Single cell type - GNAS - The Human Protein Atlas

GNAS

Search result

Field

Term

Cluster

Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GNAS
Gene descriptionⁱ Full gene name according to HGNC.	GNAS complex locus
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Disease related genes Human disease related genes Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	50

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - DNA binding (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.20
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

GNAS is part of cluster 33 Non-specific - DNA binding with confidenceⁱ 0.98
138 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CDC34	Cell division cycle 34, ubiqiutin conjugating enzyme	0.4786	33
KCMF1	Potassium channel modulatory factor 1	0.4767	33
BTBD6	BTB domain containing 6	0.4670	33
ZFPM1	Zinc finger protein, FOG family member 1	0.4622	33
GNAI2	G protein subunit alpha i2	0.4621	33
GALNT1	Polypeptide N-acetylgalactosaminyltransferase 1	0.4515	75
AQP5	Aquaporin 5	0.4485	75
VEGFB	Vascular endothelial growth factor B	0.4471	33
CTDNEP1	CTD nuclear envelope phosphatase 1	0.4463	33
EIF3G	Eukaryotic translation initiation factor 3 subunit G	0.4462	64
DUS1L	Dihydrouridine synthase 1 like	0.4459	33
STK11	Serine/threonine kinase 11	0.4379	63
GSK3A	Glycogen synthase kinase 3 alpha	0.4360	33
SAP30L	SAP30 like	0.4343	33
SLC25A28	Solute carrier family 25 member 28	0.4310	36

IMMUNE CELLS

GNAS is part of cluster 10 Non-specific - Membrane trafficking with confidenceⁱ 0.97
408 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
WDFY2	WD repeat and FYVE domain containing 2	1.0000	10
MILR1	Mast cell immunoglobulin like receptor 1	0.9762	10
YWHAG	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma	0.9762	10
DNAJC13	DnaJ heat shock protein family (Hsp40) member C13	0.9524	10
TMEM170B	Transmembrane protein 170B	0.9524	2
SLC29A3	Solute carrier family 29 member 3	0.9524	2
NKIRAS2	NFKB inhibitor interacting Ras like 2	0.9524	10
ADPGK	ADP dependent glucokinase	0.9524	10
N4BP2L1	NEDD4 binding protein 2 like 1	0.9524	10
DBNL	Drebrin like	0.9524	10
CPED1	Cadherin like and PC-esterase domain containing 1	0.9524	2
IGF2BP2	Insulin like growth factor 2 mRNA binding protein 2	0.9524	10
TTC17	Tetratricopeptide repeat domain 17	0.9286	10
KDELR2	KDEL endoplasmic reticulum protein retention receptor 2	0.9286	10
SEC13	SEC13 homolog, nuclear pore and COPII coat complex component	0.9286	2

Adipocytes	892.2 nTPM
Adipose tissue	948.4 nTPM
Breast	836.1 nTPM

Alveolar cells type 1	728.0 nTPM
Lung	728.0 nTPM

Alveolar cells type 2	771.1 nTPM
Lung	771.1 nTPM

Astrocytes	182.1 nTPM
Brain	182.1 nTPM

B-cells	363.9 nTPM
Lung	917.5 nTPM
Adipose tissue	902.5 nTPM
Salivary gland	616.5 nTPM
Thymus	571.8 nTPM
Skin	464.1 nTPM
Liver	256.0 nTPM
Lymph node	189.0 nTPM
PBMC	166.2 nTPM
Stomach	152.7 nTPM
Kidney	150.8 nTPM
Spleen	130.0 nTPM
Bone marrow	107.7 nTPM
Esophagus	106.2 nTPM

Basal squamous epithelial cells	198.8 nTPM
Esophagus	198.8 nTPM

Ciliated cells	462.1 nTPM
Lung	666.8 nTPM
Fallopian tube	562.3 nTPM
Endometrium	474.5 nTPM
Bronchus	144.8 nTPM

