Single cell type - NT5C2 - The Human Protein Atlas

NT5C2

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NT5C2
Gene descriptionⁱ Full gene name according to HGNC.	5'-nucleotidase, cytosolic II
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Cancer-related genes Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Muller glia cells - Visual perception (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.32
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

NT5C2 is part of cluster 10 Muller glia cells - Visual perception with confidenceⁱ 1
166 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MYO6	Myosin VI	0.5044	45
ASPH	Aspartate beta-hydroxylase	0.5005	45
TGFB2	Transforming growth factor beta 2	0.4502	47
KCNJ10	Potassium inwardly rectifying channel subfamily J member 10	0.4390	10
MCFD2	Multiple coagulation factor deficiency 2, ER cargo receptor complex subunit	0.4373	75
LHX2	LIM homeobox 2	0.4256	10
TTLL4	Tubulin tyrosine ligase like 4	0.4202	10
SRGAP1	SLIT-ROBO Rho GTPase activating protein 1	0.4128	10
TECPR2	Tectonin beta-propeller repeat containing 2	0.4101	51
BIN3	Bridging integrator 3	0.4096	10
CHKA	Choline kinase alpha	0.4077	3
FGD4	FYVE, RhoGEF and PH domain containing 4	0.4077	29
MTMR3	Myotubularin related protein 3	0.4041	74
SLC39A12	Solute carrier family 39 member 12	0.3949	47
SLC15A2	Solute carrier family 15 member 2	0.3920	35

IMMUNE CELLS

NT5C2 is part of cluster 28 Neutrophils - Unknown function with confidenceⁱ 0.81
118 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ACBD5	Acyl-CoA binding domain containing 5	0.9762	28
XAF1	XIAP associated factor 1	0.9762	28
GRAMD1A	GRAM domain containing 1A	0.9286	28
CHN2	Chimerin 2	0.9286	40
BTBD10	BTB domain containing 10	0.9286	42
RAP1B	RAP1B, member of RAS oncogene family	0.9286	28
SLC35F6	Solute carrier family 35 member F6	0.9048	40
OSTM1	Osteoclastogenesis associated transmembrane protein 1	0.9048	28
HGS	Hepatocyte growth factor-regulated tyrosine kinase substrate	0.9048	28
BROX	BRO1 domain and CAAX motif containing	0.9048	42
TMOD3	Tropomodulin 3	0.9048	42
HOXA1	Homeobox A1	0.9048	28
RAP2C	RAP2C, member of RAS oncogene family	0.8810	28
NMI	N-myc and STAT interactor	0.8810	28
VPS26A	VPS26 retromer complex component A	0.8810	42

Adipocytes	20.1 nTPM
Adipose tissue	25.5 nTPM
Breast	14.8 nTPM

Alveolar cells type 1	33.3 nTPM
Lung	33.3 nTPM

Alveolar cells type 2	27.7 nTPM
Lung	27.7 nTPM

Astrocytes	134.4 nTPM
Brain	134.4 nTPM

B-cells	18.1 nTPM
Adipose tissue	26.3 nTPM
PBMC	24.6 nTPM
Bone marrow	24.5 nTPM
Salivary gland	23.3 nTPM
Stomach	21.1 nTPM
Kidney	20.8 nTPM
Lymph node	20.7 nTPM
Spleen	18.7 nTPM
Thymus	16.4 nTPM
Lung	14.8 nTPM
Liver	14.5 nTPM
Skin	10.2 nTPM
Esophagus	0.0 nTPM

Ciliated cells	34.6 nTPM
Bronchus	56.0 nTPM
Endometrium	35.1 nTPM
Lung	24.7 nTPM
Fallopian tube	22.7 nTPM

Club cells	43.6 nTPM
Bronchus	48.9 nTPM
Prostate	45.4 nTPM
Lung	36.7 nTPM

Dendritic cells	34.2 nTPM
PBMC	36.0 nTPM
Adipose tissue	32.5 nTPM

Endothelial cells	19.6 nTPM
Salivary gland	27.3 nTPM
Vascular	26.2 nTPM
Endometrium	24.6 nTPM
Skeletal muscle	24.6 nTPM
Thymus	24.2 nTPM
Fallopian tube	22.5 nTPM
Prostate	22.4 nTPM
Testis	21.1 nTPM
Placenta	20.4 nTPM
Tongue	19.2 nTPM
Breast	18.5 nTPM
Esophagus	17.8 nTPM
Skin	17.5 nTPM
Lung	17.3 nTPM
Ovary	17.3 nTPM
Pancreas	12.9 nTPM
Liver	10.1 nTPM
Heart muscle	8.4 nTPM

