Single cell type - MBTD1 - The Human Protein Atlas

MBTD1

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Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MBTD1
Gene descriptionⁱ Full gene name according to HGNC.	Mbt domain containing 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Spermatocytes - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.45
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enhanced (basophil)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enhanced (basophil)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

MBTD1 is part of cluster 31 Spermatocytes - Spermatogenesis with confidenceⁱ 1
240 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MLLT10	MLLT10 histone lysine methyltransferase DOT1L cofactor	0.6725	31
ENTHD1	ENTH domain containing 1	0.5733	31
TPTE	Transmembrane phosphatase with tensin homology	0.5684	31
ANKRD62	Ankyrin repeat domain 62	0.5461	31
RNF17	Ring finger protein 17	0.5438	31
C12orf40	Chromosome 12 open reading frame 40	0.5221	31
TEX14	Testis expressed 14, intercellular bridge forming factor	0.5199	31
TDRD12	Tudor domain containing 12	0.5137	31
UPF3A	UPF3A regulator of nonsense mediated mRNA decay	0.5129	31
TDRD5	Tudor domain containing 5	0.5123	31
FKBP6	FKBP prolyl isomerase family member 6 (inactive)	0.5056	31
ZNF546	Zinc finger protein 546	0.4986	31
ARHGEF33	Rho guanine nucleotide exchange factor 33	0.4986	31
MORC1	MORC family CW-type zinc finger 1	0.4963	31
RBM46	RNA binding motif protein 46	0.4932	31

IMMUNE CELLS

MBTD1 is part of cluster 22 Eosinophils - Transcription with confidenceⁱ 0.92
357 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MACO1	Macoilin 1	1.0000	22
ATRN	Attractin	1.0000	22
NMB	Neuromedin B	1.0000	22
CHPF	Chondroitin polymerizing factor	1.0000	22
HNRNPAB	Heterogeneous nuclear ribonucleoprotein A/B	1.0000	22
RFXAP	Regulatory factor X associated protein	1.0000	22
NELFB	Negative elongation factor complex member B	1.0000	22
MSRB3	Methionine sulfoxide reductase B3	1.0000	22
AMT	Aminomethyltransferase	0.9762	22
ASMTL	Acetylserotonin O-methyltransferase like	0.9762	22
ABTB2	Ankyrin repeat and BTB domain containing 2	0.9762	22
ZFAND3	Zinc finger AN1-type containing 3	0.9762	22
SURF1	SURF1 cytochrome c oxidase assembly factor	0.9762	22
ATP2A3	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	0.9762	22
BAHD1	Bromo adjacent homology domain containing 1	0.9762	22

Adipocytes	11.3 nTPM
Adipose tissue	12.3 nTPM
Breast	10.4 nTPM

Alveolar cells type 1	4.3 nTPM
Lung	4.3 nTPM

Alveolar cells type 2	5.5 nTPM
Lung	5.5 nTPM

Astrocytes	45.2 nTPM
Brain	45.2 nTPM

B-cells	10.7 nTPM
Skin	16.9 nTPM
Lymph node	15.8 nTPM
PBMC	15.4 nTPM
Salivary gland	13.8 nTPM
Spleen	11.3 nTPM
Adipose tissue	11.1 nTPM
Kidney	10.4 nTPM
Liver	9.7 nTPM
Thymus	9.1 nTPM
Lung	8.0 nTPM
Bone marrow	6.7 nTPM
Esophagus	5.9 nTPM
Stomach	5.1 nTPM

Ciliated cells	7.6 nTPM
Endometrium	10.4 nTPM
Bronchus	7.5 nTPM
Lung	6.8 nTPM
Fallopian tube	5.7 nTPM

Club cells	8.5 nTPM
Prostate	12.8 nTPM
Bronchus	6.8 nTPM
Lung	5.7 nTPM

Endothelial cells	10.6 nTPM
Heart muscle	27.0 nTPM
Endometrium	17.0 nTPM
Esophagus	13.4 nTPM
Vascular	12.8 nTPM
Prostate	12.6 nTPM
Skeletal muscle	11.9 nTPM
Ovary	10.9 nTPM
Salivary gland	10.7 nTPM
Placenta	10.2 nTPM
Tongue	10.2 nTPM
Testis	8.9 nTPM
Liver	7.6 nTPM
Skin	7.5 nTPM
Thymus	7.5 nTPM
Breast	7.0 nTPM
Lung	5.6 nTPM
Pancreas	5.2 nTPM
Fallopian tube	4.9 nTPM

