Single cell type - RRAGB - The Human Protein Atlas

RRAGB

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RRAGB
Gene descriptionⁱ Full gene name according to HGNC.	Ras related GTP binding B
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Oocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.40
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Oocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

RRAGB is part of cluster 55 Non-specific - Transcription with confidenceⁱ 1
709 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF594	Zinc finger protein 594	0.5630	55
ZNF84	Zinc finger protein 84	0.5471	55
ZNF181	Zinc finger protein 181	0.5426	55
GNPDA2	Glucosamine-6-phosphate deaminase 2	0.5222	44
ZNF835	Zinc finger protein 835	0.5184	6
ZNF727	Zinc finger protein 727	0.5159	55
ZNF626	Zinc finger protein 626	0.5092	3
TIGD7	Tigger transposable element derived 7	0.5018	55
ZNF737	Zinc finger protein 737	0.5014	55
LYRM9	LYR motif containing 9	0.4996	6
ZSCAN26	Zinc finger and SCAN domain containing 26	0.4993	6
ZC2HC1A	Zinc finger C2HC-type containing 1A	0.4973	42
ZNF418	Zinc finger protein 418	0.4865	68
ZNF221	Zinc finger protein 221	0.4824	55
CNOT4	CCR4-NOT transcription complex subunit 4	0.4812	55

IMMUNE CELLS

RRAGB is part of cluster 5 Non-specific - Cell proliferation with confidenceⁱ 0.99
689 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HSD17B7	Hydroxysteroid 17-beta dehydrogenase 7	1.0000	5
NF1	Neurofibromin 1	0.9762	5
NUDT2	Nudix hydrolase 2	0.9762	5
KRBOX4	KRAB box domain containing 4	0.9762	5
PPOX	Protoporphyrinogen oxidase	0.9762	5
SOX30	SRY-box transcription factor 30	0.9762	5
NUP160	Nucleoporin 160	0.9762	5
THADA	THADA armadillo repeat containing	0.9524	5
NUF2	NUF2 component of NDC80 kinetochore complex	0.9524	5
LDAF1	Lipid droplet assembly factor 1	0.9524	5
GPR183	G protein-coupled receptor 183	0.9524	5
ZNF829	Zinc finger protein 829	0.9524	5
PPP4R3A	Protein phosphatase 4 regulatory subunit 3A	0.9286	5
SETD6	SET domain containing 6, protein lysine methyltransferase	0.9286	5
AMBRA1	Autophagy and beclin 1 regulator 1	0.9286	5

Adipocytes	14.2 nTPM
Breast	16.1 nTPM
Adipose tissue	12.3 nTPM

Alveolar cells type 1	7.7 nTPM
Lung	7.7 nTPM

Alveolar cells type 2	4.7 nTPM
Lung	4.7 nTPM

Astrocytes	21.7 nTPM
Brain	21.7 nTPM

B-cells	15.0 nTPM
Lymph node	31.9 nTPM
Esophagus	29.5 nTPM
PBMC	23.1 nTPM
Bone marrow	18.1 nTPM
Thymus	16.7 nTPM
Spleen	15.4 nTPM
Salivary gland	15.3 nTPM
Stomach	14.8 nTPM
Lung	14.8 nTPM
Adipose tissue	14.0 nTPM
Skin	1.7 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM

Ciliated cells	11.4 nTPM
Fallopian tube	14.6 nTPM
Endometrium	13.8 nTPM
Bronchus	9.7 nTPM
Lung	7.7 nTPM

Club cells	9.7 nTPM
Bronchus	13.1 nTPM
Prostate	8.4 nTPM
Lung	7.5 nTPM

Endothelial cells	11.6 nTPM
Heart muscle	24.8 nTPM
Esophagus	18.6 nTPM
Skeletal muscle	14.0 nTPM
Testis	13.4 nTPM
Fallopian tube	13.4 nTPM
Endometrium	12.6 nTPM
Tongue	12.2 nTPM
Ovary	11.5 nTPM
Lung	11.4 nTPM
Breast	11.4 nTPM
Salivary gland	11.1 nTPM
Prostate	10.9 nTPM
Thymus	9.8 nTPM
Vascular	9.7 nTPM
Placenta	9.1 nTPM
Skin	6.5 nTPM
Liver	5.0 nTPM
Pancreas	2.6 nTPM

Enteroendocrine cells	8.7 nTPM
Small intestine	10.3 nTPM
Rectum	10.1 nTPM
Colon	5.7 nTPM