Enteroendocrine cells	26.0 nTPM
Small intestine	30.9 nTPM
Rectum	26.8 nTPM
Colon	20.2 nTPM

Fibroblasts	21.0 nTPM
Stomach	28.8 nTPM
Vascular	28.6 nTPM
Salivary gland	27.5 nTPM
Skeletal muscle	27.1 nTPM
Adipose tissue	25.8 nTPM
Thymus	25.1 nTPM
Esophagus	24.0 nTPM
Liver	23.7 nTPM
Fallopian tube	22.7 nTPM
Prostate	21.1 nTPM
Placenta	19.6 nTPM
Breast	15.0 nTPM
Pancreas	14.3 nTPM
Lung	14.0 nTPM
Skin	10.8 nTPM
Heart muscle	7.5 nTPM

Granulocytes	15.7 nTPM
Fallopian tube	16.9 nTPM
Lung	15.6 nTPM
Tongue	14.6 nTPM

Intestinal goblet cells	21.9 nTPM
Rectum	26.1 nTPM
Colon	19.9 nTPM
Small intestine	19.7 nTPM

Lymphatic endothelial cells	25.9 nTPM
Fallopian tube	29.9 nTPM
Ovary	21.8 nTPM

Macrophages	33.0 nTPM
Fallopian tube	53.6 nTPM
Prostate	47.8 nTPM
Lung	44.1 nTPM
Salivary gland	41.3 nTPM
Vascular	41.0 nTPM
Skeletal muscle	39.2 nTPM
Bone marrow	38.5 nTPM
Adipose tissue	37.4 nTPM
Thymus	37.1 nTPM
Endometrium	32.0 nTPM
Spleen	31.1 nTPM
Kidney	27.4 nTPM
Stomach	25.7 nTPM
Tongue	24.5 nTPM
Skin	23.4 nTPM
Esophagus	21.8 nTPM
Pancreas	20.6 nTPM
Testis	20.5 nTPM
Breast	19.2 nTPM

Basal keratinocytes	14.1 nTPM
Tongue	20.0 nTPM
Skin	8.3 nTPM

Basal prostatic cells	35.4 nTPM
Prostate	35.4 nTPM

Basal squamous epithelial cells	11.5 nTPM
Esophagus	11.5 nTPM

Bipolar cells	42.3 nTPM
Eye	42.3 nTPM

Paneth cells	16.1 nTPM
Colon	28.9 nTPM
Rectum	15.8 nTPM
Small intestine	3.5 nTPM

Plasma cells	23.0 nTPM
Salivary gland	36.3 nTPM
Fallopian tube	26.4 nTPM
Stomach	24.3 nTPM
Spleen	23.6 nTPM
Thymus	21.2 nTPM
Esophagus	20.8 nTPM
Liver	19.0 nTPM
Bone marrow	12.1 nTPM

Schwann cells	17.7 nTPM
Esophagus	24.0 nTPM
Adipose tissue	17.6 nTPM
Vascular	11.5 nTPM

Serous glandular cells	39.9 nTPM
Salivary gland	57.7 nTPM
Tongue	22.1 nTPM

Smooth muscle cells	22.1 nTPM
Salivary gland	37.2 nTPM
Adipose tissue	27.2 nTPM
Skeletal muscle	25.9 nTPM
Esophagus	25.2 nTPM
Endometrium	24.7 nTPM
Vascular	23.2 nTPM
Prostate	22.5 nTPM
Tongue	22.5 nTPM
Lung	22.3 nTPM
Liver	22.1 nTPM
Breast	18.5 nTPM
Thymus	17.5 nTPM
Fallopian tube	17.3 nTPM
Ovary	17.0 nTPM
Skin	16.3 nTPM
Placenta	13.5 nTPM

Suprabasal keratinocytes	23.2 nTPM
Tongue	40.7 nTPM
Skin	5.8 nTPM

T-cells	18.6 nTPM
Skeletal muscle	25.3 nTPM
Liver	23.8 nTPM
Bone marrow	23.4 nTPM
Vascular	22.5 nTPM
Kidney	21.3 nTPM
Tongue	21.2 nTPM
Endometrium	21.1 nTPM
Lymph node	20.6 nTPM
PBMC	19.6 nTPM
Salivary gland	19.2 nTPM
Thymus	19.2 nTPM
Prostate	18.8 nTPM
Adipose tissue	18.7 nTPM
Spleen	18.2 nTPM
Fallopian tube	17.6 nTPM
Lung	17.0 nTPM
Stomach	16.6 nTPM
Breast	13.0 nTPM
Esophagus	12.2 nTPM
Skin	11.9 nTPM
Colon	9.7 nTPM

