Single cell type - ZSWIM7 - The Human Protein Atlas

ZSWIM7

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZSWIM7
Gene descriptionⁱ Full gene name according to HGNC.	Zinc finger SWIM-type containing 7
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.23
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Low cell type specificity

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ZSWIM7 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
835 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MRPS26	Mitochondrial ribosomal protein S26	0.5159	39
C2orf68	Chromosome 2 open reading frame 68	0.5058	55
ALDH7A1	Aldehyde dehydrogenase 7 family member A1	0.4911	24
COX20	Cytochrome c oxidase assembly factor COX20	0.4879	39
RBFA	Ribosome binding factor A	0.4841	39
ATP6V1B1	ATPase H+ transporting V1 subunit B1	0.4690	24
NMRAL1	NmrA like redox sensor 1	0.4672	4
LYRM9	LYR motif containing 9	0.4574	6
MRFAP1	Morf4 family associated protein 1	0.4560	24
DNAJC19	DnaJ heat shock protein family (Hsp40) member C19	0.4552	39
ARL16	ADP ribosylation factor like GTPase 16	0.4463	39
ING4	Inhibitor of growth family member 4	0.4460	39
DPH5	Diphthamide biosynthesis 5	0.4443	64
RMND1	Required for meiotic nuclear division 1 homolog	0.4428	22
PET117	PET117 cytochrome c oxidase chaperone	0.4422	39

IMMUNE CELLS

ZSWIM7 is part of cluster 10 Non-specific - Membrane trafficking with confidenceⁱ 0.95
408 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
LHFPL2	LHFPL tetraspan subfamily member 2	0.9762	10
EIF6	Eukaryotic translation initiation factor 6	0.9524	10
PARVB	Parvin beta	0.9524	10
EXOSC4	Exosome component 4	0.9524	10
ATPAF2	ATP synthase mitochondrial F1 complex assembly factor 2	0.9524	10
TMED3	Transmembrane p24 trafficking protein 3	0.9524	10
SNAPIN	SNAP associated protein	0.9524	10
SIL1	SIL1 nucleotide exchange factor	0.9524	10
TP53I3	Tumor protein p53 inducible protein 3	0.9524	10
ETFB	Electron transfer flavoprotein subunit beta	0.9524	10
MANBAL	Mannosidase beta like	0.9524	10
MTIF3	Mitochondrial translational initiation factor 3	0.9286	10
UQCRQ	Ubiquinol-cytochrome c reductase complex III subunit VII	0.9286	10
CGAS	Cyclic GMP-AMP synthase	0.9286	10
BSCL2	BSCL2 lipid droplet biogenesis associated, seipin	0.9286	10

Adipocytes	41.4 nTPM
Breast	53.9 nTPM
Adipose tissue	28.9 nTPM

Alveolar cells type 1	42.3 nTPM
Lung	42.3 nTPM

Alveolar cells type 2	46.2 nTPM
Lung	46.2 nTPM

Astrocytes	15.8 nTPM
Brain	15.8 nTPM

B-cells	33.0 nTPM
PBMC	63.1 nTPM
Skin	39.0 nTPM
Thymus	34.0 nTPM
Liver	33.8 nTPM
Salivary gland	33.3 nTPM
Bone marrow	32.6 nTPM
Lung	32.2 nTPM
Kidney	31.2 nTPM
Stomach	29.5 nTPM
Adipose tissue	28.8 nTPM
Spleen	28.6 nTPM
Lymph node	24.5 nTPM
Esophagus	17.7 nTPM

Ciliated cells	34.2 nTPM
Fallopian tube	42.6 nTPM
Endometrium	34.5 nTPM
Lung	33.7 nTPM
Bronchus	26.0 nTPM

Club cells	33.2 nTPM
Prostate	36.6 nTPM
Bronchus	31.9 nTPM
Lung	31.1 nTPM

Dendritic cells	39.0 nTPM
PBMC	50.4 nTPM
Adipose tissue	27.6 nTPM

Endothelial cells	34.1 nTPM
Breast	66.8 nTPM
Ovary	55.7 nTPM
Testis	52.2 nTPM
Placenta	51.1 nTPM
Pancreas	36.2 nTPM
Vascular	33.0 nTPM
Lung	29.7 nTPM
Skin	29.5 nTPM
Endometrium	28.7 nTPM
Prostate	28.7 nTPM
Thymus	27.9 nTPM
Tongue	27.2 nTPM
Heart muscle	27.0 nTPM
Fallopian tube	26.8 nTPM
Liver	26.5 nTPM
Salivary gland	25.0 nTPM
Skeletal muscle	21.6 nTPM
Esophagus	19.9 nTPM

