Single cell type - DHX32 - The Human Protein Atlas

DHX32

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DHX32
Gene descriptionⁱ Full gene name according to HGNC.	DEAH-box helicase 32 (putative)
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Intestinal goblet cells - Mucin production (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Early spermatids)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.44
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Early spermatids)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

DHX32 is part of cluster 16 Intestinal goblet cells - Mucin production with confidenceⁱ 1
268 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
DNAJC10	DnaJ heat shock protein family (Hsp40) member C10	0.5473	77
CAPN9	Calpain 9	0.5324	16
KLK15	Kallikrein related peptidase 15	0.5242	16
GFPT1	Glutamine--fructose-6-phosphate transaminase 1	0.5211	16
B3GNT6	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6	0.5029	16
GALNT12	Polypeptide N-acetylgalactosaminyltransferase 12	0.4987	16
ATOH1	Atonal bHLH transcription factor 1	0.4984	16
GALNT5	Polypeptide N-acetylgalactosaminyltransferase 5	0.4973	16
REP15	RAB15 effector protein	0.4936	16
ZG16	Zymogen granule protein 16	0.4927	16
COG2	Component of oligomeric golgi complex 2	0.4925	16
ANO7	Anoctamin 7	0.4919	16
FCGBP	Fc gamma binding protein	0.4917	16
GALNT3	Polypeptide N-acetylgalactosaminyltransferase 3	0.4907	45
TFF3	Trefoil factor 3	0.4850	16

IMMUNE CELLS

DHX32 is part of cluster 45 Eosinophils - Unknown function with confidenceⁱ 1
257 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PNPLA2	Patatin like phospholipase domain containing 2	1.0000	45
SEC24D	SEC24 homolog D, COPII coat complex component	1.0000	45
HERPUD2	HERPUD family member 2	1.0000	45
GSK3B	Glycogen synthase kinase 3 beta	1.0000	45
NAPG	NSF attachment protein gamma	0.9762	45
IGFBP6	Insulin like growth factor binding protein 6	0.9762	45
PPP4C	Protein phosphatase 4 catalytic subunit	0.9762	45
EIF2B5	Eukaryotic translation initiation factor 2B subunit epsilon	0.9762	45
JTB	Jumping translocation breakpoint	0.9762	45
TIMM29	Translocase of inner mitochondrial membrane 29	0.9762	45
RNPEPL1	Arginyl aminopeptidase like 1	0.9762	25
MTCH1	Mitochondrial carrier 1	0.9762	25
TMEM160	Transmembrane protein 160	0.9762	45
FAM98C	Family with sequence similarity 98 member C	0.9762	45
PPCS	Phosphopantothenoylcysteine synthetase	0.9762	25

Adipocytes	10.7 nTPM
Adipose tissue	10.9 nTPM
Breast	10.5 nTPM

Alveolar cells type 1	18.8 nTPM
Lung	18.8 nTPM

Alveolar cells type 2	24.3 nTPM
Lung	24.3 nTPM

Astrocytes	29.7 nTPM
Brain	29.7 nTPM

B-cells	6.7 nTPM
Salivary gland	14.0 nTPM
Thymus	11.0 nTPM
Lymph node	10.5 nTPM
Kidney	10.4 nTPM
Stomach	9.7 nTPM
Spleen	8.4 nTPM
Bone marrow	7.9 nTPM
Lung	5.4 nTPM
Adipose tissue	4.9 nTPM
PBMC	3.1 nTPM
Skin	1.7 nTPM
Liver	0.0 nTPM
Esophagus	0.0 nTPM

Ciliated cells	21.9 nTPM
Bronchus	33.8 nTPM
Lung	22.5 nTPM
Endometrium	17.9 nTPM
Fallopian tube	13.2 nTPM

Club cells	20.9 nTPM
Prostate	28.5 nTPM
Lung	19.8 nTPM
Bronchus	14.2 nTPM

Endothelial cells	14.5 nTPM
Testis	29.0 nTPM
Heart muscle	20.4 nTPM
Ovary	18.4 nTPM
Salivary gland	16.8 nTPM
Endometrium	16.3 nTPM
Thymus	16.3 nTPM
Vascular	16.0 nTPM
Skeletal muscle	15.4 nTPM
Tongue	15.4 nTPM
Breast	14.9 nTPM
Lung	13.3 nTPM
Pancreas	12.9 nTPM
Placenta	11.9 nTPM
Prostate	11.4 nTPM
Esophagus	10.8 nTPM
Liver	10.1 nTPM
Fallopian tube	7.3 nTPM
Skin	3.9 nTPM

