Single cell type - ENTPD2 - The Human Protein Atlas

ENTPD2

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ENTPD2
Gene descriptionⁱ Full gene name according to HGNC.	Ectonucleoside triphosphate diphosphohydrolase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Gonadal somatic cells - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Leydig cells, Peritubular myoid cells, Ependymal cells, Schwann cells, Enterocytes, Astrocytes, Breast myoepithelial cells, Colonocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.81
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Group enriched (Ependymal cell, Astrocyte)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nCPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. * Single nuclei Read more
Single cell type groups RNA single cell type group specificity: Cell type enhanced (Leydig cells, Stromal cells, Ciliated cells, Glial cells, Enterocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Group enriched (Ependymal cell, Astrocyte)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas HPA data, as well as data generated by Monaco et al and Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ENTPD2 is part of cluster 94 Gonadal somatic cells - Mixed function with confidenceⁱ 1
128 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
INSL3	Insulin like 3	0.7047	94
LPAR4	Lysophosphatidic acid receptor 4	0.6822	94
PRPS2	Phosphoribosyl pyrophosphate synthetase 2	0.6791	94
PTGDS	Prostaglandin D2 synthase	0.6753	94
PROK1	Prokineticin 1	0.6484	94
PTCH2	Patched 2	0.6437	94
LCNL1	Lipocalin like 1	0.6379	94
LTBP4	Latent transforming growth factor beta binding protein 4	0.6364	94
GLI1	GLI family zinc finger 1	0.6337	94
CYP26B1	Cytochrome P450 family 26 subfamily B member 1	0.6031	94
LHX9	LIM homeobox 9	0.5908	94
SMIM41	Small integral membrane protein 41	0.5662	94
SMOC2	SPARC related modular calcium binding 2	0.5590	94
PTCH1	Patched 1	0.5504	94
NSMF	NMDA receptor synaptonuclear signaling and neuronal migration factor	0.5502	34

IMMUNE CELLS

ENTPD2 is part of cluster 19 Eosinophils - Unknown function with confidenceⁱ 1
83 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GADD45A	Growth arrest and DNA damage inducible alpha	1.0000	19
PPP1R1B	Protein phosphatase 1 regulatory inhibitor subunit 1B	1.0000	19
F12	Coagulation factor XII	1.0000	19
NECTIN2	Nectin cell adhesion molecule 2	1.0000	19
PPDPF	Pancreatic progenitor cell differentiation and proliferation factor	1.0000	19
SEMG1	Semenogelin 1	1.0000	19
GPSM2	G protein signaling modulator 2	1.0000	19
TMIGD3	Transmembrane and immunoglobulin domain containing 3	1.0000	19
ARAP3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	1.0000	19
RXYLT1	Ribitol xylosyltransferase 1	1.0000	19
WAS	WASP actin nucleation promoting factor	1.0000	19
FKBP8	FKBP prolyl isomerase 8	1.0000	19
PRSS33	Serine protease 33	1.0000	19
RENBP	Renin binding protein	1.0000	19
CEBPE	CCAAT enhancer binding protein epsilon	1.0000	19

	Lacrimal acinar cells	Salivary acinar cells	Pancreatic acinar cells
Eye	0.0
Salivary gland		1.6
Pancreas			0.5
Mean exp	0.0	1.6	0.5

	Adipocytes
Heart muscle	0.0
Skeletal muscle	0.0
Adipose tissue	0.1
Mean exp	0.0

	Adrenal cortex cells	Adrenal medulla cells
Adrenal gland	0.0	0.0
Mean exp	0.0	0.0

	Alveolar cells type 1	Alveolar cells type 2	Transitional alveolar cells
Lung	0.2	0.1	0.1
Mean exp	0.2	0.1	0.1

	Esophageal apical cells
Esophagus	9.9
Mean exp	9.9

	B-cells
Brain	0.0
Eye	0.0
Lung	0.0
Salivary gland	0.0
Esophagus	0.0
Stomach	0.1
Liver	0.0
Kidney	2.4
Urinary bladder	0.0
Breast	0.0
Endometrium	0.0
Adipose tissue	0.0
Blood	0.0
Bone marrow	0.0
Lymph node	0.0
Thymus	0.1
Spleen	0.0
Mean exp	0.1

