Cell line - MKRN2OS - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MKRN2OS
Gene descriptionⁱ Full gene name according to HGNC.	MKRN2 opposite strand
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression based on cell line data from the DepMap portal and cell line data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Squamous epithelial cells - Keratinization (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from cancer cell lines in the Human Protein Atlas grouped according to type of cancer. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cancer enhanced (Gallbladder cancer)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.73
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from cancer cell lines in the Human Protein Atlas grouped according to type of cancer. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

CELL LINE GROUPSⁱ RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines.The analyzed cell lines are grouped according to cancer type. Detailed information about the groups is revealed by hovering over the corresponding bar in the chart. More information and cell line data can be found in the Cell line resource.
Cell line categories Alphabetical Expression RNA specificity:Cancer enhanced (Gallbladder cancer)

COMMON CELL LINES
Alphabetical Expression

EXPRESSION CLUSTERING & CORRELATIONⁱ

MKRN2OS is part of cluster 53 Squamous epithelial cells - Keratinization with confidenceⁱ 1
967 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SOWAHB	Sosondowah ankyrin repeat domain family member B	0.5921	53
CDS1	CDP-diacylglycerol synthase 1	0.5346	53
EHF	ETS homologous factor	0.5331	57
MST1R	Macrophage stimulating 1 receptor	0.5328	53
CHMP2B	Charged multivesicular body protein 2B	0.5239	8
C9orf131	Chromosome 9 open reading frame 131	0.5235	30
PRRG2	Proline rich and Gla domain 2	0.5201	53
CLDN7	Claudin 7	0.5178	53
C1orf116	Chromosome 1 open reading frame 116	0.5147	53
FUT3	Fucosyltransferase 3 (Lewis blood group)	0.4995	57
GPRC5A	G protein-coupled receptor class C group 5 member A	0.4961	53
CTDSPL	CTD small phosphatase like	0.4904	53
MAL2	Mal, T cell differentiation protein 2	0.4899	53
BICDL2	BICD family like cargo adaptor 2	0.4877	53
GALNT12	Polypeptide N-acetylgalactosaminyltransferase 12	0.4847	53

CELL LINE DATA

Alphabetical Expression Adrenocortical cancer (n=1)
Alphabetical Expression Bile duct cancer (n=7)
Alphabetical Expression Bladder cancer (n=26)
Alphabetical Expression Bone cancer (n=21)
Alphabetical Expression Brain cancer (n=80)
Alphabetical Expression Breast cancer (n=62)
Alphabetical Expression Cervical cancer (n=8)
Alphabetical Expression Colorectal cancer (n=63)
Alphabetical Expression Esophageal cancer (n=27)
Alphabetical Expression Gallbladder cancer (n=1)
Alphabetical Expression Gastric cancer (n=42)
Alphabetical Expression Head and Neck cancer (n=38)
Alphabetical Expression Kidney cancer (n=35)
Alphabetical Expression Leukemia (n=93)
Alphabetical Expression Liver cancer (n=24)
Alphabetical Expression Lung cancer (n=232)
Alphabetical Expression Lymphoma (n=76)
Alphabetical Expression Myeloma (n=34)
Alphabetical Expression Neuroblastoma (n=17)
Alphabetical Expression Non-cancerous (n=63)
Alphabetical Expression Ovarian cancer (n=59)
Alphabetical Expression Pancreatic cancer (n=46)
Alphabetical Expression Prostate cancer (n=8)
Alphabetical Expression Rhabdoid (n=14)
Alphabetical Expression Sarcoma (n=15)
Alphabetical Expression Skin cancer (n=62)
Alphabetical Expression Testis cancer (n=1)
Alphabetical Expression Thyroid cancer (n=11)
Alphabetical Expression Uncategorized (n=11)
Alphabetical Expression Uterine cancer (n=29)