Enteroendocrine cells	16.1 nTPM
Colon	24.4 nTPM
Small intestine	13.7 nTPM
Rectum	10.1 nTPM

Fibroblasts	12.1 nTPM
Heart muscle	21.3 nTPM
Vascular	16.1 nTPM
Salivary gland	15.7 nTPM
Pancreas	15.3 nTPM
Lung	14.3 nTPM
Thymus	14.3 nTPM
Placenta	14.1 nTPM
Skeletal muscle	12.7 nTPM
Prostate	12.5 nTPM
Adipose tissue	12.0 nTPM
Esophagus	10.0 nTPM
Breast	8.9 nTPM
Liver	8.3 nTPM
Fallopian tube	8.3 nTPM
Skin	5.1 nTPM
Stomach	4.3 nTPM

Granulocytes	7.6 nTPM
Lung	9.6 nTPM
Fallopian tube	8.3 nTPM
Tongue	4.9 nTPM

Intestinal goblet cells	60.8 nTPM
Rectum	77.0 nTPM
Small intestine	66.3 nTPM
Colon	39.1 nTPM

Lymphatic endothelial cells	20.4 nTPM
Ovary	21.8 nTPM
Fallopian tube	19.0 nTPM

Macrophages	9.3 nTPM
Lung	20.3 nTPM
Vascular	15.2 nTPM
Salivary gland	13.4 nTPM
Prostate	12.6 nTPM
Thymus	12.6 nTPM
Tongue	12.6 nTPM
Endometrium	11.7 nTPM
Skeletal muscle	9.5 nTPM
Breast	8.1 nTPM
Esophagus	7.7 nTPM
Stomach	7.7 nTPM
Spleen	7.0 nTPM
Fallopian tube	6.9 nTPM
Testis	6.8 nTPM
Adipose tissue	6.6 nTPM
Skin	5.6 nTPM
Bone marrow	5.1 nTPM
Pancreas	4.1 nTPM
Kidney	2.7 nTPM

Paneth cells	18.2 nTPM
Rectum	29.9 nTPM
Small intestine	13.8 nTPM
Colon	10.9 nTPM

Basal respiratory cells	9.8 nTPM
Bronchus	9.8 nTPM

Collecting duct cells	7.8 nTPM
Kidney	7.8 nTPM

Cone photoreceptor cells	27.2 nTPM
Eye	27.2 nTPM

Cytotrophoblasts	19.2 nTPM
Placenta	19.2 nTPM

Plasma cells	9.1 nTPM
Salivary gland	17.5 nTPM
Bone marrow	13.6 nTPM
Esophagus	10.4 nTPM
Stomach	9.2 nTPM
Fallopian tube	8.4 nTPM
Thymus	6.0 nTPM
Spleen	4.6 nTPM
Liver	3.5 nTPM

Schwann cells	4.7 nTPM
Vascular	12.5 nTPM
Adipose tissue	1.6 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	24.4 nTPM
Salivary gland	31.1 nTPM
Tongue	17.7 nTPM

Smooth muscle cells	10.7 nTPM
Esophagus	16.8 nTPM
Salivary gland	16.7 nTPM
Endometrium	15.8 nTPM
Tongue	15.3 nTPM
Vascular	12.7 nTPM
Prostate	10.9 nTPM
Skeletal muscle	10.7 nTPM
Thymus	10.7 nTPM
Placenta	10.2 nTPM
Adipose tissue	9.1 nTPM
Lung	8.2 nTPM
Ovary	7.5 nTPM
Liver	7.2 nTPM
Breast	6.9 nTPM
Fallopian tube	6.4 nTPM
Skin	5.4 nTPM

Suprabasal keratinocytes	22.9 nTPM
Tongue	40.3 nTPM
Skin	5.5 nTPM

T-cells	5.3 nTPM
Salivary gland	12.1 nTPM
Thymus	11.7 nTPM
Lymph node	8.1 nTPM
Tongue	7.0 nTPM
Endometrium	6.6 nTPM
Stomach	6.5 nTPM
PBMC	6.3 nTPM
Vascular	6.0 nTPM
Bone marrow	5.8 nTPM
Lung	5.7 nTPM
Liver	5.1 nTPM
Skeletal muscle	4.9 nTPM
Spleen	4.7 nTPM
Skin	3.9 nTPM
Adipose tissue	3.1 nTPM
Breast	2.9 nTPM
Fallopian tube	2.6 nTPM
Esophagus	2.4 nTPM
Prostate	2.2 nTPM
Colon	1.9 nTPM
Kidney	0.9 nTPM

