Single cell type - MRPS21 - The Human Protein Atlas

MRPS21

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MRPS21
Gene descriptionⁱ Full gene name according to HGNC.	Mitochondrial ribosomal protein S21
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Ribosomal proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Early spermatids)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.25
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Early spermatids)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

MRPS21 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 0.98
835 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MIF	Macrophage migration inhibitory factor	0.5391	39
NDUFB4	NADH:ubiquinone oxidoreductase subunit B4	0.5262	39
RNF181	Ring finger protein 181	0.5128	56
GTF2H5	General transcription factor IIH subunit 5	0.5123	39
ATP5MF	ATP synthase membrane subunit f	0.5022	39
DHX30	DExH-box helicase 30	0.4976	31
CLPP	Caseinolytic mitochondrial matrix peptidase proteolytic subunit	0.4969	15
NDUFB6	NADH:ubiquinone oxidoreductase subunit B6	0.4917	39
ISCU	Iron-sulfur cluster assembly enzyme	0.4884	39
ANAPC13	Anaphase promoting complex subunit 13	0.4874	39
MRPL57	Mitochondrial ribosomal protein L57	0.4872	39
SNRPD2	Small nuclear ribonucleoprotein D2 polypeptide	0.4776	64
C11orf1	Chromosome 11 open reading frame 1	0.4773	63
SMIM26	Small integral membrane protein 26	0.4764	64
TMA7	Translation machinery associated 7 homolog	0.4763	39

IMMUNE CELLS

MRPS21 is part of cluster 12 Non-specific - Mitochondrial translation with confidenceⁱ 0.99
566 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HEMK1	HemK methyltransferase family member 1	0.9762	12
LRRC61	Leucine rich repeat containing 61	0.9762	12
BUD23	BUD23 rRNA methyltransferase and ribosome maturation factor	0.9524	12
HID1	HID1 domain containing	0.9524	12
NOP56	NOP56 ribonucleoprotein	0.9524	12
HMGN1	High mobility group nucleosome binding domain 1	0.9286	12
ZNF589	Zinc finger protein 589	0.9286	12
CBX5	Chromobox 5	0.9286	12
MRPL17	Mitochondrial ribosomal protein L17	0.9286	12
POLD2	DNA polymerase delta 2, accessory subunit	0.9286	12
NDUFB11	NADH:ubiquinone oxidoreductase subunit B11	0.9286	13
METAP2	Methionyl aminopeptidase 2	0.9048	12
COX7C	Cytochrome c oxidase subunit 7C	0.9048	12
GPX7	Glutathione peroxidase 7	0.9048	12
DHX33	DEAH-box helicase 33	0.9048	12

Adipocytes	122.0 nTPM
Breast	152.7 nTPM
Adipose tissue	91.3 nTPM

Alveolar cells type 1	128.6 nTPM
Lung	128.6 nTPM

Alveolar cells type 2	142.5 nTPM
Lung	142.5 nTPM

Astrocytes	23.5 nTPM
Brain	23.5 nTPM

B-cells	138.3 nTPM
Liver	193.2 nTPM
Skin	186.3 nTPM
Kidney	182.0 nTPM
PBMC	158.6 nTPM
Bone marrow	152.9 nTPM
Spleen	149.1 nTPM
Thymus	140.5 nTPM
Lung	130.1 nTPM
Stomach	119.8 nTPM
Adipose tissue	118.5 nTPM
Salivary gland	106.2 nTPM
Lymph node	95.1 nTPM
Esophagus	64.9 nTPM

Basal squamous epithelial cells	198.3 nTPM
Esophagus	198.3 nTPM

Ciliated cells	208.5 nTPM
Bronchus	287.7 nTPM
Endometrium	195.5 nTPM
Fallopian tube	194.8 nTPM
Lung	156.0 nTPM

Club cells	162.5 nTPM
Bronchus	270.3 nTPM
Prostate	113.4 nTPM
Lung	103.9 nTPM

Dendritic cells	103.5 nTPM
PBMC	107.9 nTPM
Adipose tissue	99.0 nTPM

Endothelial cells	137.9 nTPM
Placenta	265.1 nTPM
Breast	196.0 nTPM
Ovary	195.5 nTPM
Pancreas	178.4 nTPM
Testis	170.6 nTPM
Heart muscle	165.2 nTPM
Liver	143.6 nTPM
Tongue	140.2 nTPM
Esophagus	127.7 nTPM
Skin	126.6 nTPM
Fallopian tube	122.2 nTPM
Endometrium	110.6 nTPM
Lung	109.3 nTPM
Prostate	96.2 nTPM
Thymus	93.7 nTPM
Vascular	93.6 nTPM
Skeletal muscle	87.6 nTPM
Salivary gland	60.0 nTPM

