Single cell type - TAF2 - The Human Protein Atlas

TAF2

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TAF2
Gene descriptionⁱ Full gene name according to HGNC.	TATA-box binding protein associated factor 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.31
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

TAF2 is part of cluster 49 Non-specific - Transcription with confidenceⁱ 1
378 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SHQ1	SHQ1, H/ACA ribonucleoprotein assembly factor	0.6043	49
PARN	Poly(A)-specific ribonuclease	0.5194	79
WDR75	WD repeat domain 75	0.4906	39
DHX15	DEAH-box helicase 15	0.4821	15
API5	Apoptosis inhibitor 5	0.4736	49
LEMD3	LEM domain containing 3	0.4579	55
NDOR1	NADPH dependent diflavin oxidoreductase 1	0.4563	49
GTF2H2C	GTF2H2 family member C	0.4525	49
NSUN2	NOP2/Sun RNA methyltransferase 2	0.4506	39
SMARCAD1	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1	0.4489	55
INTS2	Integrator complex subunit 2	0.4477	55
TYW1	TRNA-yW synthesizing protein 1 homolog	0.4474	49
TAF15	TATA-box binding protein associated factor 15	0.4468	39
CHD1L	Chromodomain helicase DNA binding protein 1 like	0.4416	49
PSMA2	Proteasome 20S subunit alpha 2	0.4346	15

IMMUNE CELLS

TAF2 is part of cluster 33 Non-specific - ATP binding with confidenceⁱ 0.7
757 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TBL3	Transducin beta like 3	0.9762	33
PPIL2	Peptidylprolyl isomerase like 2	0.9762	33
NOL10	Nucleolar protein 10	0.9762	33
HTT	Huntingtin	0.9524	33
TSR1	TSR1 ribosome maturation factor	0.9524	33
SAAL1	Serum amyloid A like 1	0.9524	33
CENPN	Centromere protein N	0.9524	33
PARS2	Prolyl-tRNA synthetase 2, mitochondrial	0.9524	33
MRPS36	Mitochondrial ribosomal protein S36	0.9524	13
FBXW9	F-box and WD repeat domain containing 9	0.9524	33
TULP4	TUB like protein 4	0.9524	33
NNT	Nicotinamide nucleotide transhydrogenase	0.9524	33
CDK5RAP1	CDK5 regulatory subunit associated protein 1	0.9524	33
HMMR	Hyaluronan mediated motility receptor	0.9524	13
FTSJ3	FtsJ RNA 2'-O-methyltransferase 3	0.9286	13

Adipocytes	19.2 nTPM
Adipose tissue	23.1 nTPM
Breast	15.3 nTPM

Alveolar cells type 1	17.6 nTPM
Lung	17.6 nTPM

Alveolar cells type 2	15.3 nTPM
Lung	15.3 nTPM

Astrocytes	39.3 nTPM
Brain	39.3 nTPM

B-cells	21.1 nTPM
Lymph node	32.4 nTPM
Bone marrow	29.6 nTPM
Stomach	28.3 nTPM
Spleen	24.2 nTPM
Esophagus	23.6 nTPM
Kidney	20.8 nTPM
Adipose tissue	19.8 nTPM
Salivary gland	19.8 nTPM
Skin	18.6 nTPM
Thymus	18.3 nTPM
Liver	14.5 nTPM
Lung	13.4 nTPM
PBMC	10.8 nTPM

Ciliated cells	14.4 nTPM
Bronchus	17.7 nTPM
Endometrium	15.1 nTPM
Fallopian tube	12.9 nTPM
Lung	11.7 nTPM

Club cells	14.7 nTPM
Prostate	16.9 nTPM
Bronchus	14.0 nTPM
Lung	13.2 nTPM

Dendritic cells	16.5 nTPM
Adipose tissue	18.7 nTPM
PBMC	14.4 nTPM

Endothelial cells	19.2 nTPM
Esophagus	27.1 nTPM
Heart muscle	26.7 nTPM
Endometrium	24.3 nTPM
Fallopian tube	21.5 nTPM
Thymus	20.9 nTPM
Pancreas	20.7 nTPM
Skeletal muscle	20.7 nTPM
Salivary gland	20.0 nTPM
Vascular	19.0 nTPM
Breast	18.5 nTPM
Prostate	17.8 nTPM
Liver	17.6 nTPM
Lung	16.5 nTPM
Skin	16.4 nTPM
Placenta	15.9 nTPM
Testis	15.3 nTPM
Ovary	13.8 nTPM
Tongue	13.7 nTPM

