Single cell type - ATP1A2 - The Human Protein Atlas

ATP1A2

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Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ATP1A2
Gene descriptionⁱ Full gene name according to HGNC.	ATPase Na+/K+ transporting subunit alpha 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Astrocytes - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Astrocytes, Skeletal myocytes, Cardiomyocytes, Schwann cells, Microglial cells, Oligodendrocyte precursor cells, Muller glia cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.86
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Pericyte, Fibroblast)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Astrocytes, Skeletal myocytes, Cardiomyocytes, Schwann cells, Microglial cells, Oligodendrocyte precursor cells, Muller glia cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Pericyte, Fibroblast)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ATP1A2 is part of cluster 47 Astrocytes - Unknown function with confidenceⁱ 1
196 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PRDM16	PR/SET domain 16	0.7772	47
RANBP3L	RAN binding protein 3 like	0.7716	47
FAM181B	Family with sequence similarity 181 member B	0.7632	47
NTSR2	Neurotensin receptor 2	0.7201	47
COL5A3	Collagen type V alpha 3 chain	0.7169	47
GFAP	Glial fibrillary acidic protein	0.7126	47
PRODH	Proline dehydrogenase 1	0.7071	47
SLCO1C1	Solute carrier organic anion transporter family member 1C1	0.7010	47
GRIN2C	Glutamate ionotropic receptor NMDA type subunit 2C	0.7002	47
GABRG1	Gamma-aminobutyric acid type A receptor subunit gamma1	0.6892	47
PSD2	Pleckstrin and Sec7 domain containing 2	0.6866	47
ADGRV1	Adhesion G protein-coupled receptor V1	0.6747	47
SLC1A2	Solute carrier family 1 member 2	0.6728	47
POU3F2	POU class 3 homeobox 2	0.6676	47
EYA1	EYA transcriptional coactivator and phosphatase 1	0.6661	47

Adipocytes	1.5 nTPM
Breast	2.9 nTPM
Adipose tissue	0.0 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	0.0 nTPM
Lung	0.0 nTPM

B-cells	0.2 nTPM
PBMC	1.5 nTPM
Thymus	0.7 nTPM
Lymph node	0.1 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Salivary gland	0.0 nTPM

Basal keratinocytes	0.3 nTPM
Tongue	0.5 nTPM
Skin	0.2 nTPM

Ciliated cells	0.4 nTPM
Fallopian tube	1.0 nTPM
Bronchus	0.2 nTPM
Lung	0.2 nTPM
Endometrium	0.1 nTPM

Club cells	0.1 nTPM
Prostate	0.3 nTPM
Bronchus	0.1 nTPM
Lung	0.0 nTPM

Endothelial cells	2.4 nTPM
Heart muscle	13.2 nTPM
Tongue	7.5 nTPM
Prostate	4.6 nTPM
Ovary	3.6 nTPM
Testis	3.4 nTPM
Skeletal muscle	3.2 nTPM
Vascular	3.2 nTPM
Skin	1.7 nTPM
Fallopian tube	1.0 nTPM
Breast	0.9 nTPM
Thymus	0.8 nTPM
Placenta	0.6 nTPM
Salivary gland	0.4 nTPM
Endometrium	0.1 nTPM
Lung	0.1 nTPM
Liver	0.0 nTPM
Pancreas	0.0 nTPM
Esophagus	0.0 nTPM

Enteroendocrine cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	4.6 nTPM
Heart muscle	31.0 nTPM
Vascular	13.5 nTPM
Fallopian tube	9.1 nTPM
Prostate	5.9 nTPM
Thymus	4.4 nTPM
Lung	2.6 nTPM
Skin	1.9 nTPM
Stomach	1.4 nTPM
Skeletal muscle	1.0 nTPM
Breast	0.9 nTPM
Esophagus	0.5 nTPM
Placenta	0.4 nTPM
Salivary gland	0.2 nTPM
Liver	0.0 nTPM
Pancreas	0.0 nTPM
Adipose tissue	0.0 nTPM

Granulocytes	0.0 nTPM
Lung	0.0 nTPM
Tongue	0.0 nTPM
Fallopian tube	0.0 nTPM

Intestinal goblet cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Lymphatic endothelial cells	0.2 nTPM
Fallopian tube	0.4 nTPM
Ovary	0.0 nTPM

Macrophages	0.5 nTPM
Vascular	3.1 nTPM
Esophagus	1.3 nTPM
Testis	1.2 nTPM
Skeletal muscle	1.2 nTPM
Breast	0.6 nTPM
Fallopian tube	0.3 nTPM
Prostate	0.2 nTPM
Salivary gland	0.2 nTPM
Thymus	0.2 nTPM
Tongue	0.2 nTPM
Kidney	0.0 nTPM
Endometrium	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Bipolar cells	4.0 nTPM
Eye	4.0 nTPM

Excitatory neurons	5.3 nTPM
Brain	5.3 nTPM

Plasma cells	0.2 nTPM
Fallopian tube	1.0 nTPM
Thymus	0.3 nTPM
Liver	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Salivary gland	0.0 nTPM

Schwann cells	160.5 nTPM
Vascular	445.6 nTPM
Esophagus	35.9 nTPM
Adipose tissue	0.0 nTPM

Serous glandular cells	0.4 nTPM
Salivary gland	0.7 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	47.7 nTPM
Vascular	115.4 nTPM
Prostate	83.3 nTPM
Esophagus	79.3 nTPM
Skeletal muscle	77.1 nTPM
Ovary	71.0 nTPM
Thymus	67.9 nTPM
Salivary gland	64.8 nTPM
Tongue	48.2 nTPM
Lung	34.1 nTPM
Breast	31.8 nTPM
Fallopian tube	30.3 nTPM
Skin	26.9 nTPM
Adipose tissue	19.6 nTPM
Endometrium	10.6 nTPM
Placenta	1.7 nTPM
Liver	1.3 nTPM

