News Articles


Multiplex tissue image of the month - CLXN in fallopian tube

News image of the month Oktober 2024 CLXN merge.PNG

The localization of Calaxin (gene: CLXN) in ciliated cells is highlighted in fallopian tube by multiplex immunohistochemistry (mIHC/IF)...Read more


Multiplex tissue image of the month - BOLL in testis

News image of the month September 2024 BOLL 2.PNG

Meiosis-associated Boule homolog, RNA binding protein (gene: BOLL) is localized to mid-stage developing sperm in testis with multiplex immunohistochemistry (mIHC/IF)...Read more


Multiplex tissue image of the month - MIOX in kidney

News image of the month August 2024 MIOX.PNG

The proximal tubule-specific catabolic enzyme myo-inositol oxygenase (gene: MIOX) is highlighted in kidney through multiplex immunohistochemistry (mIHC/IF)...Read more


Multiplex tissue image of the month - PRM1 in testis

News image of the month July 2024 PRM1 3.PNG

Histone-like protein Protamine 1 (gene: PRM1) is visualized in the late stage cell states of developing sperm in testis with multiplex immunohistochemistry (mIHC/IF)...Read more


Highly Multiplexed Imaging of the Kidney to inform Cancer Prevention

multiplex_kidney_ICC.png

Previously, it was believed that the presence of an oncogenic mutation within a cell was sufficient to drive tumour development. However, it is now understood that tissues may contain cells harbouring oncogenic mutations, but that these cells maintain a normal phenotype until an initiating factor promotes oncogenic transformation (Acha-Sagredo et al, 2021). Changes in the cellular milieu and tissue architecture, such as inflammation or parenchymal density, are thought to alter the behaviour of these cells, affecting the likelihood of oncogenic transformation (Ling et al, 2020; Singh et al, 2019). Nonetheless, the precise mechanisms that underlie cancer promotion, and their association with factors such as smoking or obesity, are not fully understood...Read more