Club cells	483.5 nTPM
Lung	827.3 nTPM
Prostate	494.7 nTPM
Bronchus	128.4 nTPM

Dendritic cells	601.0 nTPM
Adipose tissue	899.8 nTPM
PBMC	302.2 nTPM

Endothelial cells	597.7 nTPM
Breast	1580.0 nTPM
Thymus	850.5 nTPM
Liver	817.5 nTPM
Fallopian tube	771.0 nTPM
Vascular	756.9 nTPM
Endometrium	707.6 nTPM
Skeletal muscle	659.3 nTPM
Salivary gland	655.4 nTPM
Tongue	550.3 nTPM
Ovary	537.2 nTPM
Lung	533.8 nTPM
Prostate	528.0 nTPM
Heart muscle	392.7 nTPM
Testis	376.0 nTPM
Placenta	347.4 nTPM
Esophagus	301.9 nTPM
Skin	232.7 nTPM
Pancreas	160.3 nTPM

Enteroendocrine cells	315.8 nTPM
Rectum	452.8 nTPM
Small intestine	281.5 nTPM
Colon	213.1 nTPM

Erythroid cells	239.5 nTPM
Liver	349.6 nTPM
Bone marrow	129.5 nTPM

Fibroblasts	482.4 nTPM
Placenta	1037.5 nTPM
Adipose tissue	885.8 nTPM
Skeletal muscle	650.3 nTPM
Fallopian tube	637.8 nTPM
Vascular	568.5 nTPM
Lung	564.3 nTPM
Thymus	543.7 nTPM
Salivary gland	510.8 nTPM
Prostate	440.2 nTPM
Heart muscle	433.3 nTPM
Breast	426.1 nTPM
Liver	276.3 nTPM
Pancreas	231.0 nTPM
Skin	206.5 nTPM
Esophagus	168.9 nTPM
Stomach	136.9 nTPM

Granulocytes	553.1 nTPM
Lung	689.2 nTPM
Fallopian tube	616.1 nTPM
Tongue	354.1 nTPM

Intestinal goblet cells	217.0 nTPM
Rectum	294.0 nTPM
Colon	241.6 nTPM
Small intestine	115.5 nTPM

Bipolar cells	369.0 nTPM
Eye	369.0 nTPM

Cholangiocytes	232.8 nTPM
Liver	232.8 nTPM

Collecting duct cells	233.4 nTPM
Kidney	233.4 nTPM

Cone photoreceptor cells	93.5 nTPM
Eye	93.5 nTPM

Lymphatic endothelial cells	1126.0 nTPM
Fallopian tube	1646.5 nTPM
Ovary	605.6 nTPM

Macrophages	523.6 nTPM
Lung	1179.0 nTPM
Breast	1015.6 nTPM
Adipose tissue	963.8 nTPM
Fallopian tube	680.6 nTPM
Tongue	659.7 nTPM
Vascular	652.9 nTPM
Endometrium	620.5 nTPM
Prostate	618.9 nTPM
Salivary gland	579.5 nTPM
Skeletal muscle	578.1 nTPM
Thymus	573.9 nTPM
Testis	345.9 nTPM
Skin	314.2 nTPM
Esophagus	312.1 nTPM
Kidney	206.2 nTPM
Pancreas	193.2 nTPM
Spleen	170.4 nTPM
Bone marrow	156.1 nTPM
Stomach	128.6 nTPM

Paneth cells	235.7 nTPM
Colon	275.0 nTPM
Rectum	262.8 nTPM
Small intestine	169.2 nTPM

Plasma cells	585.8 nTPM
Fallopian tube	1418.1 nTPM
Thymus	1164.6 nTPM
Salivary gland	667.5 nTPM
Liver	591.3 nTPM
Stomach	258.4 nTPM
Spleen	224.2 nTPM
Esophagus	197.5 nTPM
Bone marrow	164.6 nTPM

Schwann cells	587.9 nTPM
Adipose tissue	1342.9 nTPM
Vascular	324.9 nTPM
Esophagus	95.8 nTPM

Serous glandular cells	1108.1 nTPM
Salivary gland	1403.0 nTPM
Tongue	813.1 nTPM

Smooth muscle cells	644.3 nTPM
Fallopian tube	1070.6 nTPM
Ovary	916.1 nTPM
Breast	881.4 nTPM
Salivary gland	833.2 nTPM
Thymus	824.6 nTPM
Adipose tissue	821.9 nTPM
Vascular	797.8 nTPM
Prostate	733.5 nTPM
Lung	686.6 nTPM
Endometrium	643.9 nTPM
Skeletal muscle	533.5 nTPM
Tongue	520.3 nTPM
Liver	375.7 nTPM
Esophagus	245.1 nTPM
Placenta	214.2 nTPM
Skin	211.0 nTPM

