
Bone marrow	3.0 nTPM
Stomach	2.1 nTPM
Spleen	1.7 nTPM
Liver	1.5 nTPM
Fallopian tube	1.3 nTPM
Thymus	0.9 nTPM
Esophagus	0.0 nTPM
Salivary gland	0.0 nTPM

Schwann cells	3.1 nTPM
Adipose tissue	6.6 nTPM
Vascular	2.6 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	3.3 nTPM
Tongue	4.4 nTPM
Salivary gland	2.2 nTPM

Smooth muscle cells	0.3 nTPM
Liver	1.7 nTPM
Tongue	0.9 nTPM
Skin	0.6 nTPM
Breast	0.6 nTPM
Salivary gland	0.4 nTPM
Fallopian tube	0.4 nTPM
Endometrium	0.2 nTPM
Placenta	0.1 nTPM
Skeletal muscle	0.1 nTPM
Thymus	0.1 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Vascular	0.0 nTPM
Ovary	0.0 nTPM

T-cells	55.5 nTPM
PBMC	108.2 nTPM
Kidney	104.6 nTPM
Skin	79.2 nTPM
Lung	72.5 nTPM
Bone marrow	69.5 nTPM
Esophagus	68.1 nTPM
Liver	65.6 nTPM
Stomach	64.3 nTPM
Spleen	57.3 nTPM
Prostate	50.2 nTPM
Skeletal muscle	45.4 nTPM
Thymus	44.3 nTPM
Tongue	43.5 nTPM
Colon	42.9 nTPM
Fallopian tube	41.4 nTPM
Vascular	41.0 nTPM
Lymph node	38.7 nTPM
Breast	38.2 nTPM
Salivary gland	34.8 nTPM
Adipose tissue	29.4 nTPM
Endometrium	26.1 nTPM

Undifferentiated cells	0.2 nTPM
Rectum	0.3 nTPM
Colon	0.2 nTPM
Small intestine	0.1 nTPM

Amygdala excitatory	1.0 nTPM
Hippocampus	1.4 nTPM
Cerebral cortex	1.1 nTPM
Basal ganglia	1.0 nTPM
Amygdala	0.9 nTPM
Thalamus	0.9 nTPM
Hypothalamus	0.5 nTPM

Astrocyte	1.2 nTPM
Spinal cord	2.7 nTPM
Cerebellum	2.2 nTPM
Hypothalamus	1.1 nTPM
Pons	1.1 nTPM
Basal ganglia	1.0 nTPM
Midbrain	1.0 nTPM
Medulla oblongata	0.9 nTPM
Thalamus	0.9 nTPM
Hippocampus	0.7 nTPM
Cerebral cortex	0.6 nTPM
Amygdala	0.5 nTPM

Bergmann glia	2.2 nTPM
Medulla oblongata	4.3 nTPM
Pons	1.4 nTPM
Cerebellum	1.0 nTPM

Central nervous system macrophage	1.2 nTPM
Cerebellum	2.4 nTPM
Hypothalamus	1.6 nTPM
Amygdala	1.5 nTPM
Midbrain	1.3 nTPM
Pons	1.1 nTPM
Basal ganglia	1.0 nTPM
Medulla oblongata	1.0 nTPM
Spinal cord	0.9 nTPM
Thalamus	0.8 nTPM
Cerebral cortex	0.7 nTPM
Hippocampus	0.5 nTPM

Cerebellar inhibitory	0.4 nTPM
Cerebellum	0.7 nTPM
Midbrain	0.6 nTPM
Pons	0.5 nTPM
Medulla oblongata	0.4 nTPM
Spinal cord	0.0 nTPM

Cge interneuron	0.7 nTPM
Basal ganglia	0.9 nTPM
Amygdala	0.8 nTPM
Cerebral cortex	0.8 nTPM
Hippocampus	0.8 nTPM
Hypothalamus	0.5 nTPM
Thalamus	0.5 nTPM
Midbrain	0.3 nTPM

Choroid plexus epithelial cell	1.8 nTPM
Hippocampus	2.8 nTPM
Thalamus	2.7 nTPM
Medulla oblongata	1.2 nTPM
Basal ganglia	0.6 nTPM

Committed oligodendrocyte precursor	0.6 nTPM
Hypothalamus	2.0 nTPM
Cerebellum	1.6 nTPM
Medulla oblongata	1.3 nTPM
Pons	0.9 nTPM
Midbrain	0.8 nTPM
Hippocampus	0.3 nTPM
Thalamus	0.2 nTPM
Amygdala	0.0 nTPM
Basal ganglia	0.0 nTPM
Cerebral cortex	0.0 nTPM
Spinal cord	0.0 nTPM

Deep-layer corticothalamic and 6b	1.1 nTPM
Midbrain	3.3 nTPM
Hippocampus	0.8 nTPM
Cerebral cortex	0.7 nTPM
Hypothalamus	0.7 nTPM
Amygdala	0.6 nTPM
Basal ganglia	0.4 nTPM

Deep-layer intratelencephalic	0.7 nTPM
Basal ganglia	0.9 nTPM
Amygdala	0.7 nTPM
Cerebral cortex	0.7 nTPM
Hippocampus	0.7 nTPM
Hypothalamus	0.7 nTPM

Deep-layer near-projecting	1.1 nTPM
Hypothalamus	1.7 nTPM
Amygdala	1.2 nTPM
Hippocampus	1.0 nTPM
Basal ganglia	0.8 nTPM
Cerebral cortex	0.6 nTPM

Eccentric medium spiny neuron	0.7 nTPM
Hippocampus	1.2 nTPM
Hypothalamus	0.8 nTPM
Basal ganglia	0.6 nTPM
Cerebral cortex	0.6 nTPM
Thalamus	0.6 nTPM
Amygdala	0.5 nTPM

Endothelial cell	1.2 nTPM
Hypothalamus	3.7 nTPM
Cerebral cortex	3.2 nTPM
Midbrain	1.9 nTPM
Spinal cord	1.7 nTPM
Thalamus	1.1 nTPM
Cerebellum	0.8 nTPM
Hippocampus	0.6 nTPM
Pons	0.6 nTPM
Amygdala	0.0 nTPM
Basal ganglia	0.0 nTPM
Medulla oblongata	0.0 nTPM

Ependymal cell	1.0 nTPM
Midbrain	3.2 nTPM
Hypothalamus	1.8 nTPM
Medulla oblongata	1.3 nTPM
Thalamus	0.8 nTPM
Hippocampus	0.7 nTPM
Amygdala	0.6 nTPM
Basal ganglia	0.6 nTPM
Pons	0.4 nTPM
Spinal cord	0.0 nTPM