Enteroendocrine cells	11.7 nTPM
Colon	14.9 nTPM
Rectum	13.4 nTPM
Small intestine	6.9 nTPM

Fibroblasts	16.4 nTPM
Esophagus	23.8 nTPM
Fallopian tube	22.2 nTPM
Skin	20.7 nTPM
Skeletal muscle	20.4 nTPM
Adipose tissue	20.0 nTPM
Vascular	18.7 nTPM
Thymus	17.9 nTPM
Salivary gland	16.0 nTPM
Lung	15.2 nTPM
Breast	14.9 nTPM
Stomach	14.4 nTPM
Pancreas	12.8 nTPM
Liver	11.9 nTPM
Placenta	11.9 nTPM
Prostate	11.9 nTPM
Heart muscle	10.7 nTPM

Granulocytes	15.6 nTPM
Fallopian tube	20.6 nTPM
Tongue	14.6 nTPM
Lung	11.6 nTPM

Intestinal goblet cells	12.2 nTPM
Rectum	14.3 nTPM
Colon	13.5 nTPM
Small intestine	8.6 nTPM

Lymphatic endothelial cells	27.2 nTPM
Ovary	32.7 nTPM
Fallopian tube	21.8 nTPM

Macrophages	16.3 nTPM
Spleen	31.1 nTPM
Bone marrow	19.3 nTPM
Endometrium	19.1 nTPM
Kidney	17.7 nTPM
Adipose tissue	17.7 nTPM
Testis	17.4 nTPM
Fallopian tube	17.4 nTPM
Salivary gland	17.2 nTPM
Thymus	17.1 nTPM
Prostate	16.7 nTPM
Vascular	16.5 nTPM
Skeletal muscle	15.0 nTPM
Pancreas	14.4 nTPM
Esophagus	14.1 nTPM
Tongue	14.1 nTPM
Lung	13.3 nTPM
Stomach	12.9 nTPM
Breast	12.0 nTPM
Skin	6.7 nTPM

Basal keratinocytes	19.6 nTPM
Skin	21.7 nTPM
Tongue	17.5 nTPM

Basal squamous epithelial cells	23.9 nTPM
Esophagus	23.9 nTPM

Cholangiocytes	9.5 nTPM
Liver	9.5 nTPM

Collecting duct cells	17.5 nTPM
Kidney	17.5 nTPM

Paneth cells	12.6 nTPM
Colon	25.3 nTPM
Rectum	9.0 nTPM
Small intestine	3.5 nTPM

Plasma cells	21.2 nTPM
Spleen	30.8 nTPM
Thymus	27.2 nTPM
Bone marrow	24.2 nTPM
Stomach	20.1 nTPM
Salivary gland	18.8 nTPM
Liver	18.0 nTPM
Esophagus	15.6 nTPM
Fallopian tube	14.8 nTPM

Schwann cells	19.7 nTPM
Esophagus	24.0 nTPM
Vascular	18.8 nTPM
Adipose tissue	16.4 nTPM

Serous glandular cells	14.1 nTPM
Salivary gland	14.9 nTPM
Tongue	13.3 nTPM

Smooth muscle cells	16.4 nTPM
Esophagus	21.6 nTPM
Lung	20.0 nTPM
Vascular	19.2 nTPM
Adipose tissue	17.6 nTPM
Endometrium	17.5 nTPM
Tongue	17.4 nTPM
Skeletal muscle	17.1 nTPM
Liver	17.0 nTPM
Fallopian tube	16.7 nTPM
Skin	16.4 nTPM
Thymus	15.2 nTPM
Salivary gland	14.4 nTPM
Placenta	14.3 nTPM
Prostate	14.0 nTPM
Ovary	12.6 nTPM
Breast	11.5 nTPM

Suprabasal keratinocytes	20.3 nTPM
Skin	21.6 nTPM
Tongue	19.0 nTPM

T-cells	20.1 nTPM
Spleen	34.1 nTPM
Lymph node	29.2 nTPM
Stomach	28.4 nTPM
Bone marrow	26.7 nTPM
Tongue	22.6 nTPM
Colon	22.4 nTPM
Endometrium	21.5 nTPM
Thymus	21.3 nTPM
Adipose tissue	20.3 nTPM
Prostate	20.0 nTPM
Vascular	19.7 nTPM
Esophagus	19.5 nTPM
Salivary gland	19.5 nTPM
Fallopian tube	18.8 nTPM
Kidney	16.8 nTPM
Liver	15.5 nTPM
Breast	15.5 nTPM
Skin	14.4 nTPM
Lung	14.2 nTPM
Skeletal muscle	12.1 nTPM
PBMC	10.7 nTPM

