Single cell type - TAC1 - The Human Protein Atlas

TAC1

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Cluster

Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TAC1
Gene descriptionⁱ Full gene name according to HGNC.	Tachykinin precursor 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Neurons - Neuronal signaling (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (Inhibitory neurons, Enteroendocrine cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.88
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Group enriched (MGE interneuron, Mammillary body, Eccentric medium spiny neuron, Medium spiny neuron, LAMP5-LHX6 and Chandelier, Splatter)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data.	Protein predicted to be secreted

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Group enriched (Inhibitory neurons, Enteroendocrine cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Group enriched (MGE interneuron, Mammillary body, Eccentric medium spiny neuron, Medium spiny neuron, LAMP5-LHX6 and Chandelier, Splatter)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

TAC1 is part of cluster 8 Neurons - Neuronal signaling with confidenceⁱ 0.99
265 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
KCNJ6	Potassium inwardly rectifying channel subfamily J member 6	0.6587	8
TRPC4	Transient receptor potential cation channel subfamily C member 4	0.6548	8
SLIT2	Slit guidance ligand 2	0.6527	8
NHS	NHS actin remodeling regulator	0.6302	8
DLGAP1	DLG associated protein 1	0.6279	8
OVCH1	Ovochymase 1	0.6071	8
SETBP1	SET binding protein 1	0.6038	8
ADCY8	Adenylate cyclase 8	0.6006	8
MEPE	Matrix extracellular phosphoglycoprotein	0.5992	8
ABTB3	Ankyrin repeat and BTB domain containing 3	0.5919	8
VWC2	Von Willebrand factor C domain containing 2	0.5914	8
PPARGC1A	PPARG coactivator 1 alpha	0.5859	8
HERC3	HECT and RLD domain containing E3 ubiquitin protein ligase 3	0.5796	8
AKAIN1	A-kinase anchor inhibitor 1	0.5726	8
RAI2	Retinoic acid induced 2	0.5683	37

Adipocytes	0.1 nTPM
Breast	0.3 nTPM
Adipose tissue	0.0 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	0.1 nTPM
Lung	0.1 nTPM

Astrocytes	2.8 nTPM
Brain	2.8 nTPM

B-cells	0.4 nTPM
Kidney	5.2 nTPM
Thymus	0.4 nTPM
Salivary gland	0.1 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM

Ciliated cells	2.4 nTPM
Fallopian tube	8.2 nTPM
Endometrium	1.5 nTPM
Bronchus	0.1 nTPM
Lung	0.0 nTPM

Club cells	0.1 nTPM
Prostate	0.4 nTPM
Bronchus	0.0 nTPM
Lung	0.0 nTPM

Endothelial cells	0.5 nTPM
Skin	3.4 nTPM
Vascular	2.3 nTPM
Fallopian tube	2.1 nTPM
Breast	0.9 nTPM
Thymus	0.2 nTPM
Tongue	0.2 nTPM
Endometrium	0.1 nTPM
Testis	0.0 nTPM
Heart muscle	0.0 nTPM
Liver	0.0 nTPM
Placenta	0.0 nTPM
Pancreas	0.0 nTPM
Skeletal muscle	0.0 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM
Ovary	0.0 nTPM

Enteroendocrine cells	71.0 nTPM
Small intestine	212.9 nTPM
Colon	0.3 nTPM
Rectum	0.0 nTPM

Fibroblasts	20.3 nTPM
Fallopian tube	128.9 nTPM
Vascular	68.2 nTPM
Breast	39.7 nTPM
Prostate	25.1 nTPM
Stomach	23.1 nTPM
Thymus	22.3 nTPM
Skeletal muscle	4.8 nTPM
Skin	4.6 nTPM
Salivary gland	4.4 nTPM
Esophagus	2.9 nTPM
Lung	0.3 nTPM
Adipose tissue	0.2 nTPM
Pancreas	0.1 nTPM
Heart muscle	0.0 nTPM
Liver	0.0 nTPM
Placenta	0.0 nTPM

Granulocytes	0.8 nTPM
Fallopian tube	2.5 nTPM
Lung	0.0 nTPM
Tongue	0.0 nTPM

Intestinal goblet cells	0.3 nTPM
Small intestine	0.7 nTPM
Colon	0.2 nTPM
Rectum	0.0 nTPM

Lymphatic endothelial cells	0.2 nTPM
Fallopian tube	0.3 nTPM
Ovary	0.0 nTPM

Macrophages	0.2 nTPM
Vascular	1.5 nTPM
Kidney	0.9 nTPM
Breast	0.7 nTPM
Endometrium	0.6 nTPM
Salivary gland	0.2 nTPM
Thymus	0.2 nTPM
Fallopian tube	0.1 nTPM
Testis	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Tongue	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Cholangiocytes	5.7 nTPM
Liver	5.7 nTPM

Cone photoreceptor cells	1.7 nTPM
Eye	1.7 nTPM

Excitatory neurons	1.1 nTPM
Brain	1.1 nTPM

Plasma cells	0.2 nTPM
Fallopian tube	1.6 nTPM
Thymus	0.1 nTPM
Liver	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Salivary gland	0.0 nTPM

Schwann cells	0.5 nTPM
Vascular	1.6 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM

Serous glandular cells	1.2 nTPM
Salivary gland	2.4 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	2.0 nTPM
Fallopian tube	17.4 nTPM
Skin	4.1 nTPM
Vascular	3.3 nTPM
Tongue	2.4 nTPM
Skeletal muscle	1.7 nTPM
Breast	1.4 nTPM
Salivary gland	0.5 nTPM
Thymus	0.4 nTPM
Endometrium	0.3 nTPM
Liver	0.0 nTPM
Placenta	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Ovary	0.0 nTPM

