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The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.
The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".
Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.
Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.
& Survival analysisi
Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.
MT-CO3 is potential prognostic, high expression is favorable in Pancreatic Adenocarcinoma (TCGA)
Stage:
Survival analysis
Current cut offi
Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.
:
Best expression cut offi
Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .
When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.
Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.
Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.
: N/A
P scorei
Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.
N/A
5-year survival highi
5-year survival for patients with higher expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
5-year survival lowi
5-year survival for patients with lower expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
TCGA RNA samplesi
RNA-seq data is reported as average FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.
Average TPM
12146.7
Number of samples
176
Samples
Sample
Description
TPM
TCGA-FB-AAQ6-01A
0 years, male, white, stage:Stage IA, dead, 244 days
32653.5
TCGA-3A-A9IL-01A
0 years, female, white, stage:Stage I, alive, 2741 days
28599.3
TCGA-RB-A7B8-01A
0 years, female, white, stage:Stage IIB, dead, 466 days
27294.1
TCGA-FB-AAPY-01A
0 years, male, white, stage:Stage IIB, dead, 1059 days
26714.4
TCGA-IB-A5SP-01A
0 years, male, white, stage:Stage IIA, alive, 482 days
26558.8
TCGA-FB-AAQ1-01A
0 years, male, white, stage:Stage IIB, dead, 123 days
26251.0
TCGA-HV-A5A5-01A
0 years, female, asian, stage:Stage IIB, alive, 289 days
26197.3
TCGA-2J-AABK-01A
0 years, male, white, stage:Stage IIB, alive, 484 days
25794.5
TCGA-LB-A7SX-01A
0 years, female, black or african american, stage:Stage IIB, dead, 393 days
25685.8
TCGA-3A-A9IN-01A
0 years, female, white, stage:Stage IB, alive, 2084 days
25561.4
TCGA-H8-A6C1-01A
0 years, male, white, stage:Stage IIA, alive, 671 days
25351.8
TCGA-F2-A8YN-01A
0 years, male, white, stage:Stage IIA, alive, 517 days
25270.5
TCGA-2L-AAQJ-01A
0 years, female, white, stage:Stage III, dead, 394 days
22753.1
TCGA-FB-AAQ3-01A
0 years, female, white, stage:Stage IIB, dead, 31 days
22322.2
TCGA-2J-AABH-01A
0 years, male, white, stage:Stage IIA, alive, 1287 days
22261.5
TCGA-Q3-AA2A-01A
0 years, female, white, stage:Stage IB, alive, 95 days
21131.6
TCGA-FB-AAPQ-01A
0 years, male, white, stage:Stage IIB, dead, 1130 days
20573.3
TCGA-HV-A5A6-01A
0 years, female, asian, stage:Stage IIB, dead, 2036 days
20523.7
TCGA-M8-A5N4-01A
0 years, female, stage:Stage IIA, alive, 584 days
20414.3
TCGA-2J-AABT-01A
0 years, female, white, stage:Stage IIB, alive, 319 days
20084.9
TCGA-2L-AAQM-01A
0 years, male, white, stage:Stage IIB, alive, 1383 days
19867.9
TCGA-3A-A9IV-01A
0 years, female, white, stage:Stage IB, alive, 1103 days
19743.0
TCGA-US-A779-01A
