Transcription factor landscape - Immune cell - monocytes

Transcriptome analysis shows that 48% (n=9616) of all human proteins (n=20162) are detected in monocytes and 620 of these genes show an elevated expression in any monocytes compared to other cell type groups. Learn more about genes with elevated expression here.

In-depth analysis of transcription factor genes expressed in monocytes highlights 39 transcription factors with elevated expression in monocytes compared to other immune lineages. In total, 9 transcription factors are classified as enriched in monocytes.

Here we provide the expression overview of all transcription factors that show enriched expression levels in monocytes compared to other cell types. The gene expression overview, across different cell types is accopanied by the top 3 nearest neighbours based on single cell RNA expression and correlation in the clustering analysis.

Enriched transcription factors
Gene Expression Expression clustering
MAFB
Lineage enriched (Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
KNSTRN Kinetochore localized astrin (SPAG5) binding protein 1.0000 40
KCNMA1 Potassium calcium-activated channel subfamily M alpha 1 1.0000 40
SLC5A10 Solute carrier family 5 member 10 1.0000 40
NR4A1
Lineage enriched (Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
KNSTRN Kinetochore localized astrin (SPAG5) binding protein 1.0000 40
KCNMA1 Potassium calcium-activated channel subfamily M alpha 1 1.0000 40
SLC5A10 Solute carrier family 5 member 10 1.0000 40
PLAGL2
Lineage enriched (Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
POFUT1 Protein O-fucosyltransferase 1 1.0000 40
INSIG1 Insulin induced gene 1 1.0000 40
CABP4 Calcium binding protein 4 1.0000 40
TCF7L2
Lineage enriched (Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
CEACAM8 CEA cell adhesion molecule 8 1.0000 37
RIN1 Ras and Rab interactor 1 1.0000 37
SPRED1 Sprouty related EVH1 domain containing 1 1.0000 37
SPIC
Lineage enriched (Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
KNSTRN Kinetochore localized astrin (SPAG5) binding protein 1.0000 40
KCNMA1 Potassium calcium-activated channel subfamily M alpha 1 1.0000 40
SLC5A10 Solute carrier family 5 member 10 1.0000 40
KLF1
Lineage enriched (Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
KNSTRN Kinetochore localized astrin (SPAG5) binding protein 1.0000 40
KCNMA1 Potassium calcium-activated channel subfamily M alpha 1 1.0000 40
SLC5A10 Solute carrier family 5 member 10 1.0000 40
THAP10
Lineage enriched (Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
LILRA5 Leukocyte immunoglobulin like receptor A5 1.0000 40
WBP1L WW domain binding protein 1 like 1.0000 40
RNF144B Ring finger protein 144B 1.0000 40
EGR2
Lineage enriched (Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
CALHM6 Calcium homeostasis modulator family member 6 1.0000 40
MTSS1 MTSS I-BAR domain containing 1 1.0000 40
RASL11A RAS like family 11 member A 1.0000 40
SOX15
Lineage enriched (Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
ATF3 Activating transcription factor 3 1.0000 37
EFNB1 Ephrin B1 1.0000 37
FGFRL1 Fibroblast growth factor receptor like 1 1.0000 37