Enteroendocrine cells	13.7 nTPM
Small intestine	17.2 nTPM
Rectum	13.4 nTPM
Colon	10.6 nTPM

Fibroblasts	10.8 nTPM
Heart muscle	25.2 nTPM
Breast	14.8 nTPM
Esophagus	14.5 nTPM
Placenta	13.2 nTPM
Salivary gland	13.0 nTPM
Liver	11.9 nTPM
Adipose tissue	11.8 nTPM
Prostate	11.2 nTPM
Vascular	10.4 nTPM
Skin	9.1 nTPM
Skeletal muscle	9.1 nTPM
Stomach	7.2 nTPM
Fallopian tube	7.2 nTPM
Thymus	6.2 nTPM
Lung	5.3 nTPM
Pancreas	2.7 nTPM

Granulocytes	8.5 nTPM
Tongue	14.6 nTPM
Lung	7.6 nTPM
Fallopian tube	3.3 nTPM

Intestinal goblet cells	15.4 nTPM
Small intestine	22.0 nTPM
Rectum	15.0 nTPM
Colon	9.1 nTPM

Lymphatic endothelial cells	3.9 nTPM
Fallopian tube	7.7 nTPM
Ovary	0.0 nTPM

Macrophages	11.6 nTPM
Bone marrow	18.2 nTPM
Esophagus	18.0 nTPM
Kidney	16.8 nTPM
Tongue	14.1 nTPM
Salivary gland	13.8 nTPM
Spleen	13.0 nTPM
Thymus	12.4 nTPM
Prostate	11.6 nTPM
Skeletal muscle	11.3 nTPM
Adipose tissue	11.2 nTPM
Skin	11.1 nTPM
Vascular	10.8 nTPM
Breast	10.7 nTPM
Fallopian tube	10.7 nTPM
Endometrium	10.5 nTPM
Testis	8.7 nTPM
Lung	8.4 nTPM
Stomach	5.1 nTPM
Pancreas	4.1 nTPM

Paneth cells	6.2 nTPM
Rectum	11.4 nTPM
Colon	3.6 nTPM
Small intestine	3.5 nTPM

Basal prostatic cells	7.9 nTPM
Prostate	7.9 nTPM

Basal squamous epithelial cells	13.5 nTPM
Esophagus	13.5 nTPM

Bipolar cells	7.3 nTPM
Eye	7.3 nTPM

Cholangiocytes	15.3 nTPM
Liver	15.3 nTPM

Plasma cells	5.0 nTPM
Salivary gland	12.5 nTPM
Stomach	8.0 nTPM
Fallopian tube	5.5 nTPM
Spleen	5.3 nTPM
Thymus	4.8 nTPM
Liver	4.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Schwann cells	11.9 nTPM
Adipose tissue	14.4 nTPM
Esophagus	12.0 nTPM
Vascular	9.4 nTPM

Serous glandular cells	15.2 nTPM
Tongue	17.7 nTPM
Salivary gland	12.6 nTPM

Smooth muscle cells	8.3 nTPM
Endometrium	13.6 nTPM
Skin	10.8 nTPM
Adipose tissue	10.7 nTPM
Liver	10.2 nTPM
Skeletal muscle	10.2 nTPM
Salivary gland	9.9 nTPM
Ovary	9.7 nTPM
Prostate	7.3 nTPM
Vascular	7.2 nTPM
Breast	7.2 nTPM
Lung	7.1 nTPM
Tongue	6.6 nTPM
Placenta	6.4 nTPM
Esophagus	6.0 nTPM
Thymus	5.0 nTPM
Fallopian tube	4.9 nTPM

Suprabasal keratinocytes	17.6 nTPM
Skin	23.9 nTPM
Tongue	11.2 nTPM

T-cells	9.1 nTPM
Salivary gland	16.5 nTPM
Vascular	13.3 nTPM
Endometrium	12.1 nTPM
Lymph node	11.5 nTPM
Adipose tissue	11.0 nTPM
Prostate	11.0 nTPM
PBMC	10.9 nTPM
Kidney	9.8 nTPM
Colon	9.7 nTPM
Thymus	9.2 nTPM
Tongue	9.2 nTPM
Spleen	8.5 nTPM
Liver	8.2 nTPM
Fallopian tube	8.2 nTPM
Skin	7.0 nTPM
Breast	6.9 nTPM
Skeletal muscle	6.4 nTPM
Bone marrow	6.4 nTPM
Lung	6.0 nTPM
Stomach	5.4 nTPM
Esophagus	4.9 nTPM