0 years, female, white, stage:Stage IIB, dead, 511 days
19169.7
TCGA-2J-AABE-01A
0 years, male, white, stage:Stage IIA, alive, 676 days
18679.8
TCGA-HZ-A4BK-01A
0 years, male, white, stage:Stage IIB, alive, 657 days
18518.8
TCGA-US-A77E-01A
0 years, male, white, stage:Stage IIB, dead, 430 days
18309.3
TCGA-F2-A44G-01A
0 years, female, white, stage:Stage IIB, dead, 233 days
18147.5
TCGA-3A-A9IO-01A
0 years, male, white, stage:'--, alive, 1942 days
17714.5
TCGA-HZ-A8P1-01A
0 years, male, white, stage:Stage IB, alive, 7 days
17585.6
TCGA-3A-A9IS-01A
0 years, male, white, stage:Stage IB, alive, 998 days
17137.3
TCGA-XN-A8T5-01A
0 years, female, white, stage:Stage IB, alive, 720 days
17040.0
TCGA-3A-A9I7-01A
0 years, male, black or african american, stage:Stage IIB, alive, 1323 days
16504.1
TCGA-FB-AAPU-01A
0 years, female, asian, stage:Stage IIA, dead, 381 days
16223.4
TCGA-XD-AAUI-01A
0 years, female, white, stage:Stage IIB, dead, 366 days
16219.7
TCGA-IB-AAUO-01A
0 years, female, white, stage:Stage IIB, dead, 239 days
15999.5
TCGA-F2-A44H-01A
0 years, male, white, stage:Stage IIA, alive, 586 days
15642.5
TCGA-HV-AA8V-01A
0 years, male, asian, stage:Stage IIB, alive, 920 days
15565.1
TCGA-HZ-A77P-01A
0 years, male, white, stage:Stage IIB, alive, 330 days
15504.0
TCGA-HZ-A9TJ-01A
0 years, male, white, stage:Stage IV, alive, 603 days
15475.1
TCGA-HV-AA8X-01A
0 years, female, asian, stage:Stage IIB, dead, 532 days
15452.7
TCGA-FB-AAPS-01A
0 years, female, white, stage:Stage IIB, alive, 228 days
15401.9
TCGA-HV-A5A3-01A
0 years, male, asian, stage:Stage IIA, dead, 128 days
15211.4
TCGA-2J-AAB4-01A
0 years, male, white, stage:Stage IIB, alive, 729 days
15206.3
TCGA-HZ-8638-01A
0 years, female, white, stage:Stage IA, dead, 151 days
15144.0
TCGA-IB-7649-01A
0 years, female, stage:Stage IIB, dead, 467 days
15011.1
TCGA-3A-A9IH-01A
0 years, female, white, stage:Stage IA, alive, 1021 days
14653.4
TCGA-3E-AAAY-01A
0 years, male, white, stage:Stage IIB, alive, 2285 days
14634.3
TCGA-FB-AAPP-01A
0 years, male, white, stage:Stage IIB, dead, 485 days
14225.1
TCGA-2J-AABU-01A
0 years, male, white, stage:Stage IIB, dead, 277 days
14199.7
TCGA-HZ-8519-01A
0 years, male, white, stage:Stage IA, alive, 454 days
14198.4
TCGA-L1-A7W4-01A
0 years, female, white, stage:Stage IIB, dead, 278 days
13976.5
TCGA-FB-AAPZ-01A
0 years, male, white, stage:Stage IIB, alive, 716 days
13657.1
TCGA-2J-AAB8-01A
0 years, male, white, stage:Stage IIB, alive, 80 days
13646.6
TCGA-HZ-8637-01A
0 years, female, white, stage:Stage IIB, dead, 517 days
13435.4
TCGA-Q3-A5QY-01A
0 years, male, white, stage:Stage IIB, alive, 416 days
13396.9
TCGA-S4-A8RM-01A
0 years, male, white, stage:Stage IIB, alive, 737 days
13376.7
TCGA-H6-A45N-01A
0 years, female, white, stage:Stage IIB, dead, 397 days
13239.2
TCGA-3A-A9IR-01A
0 years, female, white, stage:Stage IB, alive, 1542 days
13098.3
TCGA-3A-A9J0-01A
0 years, male, white, stage:Stage IIB, alive, 743 days
13097.0
TCGA-2J-AABF-01A
0 years, male, white, stage:Stage IIB, dead, 691 days
13031.8
TCGA-3A-A9I9-01A
0 years, male, white, stage:Stage IIA, dead, 634 days
