Single cell type - TEAD3 - The Human Protein Atlas

TEAD3

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Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TEAD3
Gene descriptionⁱ Full gene name according to HGNC.	TEA domain transcription factor 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Extravillous trophoblasts - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Syncytiotrophoblasts, Extravillous trophoblasts, Cytotrophoblasts)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.62
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Vascular associated smooth muscle cell, Pericyte)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Syncytiotrophoblasts, Extravillous trophoblasts, Cytotrophoblasts)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Vascular associated smooth muscle cell, Pericyte)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

TEAD3 is part of cluster 4 Extravillous trophoblasts - Unknown function with confidenceⁱ 1
182 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SYDE1	Synapse defective Rho GTPase homolog 1	0.7303	4
PGF	Placental growth factor	0.6900	4
GCM1	Glial cells missing transcription factor 1	0.6681	4
FAM120AOS	Family with sequence similarity 120A opposite strand	0.6635	4
CDKN1C	Cyclin dependent kinase inhibitor 1C	0.6563	4
CSH1	Chorionic somatomammotropin hormone 1	0.6445	4
ACAN	Aggrecan	0.6440	4
FSTL3	Follistatin like 3	0.6428	4
GPR78	G protein-coupled receptor 78	0.6410	4
BZW2	Basic leucine zipper and W2 domains 2	0.6350	4
GATA3	GATA binding protein 3	0.6334	4
FANCE	FA complementation group E	0.6242	4
XAGE2	X antigen family member 2	0.6223	4
HTRA4	HtrA serine peptidase 4	0.6204	4
TINCR	TINCR ubiquitin domain containing	0.6183	4

Adipocytes	2.2 nTPM
Breast	2.6 nTPM
Adipose tissue	1.8 nTPM

Alveolar cells type 1	17.5 nTPM
Lung	17.5 nTPM

Alveolar cells type 2	10.4 nTPM
Lung	10.4 nTPM

Astrocytes	7.4 nTPM
Brain	7.4 nTPM

B-cells	0.2 nTPM
Adipose tissue	0.8 nTPM
Salivary gland	0.8 nTPM
Thymus	0.6 nTPM
Lymph node	0.4 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM

Ciliated cells	12.1 nTPM
Fallopian tube	17.6 nTPM
Bronchus	16.9 nTPM
Endometrium	7.8 nTPM
Lung	6.0 nTPM

Club cells	16.6 nTPM
Lung	18.1 nTPM
Prostate	16.6 nTPM
Bronchus	15.2 nTPM

Endothelial cells	1.8 nTPM
Prostate	3.8 nTPM
Skeletal muscle	3.4 nTPM
Lung	3.3 nTPM
Tongue	3.2 nTPM
Fallopian tube	2.6 nTPM
Endometrium	2.3 nTPM
Ovary	2.2 nTPM
Skin	1.9 nTPM
Heart muscle	1.4 nTPM
Salivary gland	1.4 nTPM
Thymus	1.4 nTPM
Liver	1.3 nTPM
Testis	1.2 nTPM
Placenta	1.1 nTPM
Esophagus	0.8 nTPM
Vascular	0.7 nTPM
Pancreas	0.0 nTPM
Breast	0.0 nTPM

Enteroendocrine cells	11.1 nTPM
Small intestine	13.7 nTPM
Rectum	10.1 nTPM
Colon	9.5 nTPM

Fibroblasts	13.5 nTPM
Placenta	32.6 nTPM
Pancreas	21.4 nTPM
Fallopian tube	19.3 nTPM
Lung	19.0 nTPM
Stomach	17.3 nTPM
Prostate	15.2 nTPM
Skeletal muscle	13.0 nTPM
Breast	11.2 nTPM
Adipose tissue	11.0 nTPM
Skin	10.8 nTPM
Thymus	10.4 nTPM
Heart muscle	10.3 nTPM
Esophagus	9.5 nTPM
Vascular	8.3 nTPM
Salivary gland	6.3 nTPM
Liver	0.0 nTPM

