Single cell type - ELOVL5 - The Human Protein Atlas

ELOVL5

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ELOVL5
Gene descriptionⁱ Full gene name according to HGNC.	ELOVL fatty acid elongase 5
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Basal prostatic cells - Lipid metabolism (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Basal prostatic cells, Prostatic glandular cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.39
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Basal prostatic cells, Prostatic glandular cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ELOVL5 is part of cluster 3 Basal prostatic cells - Lipid metabolism with confidenceⁱ 1
162 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CITED1	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1	0.6172	3
HCAR1	Hydroxycarboxylic acid receptor 1	0.6092	3
RASL10B	RAS like family 10 member B	0.5621	3
CBLL1	Cbl proto-oncogene like 1	0.5617	3
GSTM3	Glutathione S-transferase mu 3	0.5483	3
DUSP4	Dual specificity phosphatase 4	0.5436	3
FAM107B	Family with sequence similarity 107 member B	0.5395	3
AR	Androgen receptor	0.5384	40
UHMK1	U2AF homology motif kinase 1	0.5374	3
IVD	Isovaleryl-CoA dehydrogenase	0.5373	3
FAM167A	Family with sequence similarity 167 member A	0.5337	3
CST4	Cystatin S	0.5322	3
EDDM3A	Epididymal protein 3A	0.5225	3
PNMT	Phenylethanolamine N-methyltransferase	0.5187	3
POU3F3	POU class 3 homeobox 3	0.5151	3

IMMUNE CELLS

ELOVL5 is part of cluster 21 Neutrophils - Unknown function with confidenceⁱ 1
492 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ENSG00000288634	Novel protein	0.9762	21
LIMS4	LIM zinc finger domain containing 4	0.9524	21
FLOT2	Flotillin 2	0.9524	21
AHCTF1	AT-hook containing transcription factor 1	0.9524	21
CANT1	Calcium activated nucleotidase 1	0.9286	21
ENSG00000288529	Novel protein	0.9286	21
ENSG00000260170	Novel protein	0.9286	21
MAP3K7CL	MAP3K7 C-terminal like	0.9286	21
TBL1X	Transducin beta like 1 X-linked	0.9286	21
HYAL1	Hyaluronidase 1	0.9048	21
LRRC51	Leucine rich repeat containing 51	0.9048	21
JPT1	Jupiter microtubule associated homolog 1	0.9048	7
RGL2	Ral guanine nucleotide dissociation stimulator like 2	0.9048	21
PACRG	Parkin coregulated	0.9048	21
H2BC17	H2B clustered histone 17	0.9048	21

Adipocytes	46.5 nTPM
Adipose tissue	56.9 nTPM
Breast	36.0 nTPM

Alveolar cells type 1	86.0 nTPM
Lung	86.0 nTPM

Alveolar cells type 2	74.3 nTPM
Lung	74.3 nTPM

Astrocytes	71.5 nTPM
Brain	71.5 nTPM

B-cells	117.5 nTPM
Skin	177.9 nTPM
Spleen	145.9 nTPM
Bone marrow	139.8 nTPM
Stomach	134.1 nTPM
PBMC	129.3 nTPM
Lymph node	126.2 nTPM
Adipose tissue	122.2 nTPM
Kidney	119.6 nTPM
Esophagus	118.0 nTPM
Thymus	104.5 nTPM
Liver	72.5 nTPM
Salivary gland	71.9 nTPM
Lung	65.7 nTPM

Ciliated cells	40.4 nTPM
Bronchus	53.2 nTPM
Fallopian tube	41.7 nTPM
Endometrium	33.5 nTPM
Lung	33.0 nTPM

Club cells	38.6 nTPM
Bronchus	43.2 nTPM
Lung	40.6 nTPM
Prostate	32.0 nTPM

Dendritic cells	44.0 nTPM
Adipose tissue	59.2 nTPM
PBMC	28.8 nTPM

Endothelial cells	46.3 nTPM
Skeletal muscle	69.4 nTPM
Skin	69.1 nTPM
Prostate	67.2 nTPM
Fallopian tube	67.0 nTPM
Pancreas	51.7 nTPM
Liver	51.6 nTPM
Heart muscle	51.1 nTPM
Endometrium	48.9 nTPM
Testis	47.6 nTPM
Placenta	43.1 nTPM
Lung	42.9 nTPM
Thymus	40.2 nTPM
Esophagus	40.1 nTPM
Vascular	37.5 nTPM
Salivary gland	31.5 nTPM
Breast	29.0 nTPM
Tongue	25.5 nTPM
Ovary	20.2 nTPM