13028.4
TCGA-3A-A9IB-01A
0 years, female, white, stage:Stage IIB, dead, 224 days
13005.3
TCGA-FB-AAQ2-01A
0 years, female, white, stage:Stage IIB, dead, 153 days
12995.9
TCGA-US-A776-01A
0 years, male, white, stage:Stage IIA, alive, 1216 days
12978.6
TCGA-US-A77G-01A
0 years, male, white, stage:Stage IIB, dead, 12 days
12947.7
TCGA-2L-AAQE-01A
0 years, male, white, stage:Stage IIB, dead, 684 days
12920.5
TCGA-3E-AAAZ-01A
0 years, male, white, stage:Stage IIA, dead, 2182 days
12904.2
TCGA-3A-A9IJ-01A
0 years, male, white, stage:Stage IB, alive, 1854 days
12823.5
TCGA-2J-AAB6-01A
0 years, male, white, stage:Stage IIA, dead, 293 days
12689.8
TCGA-2J-AABA-01A
0 years, male, white, stage:Stage IIB, dead, 607 days
12646.3
TCGA-FB-A7DR-01A
0 years, male, asian, stage:Stage IIA, dead, 353 days
12636.4
TCGA-YH-A8SY-01A
0 years, female, white, stage:'--, alive, 388 days
12567.2
TCGA-HZ-A49H-01A
0 years, female, white, stage:Stage IIB, alive, 491 days
12561.5
TCGA-FB-A545-01A
0 years, female, white, stage:Stage IIB, dead, 732 days
12307.5
TCGA-IB-A6UF-01A
0 years, male, white, stage:Stage IIB, alive, 666 days
12300.2
TCGA-XD-AAUH-01A
0 years, female, white, stage:Stage IIB, alive, 395 days
12291.7
TCGA-HV-A7OP-01A
0 years, male, asian, stage:Stage IIB, alive, 978 days
12281.4
TCGA-2J-AABR-01A
0 years, female, white, stage:Stage IIA, alive, 438 days
12262.1
TCGA-2J-AAB1-01A
0 years, male, white, stage:Stage IIB, dead, 66 days
12022.4
TCGA-HZ-8315-01A
0 years, female, white, stage:Stage IIA, dead, 299 days
11921.4
TCGA-3A-A9I5-01A
0 years, male, white, stage:'--, alive, 1794 days
11919.0
TCGA-XN-A8T3-01A
0 years, male, white, stage:Stage IB, alive, 951 days
11739.2
TCGA-HZ-A49G-01A
0 years, female, white, stage:Stage IIB, alive, 660 days
11728.7
TCGA-IB-A5SO-01A
0 years, male, white, stage:Stage IIB, dead, 365 days
11721.8
TCGA-3A-A9IX-01A
0 years, male, white, stage:Stage IA, alive, 1037 days
11663.1
TCGA-HZ-A77Q-01A
0 years, female, white, stage:Stage IIB, alive, 33 days
11350.4
TCGA-FB-AAQ0-01A
0 years, male, white, stage:Stage IIA, dead, 473 days
11166.2
TCGA-YY-A8LH-01A
0 years, female, white, stage:Stage IIB, alive, 2016 days
11160.4
TCGA-HZ-A4BH-01A
0 years, male, white, stage:Stage IIB, alive, 194 days
11155.8
TCGA-FB-A78T-01A
0 years, female, white, stage:Stage IIB, dead, 375 days
11151.6
TCGA-PZ-A5RE-01A
0 years, female, white, stage:Stage IIB, dead, 470 days
11144.9
TCGA-IB-AAUQ-01A
0 years, male, white, stage:Stage IIB, dead, 183 days
11122.0
TCGA-2L-AAQL-01A
0 years, male, white, stage:Stage IIB, dead, 292 days
11028.6
TCGA-2L-AAQI-01A
0 years, male, white, stage:Stage IIB, dead, 103 days
10999.7
TCGA-IB-A7M4-01A
0 years, male, white, stage:Stage IIB, alive, 483 days
10991.6
TCGA-IB-AAUR-01A
0 years, male, white, stage:Stage IIB, alive, 338 days
10847.9
TCGA-IB-AAUU-01A
0 years, male, white, stage:Stage IIB, alive, 245 days
10826.0
TCGA-S4-A8RP-01A
0 years, female, white, stage:Stage IIB, dead, 702 days
10724.8
TCGA-FB-A4P6-01A
0 years, male, white, stage:Stage IIB, alive, 767 days
10716.9
TCGA-HV-A5A4-01A
