Single cell type - CAPZB - The Human Protein Atlas

CAPZB

Search result

Field

Term

Cluster

Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CAPZB
Gene descriptionⁱ Full gene name according to HGNC.	Capping actin protein of muscle Z-line subunit beta
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Late spermatids - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enriched (Late spermatids)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.39
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Central nervous system macrophage)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enriched (Late spermatids)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Central nervous system macrophage)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

CAPZB is part of cluster 36 Late spermatids - Unknown function with confidenceⁱ 1
427 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MCRIP1	MAPK regulated corepressor interacting protein 1	0.6358	36
KLHL10	Kelch like family member 10	0.6101	36
PHKG2	Phosphorylase kinase catalytic subunit gamma 2	0.6056	36
CCDC91	Coiled-coil domain containing 91	0.6053	36
METAP1	Methionyl aminopeptidase 1	0.6018	36
ODF1	Outer dense fiber of sperm tails 1	0.5997	36
RCC1	Regulator of chromosome condensation 1	0.5970	36
DUSP21	Dual specificity phosphatase 21	0.5938	36
FSCB	Fibrous sheath CABYR binding protein	0.5927	36
SHARPIN	SHANK associated RH domain interactor	0.5925	36
BOD1L2	Biorientation of chromosomes in cell division 1 like 2	0.5880	36
GUCA1ANB	GUCA1A neighbor	0.5876	36
ACTL7A	Actin like 7A	0.5860	36
LELP1	Late cornified envelope like proline rich 1	0.5849	36
PAIP2	Poly(A) binding protein interacting protein 2	0.5843	63

IMMUNE CELLS

CAPZB is part of cluster 25 Non-specific - Unknown function with confidenceⁱ 0.89
355 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HSD17B1	Hydroxysteroid 17-beta dehydrogenase 1	1.0000	25
PSMD4	Proteasome 26S subunit ubiquitin receptor, non-ATPase 4	1.0000	25
DOK2	Docking protein 2	1.0000	25
CEP85	Centrosomal protein 85	0.9762	25
ZHX1-C8orf76	ZHX1-C8orf76 readthrough	0.9762	25
ZNF674	Zinc finger protein 674	0.9762	25
PPP1CA	Protein phosphatase 1 catalytic subunit alpha	0.9762	25
FDPS	Farnesyl diphosphate synthase	0.9762	25
CALM3	Calmodulin 3	0.9762	25
PSTPIP2	Proline-serine-threonine phosphatase interacting protein 2	0.9762	25
PPFIA4	PTPRF interacting protein alpha 4	0.9762	25
CCDC170	Coiled-coil domain containing 170	0.9762	25
ZBTB45	Zinc finger and BTB domain containing 45	0.9762	25
HARS2	Histidyl-tRNA synthetase 2, mitochondrial	0.9762	25
EIF2B1	Eukaryotic translation initiation factor 2B subunit alpha	0.9762	25

Adipocytes	191.9 nTPM
Breast	215.7 nTPM
Adipose tissue	168.1 nTPM

Alveolar cells type 1	163.0 nTPM
Lung	163.0 nTPM

Alveolar cells type 2	121.2 nTPM
Lung	121.2 nTPM

Astrocytes	50.2 nTPM
Brain	50.2 nTPM

B-cells	159.9 nTPM
Skin	269.3 nTPM
PBMC	183.2 nTPM
Spleen	172.9 nTPM
Lung	163.7 nTPM
Lymph node	161.8 nTPM
Stomach	156.1 nTPM
Esophagus	153.4 nTPM
Thymus	152.6 nTPM
Kidney	150.8 nTPM
Bone marrow	146.4 nTPM
Liver	130.4 nTPM
Adipose tissue	126.3 nTPM
Salivary gland	111.5 nTPM

Basal squamous epithelial cells	104.8 nTPM
Esophagus	104.8 nTPM

Ciliated cells	106.8 nTPM
Bronchus	119.3 nTPM
Fallopian tube	108.0 nTPM
Lung	107.5 nTPM
Endometrium	92.3 nTPM

