News ArticlesMultiplex tissue image of the month - CLXN in fallopian tubeThe localization of Calaxin (gene: CLXN) in ciliated cells is highlighted in fallopian tube by multiplex immunohistochemistry (mIHC/IF)...Read more Multiplex tissue image of the month - BOLL in testisMeiosis-associated Boule homolog, RNA binding protein (gene: BOLL) is localized to mid-stage developing sperm in testis with multiplex immunohistochemistry (mIHC/IF)...Read more Multiplex tissue image of the month - MIOX in kidneyThe proximal tubule-specific catabolic enzyme myo-inositol oxygenase (gene: MIOX) is highlighted in kidney through multiplex immunohistochemistry (mIHC/IF)...Read more Multiplex tissue image of the month - PRM1 in testisHistone-like protein Protamine 1 (gene: PRM1) is visualized in the late stage cell states of developing sperm in testis with multiplex immunohistochemistry (mIHC/IF)...Read more Highly Multiplexed Imaging of the Kidney to inform Cancer PreventionPreviously, it was believed that the presence of an oncogenic mutation within a cell was sufficient to drive tumour development. However, it is now understood that tissues may contain cells harbouring oncogenic mutations, but that these cells maintain a normal phenotype until an initiating factor promotes oncogenic transformation (Acha-Sagredo et al, 2021). Changes in the cellular milieu and tissue architecture, such as inflammation or parenchymal density, are thought to alter the behaviour of these cells, affecting the likelihood of oncogenic transformation (Ling et al, 2020; Singh et al, 2019). Nonetheless, the precise mechanisms that underlie cancer promotion, and their association with factors such as smoking or obesity, are not fully understood...Read more |