0 years, female, asian, stage:Stage IIA, alive, 232 days
10676.6
TCGA-RB-AA9M-01A
0 years, male, white, stage:Stage IIB, alive, 286 days
10674.3
TCGA-2J-AABI-01A
0 years, female, white, stage:Stage IIA, alive, 969 days
10423.7
TCGA-HZ-7289-01A
0 years, male, white, stage:Stage IIB, dead, 661 days
10397.1
TCGA-HZ-8317-01A
0 years, female, white, stage:Stage IIB, dead, 378 days
10061.5
TCGA-2J-AABO-01A
0 years, male, white, stage:Stage IIB, alive, 440 days
9907.8
TCGA-XD-AAUG-01A
0 years, female, white, stage:Stage IV, alive, 420 days
9904.0
TCGA-IB-7887-01A
0 years, female, white, stage:Stage IIB, dead, 110 days
9811.9
TCGA-IB-AAUV-01A
0 years, male, white, stage:Stage IIB, alive, 404 days
9771.7
TCGA-IB-AAUS-01A
0 years, female, white, stage:Stage IIB, alive, 225 days
9634.3
TCGA-FB-A4P5-01A
0 years, female, white, stage:Stage IIB, dead, 179 days
9622.9
TCGA-IB-A5SQ-01A
0 years, female, white, stage:Stage IB, dead, 219 days
9616.7
TCGA-RL-AAAS-01A
0 years, female, white, stage:Stage IB, alive, 9 days
9507.6
TCGA-IB-A6UG-01A
0 years, male, white, stage:Stage IIB, dead, 41 days
9461.9
TCGA-2L-AAQA-01A
0 years, male, white, stage:Stage IIB, dead, 143 days
9209.4
TCGA-IB-7645-01A
0 years, female, stage:Stage IIB, dead, 1502 days
8887.1
TCGA-OE-A75W-01A
0 years, male, white, stage:Stage IIA, dead, 267 days
8846.9
TCGA-US-A77J-01A
0 years, female, white, stage:Stage IIB, dead, 568 days
8844.2
TCGA-IB-AAUT-01A
0 years, male, white, stage:Stage IIB, alive, 287 days
8797.2
TCGA-IB-AAUW-01A
0 years, female, white, stage:Stage IIB, dead, 230 days
8764.9
TCGA-IB-AAUP-01A
0 years, male, white, stage:Stage IIB, alive, 431 days
8714.7
TCGA-IB-AAUN-01A
0 years, female, white, stage:Stage IB, dead, 144 days
8698.6
TCGA-IB-7897-01A
0 years, female, white, stage:Stage IIB, dead, 486 days
8496.0
TCGA-HZ-7924-01A
0 years, female, white, stage:Stage IIA, alive, 840 days
8471.8
TCGA-IB-A7LX-01A
0 years, male, white, stage:Stage IIB, dead, 250 days
8413.3
TCGA-US-A774-01A
0 years, female, white, stage:Stage IIB, dead, 695 days
8405.7
TCGA-FB-A5VM-01A
0 years, male, white, stage:Stage IB, dead, 498 days
8377.0
TCGA-HZ-A49I-01A
0 years, male, white, stage:Stage IIB, dead, 308 days
8315.9
TCGA-XD-AAUL-01A
0 years, male, white, stage:Stage IIA, alive, 498 days
8220.7
TCGA-HZ-7925-01A
0 years, male, white, stage:Stage IIB, dead, 614 days
8177.5
TCGA-HZ-7926-01A
0 years, male, black or african american, stage:Stage IIB, dead, 518 days
8141.9
TCGA-YB-A89D-01A
0 years, male, white, stage:Stage IIB, alive, 350 days
7980.4
TCGA-IB-7889-01A
0 years, female, white, stage:Stage IIB, dead, 481 days
7747.4
TCGA-S4-A8RO-01A
0 years, female, white, stage:Stage IIB, alive, 525 days
7747.1
TCGA-IB-7646-01A
0 years, male, white, stage:Stage IIB, dead, 145 days
7738.3
TCGA-IB-7885-01A
0 years, female, white, stage:Stage IIB, alive, 1257 days
7727.3
TCGA-F2-A7TX-01A
0 years, male, white, stage:Stage IIB, dead, 95 days
7692.5
TCGA-2J-AAB9-01A
0 years, female, white, stage:Stage IIB, dead, 627 days
7604.6
TCGA-HZ-7923-01A
0 years, male, white, stage:Stage IIA, alive, 314 days
7431.8
TCGA-Z5-AAPL-01A