Undifferentiated cells	11.2 nTPM
Rectum	14.6 nTPM
Small intestine	12.2 nTPM
Colon	6.6 nTPM

Amygdala excitatory	80.3 nTPM
Hypothalamus	99.8 nTPM
Amygdala	82.1 nTPM
Thalamus	79.9 nTPM
Cerebral cortex	76.5 nTPM
Hippocampus	76.1 nTPM
Basal ganglia	67.3 nTPM

Astrocyte	83.4 nTPM
Amygdala	111.0 nTPM
Hypothalamus	90.7 nTPM
Hippocampus	88.0 nTPM
Basal ganglia	86.9 nTPM
Midbrain	82.8 nTPM
Cerebral cortex	81.9 nTPM
Thalamus	81.8 nTPM
Pons	78.8 nTPM
Cerebellum	76.1 nTPM
Medulla oblongata	70.3 nTPM
Spinal cord	68.9 nTPM

Bergmann glia	96.1 nTPM
Cerebellum	99.6 nTPM
Medulla oblongata	98.0 nTPM
Pons	90.6 nTPM

Central nervous system macrophage	159.9 nTPM
Amygdala	216.7 nTPM
Hypothalamus	177.1 nTPM
Midbrain	170.9 nTPM
Hippocampus	166.2 nTPM
Basal ganglia	159.9 nTPM
Cerebellum	152.3 nTPM
Thalamus	147.3 nTPM
Pons	145.2 nTPM
Spinal cord	143.7 nTPM
Cerebral cortex	141.6 nTPM
Medulla oblongata	138.0 nTPM

Cerebellar inhibitory	85.2 nTPM
Medulla oblongata	102.2 nTPM
Cerebellum	95.5 nTPM
Midbrain	84.6 nTPM
Pons	75.2 nTPM
Spinal cord	68.7 nTPM

Cge interneuron	68.1 nTPM
Hypothalamus	87.3 nTPM
Amygdala	73.2 nTPM
Thalamus	65.2 nTPM
Basal ganglia	64.5 nTPM
Cerebral cortex	63.2 nTPM
Hippocampus	62.1 nTPM
Midbrain	61.4 nTPM

Choroid plexus epithelial cell	118.1 nTPM
Basal ganglia	190.9 nTPM
Medulla oblongata	110.6 nTPM
Thalamus	93.2 nTPM
Hippocampus	77.7 nTPM

Committed oligodendrocyte precursor	96.8 nTPM
Hypothalamus	129.7 nTPM
Spinal cord	125.1 nTPM
Thalamus	118.0 nTPM
Amygdala	115.0 nTPM
Cerebral cortex	97.5 nTPM
Hippocampus	96.5 nTPM
Cerebellum	85.6 nTPM
Basal ganglia	84.9 nTPM
Pons	76.1 nTPM
Midbrain	71.4 nTPM
Medulla oblongata	64.5 nTPM

Deep-layer corticothalamic and 6b	81.2 nTPM
Hypothalamus	97.8 nTPM
Amygdala	80.5 nTPM
Midbrain	79.9 nTPM
Cerebral cortex	78.1 nTPM
Hippocampus	75.6 nTPM
Basal ganglia	75.1 nTPM

Deep-layer intratelencephalic	79.8 nTPM
Hypothalamus	99.4 nTPM
Amygdala	81.4 nTPM
Cerebral cortex	74.7 nTPM
Basal ganglia	72.4 nTPM
Hippocampus	71.1 nTPM

Deep-layer near-projecting	78.0 nTPM
Hypothalamus	102.1 nTPM
Amygdala	80.1 nTPM
Cerebral cortex	72.9 nTPM
Basal ganglia	71.6 nTPM
Hippocampus	63.4 nTPM

Eccentric medium spiny neuron	86.0 nTPM
Thalamus	90.4 nTPM
Basal ganglia	87.1 nTPM
Amygdala	86.3 nTPM
Hypothalamus	86.0 nTPM
Cerebral cortex	83.8 nTPM
Hippocampus	82.5 nTPM

Endothelial cell	98.3 nTPM
Spinal cord	122.5 nTPM
Basal ganglia	118.4 nTPM
Hypothalamus	112.9 nTPM
Hippocampus	107.1 nTPM
Amygdala	105.1 nTPM
Cerebral cortex	92.7 nTPM
Midbrain	92.6 nTPM
Cerebellum	91.4 nTPM
Pons	91.1 nTPM
Thalamus	85.9 nTPM
Medulla oblongata	61.5 nTPM