Undifferentiated cells	22.5 nTPM
Rectum	29.2 nTPM
Small intestine	20.3 nTPM
Colon	18.1 nTPM

Amygdala excitatory	51.0 nTPM
Basal ganglia	53.6 nTPM
Hippocampus	53.0 nTPM
Amygdala	51.9 nTPM
Cerebral cortex	51.6 nTPM
Thalamus	48.1 nTPM
Hypothalamus	47.7 nTPM

Astrocyte	73.7 nTPM
Amygdala	90.9 nTPM
Cerebral cortex	90.4 nTPM
Hippocampus	85.1 nTPM
Thalamus	84.3 nTPM
Midbrain	83.4 nTPM
Basal ganglia	75.1 nTPM
Hypothalamus	68.3 nTPM
Cerebellum	64.4 nTPM
Pons	63.5 nTPM
Medulla oblongata	56.3 nTPM
Spinal cord	48.9 nTPM

Bergmann glia	41.8 nTPM
Cerebellum	54.8 nTPM
Medulla oblongata	36.2 nTPM
Pons	34.5 nTPM

Central nervous system macrophage	71.0 nTPM
Amygdala	89.6 nTPM
Hippocampus	79.4 nTPM
Midbrain	76.9 nTPM
Hypothalamus	73.5 nTPM
Pons	72.3 nTPM
Thalamus	69.8 nTPM
Cerebellum	69.2 nTPM
Cerebral cortex	67.4 nTPM
Basal ganglia	66.5 nTPM
Medulla oblongata	61.9 nTPM
Spinal cord	54.8 nTPM

Cerebellar inhibitory	90.7 nTPM
Midbrain	98.9 nTPM
Cerebellum	95.0 nTPM
Spinal cord	93.5 nTPM
Medulla oblongata	88.8 nTPM
Pons	77.4 nTPM

Cge interneuron	44.8 nTPM
Hypothalamus	50.5 nTPM
Cerebral cortex	48.9 nTPM
Hippocampus	48.2 nTPM
Amygdala	47.0 nTPM
Midbrain	43.1 nTPM
Basal ganglia	41.9 nTPM
Thalamus	34.1 nTPM

Choroid plexus epithelial cell	109.7 nTPM
Basal ganglia	162.3 nTPM
Medulla oblongata	114.0 nTPM
Thalamus	82.2 nTPM
Hippocampus	80.4 nTPM

Committed oligodendrocyte precursor	70.3 nTPM
Pons	87.6 nTPM
Medulla oblongata	78.8 nTPM
Hippocampus	77.9 nTPM
Spinal cord	73.6 nTPM
Cerebral cortex	71.6 nTPM
Midbrain	70.6 nTPM
Thalamus	67.1 nTPM
Amygdala	66.0 nTPM
Cerebellum	63.4 nTPM
Basal ganglia	59.1 nTPM
Hypothalamus	57.4 nTPM

Deep-layer corticothalamic and 6b	40.2 nTPM
Hippocampus	47.4 nTPM
Hypothalamus	40.9 nTPM
Cerebral cortex	40.2 nTPM
Midbrain	39.9 nTPM
Basal ganglia	36.4 nTPM
Amygdala	36.1 nTPM

Deep-layer intratelencephalic	44.2 nTPM
Amygdala	45.2 nTPM
Cerebral cortex	44.8 nTPM
Hypothalamus	44.7 nTPM
Basal ganglia	43.2 nTPM
Hippocampus	43.2 nTPM

Deep-layer near-projecting	60.1 nTPM
Hypothalamus	70.2 nTPM
Cerebral cortex	65.0 nTPM
Basal ganglia	63.0 nTPM
Amygdala	60.8 nTPM
Hippocampus	41.6 nTPM

Eccentric medium spiny neuron	66.9 nTPM
Hypothalamus	78.7 nTPM
Amygdala	73.4 nTPM
Thalamus	66.2 nTPM
Basal ganglia	65.9 nTPM
Cerebral cortex	62.4 nTPM
Hippocampus	54.7 nTPM

Endothelial cell	49.3 nTPM
Hippocampus	63.5 nTPM
Spinal cord	60.4 nTPM
Amygdala	59.2 nTPM
Midbrain	52.0 nTPM
Medulla oblongata	50.3 nTPM
Pons	48.1 nTPM
Hypothalamus	45.9 nTPM
Thalamus	45.2 nTPM
Basal ganglia	44.7 nTPM
Cerebellum	39.5 nTPM
Cerebral cortex	33.2 nTPM