Enteroendocrine cells	37.7 nTPM
Colon	40.0 nTPM
Small intestine	37.8 nTPM
Rectum	35.2 nTPM

Fibroblasts	31.7 nTPM
Heart muscle	53.8 nTPM
Liver	46.3 nTPM
Pancreas	41.2 nTPM
Breast	38.8 nTPM
Lung	35.6 nTPM
Salivary gland	33.6 nTPM
Vascular	32.1 nTPM
Thymus	31.5 nTPM
Fallopian tube	31.0 nTPM
Placenta	30.2 nTPM
Adipose tissue	29.1 nTPM
Prostate	29.0 nTPM
Esophagus	22.3 nTPM
Skin	21.6 nTPM
Skeletal muscle	21.2 nTPM
Stomach	10.1 nTPM

Granulocytes	37.4 nTPM
Lung	54.5 nTPM
Fallopian tube	38.4 nTPM
Tongue	19.4 nTPM

Intestinal goblet cells	31.2 nTPM
Rectum	39.4 nTPM
Colon	29.8 nTPM
Small intestine	24.3 nTPM

Lymphatic endothelial cells	40.0 nTPM
Ovary	49.1 nTPM
Fallopian tube	30.8 nTPM

Macrophages	46.5 nTPM
Testis	78.7 nTPM
Kidney	73.5 nTPM
Adipose tissue	62.5 nTPM
Prostate	62.0 nTPM
Breast	61.0 nTPM
Stomach	48.9 nTPM
Lung	48.7 nTPM
Fallopian tube	45.5 nTPM
Tongue	45.4 nTPM
Bone marrow	44.6 nTPM
Salivary gland	42.6 nTPM
Skeletal muscle	39.0 nTPM
Thymus	36.9 nTPM
Endometrium	35.7 nTPM
Vascular	32.7 nTPM
Spleen	32.1 nTPM
Skin	31.2 nTPM
Pancreas	30.8 nTPM
Esophagus	30.8 nTPM

Basal keratinocytes	30.3 nTPM
Tongue	34.9 nTPM
Skin	25.8 nTPM

Basal prostatic cells	33.9 nTPM
Prostate	33.9 nTPM

Basal respiratory cells	48.5 nTPM
Bronchus	48.5 nTPM

Cholangiocytes	63.0 nTPM
Liver	63.0 nTPM

Paneth cells	41.1 nTPM
Rectum	42.0 nTPM
Small intestine	41.4 nTPM
Colon	39.8 nTPM

Plasma cells	23.4 nTPM
Fallopian tube	30.2 nTPM
Liver	26.0 nTPM
Bone marrow	25.7 nTPM
Salivary gland	23.7 nTPM
Stomach	22.2 nTPM
Thymus	21.8 nTPM
Spleen	21.7 nTPM
Esophagus	15.6 nTPM

Schwann cells	54.1 nTPM
Esophagus	83.9 nTPM
Adipose tissue	50.4 nTPM
Vascular	28.2 nTPM

Serous glandular cells	34.3 nTPM
Salivary gland	37.7 nTPM
Tongue	30.9 nTPM

Smooth muscle cells	33.6 nTPM
Ovary	54.9 nTPM
Fallopian tube	45.9 nTPM
Breast	41.5 nTPM
Endometrium	35.7 nTPM
Liver	34.8 nTPM
Placenta	34.5 nTPM
Adipose tissue	33.6 nTPM
Vascular	33.5 nTPM
Thymus	31.4 nTPM
Lung	30.6 nTPM
Prostate	28.6 nTPM
Skin	27.4 nTPM
Skeletal muscle	26.6 nTPM
Esophagus	26.4 nTPM
Salivary gland	26.2 nTPM
Tongue	25.1 nTPM

Suprabasal keratinocytes	30.8 nTPM
Tongue	35.1 nTPM
Skin	26.4 nTPM

T-cells	32.0 nTPM
PBMC	55.9 nTPM
Prostate	43.3 nTPM
Fallopian tube	39.1 nTPM
Breast	38.4 nTPM
Thymus	37.6 nTPM
Vascular	36.6 nTPM
Kidney	36.4 nTPM
Salivary gland	36.2 nTPM
Skin	32.6 nTPM
Liver	31.6 nTPM
Lung	31.5 nTPM
Tongue	31.1 nTPM
Endometrium	27.6 nTPM
Colon	26.3 nTPM
Adipose tissue	25.6 nTPM
Bone marrow	25.6 nTPM
Skeletal muscle	25.3 nTPM
Spleen	25.3 nTPM
Stomach	24.8 nTPM
Lymph node	22.1 nTPM
Esophagus	19.5 nTPM