0 years, female, white, stage:Stage IIA, alive, 467 days
7426.6
TCGA-IB-8127-01A
0 years, male, white, stage:Stage IIB, alive, 522 days
7347.8
TCGA-3A-A9IC-01A
0 years, female, white, stage:Stage IIB, dead, 738 days
7316.6
TCGA-IB-7652-01A
0 years, female, asian, stage:Stage IIB, alive, 1116 days
7099.9
TCGA-IB-A5ST-01A
0 years, female, white, stage:Stage IIB, alive, 635 days
7080.8
TCGA-3A-A9IU-01A
0 years, male, white, stage:Stage IIB, dead, 458 days
7032.3
TCGA-3A-A9IZ-01A
0 years, male, white, stage:Stage IIB, dead, 308 days
7022.0
TCGA-IB-8126-01A
0 years, female, white, stage:Stage III, alive, 462 days
7015.0
TCGA-HZ-7920-01A
0 years, male, white, stage:Stage IB, dead, 236 days
6639.1
TCGA-HZ-8636-01A
0 years, female, white, stage:Stage IV, dead, 545 days
6637.0
TCGA-HZ-8001-01A
0 years, male, white, stage:Stage III, alive, 706 days
6626.1
TCGA-IB-AAUM-01A
0 years, male, white, stage:Stage IIB, alive, 8 days
6598.4
TCGA-HZ-8002-01A
0 years, male, white, stage:Stage IIB, dead, 366 days
6538.2
TCGA-F2-7276-01A
0 years, male, white, stage:Stage IIB, dead, 216 days
6491.8
TCGA-LB-A8F3-01A
0 years, female, black or african american, stage:Stage IIA, alive, 379 days
6428.0
TCGA-F2-6879-01A
0 years, male, white, stage:Stage IIB, dead, 334 days
6253.3
TCGA-IB-A5SS-01A
0 years, female, white, stage:Stage IIB, dead, 460 days
5956.5
TCGA-H6-8124-01A
0 years, female, white, stage:Stage IIB, alive, 392 days
5862.2
TCGA-IB-7644-01A
0 years, female, white, stage:Stage IV, dead, 394 days
5709.7
TCGA-HZ-7919-01A
0 years, female, white, stage:Stage IIB, dead, 593 days
5536.4
TCGA-LB-A9Q5-01A
0 years, female, white, stage:Stage IIB, dead, 313 days
5191.6
TCGA-IB-7651-01A
0 years, female, white, stage:Stage IIB, dead, 603 days
5133.6
TCGA-HZ-A77O-01A
0 years, female, white, stage:Stage IIB, dead, 160 days
5058.3
TCGA-F2-6880-01A
0 years, male, white, stage:Stage IIB, alive, 295 days
4993.2
TCGA-IB-7890-01A
0 years, male, stage:Stage IB, dead, 598 days
4953.2
TCGA-HV-A7OL-01A
0 years, male, asian, stage:Stage IIA, alive, 252 days
4777.4
TCGA-2J-AABP-01A
0 years, female, white, stage:Stage IIB, alive, 463 days
4606.7
TCGA-IB-7888-01A
0 years, female, black or african american, stage:Stage IIA, dead, 1332 days
4410.4
TCGA-IB-7893-01A
0 years, male, white, stage:Stage IIA, dead, 117 days
4252.7
TCGA-IB-7654-01A
0 years, male, white, stage:Stage IIB, dead, 476 days
4064.4
TCGA-F2-7273-01A
0 years, male, black or african american, stage:Stage IIB, dead, 592 days
4057.6
TCGA-2J-AABV-01A
0 years, male, white, stage:Stage IIB, dead, 652 days
3924.7
TCGA-IB-7891-01A
0 years, female, white, stage:Stage IIB, dead, 913 days
3913.6
TCGA-HZ-8005-01A
0 years, male, white, stage:Stage IIB, dead, 120 days
3506.1
TCGA-IB-7886-01A
0 years, male, white, stage:Stage IIB, dead, 123 days
3189.4
TCGA-HZ-8003-01A
0 years, female, white, stage:Stage IIB, dead, 596 days
3064.3
TCGA-HZ-7922-01A
0 years, female, white, stage:Stage IIB, alive, 4 days
2875.3
TCGA-HZ-7918-01A
0 years, male, white, stage:Stage IIB, alive, 969 days
The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.
