Single cell type - SCGB2B2 - The Human Protein Atlas

SCGB2B2

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(1 genes):

BMS1

Field

Term

Cluster

Pathway

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SCGB2B2
Gene descriptionⁱ Full gene name according to HGNC.	Secretoglobin family 2B member 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Neurons - Neuronal signaling (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Oligodendrocytes, Astrocytes, Oligodendrocyte precursor cells, Inhibitory neurons, Late spermatids, Excitatory neurons, Microglial cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.92
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data.	Protein predicted to be secreted

ASSAYSⁱ

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Astrocytes, Oligodendrocyte precursor cells, Inhibitory neurons, Late spermatids, Excitatory neurons, Microglial cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

SCGB2B2 is part of cluster 8 Neurons - Neuronal signaling with confidenceⁱ 0.99
265 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HSPE1-MOB4	HSPE1-MOB4 readthrough	0.7564	8
EFR3B	EFR3 homolog B	0.7238	8
INVS	Inversin	0.7016	8
GRID1	Glutamate ionotropic receptor delta type subunit 1	0.6987	65
FHIT	Fragile histidine triad diadenosine triphosphatase	0.6953	76
PRKN	Parkin RBR E3 ubiquitin protein ligase	0.6910	8
RAD52	RAD52 homolog, DNA repair protein	0.6882	8
BCAS3	BCAS3 microtubule associated cell migration factor	0.6525	51
CLEC16A	C-type lectin domain containing 16A	0.6523	8
ENOX1	Ecto-NOX disulfide-thiol exchanger 1	0.6399	8
WWOX	WW domain containing oxidoreductase	0.6342	76
PPP2R2B	Protein phosphatase 2 regulatory subunit Bbeta	0.6312	51
HERC3	HECT and RLD domain containing E3 ubiquitin protein ligase 3	0.6145	8
SUPT3H	SPT3 homolog, SAGA and STAGA complex component	0.6073	8
NRF1	Nuclear respiratory factor 1	0.6040	76

Adipocytes	0.0 nTPM
Adipose tissue	0.0 nTPM
Breast	0.0 nTPM

Alveolar cells type 1	0.2 nTPM
Lung	0.2 nTPM

Alveolar cells type 2	0.0 nTPM
Lung	0.0 nTPM

B-cells	0.0 nTPM
Lymph node	0.2 nTPM
Salivary gland	0.1 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Thymus	0.0 nTPM

Basal keratinocytes	0.2 nTPM
Skin	0.4 nTPM
Tongue	0.1 nTPM

Ciliated cells	0.1 nTPM
Lung	0.2 nTPM
Endometrium	0.1 nTPM
Fallopian tube	0.1 nTPM
Bronchus	0.0 nTPM

Club cells	0.0 nTPM
Bronchus	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM

Endothelial cells	0.0 nTPM
Lung	0.1 nTPM
Fallopian tube	0.1 nTPM
Ovary	0.1 nTPM
Testis	0.0 nTPM
Heart muscle	0.0 nTPM
Liver	0.0 nTPM
Placenta	0.0 nTPM
Endometrium	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Esophagus	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Tongue	0.0 nTPM
Vascular	0.0 nTPM
Breast	0.0 nTPM

Enteroendocrine cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Fibroblasts	0.1 nTPM
Esophagus	1.3 nTPM
Lung	0.3 nTPM
Thymus	0.2 nTPM
Breast	0.2 nTPM
Skin	0.1 nTPM
Skeletal muscle	0.1 nTPM
Adipose tissue	0.1 nTPM
Salivary gland	0.1 nTPM
Heart muscle	0.0 nTPM
Liver	0.0 nTPM
Placenta	0.0 nTPM
Pancreas	0.0 nTPM
Stomach	0.0 nTPM
Prostate	0.0 nTPM
Vascular	0.0 nTPM
Fallopian tube	0.0 nTPM

Granulocytes	0.0 nTPM
Lung	0.0 nTPM
Tongue	0.0 nTPM
Fallopian tube	0.0 nTPM

Intestinal goblet cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Lymphatic endothelial cells	0.0 nTPM
Fallopian tube	0.1 nTPM
Ovary	0.0 nTPM

Macrophages	0.0 nTPM
Salivary gland	0.1 nTPM
Testis	0.0 nTPM
Kidney	0.0 nTPM
Endometrium	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Thymus	0.0 nTPM
Tongue	0.0 nTPM
Vascular	0.0 nTPM
Breast	0.0 nTPM
Fallopian tube	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Astrocytes	60.4 nTPM
Brain	60.4 nTPM

Early spermatids	3.8 nTPM
Testis	3.8 nTPM

Plasma cells	0.0 nTPM
Liver	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Fallopian tube	0.0 nTPM

Schwann cells	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Vascular	0.0 nTPM

Serous glandular cells	0.0 nTPM
Salivary gland	0.0 nTPM
Tongue	0.0 nTPM

Smooth muscle cells	0.0 nTPM
Liver	0.4 nTPM
Endometrium	0.2 nTPM
Placenta	0.1 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Salivary gland	0.0 nTPM
Thymus	0.0 nTPM
Tongue	0.0 nTPM
Vascular	0.0 nTPM
Breast	0.0 nTPM
Fallopian tube	0.0 nTPM
Ovary	0.0 nTPM