	Ocular epithelial cells	Mesothelial cells	Urothelial cells	Epicardial cells	Prostatic hillock cells
Eye	2.2
Urinary bladder			0.3
Prostate					1.2
Heart muscle				0.0
Adipose tissue		0.8
Thymus		1.9
Mean exp	2.2	1.3	0.3	0.0	1.2

	Respiratory basal cells	Esophageal basal cells	Salivary basal cells	Basal keratinocytes	Epididymal basal cells	Basal prostatic cells
Lung	1.1
Tongue				1.6
Salivary gland			0.9
Esophagus		4.3
Epididymis					1.1
Prostate						1.8
Skin				2.2
Mean exp	1.1	4.3	0.9	1.9	1.1	1.8

	Ependymal cells	Choroid plexus epithelial cells	Respiratory ciliated cells	Respiratory deuterosomal cells	Epididymal efferent duct ciliated cells	Fallopian tube ciliated cells	Endometrial ciliated cells
Brain	77.5	0.2
Lung			3.4	4.1
Epididymis					22.7
Fallopian tube						10.9
Endometrium							14.3
Mean exp	77.5	0.2	3.4	4.1	22.7	10.9	14.3

	Cdc	Pdcs
Lung		0.0
Breast	0.0	0.0
Endometrium		0.0
Adipose tissue	0.0
Skin	0.3
Blood		0.0
Lymph node	0.0
Mean exp	0.1	0.0

	Salivary duct cells	Cholangiocytes	Pancreatic duct cells	Renal collecting duct intercalated cells	Renal collecting duct principal cells	Renal connecting tubule cells	Epididymal efferent duct absorptive cells
Salivary gland	2.0
Liver		7.4
Pancreas			4.0
Kidney				2.9	0.2	0.6
Epididymis							15.5
Mean exp	2.0	7.4	4.0	2.9	0.2	0.6	15.5

	Vascular endothelial cells	Lymphatic endothelial cells
Brain	1.1
Eye	0.6	0.0
Pituitary gland	2.8
Lung	0.2	0.0
Tongue	1.0	0.0
Salivary gland	0.6	0.0
Esophagus	1.3	3.8
Stomach	0.5
Liver	0.3
Pancreas	0.4
Kidney	0.5	0.0
Urinary bladder	1.5	0.0
Testis	2.7	0.0
Epididymis	1.7
Prostate	1.1	0.0
Breast	2.0	0.0
Ovary	3.0	0.0
Fallopian tube	1.0	0.1
Endometrium	0.2	0.0
Placenta	0.0
Heart muscle	5.6
Skeletal muscle	0.0
Vasculature	1.5	0.0
Adipose tissue	1.7	0.0
Skin	0.0	1.1
Lymph node	0.0	0.0
Spleen		0.0
Thymus	1.0	0.0
Mean exp	1.2	0.3

	Enterocytes	Colonocytes
Small intestine	55.9
Colon		23.6
Rectum		28.6
Mean exp	55.9	26.1

	Neuroendocrine cells
Stomach	13.1
Small intestine	16.6
Colon	17.4
Rectum	25.8
Mean exp	18.2

	Erythrocyte progenitors	Erythrocytes
Blood		0.0
Bone marrow	0.0	0.0
Spleen		0.0
Mean exp	0.0	0.0

	Astrocytes	Bergmann glia	Müller glia	Pituicytes/fscs	Oligodendrocyte progenitor cells	Oligodendrocytes	Schwann cells	Microglia
Brain	44.3	10.3			0.7	0.8		0.4
Eye			7.0				0.0
Pituitary gland				1.6
Tongue							190.1
Urinary bladder							15.8
Vasculature							47.2
Mean exp	44.3	10.3	7.0	1.6	0.7	0.8	63.3	0.4

	Fibro-adipogenic progenitors
Skeletal muscle	0.2
Adipose tissue	0.3
Mean exp	0.3

	Fibroblasts
Brain	1.0
Eye	2.1
Lung	1.0
Tongue	1.3
Salivary gland	0.5
Esophagus	1.6
Stomach	1.8
Pancreas	1.3
Kidney	0.2
Urinary bladder	0.7
Epididymis	30.0
Prostate	2.3
Breast	1.4
Fallopian tube	10.4
Placenta	3.9
Heart muscle	1.7
Vasculature	4.0
Skin	2.5
Lymph node	0.0
Thymus	0.2
Mean exp	3.4