T-cells	0.3 nTPM
Vascular	3.2 nTPM
Prostate	0.6 nTPM
Endometrium	0.4 nTPM
Skin	0.4 nTPM
Fallopian tube	0.4 nTPM
Lung	0.3 nTPM
PBMC	0.2 nTPM
Lymph node	0.2 nTPM
Thymus	0.1 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Salivary gland	0.0 nTPM
Tongue	0.0 nTPM
Breast	0.0 nTPM

Undifferentiated cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Amygdala excitatory	5.5 nTPM
Hippocampus	9.6 nTPM
Cerebral cortex	9.5 nTPM
Amygdala	8.9 nTPM
Basal ganglia	2.4 nTPM
Hypothalamus	2.3 nTPM
Thalamus	0.5 nTPM

Astrocyte	900.9 nTPM
Cerebellum	1231.0 nTPM
Cerebral cortex	1101.7 nTPM
Thalamus	1042.0 nTPM
Midbrain	1001.4 nTPM
Basal ganglia	965.9 nTPM
Hippocampus	917.3 nTPM
Pons	898.2 nTPM
Amygdala	853.6 nTPM
Medulla oblongata	682.2 nTPM
Hypothalamus	647.8 nTPM
Spinal cord	568.7 nTPM

Bergmann glia	953.1 nTPM
Cerebellum	1036.3 nTPM
Medulla oblongata	1018.7 nTPM
Pons	804.2 nTPM

Central nervous system macrophage	7.0 nTPM
Cerebellum	12.3 nTPM
Hippocampus	10.6 nTPM
Amygdala	8.0 nTPM
Spinal cord	7.9 nTPM
Cerebral cortex	7.7 nTPM
Midbrain	6.7 nTPM
Basal ganglia	6.6 nTPM
Medulla oblongata	5.0 nTPM
Thalamus	4.7 nTPM
Pons	4.0 nTPM
Hypothalamus	3.1 nTPM

Cerebellar inhibitory	2.1 nTPM
Cerebellum	3.5 nTPM
Pons	3.1 nTPM
Medulla oblongata	2.9 nTPM
Midbrain	0.9 nTPM
Spinal cord	0.0 nTPM

Cge interneuron	1.3 nTPM
Hypothalamus	1.9 nTPM
Hippocampus	1.6 nTPM
Thalamus	1.4 nTPM
Midbrain	1.3 nTPM
Amygdala	1.1 nTPM
Cerebral cortex	1.1 nTPM
Basal ganglia	0.9 nTPM

Choroid plexus epithelial cell	12.7 nTPM
Medulla oblongata	31.8 nTPM
Thalamus	8.2 nTPM
Hippocampus	5.5 nTPM
Basal ganglia	5.3 nTPM

Committed oligodendrocyte precursor	24.4 nTPM
Basal ganglia	51.5 nTPM
Cerebral cortex	43.7 nTPM
Medulla oblongata	37.4 nTPM
Amygdala	33.8 nTPM
Hippocampus	31.0 nTPM
Cerebellum	23.8 nTPM
Midbrain	11.8 nTPM
Hypothalamus	10.9 nTPM
Pons	10.6 nTPM
Spinal cord	7.4 nTPM
Thalamus	6.5 nTPM

Deep-layer corticothalamic and 6b	1.7 nTPM
Hypothalamus	3.2 nTPM
Basal ganglia	2.2 nTPM
Cerebral cortex	1.7 nTPM
Amygdala	1.2 nTPM
Midbrain	1.1 nTPM
Hippocampus	0.9 nTPM

Deep-layer intratelencephalic	4.9 nTPM
Cerebral cortex	5.7 nTPM
Hypothalamus	5.4 nTPM
Basal ganglia	5.1 nTPM
Amygdala	4.8 nTPM
Hippocampus	3.7 nTPM

Deep-layer near-projecting	1.3 nTPM
Hypothalamus	2.8 nTPM
Hippocampus	1.6 nTPM
Basal ganglia	1.0 nTPM
Cerebral cortex	0.8 nTPM
Amygdala	0.4 nTPM

Eccentric medium spiny neuron	1.0 nTPM
Hypothalamus	1.5 nTPM
Thalamus	1.4 nTPM
Amygdala	1.2 nTPM
Basal ganglia	0.9 nTPM
Cerebral cortex	0.8 nTPM
Hippocampus	0.4 nTPM

Endothelial cell	41.2 nTPM
Basal ganglia	75.5 nTPM
Thalamus	58.2 nTPM
Medulla oblongata	55.4 nTPM
Amygdala	52.5 nTPM
Midbrain	41.6 nTPM
Cerebral cortex	37.7 nTPM
Hypothalamus	33.5 nTPM
Hippocampus	30.5 nTPM
Pons	28.7 nTPM
Cerebellum	26.3 nTPM
Spinal cord	13.8 nTPM

Ependymal cell	131.4 nTPM
Amygdala	241.7 nTPM
Hippocampus	165.7 nTPM
Pons	157.5 nTPM
Hypothalamus	140.1 nTPM
Midbrain	134.0 nTPM
Basal ganglia	127.3 nTPM
Medulla oblongata	93.1 nTPM
Thalamus	90.3 nTPM
Spinal cord	32.6 nTPM