Undifferentiated cells	17.7 nTPM
Colon	21.0 nTPM
Rectum	18.7 nTPM
Small intestine	13.4 nTPM

Amygdala excitatory	247.0 nTPM
Hypothalamus	286.3 nTPM
Amygdala	265.6 nTPM
Thalamus	264.5 nTPM
Hippocampus	223.7 nTPM
Cerebral cortex	221.0 nTPM
Basal ganglia	220.8 nTPM

Astrocyte	347.2 nTPM
Hypothalamus	378.9 nTPM
Midbrain	375.2 nTPM
Amygdala	372.5 nTPM
Thalamus	369.0 nTPM
Cerebellum	366.5 nTPM
Pons	336.3 nTPM
Cerebral cortex	334.3 nTPM
Spinal cord	333.1 nTPM
Hippocampus	332.9 nTPM
Basal ganglia	325.3 nTPM
Medulla oblongata	294.7 nTPM

Bergmann glia	255.4 nTPM
Cerebellum	288.7 nTPM
Medulla oblongata	242.9 nTPM
Pons	234.5 nTPM

Central nervous system macrophage	226.0 nTPM
Hypothalamus	269.5 nTPM
Amygdala	253.7 nTPM
Basal ganglia	240.1 nTPM
Spinal cord	228.7 nTPM
Hippocampus	226.9 nTPM
Cerebellum	226.6 nTPM
Thalamus	225.9 nTPM
Midbrain	222.6 nTPM
Pons	205.4 nTPM
Cerebral cortex	193.9 nTPM
Medulla oblongata	192.4 nTPM

Cerebellar inhibitory	185.0 nTPM
Medulla oblongata	201.1 nTPM
Cerebellum	193.2 nTPM
Midbrain	192.5 nTPM
Pons	175.7 nTPM
Spinal cord	162.2 nTPM

Cge interneuron	158.1 nTPM
Hypothalamus	191.5 nTPM
Amygdala	172.0 nTPM
Midbrain	152.5 nTPM
Cerebral cortex	150.4 nTPM
Hippocampus	149.0 nTPM
Basal ganglia	147.9 nTPM
Thalamus	143.6 nTPM

Choroid plexus epithelial cell	784.6 nTPM
Basal ganglia	1040.6 nTPM
Medulla oblongata	907.0 nTPM
Thalamus	602.9 nTPM
Hippocampus	587.9 nTPM

Committed oligodendrocyte precursor	158.0 nTPM
Medulla oblongata	271.1 nTPM
Basal ganglia	169.2 nTPM
Spinal cord	165.6 nTPM
Thalamus	158.9 nTPM
Hypothalamus	157.0 nTPM
Amygdala	145.5 nTPM
Midbrain	144.5 nTPM
Cerebellum	142.7 nTPM
Hippocampus	139.4 nTPM
Pons	126.6 nTPM
Cerebral cortex	117.2 nTPM

Deep-layer corticothalamic and 6b	232.8 nTPM
Hypothalamus	309.9 nTPM
Amygdala	241.8 nTPM
Hippocampus	225.3 nTPM
Basal ganglia	219.3 nTPM
Cerebral cortex	210.8 nTPM
Midbrain	189.7 nTPM

Deep-layer intratelencephalic	227.8 nTPM
Hypothalamus	296.9 nTPM
Amygdala	228.9 nTPM
Hippocampus	210.0 nTPM
Basal ganglia	203.7 nTPM
Cerebral cortex	199.3 nTPM

Deep-layer near-projecting	210.9 nTPM
Hypothalamus	284.7 nTPM
Amygdala	212.9 nTPM
Basal ganglia	198.9 nTPM
Cerebral cortex	188.3 nTPM
Hippocampus	169.8 nTPM

Eccentric medium spiny neuron	236.2 nTPM
Amygdala	250.2 nTPM
Basal ganglia	241.3 nTPM
Thalamus	240.4 nTPM
Hypothalamus	236.3 nTPM
Cerebral cortex	232.0 nTPM
Hippocampus	216.8 nTPM