Enteroendocrine cells	5.2 nTPM
Rectum	13.4 nTPM
Colon	2.1 nTPM
Small intestine	0.0 nTPM

Fibroblasts	47.3 nTPM
Thymus	79.8 nTPM
Prostate	76.6 nTPM
Fallopian tube	61.3 nTPM
Stomach	60.5 nTPM
Pancreas	57.5 nTPM
Skin	51.0 nTPM
Salivary gland	50.5 nTPM
Lung	48.8 nTPM
Vascular	47.1 nTPM
Skeletal muscle	43.2 nTPM
Liver	34.4 nTPM
Esophagus	32.9 nTPM
Adipose tissue	30.9 nTPM
Heart muscle	29.2 nTPM
Breast	28.3 nTPM
Placenta	25.3 nTPM

Granulocytes	126.4 nTPM
Fallopian tube	228.1 nTPM
Tongue	82.5 nTPM
Lung	68.6 nTPM

Intestinal goblet cells	1.8 nTPM
Colon	2.7 nTPM
Small intestine	2.4 nTPM
Rectum	0.3 nTPM

Lymphatic endothelial cells	19.3 nTPM
Fallopian tube	33.1 nTPM
Ovary	5.5 nTPM

Macrophages	53.6 nTPM
Fallopian tube	109.7 nTPM
Adipose tissue	107.8 nTPM
Prostate	73.6 nTPM
Skeletal muscle	71.2 nTPM
Testis	68.8 nTPM
Bone marrow	57.8 nTPM
Kidney	57.5 nTPM
Spleen	57.1 nTPM
Skin	53.5 nTPM
Esophagus	48.8 nTPM
Tongue	48.4 nTPM
Stomach	43.7 nTPM
Endometrium	42.4 nTPM
Breast	38.1 nTPM
Lung	34.9 nTPM
Salivary gland	32.7 nTPM
Vascular	29.2 nTPM
Thymus	23.7 nTPM
Pancreas	18.5 nTPM

Bipolar cells	12.7 nTPM
Eye	12.7 nTPM

Cholangiocytes	22.9 nTPM
Liver	22.9 nTPM

Collecting duct cells	13.6 nTPM
Kidney	13.6 nTPM

Cone photoreceptor cells	3.4 nTPM
Eye	3.4 nTPM

Paneth cells	2.6 nTPM
Small intestine	6.9 nTPM
Rectum	1.0 nTPM
Colon	0.0 nTPM

Plasma cells	34.5 nTPM
Stomach	47.7 nTPM
Spleen	45.9 nTPM
Esophagus	41.6 nTPM
Liver	35.5 nTPM
Thymus	33.9 nTPM
Bone marrow	33.2 nTPM
Fallopian tube	20.9 nTPM
Salivary gland	17.0 nTPM

Schwann cells	114.6 nTPM
Adipose tissue	205.7 nTPM
Esophagus	83.9 nTPM
Vascular	54.3 nTPM

Serous glandular cells	20.8 nTPM
Salivary gland	24.0 nTPM
Tongue	17.7 nTPM

Smooth muscle cells	54.1 nTPM
Skin	139.4 nTPM
Prostate	110.1 nTPM
Skeletal muscle	81.5 nTPM
Placenta	63.5 nTPM
Esophagus	60.1 nTPM
Adipose tissue	58.6 nTPM
Thymus	54.1 nTPM
Liver	43.7 nTPM
Endometrium	40.4 nTPM
Vascular	37.9 nTPM
Fallopian tube	37.5 nTPM
Salivary gland	37.1 nTPM
Breast	35.3 nTPM
Tongue	31.7 nTPM
Ovary	19.7 nTPM
Lung	15.3 nTPM

Suprabasal keratinocytes	33.1 nTPM
Skin	54.1 nTPM
Tongue	12.0 nTPM

T-cells	84.2 nTPM
Spleen	138.5 nTPM
Esophagus	136.3 nTPM
Adipose tissue	134.2 nTPM
Colon	120.9 nTPM
Fallopian tube	111.6 nTPM
Stomach	108.7 nTPM
Skin	108.6 nTPM
Lymph node	92.3 nTPM
Prostate	79.6 nTPM
Bone marrow	79.4 nTPM
Tongue	73.1 nTPM
Vascular	72.4 nTPM
Liver	70.2 nTPM
Kidney	67.4 nTPM
Endometrium	62.3 nTPM
Breast	59.4 nTPM
Thymus	59.3 nTPM
Skeletal muscle	57.8 nTPM
PBMC	55.9 nTPM
Lung	44.7 nTPM
Salivary gland	34.8 nTPM