Granulocytes	1.1 nTPM
Fallopian tube	2.9 nTPM
Lung	0.5 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	17.3 nTPM
Small intestine	26.8 nTPM
Rectum	15.8 nTPM
Colon	9.3 nTPM

Lymphatic endothelial cells	0.6 nTPM
Fallopian tube	1.2 nTPM
Ovary	0.0 nTPM

Macrophages	1.0 nTPM
Endometrium	3.1 nTPM
Tongue	3.1 nTPM
Skin	2.2 nTPM
Vascular	1.6 nTPM
Skeletal muscle	1.5 nTPM
Prostate	1.4 nTPM
Breast	1.3 nTPM
Testis	1.2 nTPM
Spleen	1.0 nTPM
Fallopian tube	1.0 nTPM
Kidney	0.9 nTPM
Salivary gland	0.9 nTPM
Lung	0.3 nTPM
Adipose tissue	0.1 nTPM
Pancreas	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Stomach	0.0 nTPM
Thymus	0.0 nTPM

Paneth cells	14.8 nTPM
Rectum	19.7 nTPM
Colon	14.5 nTPM
Small intestine	10.4 nTPM

Basal keratinocytes	16.5 nTPM
Skin	21.1 nTPM
Tongue	12.0 nTPM

Basal respiratory cells	8.0 nTPM
Bronchus	8.0 nTPM

Basal squamous epithelial cells	14.6 nTPM
Esophagus	14.6 nTPM

Cholangiocytes	7.6 nTPM
Liver	7.6 nTPM

Plasma cells	0.6 nTPM
Salivary gland	2.7 nTPM
Fallopian tube	1.0 nTPM
Thymus	0.7 nTPM
Stomach	0.4 nTPM
Spleen	0.2 nTPM
Liver	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Schwann cells	1.2 nTPM
Vascular	3.7 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	4.7 nTPM
Salivary gland	5.0 nTPM
Tongue	4.4 nTPM

Smooth muscle cells	28.2 nTPM
Fallopian tube	56.5 nTPM
Thymus	50.0 nTPM
Esophagus	45.6 nTPM
Lung	41.1 nTPM
Skin	32.5 nTPM
Skeletal muscle	31.1 nTPM
Vascular	28.8 nTPM
Placenta	27.2 nTPM
Adipose tissue	25.8 nTPM
Breast	24.3 nTPM
Salivary gland	22.5 nTPM
Ovary	21.6 nTPM
Prostate	18.2 nTPM
Endometrium	15.6 nTPM
Tongue	7.8 nTPM
Liver	1.7 nTPM

Suprabasal keratinocytes	20.4 nTPM
Skin	26.3 nTPM
Tongue	14.6 nTPM

T-cells	0.9 nTPM
Endometrium	2.9 nTPM
Tongue	2.1 nTPM
Skin	1.8 nTPM
Breast	1.5 nTPM
Salivary gland	1.3 nTPM
Thymus	1.3 nTPM
Prostate	1.1 nTPM
Colon	1.0 nTPM
Lung	0.8 nTPM
Vascular	0.8 nTPM
Fallopian tube	0.8 nTPM
Bone marrow	0.5 nTPM
PBMC	0.4 nTPM
Skeletal muscle	0.4 nTPM
Liver	0.3 nTPM
Adipose tissue	0.3 nTPM
Lymph node	0.3 nTPM
Spleen	0.3 nTPM
Stomach	0.3 nTPM
Kidney	0.0 nTPM
Esophagus	0.0 nTPM

Undifferentiated cells	11.6 nTPM
Rectum	14.0 nTPM
Small intestine	11.2 nTPM
Colon	9.7 nTPM

Amygdala excitatory	0.2 nTPM
Basal ganglia	0.4 nTPM
Cerebral cortex	0.2 nTPM
Amygdala	0.1 nTPM
Hippocampus	0.1 nTPM
Hypothalamus	0.1 nTPM
Thalamus	0.0 nTPM