Fibroblasts	15.6 nTPM
Heart muscle	27.5 nTPM
Prostate	23.8 nTPM
Breast	21.8 nTPM
Adipose tissue	19.6 nTPM
Placenta	18.9 nTPM
Salivary gland	18.7 nTPM
Esophagus	18.4 nTPM
Fallopian tube	16.4 nTPM
Skeletal muscle	14.7 nTPM
Lung	12.0 nTPM
Skin	11.5 nTPM
Stomach	11.5 nTPM
Vascular	11.4 nTPM
Thymus	10.9 nTPM
Liver	7.1 nTPM
Pancreas	6.2 nTPM

Granulocytes	15.2 nTPM
Fallopian tube	16.1 nTPM
Lung	15.1 nTPM
Tongue	14.6 nTPM

Intestinal goblet cells	5.0 nTPM
Small intestine	6.3 nTPM
Rectum	5.2 nTPM
Colon	3.4 nTPM

Lymphatic endothelial cells	16.4 nTPM
Fallopian tube	16.4 nTPM
Ovary	16.4 nTPM

Macrophages	8.5 nTPM
Breast	18.4 nTPM
Endometrium	12.3 nTPM
Pancreas	12.3 nTPM
Prostate	11.1 nTPM
Lung	10.3 nTPM
Salivary gland	10.3 nTPM
Adipose tissue	9.6 nTPM
Skeletal muscle	8.8 nTPM
Thymus	7.8 nTPM
Vascular	7.4 nTPM
Fallopian tube	7.3 nTPM
Kidney	7.1 nTPM
Testis	6.8 nTPM
Tongue	6.8 nTPM
Skin	6.7 nTPM
Esophagus	6.4 nTPM
Bone marrow	6.1 nTPM
Stomach	5.1 nTPM
Spleen	1.0 nTPM

Paneth cells	12.4 nTPM
Small intestine	31.1 nTPM
Rectum	6.1 nTPM
Colon	0.0 nTPM

Basal keratinocytes	7.0 nTPM
Skin	7.0 nTPM
Tongue	7.0 nTPM

Basal squamous epithelial cells	17.3 nTPM
Esophagus	17.3 nTPM

Bipolar cells	20.0 nTPM
Eye	20.0 nTPM

Collecting duct cells	17.5 nTPM
Kidney	17.5 nTPM

Plasma cells	7.2 nTPM
Stomach	11.7 nTPM
Salivary gland	11.6 nTPM
Fallopian tube	8.7 nTPM
Thymus	7.8 nTPM
Spleen	6.3 nTPM
Esophagus	5.2 nTPM
Liver	3.0 nTPM
Bone marrow	3.0 nTPM

Schwann cells	5.3 nTPM
Vascular	11.0 nTPM
Adipose tissue	5.1 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	4.7 nTPM
Salivary gland	9.5 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	15.0 nTPM
Prostate	22.5 nTPM
Ovary	19.6 nTPM
Lung	18.8 nTPM
Adipose tissue	18.3 nTPM
Breast	17.6 nTPM
Fallopian tube	17.4 nTPM
Tongue	15.9 nTPM
Skeletal muscle	14.9 nTPM
Vascular	14.6 nTPM
Salivary gland	14.0 nTPM
Esophagus	13.2 nTPM
Thymus	12.8 nTPM
Placenta	12.6 nTPM
Endometrium	10.6 nTPM
Skin	10.4 nTPM
Liver	6.4 nTPM

T-cells	10.1 nTPM
Esophagus	17.0 nTPM
Lymph node	15.8 nTPM
Breast	13.0 nTPM
Bone marrow	11.9 nTPM
Kidney	11.5 nTPM
Salivary gland	11.2 nTPM
Skeletal muscle	11.0 nTPM
Endometrium	10.8 nTPM
Thymus	10.5 nTPM
Fallopian tube	9.8 nTPM
Adipose tissue	9.4 nTPM
PBMC	9.0 nTPM
Spleen	9.0 nTPM
Tongue	8.8 nTPM
Prostate	8.4 nTPM
Vascular	8.0 nTPM
Lung	7.9 nTPM
Colon	7.8 nTPM
Stomach	7.8 nTPM
Skin	7.4 nTPM
Liver	5.6 nTPM

Undifferentiated cells	6.6 nTPM
Small intestine	7.5 nTPM
Rectum	7.1 nTPM
Colon	5.3 nTPM

Amygdala excitatory	49.2 nTPM
Hippocampus	58.1 nTPM
Cerebral cortex	56.9 nTPM
Amygdala	48.3 nTPM
Thalamus	47.2 nTPM
Basal ganglia	45.3 nTPM
Hypothalamus	39.7 nTPM

