Human Blood Resource - ENTPD2 - The Human Protein Atlas

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SUMMARY

TISSUE

BRAIN

SINGLE CELL

SUBCELL

CANCER

BLOOD

CELL LINE

STRUCTURE

INTERACTION

ENTPD2

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ENTPD2
Gene descriptionⁱ Full gene name according to HGNC.	Ectonucleoside triphosphate diphosphohydrolase 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane

HUMAN PROTEIN ATLAS INFORMATION
Upregulated in disease (PEA)ⁱ A gene is classified as upregulated in a disease if the average concentration of all samples of that disease is significantly higher (adj P-value<0.005 and NPX difference>=1) than the average concentration of samples of all diseases as measured by PEA . For gender specific diseases the analysis includes only samples corresponding to the same gender from the other diseases.	Pediatric retinoblastoma, Pediatric neuroblastoma
Blood-based immunoassayⁱ The blood-based immunoassay category applies to actively secreted proteins and is based on plasma or serum protein concentrations established with enzyme-linked immunosorbent assays, compiled from a literature search. The categories include: detected and not detected, where detection refers to a concentration found in the literature search.	Not analysed since only proteins predicted to be actively secreted to blood is analysed here
Mass spectrometryⁱ Detection or not of the gene in blood, based on spectral count estimations from a publicly available mass spectrometry-based plasma proteomics dataset obtained from the PeptideAtlas. Read more	Not detected
Proximity extension assayⁱ Indicates whether the protein has been measured (Data available) or not (Not available) using the Olink Explore HT proximity extension assay platform. Read more	Data available
SomaScanⁱ Indicates whether the protein has been measured (Data available) or not (Not available) using the SomaScan 11K platform. Read more	Data available

ASSAYS

PAN-DISEASE BLOOD PROTEIN PROFILES (OLINK 1536)ⁱ Blood protein levels across diseases and healthy individuals, profiled using the proximity extension assay (PEA) with the Olink Explore 1536.
Olink 1536 (OID21260) All Male Female 6045 samples across 60 cohorts. 1% below LOD. 2806 male samples across 48 cohorts. 1% below LOD. 3160 female samples across 50 cohorts. 1% below LOD. Class Median Alphabetical Show points Hide points

PAN-DISEASE EXTENDED BLOOD PROTEIN PROFILES (OLINK HT)ⁱ Blood protein levels across diseases and healthy individuals, profiled using the proximity extension assay (PEA) with the Olink Explore HT.
Olink HT (OID42413) All Male Female 2458 samples across 32 cohorts. 9% below LOD. 1072 male samples across 27 cohorts. 9% below LOD. 1377 female samples across 30 cohorts. 10% below LOD. Class Median Alphabetical Show points Hide points

PAN-DISEASE BLOOD PROTEIN PROFILES (SOMASCAN)ⁱ

SOMAmer (18887-18)

SOMAmer (18887-7)

All

Male

Female

2356 samples across 32 cohorts.
0% below LOD.

1020 male samples across 27 cohorts.
0% below LOD.

1328 female samples across 30 cohorts.
0% below LOD.

Class

Median

Alphabetical

Show points

Hide points

THE EFFECT OF AGE, BMI AND SEX ON BLOOD PROTEIN LEVELSⁱ Blood protein levels by age, BMI, and sex, measured using the proximity extension assay (PEA) with the Olink Explore 1536. In the age and sex scatterplots, samples are colored by disease class.

Olink 1536 (OID21260) Olink HT (OID42413) SOMAmer (18887-18) SOMAmer (18887-7)

LONGITUDINAL ANALYSIS OF BLOOD PROTEIN LEVELS AT AGES 4, 8, 16 AND 24ⁱ Longitudinal blood protein levels in healthy individuals measured at ages 4, 8, 16, and 24 years, shown separately for males and females. Relative protein abundances were quantified using the proximity extension assay (PEA) with the Olink Explore HT.

Olink HT (OID42413) SOMAmer (18887-18) SOMAmer (18887-7) All Above LOD Age All Above LOD Age All Above LOD Age

LONGITUDINAL ANALYSIS OF BLOOD PROTEIN LEVELS DURING TWO YEARS AT OVER 50 YEAR IN AGEⁱ Blood protein levels in 96 healthy adults (aged 50–65) measured at six visits over a two-year period, shown separately for males and females. Relative protein abundances were quantified using the proximity extension assay (PEA) with the Olink Explore HT.

Olink HT (OID42413) All Above LOD Visit

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.

contact@proteinatlas.org