Single cell type - ORAI1 - The Human Protein Atlas

ORAI1

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ORAI1
Gene descriptionⁱ Full gene name according to HGNC.	ORAI calcium release-activated calcium modulator 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	NK-cells & T-cells - Immune system & Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (NK-cells, Langerhans cells, T-cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.49
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Leukocyte, Endothelial cell, Choroid plexus epithelial cell)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (NK-cells, Langerhans cells, T-cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Leukocyte, Endothelial cell, Choroid plexus epithelial cell)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ORAI1 is part of cluster 78 NK-cells & T-cells - Immune system & Transcription with confidenceⁱ 1
392 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CASP8	Caspase 8	0.6709	78
CEMIP2	Cell migration inducing hyaluronidase 2	0.6250	78
PPP2R5C	Protein phosphatase 2 regulatory subunit B'gamma	0.6201	78
RNF125	Ring finger protein 125	0.6174	78
RUNX3	RUNX family transcription factor 3	0.6037	78
ETS1	ETS proto-oncogene 1, transcription factor	0.6007	78
GZMK	Granzyme K	0.5926	78
ABHD17A	Abhydrolase domain containing 17A, depalmitoylase	0.5845	19
MYBL1	MYB proto-oncogene like 1	0.5795	78
CNOT6L	CCR4-NOT transcription complex subunit 6 like	0.5748	78
SLFN12L	Schlafen family member 12 like	0.5733	19
ZNF831	Zinc finger protein 831	0.5731	78
CRTAM	Cytotoxic and regulatory T cell molecule	0.5604	78
CD226	CD226 molecule	0.5585	78
FYN	FYN proto-oncogene, Src family tyrosine kinase	0.5538	78

IMMUNE CELLS

ORAI1 is part of cluster 27 T-cells - Unknown function with confidenceⁱ 0.82
41 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZSCAN25	Zinc finger and SCAN domain containing 25	0.9762	11
MPHOSPH10	M-phase phosphoprotein 10	0.9524	3
TC2N	Tandem C2 domains, nuclear	0.9524	27
ARHGEF3	Rho guanine nucleotide exchange factor 3	0.9524	27
FBXO32	F-box protein 32	0.9524	27
TTC39B	Tetratricopeptide repeat domain 39B	0.9524	27
SCOC	Short coiled-coil protein	0.9524	3
TMEM123	Transmembrane protein 123	0.9524	11
RAB11FIP5	RAB11 family interacting protein 5	0.9524	27
TRIM47	Tripartite motif containing 47	0.9524	27
CACNA2D2	Calcium voltage-gated channel auxiliary subunit alpha2delta 2	0.9524	11
CISH	Cytokine inducible SH2 containing protein	0.9524	11
RASGRF2	Ras protein specific guanine nucleotide releasing factor 2	0.9524	27
TMEM106B	Transmembrane protein 106B	0.9524	27
ITGAE	Integrin subunit alpha E	0.9524	27

Adipocytes	32.6 nTPM
Breast	45.3 nTPM
Adipose tissue	20.0 nTPM

Alveolar cells type 1	28.3 nTPM
Lung	28.3 nTPM

Alveolar cells type 2	30.6 nTPM
Lung	30.6 nTPM

Astrocytes	0.9 nTPM
Brain	0.9 nTPM

B-cells	48.9 nTPM
Thymus	111.5 nTPM
Adipose tissue	109.1 nTPM
Lung	72.4 nTPM
Salivary gland	63.3 nTPM
Skin	57.6 nTPM
PBMC	49.3 nTPM
Liver	43.5 nTPM
Stomach	32.5 nTPM
Kidney	26.0 nTPM
Spleen	23.3 nTPM
Bone marrow	18.8 nTPM
Lymph node	16.4 nTPM
Esophagus	11.8 nTPM

Ciliated cells	16.9 nTPM
Lung	34.8 nTPM
Endometrium	16.2 nTPM
Fallopian tube	13.0 nTPM
Bronchus	3.8 nTPM

Club cells	15.8 nTPM
Lung	32.1 nTPM
Prostate	12.4 nTPM
Bronchus	2.8 nTPM

Dendritic cells	12.9 nTPM
PBMC	14.4 nTPM
Adipose tissue	11.4 nTPM

Endothelial cells	43.0 nTPM
Testis	85.5 nTPM
Fallopian tube	62.1 nTPM
Lung	59.3 nTPM
Thymus	59.3 nTPM
Tongue	49.4 nTPM
Vascular	49.2 nTPM
Liver	49.1 nTPM
Endometrium	49.0 nTPM
Salivary gland	41.6 nTPM
Placenta	41.4 nTPM
Skin	41.2 nTPM
Ovary	40.6 nTPM
Esophagus	38.8 nTPM
Prostate	37.3 nTPM
Skeletal muscle	24.5 nTPM
Pancreas	20.7 nTPM
Breast	19.3 nTPM
Heart muscle	5.0 nTPM