The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".
Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.
Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.
& Survival analysisi
Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.
MT-CO3 is not prognostic in Pancreatic Adenocarcinoma (validation)
Stage:
Survival analysis
Current cut offi
Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.
:
Best expression cut offi
Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .
When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.
Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.
Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.
: N/A
P scorei
Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.
N/A
5-year survival highi
5-year survival for patients with higher expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
5-year survival lowi
5-year survival for patients with lower expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
TCGA RNA samplesi
RNA-seq data is reported as average FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.
Average TPM
2053.1
Number of samples
80
Samples
Sample
Description
TPM
DO49184
0 years, male, NA, stage:, dead, 455 days
10996.9
DO49175
0 years, male, NA, stage:, dead, 414 days
5900.5
DO49168
0 years, male, NA, stage:, alive, 149 days
5101.4
DO49137
0 years, female, NA, stage:, alive, 232 days
4454.1
DO49133
0 years, female, NA, stage:, alive, 188 days
4442.8
DO49181
0 years, male, NA, stage:, dead, 1534 days
4392.4
DO49113
0 years, female, NA, stage:, alive, 413 days
4289.0
DO34640
0 years, female, NA, stage:, dead, 287 days
4000.1
DO49183
0 years, female, NA, stage:, dead, 429 days
3719.8
DO32860
0 years, male, NA, stage:, dead, 1259 days
3533.1
DO49080
0 years, male, NA, stage:, alive, 83 days
3437.6
DO49185
0 years, male, NA, stage:, alive, 179 days
3379.7
DO49087
0 years, female, NA, stage:, dead, 260 days
3185.7
DO49172
0 years, female, NA, stage:, dead, 1021 days
3128.8
DO33392
0 years, male, NA, stage:, alive, 1014 days
3078.5
DO49193
0 years, male, NA, stage:, dead, 1 days
3035.7
DO34961
0 years, male, NA, stage:, dead, 632 days
2965.9
DO49074
0 years, male, NA, stage:, dead, 168 days
2879.1
DO49127
0 years, female, NA, stage:, alive, 392 days
2874.0
DO49198
0 years, female, NA, stage:, dead, 251 days
2711.8
DO49178
0 years, male, NA, stage:, dead, 27 days
2686.2
DO49129
0 years, male, NA, stage:, alive, 337 days
2628.0
DO49135
0 years, male, NA, stage:, alive, 270 days
2582.4
DO34656
0 years, female, NA, stage:, alive, 834 days
2562.2
DO33344
0 years, male, NA, stage:, dead, 361 days
2561.2
DO49164
0 years, male, NA, stage:, alive, 272 days
2371.8
DO33488
0 years, male, NA, stage:, alive, 844 days
2259.2
DO49078
0 years, male, NA, stage:, dead, 465 days
2216.1
DO49170
0 years, male, NA, stage:, alive, 197 days
2169.1
DO34680
0 years, male, NA, stage:, dead, 99 days
2161.8
DO49138
0 years, male, NA, stage:, dead, 230 days
2133.9
DO34504
0 years, male, NA, stage:, dead, 257 days
2103.4
DO49166
0 years, female, NA, stage:, alive, 222 days
2075.0
DO34849
