Single cell type - STAU2 - The Human Protein Atlas

STAU2

Search result

Field

Term

Cluster

Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	STAU2
Gene descriptionⁱ Full gene name according to HGNC.	Staufen double-stranded RNA binding protein 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	17

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Neurons - Neuronal signaling (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Inhibitory neurons, Excitatory neurons, Oligodendrocyte precursor cells, Oligodendrocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.45
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Inhibitory neurons, Excitatory neurons, Oligodendrocyte precursor cells, Oligodendrocytes)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

STAU2 is part of cluster 8 Neurons - Neuronal signaling with confidenceⁱ 0.99
265 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PINX1	PIN2 (TERF1) interacting telomerase inhibitor 1	0.7112	8
RAPGEF4	Rap guanine nucleotide exchange factor 4	0.6903	8
KCNA6	Potassium voltage-gated channel subfamily A member 6	0.6901	8
GPRASP3	G protein-coupled receptor associated sorting protein family member 3	0.6825	8
FGF12	Fibroblast growth factor 12	0.6710	8
TMEM117	Transmembrane protein 117	0.6605	8
BIVM-ERCC5	BIVM-ERCC5 readthrough	0.6550	8
FRAS1	Fraser extracellular matrix complex subunit 1	0.6546	8
HCN1	Hyperpolarization activated cyclic nucleotide gated potassium channel 1	0.6514	8
CACNB4	Calcium voltage-gated channel auxiliary subunit beta 4	0.6439	8
FBXL17	F-box and leucine rich repeat protein 17	0.6376	8
VWA8	Von Willebrand factor A domain containing 8	0.6306	8
MAGI1	Membrane associated guanylate kinase, WW and PDZ domain containing 1	0.6283	8
ZNF385D	Zinc finger protein 385D	0.6267	8
HTR4	5-hydroxytryptamine receptor 4	0.6240	8

IMMUNE CELLS

STAU2 is part of cluster 42 Non-specific - Vesicular transport with confidenceⁱ 0.58
519 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ENSG00000263620	Novel protein	1.0000	42
VAMP2	Vesicle associated membrane protein 2	1.0000	42
DCP1A	Decapping mRNA 1A	0.9762	42
FNBP1	Formin binding protein 1	0.9762	42
MAP4K5	Mitogen-activated protein kinase kinase kinase kinase 5	0.9524	42
LTN1	Listerin E3 ubiquitin protein ligase 1	0.9524	42
ERVK3-1	Endogenous retrovirus group K3 member 1	0.9524	42
GOSR1	Golgi SNAP receptor complex member 1	0.9524	42
PDZD8	PDZ domain containing 8	0.9286	42
KLHL28	Kelch like family member 28	0.9286	45
RPS6KB1	Ribosomal protein S6 kinase B1	0.9286	22
ZNF44	Zinc finger protein 44	0.9286	42
TGFBR1	Transforming growth factor beta receptor 1	0.9286	42
ZNF611	Zinc finger protein 611	0.9286	42
DENND1B	DENN domain containing 1B	0.9286	45

Adipocytes	20.3 nTPM
Adipose tissue	25.1 nTPM
Breast	15.6 nTPM

Alveolar cells type 1	16.3 nTPM
Lung	16.3 nTPM

Alveolar cells type 2	14.7 nTPM
Lung	14.7 nTPM

Astrocytes	114.6 nTPM
Brain	114.6 nTPM

B-cells	20.5 nTPM
Kidney	46.8 nTPM
Lymph node	31.8 nTPM
Esophagus	29.5 nTPM
Lung	21.5 nTPM
Bone marrow	21.3 nTPM
Stomach	20.2 nTPM
Liver	19.3 nTPM
Salivary gland	19.2 nTPM
Thymus	14.1 nTPM
Adipose tissue	14.0 nTPM
Spleen	13.9 nTPM
PBMC	9.2 nTPM
Skin	5.1 nTPM

Ciliated cells	17.2 nTPM
Lung	19.2 nTPM
Bronchus	17.4 nTPM
Endometrium	16.5 nTPM
Fallopian tube	15.7 nTPM