Enteroendocrine cells	10.0 nTPM
Colon	16.4 nTPM
Small intestine	10.3 nTPM
Rectum	3.4 nTPM

Fibroblasts	12.6 nTPM
Liver	51.0 nTPM
Breast	18.0 nTPM
Pancreas	16.7 nTPM
Thymus	16.5 nTPM
Lung	15.5 nTPM
Prostate	15.2 nTPM
Vascular	11.8 nTPM
Salivary gland	10.4 nTPM
Fallopian tube	9.8 nTPM
Adipose tissue	8.4 nTPM
Skin	7.1 nTPM
Stomach	5.8 nTPM
Placenta	5.6 nTPM
Skeletal muscle	5.3 nTPM
Esophagus	4.2 nTPM
Heart muscle	0.3 nTPM

Granulocytes	26.3 nTPM
Lung	31.8 nTPM
Tongue	29.1 nTPM
Fallopian tube	17.9 nTPM

Intestinal goblet cells	9.5 nTPM
Rectum	10.7 nTPM
Colon	10.3 nTPM
Small intestine	7.6 nTPM

Lymphatic endothelial cells	6.9 nTPM
Fallopian tube	13.9 nTPM
Ovary	0.0 nTPM

Macrophages	33.2 nTPM
Lung	74.8 nTPM
Skin	43.5 nTPM
Prostate	40.7 nTPM
Thymus	39.7 nTPM
Breast	39.4 nTPM
Skeletal muscle	36.1 nTPM
Salivary gland	34.0 nTPM
Adipose tissue	32.2 nTPM
Kidney	31.9 nTPM
Tongue	31.3 nTPM
Pancreas	30.8 nTPM
Vascular	30.8 nTPM
Spleen	29.1 nTPM
Endometrium	27.7 nTPM
Testis	27.3 nTPM
Fallopian tube	27.2 nTPM
Bone marrow	25.3 nTPM
Stomach	15.4 nTPM
Esophagus	12.8 nTPM

Basal keratinocytes	20.1 nTPM
Tongue	25.1 nTPM
Skin	15.1 nTPM

Basal prostatic cells	26.4 nTPM
Prostate	26.4 nTPM

Basal respiratory cells	2.9 nTPM
Bronchus	2.9 nTPM

Bipolar cells	3.2 nTPM
Eye	3.2 nTPM

Paneth cells	6.8 nTPM
Rectum	9.7 nTPM
Colon	7.2 nTPM
Small intestine	3.5 nTPM

Plasma cells	15.3 nTPM
Bone marrow	30.2 nTPM
Thymus	21.2 nTPM
Liver	21.0 nTPM
Salivary gland	15.7 nTPM
Spleen	15.4 nTPM
Stomach	10.9 nTPM
Fallopian tube	8.0 nTPM
Esophagus	0.0 nTPM

Schwann cells	28.6 nTPM
Vascular	47.5 nTPM
Adipose tissue	26.2 nTPM
Esophagus	12.0 nTPM

Serous glandular cells	22.6 nTPM
Salivary gland	36.4 nTPM
Tongue	8.8 nTPM

Smooth muscle cells	11.3 nTPM
Liver	45.8 nTPM
Prostate	14.6 nTPM
Salivary gland	12.5 nTPM
Tongue	12.0 nTPM
Thymus	11.9 nTPM
Placenta	11.7 nTPM
Breast	11.2 nTPM
Endometrium	9.7 nTPM
Lung	9.4 nTPM
Skeletal muscle	9.3 nTPM
Fallopian tube	9.3 nTPM
Vascular	7.1 nTPM
Ovary	7.1 nTPM
Esophagus	3.6 nTPM
Adipose tissue	2.9 nTPM
Skin	2.4 nTPM