Suprabasal keratinocytes	448.2 nTPM
Tongue	768.9 nTPM
Skin	127.5 nTPM

T-cells	397.0 nTPM
Adipose tissue	987.9 nTPM
Fallopian tube	778.5 nTPM
Breast	770.2 nTPM
Endometrium	619.6 nTPM
Lung	589.5 nTPM
Skeletal muscle	545.2 nTPM
Thymus	544.9 nTPM
Tongue	504.4 nTPM
Salivary gland	471.9 nTPM
Vascular	447.0 nTPM
Prostate	436.7 nTPM
Skin	240.1 nTPM
Colon	224.2 nTPM
Stomach	198.9 nTPM
Liver	175.8 nTPM
PBMC	162.5 nTPM
Lymph node	156.5 nTPM
Esophagus	138.7 nTPM
Kidney	128.6 nTPM
Spleen	124.4 nTPM
Bone marrow	92.4 nTPM

Undifferentiated cells	244.5 nTPM
Rectum	283.2 nTPM
Small intestine	229.4 nTPM
Colon	220.9 nTPM

Amygdala excitatory	262.7 nTPM
Thalamus	519.5 nTPM
Basal ganglia	245.5 nTPM
Hippocampus	230.5 nTPM
Hypothalamus	206.2 nTPM
Cerebral cortex	189.2 nTPM
Amygdala	185.2 nTPM

Astrocyte	243.1 nTPM
Spinal cord	294.4 nTPM
Cerebellum	280.3 nTPM
Hypothalamus	260.9 nTPM
Thalamus	259.0 nTPM
Medulla oblongata	257.8 nTPM
Midbrain	257.3 nTPM
Pons	254.1 nTPM
Cerebral cortex	225.5 nTPM
Basal ganglia	213.5 nTPM
Hippocampus	196.3 nTPM
Amygdala	174.6 nTPM

Bergmann glia	305.0 nTPM
Pons	358.2 nTPM
Medulla oblongata	287.7 nTPM
Cerebellum	269.1 nTPM

Central nervous system macrophage	478.4 nTPM
Hypothalamus	602.5 nTPM
Basal ganglia	559.3 nTPM
Midbrain	497.6 nTPM
Cerebellum	491.2 nTPM
Pons	486.2 nTPM
Cerebral cortex	471.6 nTPM
Thalamus	469.4 nTPM
Medulla oblongata	455.9 nTPM
Spinal cord	426.6 nTPM
Hippocampus	403.3 nTPM
Amygdala	399.1 nTPM

Cerebellar inhibitory	652.5 nTPM
Pons	883.4 nTPM
Medulla oblongata	677.6 nTPM
Spinal cord	613.2 nTPM
Cerebellum	544.3 nTPM
Midbrain	544.0 nTPM

Cge interneuron	717.9 nTPM
Thalamus	897.3 nTPM
Hippocampus	826.9 nTPM
Midbrain	777.1 nTPM
Basal ganglia	776.5 nTPM
Cerebral cortex	700.2 nTPM
Amygdala	525.2 nTPM
Hypothalamus	522.2 nTPM

Choroid plexus epithelial cell	350.1 nTPM
Medulla oblongata	390.8 nTPM
Thalamus	361.7 nTPM
Hippocampus	352.2 nTPM
Basal ganglia	295.7 nTPM

Committed oligodendrocyte precursor	288.6 nTPM
Medulla oblongata	438.9 nTPM
Pons	395.7 nTPM
Midbrain	316.7 nTPM
Cerebellum	285.4 nTPM
Spinal cord	279.6 nTPM
Thalamus	279.2 nTPM
Hypothalamus	268.3 nTPM
Cerebral cortex	262.8 nTPM
Basal ganglia	239.3 nTPM
Hippocampus	228.9 nTPM
Amygdala	179.3 nTPM

Deep-layer corticothalamic and 6b	232.6 nTPM
Midbrain	317.3 nTPM
Basal ganglia	277.7 nTPM
Cerebral cortex	230.3 nTPM
Amygdala	201.6 nTPM
Hippocampus	185.0 nTPM
Hypothalamus	183.9 nTPM

Deep-layer intratelencephalic	241.3 nTPM
Cerebral cortex	304.1 nTPM
Basal ganglia	262.3 nTPM
Amygdala	229.0 nTPM
Hippocampus	210.2 nTPM
Hypothalamus	200.9 nTPM