Enriched transcription factors
Gene Expression Expression clustering
MYCL
Group enriched (Dendritic cells, Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
SPOCK3 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3 1.0000 2
COMT Catechol-O-methyltransferase 1.0000 2
MAN2B1 Mannosidase alpha class 2B member 1 1.0000 2
BATF3
Group enriched (Dendritic cells, Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
FZD1 Frizzled class receptor 1 1.0000 40
RIOK3 RIO kinase 3 1.0000 40
NHSL1 NHS like 1 1.0000 40
TFEC
Group enriched (B-cells, Dendritic cells, Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
CRIP3 Cysteine rich protein 3 1.0000 2
GPR33 G protein-coupled receptor 33 0.9762 2
PKIB CAMP-dependent protein kinase inhibitor beta 0.9762 2
CEBPA
Group enriched (Dendritic cells, Granulocytes, Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
DRAM1 DNA damage regulated autophagy modulator 1 1.0000 40
SPA17 Sperm autoantigenic protein 17 0.9762 10
SEZ6L Seizure related 6 homolog like 0.9762 40
CEBPB
Group enriched (Granulocytes, Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
NPHP3-ACAD11 NPHP3-ACAD11 readthrough (NMD candidate) 1.0000 45
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2 1.0000 45
LPCAT2 Lysophosphatidylcholine acyltransferase 2 1.0000 45
IRF5
Group enriched (B-cells, Dendritic cells, Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
STAC3 SH3 and cysteine rich domain 3 1.0000 38
AIFM3 Apoptosis inducing factor mitochondria associated 3 1.0000 38
FGD6 FYVE, RhoGEF and PH domain containing 6 1.0000 38
VDR
Group enriched (Dendritic cells, Granulocytes, Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
STX12 Syntaxin 12 1.0000 40
RYR1 Ryanodine receptor 1 1.0000 40
PRR16 Proline rich 16 1.0000 40
ZNF687
Group enriched (Granulocytes, Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 1.0000 7
TMLHE Trimethyllysine hydroxylase, epsilon 0.9762 7
CDC123 Cell division cycle 123 0.9762 7
ATF5
Group enriched (Dendritic cells, Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
MFSD2A Major facilitator superfamily domain containing 2A 1.0000 2
LHFPL6 LHFPL tetraspan subfamily member 6 0.9762 2
MGST2 Microsomal glutathione S-transferase 2 0.9762 2
BCL6
Group enriched (Granulocytes, Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
IL1B Interleukin 1 beta 1.0000 28
H2BC15 H2B clustered histone 15 1.0000 28
MX2 MX dynamin like GTPase 2 1.0000 28
EGR1
Group enriched (Granulocytes, Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
STAT6 Signal transducer and activator of transcription 6 1.0000 38
SBF2 SET binding factor 2 1.0000 38
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.9762 38
ETS2
Group enriched (Dendritic cells, Granulocytes, Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
MTF1 Metal regulatory transcription factor 1 1.0000 38
FTH1 Ferritin heavy chain 1 1.0000 38
NPTN Neuroplastin 1.0000 38
VENTX
Group enriched (Dendritic cells, Granulocytes, Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
MARCO Macrophage receptor with collagenous structure 1.0000 40
TCN2 Transcobalamin 2 1.0000 40
TMEM255B Transmembrane protein 255B 1.0000 40
BATF2
Group enriched (Granulocytes, Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
CERT1 Ceramide transporter 1 1.0000 37
GPCPD1 Glycerophosphocholine phosphodiesterase 1 1.0000 37
MFN2 Mitofusin 2 1.0000 37
MITF
Group enriched (Dendritic cells, Granulocytes, Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
GPR162 G protein-coupled receptor 162 0.9762 38
RNF130 Ring finger protein 130 0.9762 38
RPN1 Ribophorin I 0.9762 38
NR1D1
Group enriched (Monocytes, T-cells)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
PAM Peptidylglycine alpha-amidating monooxygenase 0.9762 1
KLHL25 Kelch like family member 25 0.9762 1
GPR137C G protein-coupled receptor 137C 0.9762 1
ZNF710
Group enriched (Dendritic cells, Granulocytes, Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
CMTM6 CKLF like MARVEL transmembrane domain containing 6 0.9762 37
GNGT2 G protein subunit gamma transducin 2 0.9762 37
CALM2 Calmodulin 2 0.9762 37
CEBPD
Group enriched (Granulocytes, Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
ENSG00000285938 BCL6 antisense 1 1.0000 21
NBPF26 NBPF member 26 1.0000 21
PPP1R12B Protein phosphatase 1 regulatory subunit 12B 1.0000 21
JDP2
Group enriched (B-cells, Granulocytes, Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
CALHM6 Calcium homeostasis modulator family member 6 1.0000 40
MTSS1 MTSS I-BAR domain containing 1 1.0000 40
RASL11A RAS like family 11 member A 1.0000 40
JUNB
Group enriched (Granulocytes, Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
LILRA2 Leukocyte immunoglobulin like receptor A2 1.0000 37
MAPRE3 Microtubule associated protein RP/EB family member 3 1.0000 37
TLR1 Toll like receptor 1 1.0000 37
MEF2C
Group enriched (B-cells, Dendritic cells, Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
OLFML1 Olfactomedin like 1 1.0000 23
RUBCNL Rubicon like autophagy enhancer 1.0000 23
UVRAG UV radiation resistance associated 0.9762 23
NFKBIZ
Group enriched (Granulocytes, Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
PECAM1 Platelet and endothelial cell adhesion molecule 1 1.0000 37
MCTP1 Multiple C2 and transmembrane domain containing 1 1.0000 37
PILRA Paired immunoglobin like type 2 receptor alpha 1.0000 37
RXRA
Group enriched (Granulocytes, Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
STX11 Syntaxin 11 1.0000 37
SERPINA2 Serpin family A member 2 (gene/pseudogene) 1.0000 37
PLEKHO2 Pleckstrin homology domain containing O2 1.0000 37
SMAD1
Group enriched (Granulocytes, Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
ISG20L2 Interferon stimulated exonuclease gene 20 like 2 1.0000 42
ZSWIM8 Zinc finger SWIM-type containing 8 1.0000 42
VPS39 VPS39 subunit of HOPS complex 1.0000 42
SOX4
Group enriched (Dendritic cells, Granulocytes, Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
RC3H2 Ring finger and CCCH-type domains 2 1.0000 10
ATAT1 Alpha tubulin acetyltransferase 1 1.0000 10
RFT1 RFT1 homolog 1.0000 10
BACH1
Group enriched (Granulocytes, Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
GGT1 Gamma-glutamyltransferase 1 1.0000 28
ACSL4 Acyl-CoA synthetase long chain family member 4 0.9762 28
RAB7A RAB7A, member RAS oncogene family 0.9762 28
ETV7
Group enriched (Granulocytes, Monocytes, T-cells)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
TNFRSF9 TNF receptor superfamily member 9 0.9762 33
GPR19 G protein-coupled receptor 19 0.9762 33
TAB2 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 0.9524 33
LYL1
Group enriched (B-cells, Granulocytes, Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
SLC29A1 Solute carrier family 29 member 1 (Augustine blood group) 1.0000 45
NBPF1 NBPF member 1 1.0000 45
GTF2E2 General transcription factor IIE subunit 2 1.0000 45
TFE3
Group enriched (Granulocytes, Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
SLC31A2 Solute carrier family 31 member 2 1.0000 37
SERPINA2 Serpin family A member 2 (gene/pseudogene) 1.0000 37
PLEKHO2 Pleckstrin homology domain containing O2 1.0000 37
ZXDC
Group enriched (Dendritic cells, Granulocytes, Monocytes)
3 nearest neighbours based on single cell RNA expression
Neighbouri Descriptioni Correlationi Clusteri
BICD2 BICD cargo adaptor 2 0.9762 7
TMLHE Trimethyllysine hydroxylase, epsilon 0.9524 7
LIMK1 LIM domain kinase 1 0.9524 7