	Foveolar cells	Mucous neck cells	Parietal cells	Gastric chief cells
Stomach	2.9	7.1	1.8	8.7
Mean exp	2.9	7.1	1.8	8.7

	Submucosal glandular cells	Prostatic glandular cells	Prostatic club cells	Endometrial glandular cells
Lung	2.2
Esophagus	4.6
Prostate		15.8	2.7
Endometrium				2.1
Mean exp	3.4	15.8	2.7	2.1

	Conjunctival goblet cells	Goblet cells
Eye	1.0
Small intestine		10.5
Colon		9.3
Rectum		9.6
Mean exp	1.0	9.8

	Innate lymphoid cells
Lung	0.0
Salivary gland	0.0
Urinary bladder	0.0
Breast	0.0
Fallopian tube	0.0
Endometrium	0.0
Lymph node	0.3
Spleen	0.0
Thymus	0.0
Mean exp	0.0

	Respiratory ionocytes	Salivary ionocytes
Lung	2.5
Salivary gland		3.3
Mean exp	2.5	3.3

	Breast hormone-responsive cells	Endometrial luminal cells
Breast	3.9
Endometrium		2.8
Mean exp	3.9	2.8

	Mast cells
Eye	0.0
Lung	0.0
Tongue	0.0
Salivary gland	0.0
Stomach	0.0
Pancreas	0.4
Urinary bladder	0.0
Epididymis	0.0
Fallopian tube	0.3
Vasculature	0.0
Adipose tissue	0.0
Lymph node	0.0
Mean exp	0.1

	Megakaryocyte progenitors	Megakaryocyte-erythroid progenitors	Megakaryocytes
Bone marrow	0.0	0.0	0.0
Mean exp	0.0	0.0	0.0