Undifferentiated cells	14.1 nTPM
Colon	17.6 nTPM
Rectum	12.6 nTPM
Small intestine	12.1 nTPM

Amygdala excitatory	83.5 nTPM
Thalamus	95.3 nTPM
Hypothalamus	90.8 nTPM
Amygdala	81.7 nTPM
Basal ganglia	78.6 nTPM
Cerebral cortex	77.4 nTPM
Hippocampus	77.1 nTPM

Astrocyte	61.7 nTPM
Amygdala	84.9 nTPM
Basal ganglia	67.6 nTPM
Cerebral cortex	66.2 nTPM
Hippocampus	64.3 nTPM
Hypothalamus	63.2 nTPM
Thalamus	62.2 nTPM
Midbrain	60.5 nTPM
Pons	54.1 nTPM
Spinal cord	52.8 nTPM
Medulla oblongata	52.4 nTPM
Cerebellum	50.1 nTPM

Bergmann glia	64.9 nTPM
Cerebellum	73.2 nTPM
Pons	66.2 nTPM
Medulla oblongata	55.4 nTPM

Central nervous system macrophage	93.9 nTPM
Amygdala	119.6 nTPM
Basal ganglia	103.2 nTPM
Hypothalamus	100.3 nTPM
Midbrain	95.6 nTPM
Thalamus	93.9 nTPM
Hippocampus	93.5 nTPM
Cerebral cortex	91.3 nTPM
Cerebellum	90.9 nTPM
Pons	85.9 nTPM
Medulla oblongata	80.2 nTPM
Spinal cord	78.9 nTPM

Cerebellar inhibitory	83.5 nTPM
Spinal cord	115.5 nTPM
Medulla oblongata	79.5 nTPM
Midbrain	77.1 nTPM
Cerebellum	75.3 nTPM
Pons	70.1 nTPM

Cge interneuron	71.4 nTPM
Hypothalamus	80.6 nTPM
Amygdala	79.0 nTPM
Thalamus	72.8 nTPM
Basal ganglia	68.5 nTPM
Hippocampus	67.5 nTPM
Cerebral cortex	66.6 nTPM
Midbrain	64.8 nTPM

Choroid plexus epithelial cell	86.3 nTPM
Basal ganglia	108.8 nTPM
Thalamus	93.2 nTPM
Medulla oblongata	79.5 nTPM
Hippocampus	63.8 nTPM

Committed oligodendrocyte precursor	72.6 nTPM
Spinal cord	110.4 nTPM
Amygdala	91.3 nTPM
Hypothalamus	81.3 nTPM
Thalamus	79.7 nTPM
Hippocampus	78.9 nTPM
Cerebral cortex	78.5 nTPM
Cerebellum	63.4 nTPM
Basal ganglia	58.0 nTPM
Midbrain	57.1 nTPM
Pons	52.2 nTPM
Medulla oblongata	47.8 nTPM

Deep-layer corticothalamic and 6b	83.6 nTPM
Hypothalamus	94.5 nTPM
Amygdala	92.7 nTPM
Hippocampus	84.6 nTPM
Cerebral cortex	82.1 nTPM
Basal ganglia	75.7 nTPM
Midbrain	72.1 nTPM

Deep-layer intratelencephalic	80.1 nTPM
Amygdala	89.2 nTPM
Hippocampus	81.6 nTPM
Hypothalamus	80.6 nTPM
Cerebral cortex	75.5 nTPM
Basal ganglia	73.8 nTPM

Deep-layer near-projecting	77.1 nTPM
Amygdala	85.1 nTPM
Hypothalamus	78.8 nTPM
Cerebral cortex	76.8 nTPM
Basal ganglia	74.0 nTPM
Hippocampus	70.9 nTPM

Eccentric medium spiny neuron	89.0 nTPM
Amygdala	98.3 nTPM
Thalamus	96.0 nTPM
Basal ganglia	89.8 nTPM
Hypothalamus	88.7 nTPM
Cerebral cortex	86.4 nTPM
Hippocampus	74.6 nTPM