0 years, female, NA, stage:, dead, 272 days
2025.2
DO49204
0 years, male, NA, stage:, dead, 156 days
1992.4
DO34728
0 years, female, NA, stage:, alive, 508 days
1971.1
DO49199
0 years, male, NA, stage:, dead, 1095 days
1961.0
DO34616
0 years, female, NA, stage:, alive, 666 days
1913.3
DO34448
0 years, female, NA, stage:, dead, 719 days
1906.6
DO49130
0 years, female, NA, stage:, alive, 351 days
1861.9
DO34720
0 years, male, NA, stage:, alive, 555 days
1825.9
DO33376
0 years, female, NA, stage:, alive, 909 days
1791.4
DO34312
0 years, female, NA, stage:, dead, 226 days
1774.2
DO34785
0 years, female, NA, stage:, alive, 721 days
1755.5
DO33400
0 years, female, NA, stage:, alive, 1043 days
1742.3
DO32863
0 years, male, NA, stage:, dead, 715 days
1627.3
DO34793
0 years, male, NA, stage:, dead, 427 days
1253.2
DO33128
0 years, male, NA, stage:, dead, 423 days
1216.0
DO34264
0 years, female, NA, stage:, dead, 1144 days
1186.8
DO33984
0 years, male, NA, stage:, alive, 847 days
1186.0
DO32875
0 years, male, NA, stage:, dead, 348 days
1179.5
DO49076
0 years, male, NA, stage:, dead, 480 days
1136.5
DO32900
0 years, male, NA, stage:, dead, 768 days
1081.7
DO33480
0 years, male, NA, stage:, alive, 1054 days
1061.2
DO34801
0 years, male, NA, stage:, alive, 626 days
1058.6
DO34240
0 years, male, NA, stage:, dead, 236 days
1040.6
DO33408
0 years, female, NA, stage:, alive, 909 days
1038.4
DO49090
0 years, female, NA, stage:, dead, 152 days
978.1
DO34809
0 years, female, NA, stage:, dead, 297 days
958.4
DO34288
0 years, female, NA, stage:, dead, 220 days
948.2
DO34696
0 years, male, NA, stage:, alive, 689 days
922.7
DO34368
0 years, female, NA, stage:, dead, 537 days
901.8
DO34736
0 years, female, NA, stage:, dead, 203 days
900.3
DO32829
0 years, female, NA, stage:T2N0MX, dead, 1874 days
855.3
DO33336
0 years, female, NA, stage:, dead, 451 days
826.6
DO33600
0 years, female, NA, stage:, alive, 854 days
772.1
DO34432
0 years, female, NA, stage:, dead, 400 days
769.1
DO34817
0 years, female, NA, stage:, alive, 540 days
737.4
DO49079
0 years, male, NA, stage:, dead, 332 days
700.7
DO33472
0 years, female, NA, stage:, dead, 388 days
686.3
DO33544
0 years, female, NA, stage:, dead, 412 days
652.3
DO33168
0 years, female, NA, stage:, dead, 8 days
646.4
DO33552
0 years, female, NA, stage:, alive, 873 days
644.5
DO34600
0 years, male, NA, stage:, dead, 537 days
618.7
DO34905
0 years, male, NA, stage:, alive, 1142 days
614.8
DO32878
0 years, female, NA, stage:, dead, 260 days
472.9
DO34608
0 years, female, NA, stage:, dead, 709 days
388.9
DO33368
0 years, male, NA, stage:, dead, 98 days
367.2
DO33512
female, NA, stage:, dead, 499 days
215.6
DO34336
0 years, female, NA, stage:, alive, 743 days
74.7
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PANCREATIC DUCTAL ADENOCARCINOMA - Protein relative expression (CPTAC)
Number of samples
235
Samples
Sample ID
Sample type
nRPX
CPT0186040004
Tumor
N/A
CPT0208710004
Normal
N/A
CPT0065640003
Tumor
N/A
CPT0226570004
Tumor
N/A
CPT0093980004
Tumor
N/A
CPT0086210003
Normal
N/A
CPT0123770003
Normal
N/A
CPT0247050003
Normal
N/A
CPT0063580003
Normal
