Protein detected in human plasma by mass spectrometry

In this chapter the estimated concentrations of proteins detected in human plasma based on mass spectrometry-based proteomics is presented. Protein concentrations were quantified by mass spectrometry-based plasma proteomics and estimated from spectral counts in the publicly available Peptide Atlas build (Human Plasma 2023-04). This data set contains estimated concentrations for 4294 proteins, including both proteins that are actively secreted to plasma, but also locally secreted proteins and intracellular proteins that leak into the blood stream.

Figure 1. The plot shows the concentration rank for each protein in relation to the 4294 proteins in the Peptide Atlas plasma build (x-axis) as well as estimated concentration on an absolute scale (left y-axis) with some reference proteins denoted. The bars are coloured according to location and by using mouse-over, the concentration and category for all individual proteins are displayed.The most abundant proteins in blood - for example Albumin (40 g/l) - are not shown since they have been depleted in most samples.

Table 1. A list of the proteins detected in blood by mass spectrometry.

Gene Gene description Concentration
CP Ceruloplasmin 370 mg/L
A2M Alpha-2-macroglobulin 270 mg/L
IGHG2 Immunoglobulin heavy constant gamma 2 (G2m marker) 260 mg/L
HPX Hemopexin 230 mg/L
C3 Complement C3 220 mg/L
IGHG1 Immunoglobulin heavy constant gamma 1 (G1m marker) 220 mg/L
APOB Apolipoprotein B 210 mg/L
C4B Complement C4B (Chido blood group) 200 mg/L
C4A Complement C4A (Rodgers blood group) 200 mg/L
SERPINA1 Serpin family A member 1 180 mg/L
IGHG4 Immunoglobulin heavy constant gamma 4 (G4m marker) 170 mg/L
FGA Fibrinogen alpha chain 160 mg/L
GSN Gelsolin 150 mg/L
CFH Complement factor H 130 mg/L
TF Transferrin 130 mg/L
APOA1 Apolipoprotein A1 130 mg/L
FGB Fibrinogen beta chain 130 mg/L
SERPINA3 Serpin family A member 3 130 mg/L
HP Haptoglobin 130 mg/L
RBP4 Retinol binding protein 4 120 mg/L
SERPINC1 Serpin family C member 1 110 mg/L
AHSG Alpha 2-HS glycoprotein 110 mg/L
GC GC vitamin D binding protein 110 mg/L
CFB Complement factor B 110 mg/L
IGHA1 Immunoglobulin heavy constant alpha 1 96 mg/L
ITIH1 Inter-alpha-trypsin inhibitor heavy chain 1 95 mg/L
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