Human Blood Resource - IL1RAP - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

SUMMARY

TISSUE

BRAIN

SINGLE CELL

SUBCELL

CANCER

BLOOD

CELL LINE

STRUCTURE

INTERACTION

IL1RAP

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	IL1RAP
Gene descriptionⁱ Full gene name according to HGNC.	Interleukin 1 receptor accessory protein
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Secreted, Membrane, Intracellular

HUMAN PROTEIN ATLAS INFORMATION
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Secreted to blood
Secretome annotation comment	Secreted form from proteolytic cleavage or shedding
Secretome functionⁱ All genes belonging to the secretome have been classified according to function based on Uniprot molecular function and biological processes keywords. The functional annotations are prioritized according to the following hierarchy: Blood coagulation, Complement pathway, Acute phase, Cytokine, Hormone, Neuropeptide, Growth factor, Receptor, Transport, Developmental protein, Defence, Enzyme, Enzyme inhibitor, Transcription, Immunity, Cell adhesion, Other and each gene is assigned a single function.	Receptor
Upregulated in disease (PEA)ⁱ A gene is classified as upregulated in a disease if the average concentration of all samples of that disease is significantly higher (adj P-value<0.005 and NPX difference>=1) than the average concentration of samples of all diseases as measured by PEA . For gender specific diseases the analysis includes only samples corresponding to the same gender from the other diseases.	No
Blood-based immunoassayⁱ The blood-based immunoassay category applies to actively secreted proteins and is based on plasma or serum protein concentrations established with enzyme-linked immunosorbent assays, compiled from a literature search. The categories include: detected and not detected, where detection refers to a concentration found in the literature search.	Not detected
Mass spectrometryⁱ Detection or not of the gene in blood, based on spectral count estimations from a publicly available mass spectrometry-based plasma proteomics dataset obtained from the PeptideAtlas. Read more	Detected
Proximity extension assayⁱ Indicates whether the protein has been measured (Data available) or not (Not available) using the Olink Explore HT proximity extension assay platform. Read more	Data available
SomaScanⁱ Indicates whether the protein has been measured (Data available) or not (Not available) using the SomaScan 11K platform. Read more	Data available
Targeted mass spectrometryⁱ Indicates whether the protein has dected or not using Discovery Edge 175 (ProteomEdge AB, Sweden) and targeted Mass Spectrometry readout on an LC-MS/MS (Evosep One – Thermo Scientific Stellar) at 40 Samples Per Day (SPD). Read more	Detected

ASSAYS

PAN-DISEASE BLOOD PROTEIN PROFILES (OLINK 1536)ⁱ Blood protein levels across diseases and healthy individuals, profiled using the proximity extension assay (PEA) with the Olink Explore 1536.
Olink 1536 (OID21126) All Male Female 6073 samples across 60 cohorts. 0% below LOD. 2820 male samples across 48 cohorts. 0% below LOD. 3173 female samples across 50 cohorts. 0% below LOD. Class Median Alphabetical Show points Hide points

PAN-DISEASE EXTENDED BLOOD PROTEIN PROFILES (OLINK HT)ⁱ Blood protein levels across diseases and healthy individuals, profiled using the proximity extension assay (PEA) with the Olink Explore HT.
Olink HT (OID45157) All Male Female 2450 samples across 32 cohorts. 0% below LOD. 1069 male samples across 27 cohorts. 0% below LOD. 1372 female samples across 30 cohorts. 0% below LOD. Class Median Alphabetical Show points Hide points

PAN-DISEASE BLOOD PROTEIN PROFILES (SOMASCAN)ⁱ

SOMAmer (14048-7)

SOMAmer (2630-12)

All

Male

Female

2356 samples across 32 cohorts.
0% below LOD.

1020 male samples across 27 cohorts.
0% below LOD.

1328 female samples across 30 cohorts.
0% below LOD.

Class

Median

Alphabetical

Show points

Hide points

PROTEIN CONCENTRATIONS IN THE PAN-CANCER COHORTⁱ Plasma concentrations of proteins in blood from patients having different types of cancer measured by quantitative mass spectrometry (MS) using isotope dilution strategies based on the addition of recombinant protein fragment standards.

THE EFFECT OF AGE, BMI AND SEX ON BLOOD PROTEIN LEVELSⁱ Blood protein levels by age, BMI, and sex, measured using the proximity extension assay (PEA) with the Olink Explore 1536. In the age and sex scatterplots, samples are colored by disease class.

Olink 1536 (OID21126) Olink HT (OID45157) SOMAmer (14048-7) SOMAmer (2630-12)

THE BLOOD PROTEIN CONCENTRATION ACCORDING TO MASS SPECTROMETRYⁱ The protein concentration in blood is quantified by mass spectrometry-based plasma proteomics and estimated from spectral counts in a publicly available data set obtained from the PeptideAtlas.
Detected in plasma by mass spectrometry 130 µg/L, PeptideAtlas

LONGITUDINAL ANALYSIS OF BLOOD PROTEIN LEVELS AT AGES 4, 8, 16 AND 24ⁱ Longitudinal blood protein levels in healthy individuals measured at ages 4, 8, 16, and 24 years, shown separately for males and females. Relative protein abundances were quantified using the proximity extension assay (PEA) with the Olink Explore HT.

Olink HT (OID45157) SOMAmer (14048-7) SOMAmer (2630-12) All Above LOD Age All Above LOD Age All Above LOD Age

LONGITUDINAL ANALYSIS OF BLOOD PROTEIN LEVELS DURING TWO YEARS AT OVER 50 YEAR IN AGEⁱ Blood protein levels in 96 healthy adults (aged 50–65) measured at six visits over a two-year period, shown separately for males and females. Relative protein abundances were quantified using the proximity extension assay (PEA) with the Olink Explore HT.

Olink HT (OID45157) All Above LOD Visit

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.

contact@proteinatlas.org