Undifferentiated cells	35.1 nTPM
Rectum	37.4 nTPM
Small intestine	34.7 nTPM
Colon	33.1 nTPM

Amygdala excitatory	29.3 nTPM
Hypothalamus	33.1 nTPM
Basal ganglia	32.9 nTPM
Cerebral cortex	29.7 nTPM
Amygdala	28.3 nTPM
Hippocampus	28.3 nTPM
Thalamus	23.6 nTPM

Astrocyte	43.4 nTPM
Cerebral cortex	47.5 nTPM
Basal ganglia	47.3 nTPM
Thalamus	45.4 nTPM
Pons	44.3 nTPM
Amygdala	43.7 nTPM
Midbrain	43.5 nTPM
Medulla oblongata	42.5 nTPM
Hippocampus	42.2 nTPM
Spinal cord	41.1 nTPM
Hypothalamus	40.3 nTPM
Cerebellum	39.3 nTPM

Bergmann glia	61.4 nTPM
Medulla oblongata	89.5 nTPM
Cerebellum	48.7 nTPM
Pons	46.0 nTPM

Central nervous system macrophage	61.0 nTPM
Medulla oblongata	67.0 nTPM
Cerebellum	65.1 nTPM
Basal ganglia	63.8 nTPM
Hypothalamus	63.0 nTPM
Pons	63.0 nTPM
Midbrain	62.9 nTPM
Spinal cord	61.8 nTPM
Hippocampus	57.6 nTPM
Cerebral cortex	56.0 nTPM
Amygdala	55.6 nTPM
Thalamus	55.4 nTPM

Cerebellar inhibitory	22.0 nTPM
Medulla oblongata	26.1 nTPM
Pons	24.4 nTPM
Cerebellum	20.4 nTPM
Midbrain	19.6 nTPM
Spinal cord	19.2 nTPM

Cge interneuron	26.0 nTPM
Thalamus	27.7 nTPM
Basal ganglia	27.5 nTPM
Cerebral cortex	26.9 nTPM
Hippocampus	26.9 nTPM
Midbrain	26.0 nTPM
Amygdala	25.0 nTPM
Hypothalamus	21.9 nTPM

Choroid plexus epithelial cell	33.7 nTPM
Medulla oblongata	44.5 nTPM
Hippocampus	38.8 nTPM
Basal ganglia	34.9 nTPM
Thalamus	16.4 nTPM

Committed oligodendrocyte precursor	34.9 nTPM
Cerebellum	53.9 nTPM
Hippocampus	41.7 nTPM
Midbrain	38.6 nTPM
Cerebral cortex	36.7 nTPM
Medulla oblongata	34.9 nTPM
Hypothalamus	34.1 nTPM
Basal ganglia	32.9 nTPM
Spinal cord	29.4 nTPM
Amygdala	28.8 nTPM
Pons	26.6 nTPM
Thalamus	26.3 nTPM

Deep-layer corticothalamic and 6b	35.5 nTPM
Hippocampus	39.5 nTPM
Basal ganglia	39.0 nTPM
Cerebral cortex	37.3 nTPM
Amygdala	33.9 nTPM
Midbrain	33.3 nTPM
Hypothalamus	30.2 nTPM

Deep-layer intratelencephalic	35.8 nTPM
Basal ganglia	41.2 nTPM
Hippocampus	38.5 nTPM
Cerebral cortex	36.5 nTPM
Amygdala	33.0 nTPM
Hypothalamus	29.9 nTPM

Deep-layer near-projecting	38.0 nTPM
Hippocampus	47.5 nTPM
Basal ganglia	42.0 nTPM
Amygdala	35.9 nTPM
Cerebral cortex	34.4 nTPM
Hypothalamus	30.2 nTPM

Eccentric medium spiny neuron	29.6 nTPM
Basal ganglia	32.5 nTPM
Hypothalamus	30.6 nTPM
Amygdala	29.9 nTPM
Cerebral cortex	29.3 nTPM
Thalamus	28.1 nTPM
Hippocampus	27.4 nTPM