T-cells	0.3 nTPM
Skin	2.1 nTPM
Kidney	1.8 nTPM
Fallopian tube	1.3 nTPM
Endometrium	0.6 nTPM
Vascular	0.4 nTPM
Salivary gland	0.2 nTPM
Colon	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Thymus	0.0 nTPM
Tongue	0.0 nTPM
Breast	0.0 nTPM

Undifferentiated cells	0.3 nTPM
Small intestine	0.6 nTPM
Colon	0.3 nTPM
Rectum	0.1 nTPM

Amygdala excitatory	27.0 nTPM
Hypothalamus	76.6 nTPM
Thalamus	28.6 nTPM
Basal ganglia	25.6 nTPM
Amygdala	15.8 nTPM
Cerebral cortex	13.6 nTPM
Hippocampus	1.5 nTPM

Astrocyte	3.9 nTPM
Hypothalamus	11.0 nTPM
Basal ganglia	9.6 nTPM
Medulla oblongata	4.2 nTPM
Midbrain	4.0 nTPM
Cerebral cortex	3.6 nTPM
Spinal cord	3.0 nTPM
Hippocampus	2.1 nTPM
Thalamus	1.9 nTPM
Amygdala	1.7 nTPM
Pons	1.3 nTPM
Cerebellum	0.1 nTPM

Bergmann glia	1.7 nTPM
Pons	2.9 nTPM
Medulla oblongata	2.1 nTPM
Cerebellum	0.1 nTPM

Central nervous system macrophage	5.8 nTPM
Hypothalamus	26.2 nTPM
Cerebral cortex	7.2 nTPM
Basal ganglia	6.3 nTPM
Hippocampus	4.4 nTPM
Midbrain	4.4 nTPM
Medulla oblongata	4.1 nTPM
Spinal cord	3.2 nTPM
Thalamus	3.0 nTPM
Amygdala	2.8 nTPM
Pons	2.0 nTPM
Cerebellum	0.1 nTPM

Cerebellar inhibitory	10.1 nTPM
Midbrain	27.4 nTPM
Pons	14.5 nTPM
Spinal cord	5.5 nTPM
Medulla oblongata	2.2 nTPM
Cerebellum	1.1 nTPM

Cge interneuron	9.3 nTPM
Hippocampus	33.2 nTPM
Basal ganglia	9.4 nTPM
Midbrain	6.2 nTPM
Cerebral cortex	5.9 nTPM
Hypothalamus	4.8 nTPM
Amygdala	3.5 nTPM
Thalamus	2.0 nTPM

Choroid plexus epithelial cell	1.0 nTPM
Medulla oblongata	4.1 nTPM
Basal ganglia	0.0 nTPM
Hippocampus	0.0 nTPM
Thalamus	0.0 nTPM

Committed oligodendrocyte precursor	8.8 nTPM
Basal ganglia	27.9 nTPM
Midbrain	22.7 nTPM
Medulla oblongata	19.4 nTPM
Hypothalamus	17.1 nTPM
Cerebral cortex	3.8 nTPM
Hippocampus	3.1 nTPM
Amygdala	1.7 nTPM
Thalamus	0.7 nTPM
Cerebellum	0.0 nTPM
Pons	0.0 nTPM
Spinal cord	0.0 nTPM

Deep-layer corticothalamic and 6b	4.0 nTPM
Basal ganglia	6.4 nTPM
Midbrain	4.4 nTPM
Hypothalamus	4.3 nTPM
Cerebral cortex	3.7 nTPM
Hippocampus	3.3 nTPM
Amygdala	1.8 nTPM

Deep-layer intratelencephalic	2.1 nTPM
Basal ganglia	3.4 nTPM
Hypothalamus	2.8 nTPM
Amygdala	1.9 nTPM
Cerebral cortex	1.3 nTPM
Hippocampus	1.2 nTPM

Deep-layer near-projecting	2.7 nTPM
Hypothalamus	3.9 nTPM
Hippocampus	3.6 nTPM
Basal ganglia	3.2 nTPM
Cerebral cortex	1.6 nTPM
Amygdala	1.4 nTPM

Eccentric medium spiny neuron	293.8 nTPM
Basal ganglia	524.7 nTPM
Hippocampus	444.4 nTPM
Thalamus	387.4 nTPM
Cerebral cortex	203.7 nTPM
Amygdala	158.7 nTPM
Hypothalamus	44.1 nTPM

Endothelial cell	4.7 nTPM
Hypothalamus	19.9 nTPM
Midbrain	11.3 nTPM
Basal ganglia	7.5 nTPM
Cerebral cortex	2.6 nTPM
Pons	2.5 nTPM
Amygdala	2.2 nTPM
Hippocampus	2.2 nTPM
Spinal cord	1.7 nTPM
Medulla oblongata	1.0 nTPM
Thalamus	0.6 nTPM
Cerebellum	0.0 nTPM

Ependymal cell	4.4 nTPM
Hypothalamus	12.5 nTPM
Basal ganglia	8.4 nTPM
Midbrain	6.3 nTPM
Spinal cord	3.8 nTPM
Hippocampus	2.6 nTPM
Medulla oblongata	2.4 nTPM
Thalamus	2.4 nTPM
Amygdala	0.6 nTPM
Pons	0.4 nTPM