Club cells	26.3 nTPM
Bronchus	33.0 nTPM
Lung	26.2 nTPM
Prostate	19.8 nTPM

Dendritic cells	19.5 nTPM
PBMC	25.2 nTPM
Adipose tissue	13.8 nTPM

Endothelial cells	25.6 nTPM
Liver	81.9 nTPM
Skin	29.6 nTPM
Lung	27.2 nTPM
Vascular	27.0 nTPM
Heart muscle	26.3 nTPM
Testis	26.2 nTPM
Endometrium	25.0 nTPM
Esophagus	24.5 nTPM
Skeletal muscle	23.9 nTPM
Breast	23.7 nTPM
Salivary gland	22.4 nTPM
Ovary	20.5 nTPM
Fallopian tube	19.5 nTPM
Prostate	19.3 nTPM
Tongue	18.7 nTPM
Pancreas	18.1 nTPM
Thymus	17.8 nTPM
Placenta	8.5 nTPM

Enteroendocrine cells	14.6 nTPM
Rectum	20.1 nTPM
Colon	13.4 nTPM
Small intestine	10.3 nTPM

Fibroblasts	15.5 nTPM
Heart muscle	40.8 nTPM
Liver	26.1 nTPM
Stomach	21.6 nTPM
Placenta	19.5 nTPM
Skin	17.3 nTPM
Adipose tissue	13.8 nTPM
Esophagus	13.8 nTPM
Prostate	13.2 nTPM
Skeletal muscle	12.6 nTPM
Pancreas	12.5 nTPM
Fallopian tube	12.4 nTPM
Salivary gland	12.0 nTPM
Vascular	11.9 nTPM
Lung	8.2 nTPM
Thymus	6.3 nTPM
Breast	6.0 nTPM

Granulocytes	9.7 nTPM
Fallopian tube	17.1 nTPM
Lung	12.1 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	19.0 nTPM
Small intestine	24.1 nTPM
Rectum	18.3 nTPM
Colon	14.5 nTPM

Lymphatic endothelial cells	28.5 nTPM
Fallopian tube	29.6 nTPM
Ovary	27.3 nTPM

Macrophages	19.3 nTPM
Pancreas	28.8 nTPM
Adipose tissue	24.9 nTPM
Bone marrow	24.3 nTPM
Esophagus	23.1 nTPM
Tongue	21.8 nTPM
Salivary gland	21.3 nTPM
Spleen	21.1 nTPM
Fallopian tube	20.5 nTPM
Skin	20.1 nTPM
Vascular	19.5 nTPM
Lung	19.0 nTPM
Prostate	18.8 nTPM
Testis	18.0 nTPM
Skeletal muscle	17.2 nTPM
Kidney	15.9 nTPM
Endometrium	15.4 nTPM
Thymus	13.8 nTPM
Breast	13.1 nTPM
Stomach	10.3 nTPM

Basal respiratory cells	17.5 nTPM
Bronchus	17.5 nTPM

Basal squamous epithelial cells	12.9 nTPM
Esophagus	12.9 nTPM

Cholangiocytes	22.9 nTPM
Liver	22.9 nTPM

Collecting duct cells	23.3 nTPM
Kidney	23.3 nTPM

Paneth cells	21.0 nTPM
Colon	32.6 nTPM
Rectum	16.5 nTPM
Small intestine	13.8 nTPM

Plasma cells	21.2 nTPM
Liver	37.1 nTPM
Esophagus	26.0 nTPM
Stomach	23.0 nTPM
Fallopian tube	22.5 nTPM
Salivary gland	18.8 nTPM
Spleen	15.2 nTPM
Bone marrow	13.6 nTPM
Thymus	13.1 nTPM

Schwann cells	12.4 nTPM
Vascular	20.9 nTPM
Adipose tissue	16.4 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	20.4 nTPM
Salivary gland	23.2 nTPM
Tongue	17.7 nTPM

Smooth muscle cells	16.1 nTPM
Liver	34.0 nTPM
Fallopian tube	23.1 nTPM
Vascular	20.8 nTPM
Esophagus	20.4 nTPM
Salivary gland	16.9 nTPM
Prostate	16.4 nTPM
Ovary	15.1 nTPM
Endometrium	14.8 nTPM
Lung	14.1 nTPM
Skeletal muscle	14.0 nTPM
Adipose tissue	14.0 nTPM
Skin	12.5 nTPM
Placenta	11.9 nTPM
Tongue	10.2 nTPM
Breast	9.7 nTPM
Thymus	9.5 nTPM