Club cells	137.2 nTPM
Bronchus	195.9 nTPM
Prostate	120.3 nTPM
Lung	95.3 nTPM

Dendritic cells	173.9 nTPM
PBMC	212.2 nTPM
Adipose tissue	135.5 nTPM

Endothelial cells	165.5 nTPM
Placenta	315.1 nTPM
Pancreas	245.6 nTPM
Skin	238.1 nTPM
Breast	217.9 nTPM
Liver	175.1 nTPM
Skeletal muscle	171.2 nTPM
Testis	169.1 nTPM
Lung	167.0 nTPM
Esophagus	163.6 nTPM
Fallopian tube	161.6 nTPM
Ovary	156.2 nTPM
Thymus	154.1 nTPM
Tongue	125.0 nTPM
Salivary gland	117.5 nTPM
Vascular	112.0 nTPM
Endometrium	111.0 nTPM
Heart muscle	96.8 nTPM
Prostate	81.2 nTPM

Enteroendocrine cells	132.0 nTPM
Colon	208.1 nTPM
Rectum	112.4 nTPM
Small intestine	75.5 nTPM

Fibroblasts	187.8 nTPM
Pancreas	521.4 nTPM
Fallopian tube	256.6 nTPM
Skin	208.8 nTPM
Esophagus	199.5 nTPM
Adipose tissue	196.6 nTPM
Placenta	182.3 nTPM
Breast	180.8 nTPM
Stomach	172.9 nTPM
Skeletal muscle	166.0 nTPM
Lung	157.3 nTPM
Liver	153.0 nTPM
Thymus	137.3 nTPM
Salivary gland	130.6 nTPM
Vascular	128.4 nTPM
Prostate	127.4 nTPM
Heart muscle	85.5 nTPM

Granulocytes	167.2 nTPM
Fallopian tube	203.5 nTPM
Lung	186.6 nTPM
Tongue	111.6 nTPM

Intestinal goblet cells	234.3 nTPM
Colon	292.8 nTPM
Rectum	248.2 nTPM
Small intestine	162.0 nTPM

Lymphatic endothelial cells	199.4 nTPM
Fallopian tube	240.5 nTPM
Ovary	158.2 nTPM

Bipolar cells	100.6 nTPM
Eye	100.6 nTPM

Cholangiocytes	116.4 nTPM
Liver	116.4 nTPM

Cone photoreceptor cells	88.4 nTPM
Eye	88.4 nTPM

Cytotrophoblasts	353.3 nTPM
Placenta	353.3 nTPM

Macrophages	296.6 nTPM
Pancreas	503.6 nTPM
Kidney	400.9 nTPM
Fallopian tube	373.5 nTPM
Breast	331.6 nTPM
Adipose tissue	315.7 nTPM
Testis	312.5 nTPM
Thymus	305.0 nTPM
Stomach	285.5 nTPM
Bone marrow	283.8 nTPM
Skeletal muscle	281.4 nTPM
Skin	276.3 nTPM
Vascular	274.3 nTPM
Spleen	270.7 nTPM
Esophagus	255.6 nTPM
Prostate	251.3 nTPM
Lung	248.5 nTPM
Endometrium	242.3 nTPM
Tongue	223.4 nTPM
Salivary gland	199.3 nTPM

Paneth cells	219.6 nTPM
Colon	289.5 nTPM
Rectum	189.7 nTPM
Small intestine	179.6 nTPM

Plasma cells	120.5 nTPM
Liver	164.2 nTPM
Spleen	154.0 nTPM
Bone marrow	151.0 nTPM
Thymus	135.7 nTPM
Stomach	113.9 nTPM
Fallopian tube	109.0 nTPM
Esophagus	78.0 nTPM
Salivary gland	57.8 nTPM

Schwann cells	175.9 nTPM
Adipose tissue	368.1 nTPM
Vascular	87.8 nTPM
Esophagus	71.9 nTPM

Serous glandular cells	84.1 nTPM
Salivary gland	97.4 nTPM
Tongue	70.7 nTPM

Smooth muscle cells	183.8 nTPM
Placenta	259.0 nTPM
Fallopian tube	242.7 nTPM
Thymus	223.5 nTPM
Breast	219.9 nTPM
Ovary	208.3 nTPM
Vascular	197.3 nTPM
Skeletal muscle	188.7 nTPM
Esophagus	185.0 nTPM
Skin	177.9 nTPM
Liver	162.6 nTPM
Adipose tissue	162.3 nTPM
Lung	162.2 nTPM
Tongue	148.5 nTPM
Endometrium	145.3 nTPM
Prostate	132.6 nTPM
Salivary gland	125.1 nTPM