T-cells	0.0 nTPM
Salivary gland	0.2 nTPM
Breast	0.1 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
Endometrium	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Thymus	0.0 nTPM
Tongue	0.0 nTPM
Vascular	0.0 nTPM
Fallopian tube	0.0 nTPM

Undifferentiated cells	0.1 nTPM
Rectum	0.2 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Amygdala excitatory	37.5 nTPM
Hypothalamus	42.9 nTPM
Amygdala	41.9 nTPM
Basal ganglia	37.4 nTPM
Thalamus	35.4 nTPM
Hippocampus	34.0 nTPM
Cerebral cortex	33.2 nTPM

Astrocyte	125.5 nTPM
Hypothalamus	159.9 nTPM
Amygdala	148.4 nTPM
Hippocampus	140.9 nTPM
Basal ganglia	134.3 nTPM
Thalamus	126.6 nTPM
Midbrain	123.7 nTPM
Cerebral cortex	122.7 nTPM
Spinal cord	109.7 nTPM
Pons	105.9 nTPM
Medulla oblongata	104.6 nTPM
Cerebellum	103.9 nTPM

Bergmann glia	87.8 nTPM
Cerebellum	99.2 nTPM
Medulla oblongata	93.8 nTPM
Pons	70.5 nTPM

Central nervous system macrophage	12.9 nTPM
Hypothalamus	16.4 nTPM
Hippocampus	16.2 nTPM
Amygdala	14.1 nTPM
Basal ganglia	13.1 nTPM
Midbrain	12.8 nTPM
Spinal cord	12.7 nTPM
Medulla oblongata	12.1 nTPM
Cerebral cortex	11.6 nTPM
Thalamus	11.5 nTPM
Cerebellum	11.3 nTPM
Pons	10.3 nTPM

Cerebellar inhibitory	75.6 nTPM
Spinal cord	82.5 nTPM
Midbrain	79.3 nTPM
Cerebellum	77.7 nTPM
Pons	70.7 nTPM
Medulla oblongata	67.6 nTPM

Cge interneuron	44.6 nTPM
Hypothalamus	52.1 nTPM
Amygdala	48.5 nTPM
Hippocampus	44.1 nTPM
Basal ganglia	43.2 nTPM
Thalamus	42.6 nTPM
Midbrain	41.3 nTPM
Cerebral cortex	40.4 nTPM

Choroid plexus epithelial cell	55.5 nTPM
Basal ganglia	72.0 nTPM
Thalamus	57.5 nTPM
Medulla oblongata	50.7 nTPM
Hippocampus	41.6 nTPM

Committed oligodendrocyte precursor	63.7 nTPM
Hypothalamus	100.4 nTPM
Amygdala	90.8 nTPM
Thalamus	77.4 nTPM
Hippocampus	71.4 nTPM
Cerebral cortex	67.1 nTPM
Cerebellum	65.0 nTPM
Pons	56.7 nTPM
Medulla oblongata	55.5 nTPM
Midbrain	52.9 nTPM
Basal ganglia	45.4 nTPM
Spinal cord	18.4 nTPM

Deep-layer corticothalamic and 6b	41.7 nTPM
Midbrain	61.0 nTPM
Hippocampus	43.3 nTPM
Hypothalamus	41.4 nTPM
Cerebral cortex	35.7 nTPM
Amygdala	35.4 nTPM
Basal ganglia	33.3 nTPM

Deep-layer intratelencephalic	35.1 nTPM
Hippocampus	38.6 nTPM
Hypothalamus	36.9 nTPM
Cerebral cortex	35.9 nTPM
Basal ganglia	33.6 nTPM
Amygdala	30.3 nTPM

Deep-layer near-projecting	47.4 nTPM
Hypothalamus	50.5 nTPM
Basal ganglia	49.8 nTPM
Cerebral cortex	49.8 nTPM
Amygdala	45.9 nTPM
Hippocampus	41.0 nTPM

Eccentric medium spiny neuron	51.5 nTPM
Cerebral cortex	55.6 nTPM
Amygdala	54.1 nTPM
Hypothalamus	51.9 nTPM
Basal ganglia	51.5 nTPM
Thalamus	48.7 nTPM
Hippocampus	47.3 nTPM

Endothelial cell	45.0 nTPM
Hypothalamus	65.8 nTPM
Basal ganglia	59.7 nTPM
Cerebellum	49.6 nTPM
Thalamus	46.3 nTPM
Midbrain	45.4 nTPM
Hippocampus	42.6 nTPM
Amygdala	41.4 nTPM
Spinal cord	41.4 nTPM
Cerebral cortex	37.7 nTPM
Pons	36.2 nTPM
Medulla oblongata	28.7 nTPM

Ependymal cell	83.3 nTPM
Hypothalamus	121.4 nTPM
Basal ganglia	106.5 nTPM
Amygdala	97.8 nTPM
Hippocampus	92.6 nTPM
Thalamus	78.2 nTPM
Midbrain	72.4 nTPM
Pons	69.1 nTPM
Medulla oblongata	67.8 nTPM
Spinal cord	44.1 nTPM