Suprabasal keratinocytes	25.0 nTPM
Tongue	28.8 nTPM
Skin	21.2 nTPM

T-cells	24.2 nTPM
Tongue	35.5 nTPM
Lymph node	30.2 nTPM
Prostate	29.1 nTPM
Skin	28.0 nTPM
Liver	27.4 nTPM
Colon	26.3 nTPM
Stomach	26.1 nTPM
Vascular	26.1 nTPM
Salivary gland	25.8 nTPM
Endometrium	25.3 nTPM
PBMC	25.2 nTPM
Lung	24.2 nTPM
Adipose tissue	23.7 nTPM
Fallopian tube	23.3 nTPM
Spleen	20.9 nTPM
Bone marrow	19.9 nTPM
Breast	19.5 nTPM
Thymus	19.2 nTPM
Skeletal muscle	17.8 nTPM
Esophagus	17.0 nTPM
Kidney	16.8 nTPM

Undifferentiated cells	13.8 nTPM
Small intestine	17.3 nTPM
Rectum	13.5 nTPM
Colon	10.6 nTPM

Amygdala excitatory	358.1 nTPM
Thalamus	402.5 nTPM
Hypothalamus	388.8 nTPM
Basal ganglia	344.3 nTPM
Amygdala	343.8 nTPM
Hippocampus	335.0 nTPM
Cerebral cortex	334.6 nTPM

Astrocyte	215.2 nTPM
Amygdala	313.0 nTPM
Cerebral cortex	261.9 nTPM
Hippocampus	260.5 nTPM
Basal ganglia	231.3 nTPM
Thalamus	224.2 nTPM
Hypothalamus	209.4 nTPM
Midbrain	199.1 nTPM
Cerebellum	178.5 nTPM
Pons	178.0 nTPM
Medulla oblongata	163.4 nTPM
Spinal cord	148.1 nTPM

Bergmann glia	214.6 nTPM
Cerebellum	233.3 nTPM
Pons	214.3 nTPM
Medulla oblongata	196.1 nTPM

Central nervous system macrophage	315.6 nTPM
Amygdala	454.3 nTPM
Hypothalamus	331.4 nTPM
Basal ganglia	330.9 nTPM
Hippocampus	325.1 nTPM
Midbrain	321.7 nTPM
Thalamus	319.8 nTPM
Cerebral cortex	301.2 nTPM
Pons	291.5 nTPM
Cerebellum	281.8 nTPM
Medulla oblongata	270.7 nTPM
Spinal cord	243.2 nTPM

Cerebellar inhibitory	376.6 nTPM
Pons	397.8 nTPM
Midbrain	397.5 nTPM
Medulla oblongata	384.1 nTPM
Cerebellum	370.8 nTPM
Spinal cord	332.7 nTPM

Cge interneuron	309.6 nTPM
Hypothalamus	330.6 nTPM
Thalamus	327.5 nTPM
Amygdala	321.4 nTPM
Midbrain	315.8 nTPM
Hippocampus	305.0 nTPM
Cerebral cortex	287.3 nTPM
Basal ganglia	280.0 nTPM

Choroid plexus epithelial cell	323.5 nTPM
Basal ganglia	474.4 nTPM
Medulla oblongata	347.9 nTPM
Hippocampus	249.6 nTPM
Thalamus	222.0 nTPM

Committed oligodendrocyte precursor	204.0 nTPM
Amygdala	223.9 nTPM
Cerebral cortex	222.9 nTPM
Hypothalamus	220.5 nTPM
Thalamus	215.2 nTPM
Medulla oblongata	213.0 nTPM
Cerebellum	206.1 nTPM
Hippocampus	199.7 nTPM
Basal ganglia	198.8 nTPM
Midbrain	195.7 nTPM
Pons	178.8 nTPM
Spinal cord	169.2 nTPM

Deep-layer corticothalamic and 6b	425.4 nTPM
Amygdala	449.1 nTPM
Midbrain	433.8 nTPM
Hippocampus	432.6 nTPM
Hypothalamus	432.2 nTPM
Basal ganglia	418.4 nTPM
Cerebral cortex	386.1 nTPM

Deep-layer intratelencephalic	379.5 nTPM
Hypothalamus	424.4 nTPM
Amygdala	387.2 nTPM
Hippocampus	374.8 nTPM
Cerebral cortex	370.8 nTPM
Basal ganglia	340.1 nTPM

Deep-layer near-projecting	516.0 nTPM
Hypothalamus	571.0 nTPM
Amygdala	550.1 nTPM
Basal ganglia	490.1 nTPM
Cerebral cortex	489.0 nTPM
Hippocampus	479.7 nTPM

Eccentric medium spiny neuron	327.1 nTPM
Amygdala	368.0 nTPM
Thalamus	337.4 nTPM
Cerebral cortex	322.5 nTPM
Basal ganglia	315.0 nTPM
Hippocampus	314.2 nTPM
Hypothalamus	305.5 nTPM