Suprabasal keratinocytes	236.6 nTPM
Tongue	297.5 nTPM
Skin	175.6 nTPM

T-cells	254.2 nTPM
Kidney	417.6 nTPM
Stomach	328.7 nTPM
Liver	327.2 nTPM
Skin	306.3 nTPM
Colon	293.5 nTPM
Breast	288.3 nTPM
PBMC	286.7 nTPM
Bone marrow	285.8 nTPM
Spleen	279.8 nTPM
Fallopian tube	259.8 nTPM
Adipose tissue	253.6 nTPM
Lung	252.2 nTPM
Skeletal muscle	244.2 nTPM
Esophagus	243.4 nTPM
Lymph node	238.7 nTPM
Thymus	229.5 nTPM
Tongue	216.4 nTPM
Salivary gland	160.7 nTPM
Endometrium	146.4 nTPM
Vascular	146.3 nTPM
Prostate	132.2 nTPM

Undifferentiated cells	157.6 nTPM
Colon	174.1 nTPM
Small intestine	165.8 nTPM
Rectum	133.1 nTPM

Amygdala excitatory	116.0 nTPM
Hypothalamus	174.6 nTPM
Amygdala	120.4 nTPM
Basal ganglia	109.2 nTPM
Hippocampus	99.8 nTPM
Thalamus	96.6 nTPM
Cerebral cortex	95.6 nTPM

Astrocyte	115.7 nTPM
Cerebellum	130.7 nTPM
Spinal cord	126.2 nTPM
Thalamus	123.9 nTPM
Amygdala	123.3 nTPM
Hippocampus	120.7 nTPM
Midbrain	118.8 nTPM
Cerebral cortex	108.7 nTPM
Pons	108.3 nTPM
Basal ganglia	104.6 nTPM
Medulla oblongata	104.0 nTPM
Hypothalamus	103.6 nTPM

Bergmann glia	93.6 nTPM
Cerebellum	107.8 nTPM
Pons	96.4 nTPM
Medulla oblongata	76.7 nTPM

Central nervous system macrophage	696.6 nTPM
Amygdala	977.3 nTPM
Hippocampus	879.7 nTPM
Cerebral cortex	877.6 nTPM
Midbrain	718.9 nTPM
Thalamus	701.0 nTPM
Cerebellum	661.0 nTPM
Hypothalamus	619.2 nTPM
Pons	618.8 nTPM
Basal ganglia	592.1 nTPM
Spinal cord	513.1 nTPM
Medulla oblongata	503.9 nTPM

Cerebellar inhibitory	143.5 nTPM
Midbrain	163.9 nTPM
Cerebellum	151.9 nTPM
Medulla oblongata	140.9 nTPM
Spinal cord	134.7 nTPM
Pons	126.0 nTPM

Cge interneuron	124.2 nTPM
Hypothalamus	179.6 nTPM
Amygdala	128.9 nTPM
Hippocampus	115.5 nTPM
Basal ganglia	114.2 nTPM
Midbrain	111.8 nTPM
Cerebral cortex	111.4 nTPM
Thalamus	108.2 nTPM

Choroid plexus epithelial cell	110.6 nTPM
Basal ganglia	202.8 nTPM
Medulla oblongata	104.7 nTPM
Thalamus	74.0 nTPM
Hippocampus	61.0 nTPM

Committed oligodendrocyte precursor	113.8 nTPM
Hypothalamus	161.1 nTPM
Thalamus	143.2 nTPM
Amygdala	134.8 nTPM
Hippocampus	123.7 nTPM
Cerebral cortex	110.8 nTPM
Cerebellum	104.6 nTPM
Basal ganglia	102.9 nTPM
Pons	101.8 nTPM
Spinal cord	95.7 nTPM
Midbrain	88.2 nTPM
Medulla oblongata	85.2 nTPM

Deep-layer corticothalamic and 6b	119.3 nTPM
Hypothalamus	180.0 nTPM
Amygdala	122.8 nTPM
Hippocampus	108.0 nTPM
Basal ganglia	107.4 nTPM
Cerebral cortex	103.5 nTPM
Midbrain	94.3 nTPM

Deep-layer intratelencephalic	115.4 nTPM
Hypothalamus	176.3 nTPM
Hippocampus	109.0 nTPM
Amygdala	103.8 nTPM
Basal ganglia	95.0 nTPM
Cerebral cortex	93.1 nTPM

Deep-layer near-projecting	109.0 nTPM
Hypothalamus	162.0 nTPM
Amygdala	113.3 nTPM
Basal ganglia	92.6 nTPM
Cerebral cortex	91.0 nTPM
Hippocampus	86.2 nTPM