Astrocyte	16.2 nTPM
Cerebellum	20.7 nTPM
Midbrain	19.4 nTPM
Pons	18.0 nTPM
Hippocampus	17.1 nTPM
Thalamus	17.1 nTPM
Cerebral cortex	16.4 nTPM
Medulla oblongata	15.5 nTPM
Spinal cord	15.2 nTPM
Amygdala	15.0 nTPM
Basal ganglia	13.2 nTPM
Hypothalamus	10.7 nTPM

Bergmann glia	8.3 nTPM
Cerebellum	9.1 nTPM
Medulla oblongata	8.5 nTPM
Pons	7.2 nTPM

Central nervous system macrophage	0.3 nTPM
Cerebellum	0.5 nTPM
Basal ganglia	0.4 nTPM
Hippocampus	0.4 nTPM
Hypothalamus	0.4 nTPM
Midbrain	0.4 nTPM
Amygdala	0.3 nTPM
Cerebral cortex	0.3 nTPM
Pons	0.3 nTPM
Medulla oblongata	0.1 nTPM
Thalamus	0.1 nTPM
Spinal cord	0.0 nTPM

Cerebellar inhibitory	0.1 nTPM
Midbrain	0.3 nTPM
Cerebellum	0.1 nTPM
Pons	0.1 nTPM
Medulla oblongata	0.0 nTPM
Spinal cord	0.0 nTPM

Cge interneuron	0.1 nTPM
Basal ganglia	0.2 nTPM
Midbrain	0.2 nTPM
Amygdala	0.1 nTPM
Cerebral cortex	0.1 nTPM
Hippocampus	0.1 nTPM
Hypothalamus	0.1 nTPM
Thalamus	0.0 nTPM

Choroid plexus epithelial cell	12.2 nTPM
Basal ganglia	19.9 nTPM
Thalamus	13.7 nTPM
Medulla oblongata	9.8 nTPM
Hippocampus	5.5 nTPM

Committed oligodendrocyte precursor	2.4 nTPM
Medulla oblongata	5.2 nTPM
Cerebral cortex	5.1 nTPM
Basal ganglia	4.4 nTPM
Hippocampus	3.9 nTPM
Midbrain	3.4 nTPM
Pons	1.8 nTPM
Cerebellum	1.6 nTPM
Thalamus	1.4 nTPM
Amygdala	0.0 nTPM
Hypothalamus	0.0 nTPM
Spinal cord	0.0 nTPM

Deep-layer corticothalamic and 6b	0.3 nTPM
Midbrain	1.1 nTPM
Basal ganglia	0.3 nTPM
Amygdala	0.2 nTPM
Cerebral cortex	0.1 nTPM
Hippocampus	0.1 nTPM
Hypothalamus	0.1 nTPM

Deep-layer intratelencephalic	0.1 nTPM
Amygdala	0.2 nTPM
Basal ganglia	0.2 nTPM
Cerebral cortex	0.1 nTPM
Hippocampus	0.1 nTPM
Hypothalamus	0.0 nTPM

Deep-layer near-projecting	0.2 nTPM
Basal ganglia	0.4 nTPM
Hippocampus	0.3 nTPM
Hypothalamus	0.2 nTPM
Cerebral cortex	0.1 nTPM
Amygdala	0.0 nTPM

Eccentric medium spiny neuron	0.1 nTPM
Cerebral cortex	0.2 nTPM
Thalamus	0.2 nTPM
Amygdala	0.1 nTPM
Basal ganglia	0.1 nTPM
Hypothalamus	0.1 nTPM
Hippocampus	0.0 nTPM

Endothelial cell	0.9 nTPM
Pons	2.5 nTPM
Basal ganglia	1.9 nTPM
Thalamus	1.7 nTPM
Cerebral cortex	1.3 nTPM
Hypothalamus	1.2 nTPM
Medulla oblongata	1.0 nTPM
Hippocampus	0.3 nTPM
Amygdala	0.0 nTPM
Cerebellum	0.0 nTPM
Midbrain	0.0 nTPM
Spinal cord	0.0 nTPM