Astrocyte	47.9 nTPM
Hypothalamus	57.2 nTPM
Amygdala	55.0 nTPM
Cerebral cortex	51.4 nTPM
Basal ganglia	50.4 nTPM
Thalamus	47.3 nTPM
Hippocampus	46.2 nTPM
Midbrain	45.9 nTPM
Spinal cord	45.5 nTPM
Pons	45.3 nTPM
Medulla oblongata	44.0 nTPM
Cerebellum	38.7 nTPM

Bergmann glia	49.5 nTPM
Cerebellum	55.4 nTPM
Pons	54.7 nTPM
Medulla oblongata	38.4 nTPM

Central nervous system macrophage	70.2 nTPM
Amygdala	85.1 nTPM
Hypothalamus	78.5 nTPM
Midbrain	72.1 nTPM
Basal ganglia	70.8 nTPM
Cerebellum	70.2 nTPM
Pons	70.1 nTPM
Thalamus	70.1 nTPM
Cerebral cortex	66.7 nTPM
Hippocampus	64.8 nTPM
Medulla oblongata	63.1 nTPM
Spinal cord	60.9 nTPM

Cerebellar inhibitory	52.2 nTPM
Spinal cord	63.2 nTPM
Midbrain	54.7 nTPM
Cerebellum	53.4 nTPM
Medulla oblongata	47.7 nTPM
Pons	41.8 nTPM

Cge interneuron	43.3 nTPM
Amygdala	47.4 nTPM
Cerebral cortex	45.3 nTPM
Hippocampus	45.3 nTPM
Basal ganglia	44.5 nTPM
Thalamus	43.2 nTPM
Midbrain	42.6 nTPM
Hypothalamus	34.6 nTPM

Choroid plexus epithelial cell	43.8 nTPM
Basal ganglia	50.2 nTPM
Thalamus	46.6 nTPM
Hippocampus	41.6 nTPM
Medulla oblongata	37.0 nTPM

Committed oligodendrocyte precursor	42.1 nTPM
Hippocampus	51.0 nTPM
Amygdala	47.4 nTPM
Cerebral cortex	46.9 nTPM
Spinal cord	44.1 nTPM
Thalamus	43.2 nTPM
Midbrain	41.2 nTPM
Pons	40.7 nTPM
Hypothalamus	40.3 nTPM
Cerebellum	39.6 nTPM
Basal ganglia	37.8 nTPM
Medulla oblongata	31.0 nTPM

Deep-layer corticothalamic and 6b	49.6 nTPM
Cerebral cortex	53.9 nTPM
Midbrain	53.3 nTPM
Amygdala	52.4 nTPM
Basal ganglia	52.0 nTPM
Hippocampus	51.9 nTPM
Hypothalamus	33.9 nTPM

Deep-layer intratelencephalic	45.5 nTPM
Amygdala	50.1 nTPM
Basal ganglia	48.6 nTPM
Hippocampus	48.2 nTPM
Cerebral cortex	46.2 nTPM
Hypothalamus	34.6 nTPM

Deep-layer near-projecting	55.2 nTPM
Hippocampus	60.5 nTPM
Basal ganglia	60.1 nTPM
Cerebral cortex	59.5 nTPM
Amygdala	57.5 nTPM
Hypothalamus	38.3 nTPM

Eccentric medium spiny neuron	52.0 nTPM
Amygdala	54.6 nTPM
Hypothalamus	53.3 nTPM
Basal ganglia	53.1 nTPM
Thalamus	52.3 nTPM
Cerebral cortex	51.7 nTPM
Hippocampus	46.8 nTPM

Endothelial cell	53.8 nTPM
Amygdala	67.1 nTPM
Cerebellum	65.0 nTPM
Spinal cord	63.9 nTPM
Medulla oblongata	53.3 nTPM
Basal ganglia	53.1 nTPM
Hippocampus	52.3 nTPM
Hypothalamus	52.1 nTPM
Thalamus	50.3 nTPM
Cerebral cortex	45.4 nTPM
Midbrain	45.4 nTPM
Pons	43.7 nTPM

Ependymal cell	49.2 nTPM
Amygdala	62.0 nTPM
Hypothalamus	60.7 nTPM
Hippocampus	53.2 nTPM
Basal ganglia	49.9 nTPM
Spinal cord	49.8 nTPM
Thalamus	48.6 nTPM
Medulla oblongata	40.2 nTPM
Pons	40.1 nTPM
Midbrain	38.1 nTPM