Enteroendocrine cells	140.2 nTPM
Small intestine	188.8 nTPM
Rectum	124.1 nTPM
Colon	107.5 nTPM

Erythroid cells	218.2 nTPM
Liver	265.7 nTPM
Bone marrow	170.6 nTPM

Fibroblasts	169.6 nTPM
Placenta	268.3 nTPM
Heart muscle	260.2 nTPM
Pancreas	253.9 nTPM
Adipose tissue	192.3 nTPM
Breast	174.9 nTPM
Esophagus	168.4 nTPM
Skin	164.0 nTPM
Liver	154.2 nTPM
Vascular	146.4 nTPM
Thymus	144.2 nTPM
Prostate	143.2 nTPM
Fallopian tube	142.9 nTPM
Lung	136.9 nTPM
Skeletal muscle	127.6 nTPM
Stomach	119.6 nTPM
Salivary gland	116.3 nTPM

Granulocytes	193.1 nTPM
Tongue	237.7 nTPM
Fallopian tube	173.3 nTPM
Lung	168.4 nTPM

Intestinal goblet cells	116.1 nTPM
Small intestine	136.4 nTPM
Rectum	112.7 nTPM
Colon	99.4 nTPM

Bipolar cells	65.0 nTPM
Eye	65.0 nTPM

Cholangiocytes	181.2 nTPM
Liver	181.2 nTPM

Collecting duct cells	262.6 nTPM
Kidney	262.6 nTPM

Cone photoreceptor cells	125.7 nTPM
Eye	125.7 nTPM

Lymphatic endothelial cells	202.3 nTPM
Ovary	245.5 nTPM
Fallopian tube	159.1 nTPM

Macrophages	131.1 nTPM
Kidney	276.1 nTPM
Testis	197.1 nTPM
Pancreas	185.0 nTPM
Adipose tissue	143.6 nTPM
Breast	140.2 nTPM
Lung	137.1 nTPM
Endometrium	129.8 nTPM
Stomach	126.0 nTPM
Esophagus	124.6 nTPM
Skin	123.7 nTPM
Prostate	116.5 nTPM
Fallopian tube	114.0 nTPM
Thymus	106.3 nTPM
Bone marrow	101.3 nTPM
Tongue	101.3 nTPM
Spleen	100.3 nTPM
Skeletal muscle	95.8 nTPM
Vascular	95.6 nTPM
Salivary gland	75.5 nTPM

Paneth cells	126.8 nTPM
Small intestine	190.0 nTPM
Rectum	110.7 nTPM
Colon	79.6 nTPM

Plasma cells	172.7 nTPM
Liver	268.9 nTPM
Spleen	223.7 nTPM
Thymus	177.2 nTPM
Bone marrow	175.2 nTPM
Stomach	171.7 nTPM
Fallopian tube	158.9 nTPM
Esophagus	124.7 nTPM
Salivary gland	81.5 nTPM

Schwann cells	106.5 nTPM
Adipose tissue	178.8 nTPM
Esophagus	71.9 nTPM
Vascular	69.0 nTPM

Serous glandular cells	107.2 nTPM
Salivary gland	108.4 nTPM
Tongue	106.1 nTPM

Smooth muscle cells	159.0 nTPM
Placenta	294.5 nTPM
Liver	242.0 nTPM
Ovary	219.6 nTPM
Breast	171.4 nTPM
Esophagus	169.4 nTPM
Fallopian tube	161.1 nTPM
Prostate	159.3 nTPM
Skin	154.1 nTPM
Endometrium	144.4 nTPM
Tongue	140.4 nTPM
Adipose tissue	132.7 nTPM
Vascular	126.8 nTPM
Thymus	120.7 nTPM
Skeletal muscle	110.1 nTPM
Lung	105.8 nTPM
Salivary gland	92.2 nTPM