Suprabasal keratinocytes	23.0 nTPM
Skin	35.3 nTPM
Tongue	10.7 nTPM

T-cells	70.6 nTPM
Adipose tissue	193.2 nTPM
Breast	104.9 nTPM
Lung	103.3 nTPM
Fallopian tube	99.1 nTPM
Skeletal muscle	85.8 nTPM
Kidney	78.0 nTPM
Thymus	76.7 nTPM
Tongue	73.3 nTPM
Vascular	72.8 nTPM
PBMC	67.7 nTPM
Prostate	66.4 nTPM
Skin	61.7 nTPM
Spleen	59.8 nTPM
Bone marrow	57.3 nTPM
Colon	48.7 nTPM
Stomach	48.1 nTPM
Salivary gland	44.8 nTPM
Liver	41.9 nTPM
Endometrium	40.7 nTPM
Esophagus	36.5 nTPM
Lymph node	22.1 nTPM

Undifferentiated cells	21.3 nTPM
Colon	23.4 nTPM
Small intestine	22.4 nTPM
Rectum	18.1 nTPM

Amygdala excitatory	0.6 nTPM
Thalamus	1.8 nTPM
Basal ganglia	0.4 nTPM
Amygdala	0.3 nTPM
Cerebral cortex	0.3 nTPM
Hippocampus	0.3 nTPM
Hypothalamus	0.2 nTPM

Astrocyte	1.8 nTPM
Cerebral cortex	2.9 nTPM
Basal ganglia	2.7 nTPM
Hippocampus	2.2 nTPM
Amygdala	2.1 nTPM
Midbrain	2.0 nTPM
Thalamus	1.8 nTPM
Medulla oblongata	1.5 nTPM
Pons	1.5 nTPM
Hypothalamus	1.4 nTPM
Cerebellum	1.3 nTPM
Spinal cord	1.0 nTPM

Bergmann glia	2.1 nTPM
Cerebellum	2.8 nTPM
Medulla oblongata	2.1 nTPM
Pons	1.4 nTPM

Central nervous system macrophage	8.7 nTPM
Pons	11.0 nTPM
Basal ganglia	10.0 nTPM
Spinal cord	10.0 nTPM
Medulla oblongata	9.5 nTPM
Midbrain	9.4 nTPM
Cerebral cortex	8.8 nTPM
Hippocampus	8.6 nTPM
Thalamus	8.4 nTPM
Cerebellum	7.7 nTPM
Amygdala	6.6 nTPM
Hypothalamus	6.1 nTPM

Cerebellar inhibitory	0.2 nTPM
Midbrain	0.3 nTPM
Cerebellum	0.2 nTPM
Medulla oblongata	0.2 nTPM
Pons	0.1 nTPM
Spinal cord	0.0 nTPM

Cge interneuron	1.8 nTPM
Basal ganglia	2.6 nTPM
Amygdala	1.9 nTPM
Hippocampus	1.7 nTPM
Thalamus	1.7 nTPM
Midbrain	1.6 nTPM
Cerebral cortex	1.4 nTPM
Hypothalamus	1.4 nTPM

Choroid plexus epithelial cell	18.1 nTPM
Thalamus	30.1 nTPM
Medulla oblongata	15.5 nTPM
Hippocampus	13.9 nTPM
Basal ganglia	12.8 nTPM

Committed oligodendrocyte precursor	5.1 nTPM
Medulla oblongata	15.5 nTPM
Pons	8.0 nTPM
Amygdala	7.9 nTPM
Midbrain	5.0 nTPM
Hippocampus	3.9 nTPM
Spinal cord	3.7 nTPM
Basal ganglia	3.3 nTPM
Thalamus	3.2 nTPM
Hypothalamus	2.0 nTPM
Cerebral cortex	1.9 nTPM
Cerebellum	1.6 nTPM

Deep-layer corticothalamic and 6b	0.6 nTPM
Midbrain	1.1 nTPM
Basal ganglia	0.6 nTPM
Amygdala	0.5 nTPM
Cerebral cortex	0.4 nTPM
Hippocampus	0.4 nTPM
Hypothalamus	0.4 nTPM

Deep-layer intratelencephalic	0.3 nTPM
Hypothalamus	0.5 nTPM
Amygdala	0.4 nTPM
Basal ganglia	0.4 nTPM
Cerebral cortex	0.3 nTPM
Hippocampus	0.3 nTPM

Deep-layer near-projecting	1.0 nTPM
Hippocampus	1.6 nTPM
Amygdala	1.1 nTPM
Basal ganglia	0.9 nTPM
Hypothalamus	0.9 nTPM
Cerebral cortex	0.7 nTPM

Eccentric medium spiny neuron	0.3 nTPM
Hippocampus	0.4 nTPM
Cerebral cortex	0.3 nTPM
Amygdala	0.2 nTPM
Basal ganglia	0.2 nTPM
Hypothalamus	0.2 nTPM
Thalamus	0.2 nTPM