Human Blood Resource - L3HYPDH - The Human Protein Atlas

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SUMMARY

TISSUE

BRAIN

SINGLE CELL

SUBCELL

CANCER

BLOOD

CELL LINE

STRUCTURE

INTERACTION

L3HYPDH

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	L3HYPDH
Gene descriptionⁱ Full gene name according to HGNC.	Trans-L-3-hydroxyproline dehydratase
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular

HUMAN PROTEIN ATLAS INFORMATION
Upregulated in disease (PEA)ⁱ A gene is classified as upregulated in a disease if the average concentration of all samples of that disease is significantly higher (adj P-value<0.005 and NPX difference>=1) than the average concentration of samples of all diseases as measured by PEA . For gender specific diseases the analysis includes only samples corresponding to the same gender from the other diseases.	Not analyzed
Blood-based immunoassayⁱ The blood-based immunoassay category applies to actively secreted proteins and is based on plasma or serum protein concentrations established with enzyme-linked immunosorbent assays, compiled from a literature search. The categories include: detected and not detected, where detection refers to a concentration found in the literature search.	Not analysed since only proteins predicted to be actively secreted to blood is analysed here
Mass spectrometryⁱ Detection or not of the gene in blood, based on spectral count estimations from a publicly available mass spectrometry-based plasma proteomics dataset obtained from the PeptideAtlas. Read more	Detected
Proximity extension assayⁱ Indicates whether the protein has been measured (Data available) or not (Not available) using the Olink Explore HT proximity extension assay platform. Read more	Data available
SomaScanⁱ Indicates whether the protein has been measured (Data available) or not (Not available) using the SomaScan 11K platform. Read more	Data available

ASSAYS

PAN-DISEASE EXTENDED BLOOD PROTEIN PROFILES (OLINK HT)ⁱ Blood protein levels across diseases and healthy individuals, profiled using the proximity extension assay (PEA) with the Olink Explore HT.
Olink HT (OID44737) All Male Female 2457 samples across 32 cohorts. 0% below LOD. 1073 male samples across 27 cohorts. 0% below LOD. 1375 female samples across 30 cohorts. 0% below LOD. Class Median Alphabetical Show points Hide points

PAN-DISEASE BLOOD PROTEIN PROFILES (SOMASCAN)ⁱ Blood protein levels across diseases and healthy individuals, profiled using SomaScan.
SOMAmer (23380-16) All Male Female 2356 samples across 32 cohorts. 0% below LOD. 1020 male samples across 27 cohorts. 0% below LOD. 1328 female samples across 30 cohorts. 0% below LOD. Class Median Alphabetical Show points Hide points

THE EFFECT OF AGE, BMI AND SEX ON BLOOD PROTEIN LEVELSⁱ Blood protein levels by age, BMI, and sex, measured using the proximity extension assay (PEA) with the Olink Explore 1536. In the age and sex scatterplots, samples are colored by disease class.

Olink HT (OID44737) SOMAmer (23380-16)

THE BLOOD PROTEIN CONCENTRATION ACCORDING TO MASS SPECTROMETRYⁱ The protein concentration in blood is quantified by mass spectrometry-based plasma proteomics and estimated from spectral counts in a publicly available data set obtained from the PeptideAtlas.
Detected in plasma by mass spectrometry 28 ng/L, PeptideAtlas

LONGITUDINAL ANALYSIS OF BLOOD PROTEIN LEVELS AT AGES 4, 8, 16 AND 24ⁱ Longitudinal blood protein levels in healthy individuals measured at ages 4, 8, 16, and 24 years, shown separately for males and females. Relative protein abundances were quantified using the proximity extension assay (PEA) with the Olink Explore HT.

Olink HT (OID44737) SOMAmer (23380-16) All Above LOD Age All Above LOD Age

LONGITUDINAL ANALYSIS OF BLOOD PROTEIN LEVELS DURING TWO YEARS AT OVER 50 YEAR IN AGEⁱ Blood protein levels in 96 healthy adults (aged 50–65) measured at six visits over a two-year period, shown separately for males and females. Relative protein abundances were quantified using the proximity extension assay (PEA) with the Olink Explore HT.

Olink HT (OID44737) All Above LOD Visit

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.

contact@proteinatlas.org