Undifferentiated cells	5.7 nTPM
Colon	10.6 nTPM
Small intestine	6.0 nTPM
Rectum	0.6 nTPM

Amygdala excitatory	33.1 nTPM
Hypothalamus	43.7 nTPM
Cerebral cortex	34.2 nTPM
Thalamus	32.2 nTPM
Basal ganglia	31.9 nTPM
Hippocampus	29.1 nTPM
Amygdala	27.5 nTPM

Astrocyte	137.9 nTPM
Spinal cord	334.7 nTPM
Hypothalamus	259.6 nTPM
Medulla oblongata	136.9 nTPM
Basal ganglia	120.2 nTPM
Cerebral cortex	118.0 nTPM
Amygdala	107.7 nTPM
Pons	105.9 nTPM
Thalamus	94.1 nTPM
Hippocampus	93.7 nTPM
Midbrain	92.4 nTPM
Cerebellum	53.3 nTPM

Bergmann glia	63.6 nTPM
Cerebellum	72.1 nTPM
Pons	71.9 nTPM
Medulla oblongata	46.9 nTPM

Central nervous system macrophage	112.5 nTPM
Hypothalamus	151.6 nTPM
Pons	141.2 nTPM
Spinal cord	135.1 nTPM
Cerebellum	119.2 nTPM
Amygdala	116.7 nTPM
Midbrain	115.6 nTPM
Medulla oblongata	114.9 nTPM
Thalamus	95.5 nTPM
Basal ganglia	91.4 nTPM
Hippocampus	80.8 nTPM
Cerebral cortex	75.7 nTPM

Cerebellar inhibitory	126.6 nTPM
Spinal cord	173.2 nTPM
Medulla oblongata	138.8 nTPM
Cerebellum	117.6 nTPM
Midbrain	115.7 nTPM
Pons	87.4 nTPM

Cge interneuron	44.7 nTPM
Hypothalamus	51.8 nTPM
Amygdala	46.8 nTPM
Thalamus	44.3 nTPM
Hippocampus	44.0 nTPM
Midbrain	43.3 nTPM
Cerebral cortex	42.1 nTPM
Basal ganglia	40.9 nTPM

Choroid plexus epithelial cell	50.4 nTPM
Basal ganglia	63.5 nTPM
Thalamus	52.1 nTPM
Hippocampus	47.1 nTPM
Medulla oblongata	38.7 nTPM

Committed oligodendrocyte precursor	92.8 nTPM
Hypothalamus	129.7 nTPM
Cerebellum	111.0 nTPM
Pons	110.7 nTPM
Midbrain	110.0 nTPM
Thalamus	104.9 nTPM
Amygdala	104.3 nTPM
Basal ganglia	82.7 nTPM
Cerebral cortex	74.1 nTPM
Hippocampus	72.7 nTPM
Medulla oblongata	65.8 nTPM
Spinal cord	55.2 nTPM

Deep-layer corticothalamic and 6b	54.7 nTPM
Amygdala	66.5 nTPM
Basal ganglia	65.7 nTPM
Hypothalamus	65.5 nTPM
Cerebral cortex	51.5 nTPM
Hippocampus	48.9 nTPM
Midbrain	30.0 nTPM

Deep-layer intratelencephalic	40.1 nTPM
Amygdala	60.3 nTPM
Hypothalamus	38.2 nTPM
Cerebral cortex	38.0 nTPM
Basal ganglia	34.9 nTPM
Hippocampus	29.3 nTPM

Deep-layer near-projecting	34.6 nTPM
Basal ganglia	38.5 nTPM
Amygdala	37.1 nTPM
Cerebral cortex	35.3 nTPM
Hypothalamus	35.1 nTPM
Hippocampus	27.0 nTPM

Eccentric medium spiny neuron	33.4 nTPM
Amygdala	38.0 nTPM
Cerebral cortex	37.6 nTPM
Thalamus	35.2 nTPM
Hypothalamus	33.2 nTPM
Basal ganglia	29.3 nTPM
Hippocampus	26.9 nTPM