Acinar cells - 1.6 nCPM

Adipocytes - 0.0 nCPM

Adrenal endocrine cells - 0.0 nCPM

Alveolar cells - 0.2 nCPM

Apical squamous epithelial cells - 9.9 nCPM

B-cells - 0.1 nCPM

Barrier epithelial cells - 2.2 nCPM

Basal cells - 4.3 nCPM

Ciliated cells - 77.5 nCPM

Dendritic cells - 0.1 nCPM

Ductal cells - 15.5 nCPM

Endothelial cells - 1.2 nCPM

Enterocytes - 55.9 nCPM

Enteroendocrine cells - 18.2 nCPM

Erythrocytes - 0.0 nCPM

Fibro-adipogenic progenitors - 0.3 nCPM

Fibroblasts - 3.4 nCPM

Gastric glandular cells - 8.7 nCPM

Glandular cells - 15.8 nCPM

Glial cells - 63.3 nCPM

Goblet cells - 9.8 nCPM

Hepatocytes - 1.5 nCPM

Innate lymphoid cells - 0.0 nCPM

Ionocytes - 3.3 nCPM

Leydig cells - 204.1 nCPM

Luminal cells - 3.9 nCPM

Mast cells - 0.1 nCPM

Megakaryocytes - 0.0 nCPM

Mononuclear phagocytes - 0.4 nCPM

Mural cells - 5.3 nCPM

Myocytes - 0.8 nCPM

Neuronal cells - 0.8 nCPM

Neutrophils - 0.5 nCPM

Nk-cells - 0.0 nCPM

Oocytes - 0.0 nCPM

Pancreatic islet cells - 6.7 nCPM

Pigment cells - 6.5 nCPM

Pituitary endocrine cells - 3.9 nCPM

Plasma cells - 0.1 nCPM

Platelets - 0.0 nCPM

Proliferating cells - 18.6 nCPM

Renal nephron cells - 7.3 nCPM

Reproductive supporting cells - 4.1 nCPM

Secretory cells - 15.4 nCPM

Secretory gland support - 32.7 nCPM

Smooth muscle cells - 0.5 nCPM

Spermatogenic cell types - 5.1 nCPM

Stellate cells - 0.0 nCPM

Stem cells - 14.2 nCPM

Stromal cells - 98.8 nCPM

Suprabasal cells - 4.7 nCPM

T-cells - 0.2 nCPM

Trophoblast cells - 1.6 nCPM

	Monocyte progenitors	Monocytes	Macrophages	Kupffer cells	Hofbauer cells
Brain		0.0	0.0
Eye		0.0	0.3
Pituitary gland			1.0
Lung		0.1	0.0
Tongue		3.7	0.3
Salivary gland		0.0	0.4
Esophagus			2.0
Stomach		0.0	0.0
Liver		0.0	0.0	0.0
Pancreas		0.4	0.1
Kidney			0.4
Urinary bladder		0.0	0.0
Testis			1.8
Prostate		0.0	0.2
Breast		0.0	1.8
Ovary			0.0
Fallopian tube		0.2	0.1
Endometrium			0.8
Placenta					0.2
Heart muscle			0.9
Skeletal muscle			0.0
Vasculature		0.0	0.0
Adipose tissue			0.2
Skin			0.0
Blood		0.0
Bone marrow	0.0	0.0	0.0
Lymph node		0.0	0.0
Thymus		0.0	0.2
Spleen		0.0	0.0
Mean exp	0.0	0.2	0.4	0.0	0.2

	Pericytes	Vascular smooth muscle cells
Brain	0.7	1.0
Eye	23.4	0.0
Pituitary gland	0.0
Lung	0.9	0.0
Tongue	11.1	0.0
Salivary gland	0.0	0.9
Stomach	0.0	0.0
Pancreas	0.9
Kidney	1.0	0.0
Urinary bladder	3.2	0.4
Testis	4.2
Epididymis	18.4	0.0
Prostate	7.7	0.0
Breast	6.7	1.7
Ovary	3.5	0.4
Fallopian tube	8.0	0.4
Placenta	2.4
Heart muscle	10.4	0.0
Skeletal muscle	5.8	0.0
Vasculature	5.2	0.1
Adipose tissue	0.0	0.7
Skin	2.1	0.0
Thymus	5.8	0.7
Mean exp	5.3	0.3

	Cardiomyocytes	Myonuclei
Heart muscle	0.8
Skeletal muscle		0.0
Mean exp	0.8	0.0

	Brain excitatory neurons	Brain inhibitory neurons	Retinal amacrine cells	Retinal horizontal cells	Retinal ganglion cells	Retinal bipolar cells	Rod photoreceptor cells	Cone photoreceptor cells	Other brain neurons
Brain	0.7	0.8							0.1
Eye			0.8	0.0	0.0	0.0	0.4	0.0
Mean exp	0.7	0.8	0.8	0.0	0.0	0.0	0.4	0.0	0.1

	Neutrophil progenitors	Neutrophils
Eye		0.0
Lung		0.0
Salivary gland		1.4
Urinary bladder		0.0
Prostate		0.0
Vasculature		0.0
Blood	1.5	0.9
Bone marrow	0.0	0.7
Lymph node		0.0
Spleen	0.5	1.1
Thymus	0.0	0.4
Mean exp	0.5	0.4

	Nk-cells
Brain	0.0
Eye	0.0
Lung	0.0
Salivary gland	0.0
Stomach	0.0
Colon	0.0
Liver	0.0
Kidney	0.0
Urinary bladder	0.0
Prostate	0.0
Fallopian tube	0.0
Endometrium	0.3
Vasculature	0.0
Blood	0.0
Bone marrow	0.3
Lymph node	0.0
Spleen	0.0
Thymus	0.0
Mean exp	0.0

	Melanocytes	Retinal pigment epithelial cells
Eye	0.9	0.0
Skin	12.2
Mean exp	6.5	0.0

	Corticotrophs	Gonadotrophs	Lactotrophs	Somatotrophs	Thyrotrophs
Pituitary gland	1.2	1.3	0.9	0.3	3.9
Mean exp	1.2	1.3	0.9	0.3	3.9

	Plasma cells
Eye	0.4
Lung	0.0
Salivary gland	0.0
Stomach	0.1
Liver	0.0
Urinary bladder	0.4
Breast	0.0
Fallopian tube	0.0
Blood	0.0
Bone marrow	0.3
Lymph node	0.0
Spleen	0.1
Thymus	0.0
Mean exp	0.1

	Gastric progenitor cells	Enteric transient amplifying cells
Stomach	1.3
Small intestine		20.8
Colon		23.0
Rectum		12.2
Mean exp	1.3	18.6