Suprabasal keratinocytes	206.6 nTPM
Tongue	271.4 nTPM
Skin	141.9 nTPM

T-cells	133.4 nTPM
PBMC	211.9 nTPM
Kidney	208.4 nTPM
Skin	187.2 nTPM
Liver	161.1 nTPM
Thymus	143.8 nTPM
Prostate	141.9 nTPM
Bone marrow	139.7 nTPM
Fallopian tube	137.1 nTPM
Adipose tissue	136.2 nTPM
Stomach	129.3 nTPM
Breast	124.3 nTPM
Lymph node	123.3 nTPM
Colon	120.9 nTPM
Spleen	119.4 nTPM
Salivary gland	113.9 nTPM
Esophagus	111.9 nTPM
Endometrium	104.1 nTPM
Lung	102.6 nTPM
Vascular	96.1 nTPM
Tongue	94.3 nTPM
Skeletal muscle	93.8 nTPM

Undifferentiated cells	159.0 nTPM
Small intestine	211.4 nTPM
Colon	144.3 nTPM
Rectum	121.4 nTPM

Amygdala excitatory	38.6 nTPM
Thalamus	48.1 nTPM
Cerebral cortex	42.0 nTPM
Basal ganglia	40.4 nTPM
Hippocampus	38.1 nTPM
Amygdala	36.1 nTPM
Hypothalamus	26.9 nTPM

Astrocyte	50.1 nTPM
Cerebral cortex	59.5 nTPM
Hippocampus	57.8 nTPM
Pons	57.6 nTPM
Thalamus	56.9 nTPM
Basal ganglia	55.6 nTPM
Midbrain	53.7 nTPM
Medulla oblongata	49.3 nTPM
Cerebellum	49.2 nTPM
Amygdala	39.4 nTPM
Spinal cord	36.5 nTPM
Hypothalamus	35.4 nTPM

Bergmann glia	63.5 nTPM
Medulla oblongata	68.2 nTPM
Cerebellum	62.0 nTPM
Pons	60.4 nTPM

Central nervous system macrophage	50.5 nTPM
Medulla oblongata	61.3 nTPM
Cerebral cortex	58.2 nTPM
Pons	56.7 nTPM
Basal ganglia	54.6 nTPM
Spinal cord	53.9 nTPM
Midbrain	52.9 nTPM
Hippocampus	51.1 nTPM
Thalamus	50.4 nTPM
Cerebellum	44.2 nTPM
Hypothalamus	39.0 nTPM
Amygdala	32.8 nTPM

Cerebellar inhibitory	70.2 nTPM
Pons	85.4 nTPM
Medulla oblongata	71.8 nTPM
Spinal cord	66.0 nTPM
Cerebellum	65.8 nTPM
Midbrain	62.2 nTPM

Cge interneuron	64.3 nTPM
Thalamus	85.2 nTPM
Midbrain	82.0 nTPM
Hippocampus	69.3 nTPM
Basal ganglia	61.7 nTPM
Cerebral cortex	59.9 nTPM
Amygdala	54.7 nTPM
Hypothalamus	36.9 nTPM

Choroid plexus epithelial cell	91.2 nTPM
Hippocampus	147.0 nTPM
Medulla oblongata	104.5 nTPM
Thalamus	60.3 nTPM
Basal ganglia	52.9 nTPM

Committed oligodendrocyte precursor	50.0 nTPM
Medulla oblongata	80.0 nTPM
Spinal cord	69.9 nTPM
Pons	62.0 nTPM
Midbrain	55.4 nTPM
Cerebral cortex	50.0 nTPM
Cerebellum	47.6 nTPM
Basal ganglia	46.0 nTPM
Hippocampus	43.7 nTPM
Thalamus	33.8 nTPM
Hypothalamus	31.4 nTPM
Amygdala	29.9 nTPM

Deep-layer corticothalamic and 6b	52.6 nTPM
Midbrain	76.5 nTPM
Basal ganglia	60.3 nTPM
Cerebral cortex	51.7 nTPM
Hippocampus	49.4 nTPM
Amygdala	45.8 nTPM
Hypothalamus	31.7 nTPM

Deep-layer intratelencephalic	53.4 nTPM
Basal ganglia	67.5 nTPM
Cerebral cortex	59.6 nTPM
Hippocampus	54.7 nTPM
Amygdala	51.6 nTPM
Hypothalamus	33.5 nTPM