N/A
CPT0236340004
Tumor
N/A
CPT0236710004
Normal
N/A
C3N-02573-03
Normal
N/A
CPT0238530005
Tumor
N/A
CPT0347880002
Normal
N/A
CPT0161990005
Tumor
N/A
CPT0081060004
Tumor
N/A
CPT0124410004
Tumor
N/A
CPT0207990004
Normal
N/A
CPT0198910005
Tumor
N/A
CPT0246260004
Tumor
N/A
CPT0019300004
Tumor
N/A
CPT0125130003
Tumor
N/A
CPT0198700005
Tumor
N/A
CPT0226650004
Tumor
N/A
CPT0276030003
Normal
N/A
CPT0088260004
Tumor
N/A
CPT0239140004
Normal
N/A
CPT0187930005
Tumor
N/A
CPT0000250017
Tumor
N/A
CPT0081360004
Tumor
N/A
CPT0208690004
Tumor
N/A
CPT0124360003
Tumor
N/A
CPT0166780004
Normal
N/A
CPT0241510004
Normal
N/A
CPT0125090003
Tumor
N/A
CPT0063570003
Tumor
N/A
CPT0108410003
Normal
N/A
CPT0123990003
Tumor
N/A
CPT0236780005
Tumor
N/A
CPT0078160004
Tumor
N/A
CPT0248320003
Normal
N/A
CPT0109010004
Tumor
N/A
CPT0014040003
Tumor
N/A
CPT0248410004
Tumor
N/A
CPT0241500004
Tumor
N/A
CPT0208850004
Normal
N/A
CPT0174800003
Normal
N/A
CPT0247040003
Tumor
N/A
CPT0183450005
Tumor
N/A
CPT0125010003
Normal
N/A
CPT0094740004
Tumor
N/A
CPT0185920004
Tumor
N/A
CPT0226680005
Tumor
N/A
CPT0011540003
Normal
N/A
CPT0094030003
Tumor
N/A
CPT0166650006
Tumor
N/A
CPT0203850004
Tumor
N/A
CPT0094230004
Tumor
N/A
CPT0209650004
Normal
N/A
CPT0224470004
Normal
N/A
CPT0238940004
Normal
N/A
CPT0123650003
Tumor
N/A
C3L-01687-04
Normal
N/A
CPT0198930003
Normal
N/A
CPT0239920004
Normal
N/A
CPT0162670004
Normal
N/A
CPT0218200004
Tumor
N/A
CPT0226760004
Tumor
N/A
CPT0138890003
Normal
N/A
CPT0237850004
Normal
N/A
CPT0208840004
Tumor
N/A
CPT0246940003
Tumor
N/A
CPT0123860003
Tumor
N/A
CPT0088320003
Tumor
N/A
CPT0246950003
Normal
N/A
CPT0064110003
Normal
N/A
CPT0109110004
Tumor
N/A
CPT0227930004
Tumor
N/A
CPT0066020003
Normal
N/A
CPT0247000003
Normal
N/A
CPT0025750003
Tumor
N/A
CPT0094630004
Tumor
N/A
CPT0239100009
Tumor
N/A
CPT0248620003
Normal
N/A
CPT0077930004
Tumor
N/A
CPT0078250003
Tumor
N/A
CPT0355190003
Normal
N/A
CPT0078030003
Normal
N/A
CPT0347760002
Normal
N/A
C3L-00401-04
Normal
N/A
CPT0197440004
Normal
N/A
CPT0081260004
Tumor
N/A
CPT0086190004
Tumor
N/A
CPT0087890004
Tumor
N/A
CPT0077810003
Normal
N/A
CPT0109300004
Tumor
N/A
CPT0019410004
Tumor
N/A
CPT0246840003
Tumor
N/A
CPT0235230004
Tumor
N/A
CPT0236800004
Normal
N/A
CPT0238820005
Tumor
N/A
CPT0017130003
Normal
N/A
CPT0008800003
Tumor
N/A
CPT0077790004
Tumor
N/A
CPT0001750003
Normal
N/A
CPT0237270005
Tumor
N/A
CPT0187550004
Tumor
N/A
KoreanReference3
Tumor
N/A
CPT0077860003
Tumor
N/A
WU-pooled sample
Tumor
N/A
KoreanReference2
Tumor
N/A
CPT0089750004
Normal
N/A
CPT0238740004
Normal
N/A
CPT0014060003
Normal
N/A
CPT0239910004
Tumor
N/A
CPT0238610009
Tumor
N/A
CPT0109130003
Normal
N/A
CPT0347850002
Normal
N/A
CPT0238040005
Tumor
N/A
CPT0089720003
Tumor
N/A
CPT0236700005
Tumor
N/A
CPT0138900004
Tumor
N/A
CPT0254680003
Tumor
N/A
CPT0064520004
Tumor
N/A
CPT0123890003
Normal
N/A
CPT0241320005
Tumor
N/A
CPT0246720003
Tumor
N/A
CPT0064570003
Normal
N/A
CPT0221250004
Normal
N/A
CPT0166680004
Normal
N/A
CPT0123460003
Normal
N/A
CPT0093930004
Tumor
N/A
CPT0226530004
Tumor
N/A
CPT0064090003
Tumor
N/A
CPT0355200003
Normal
N/A
CPT0094760003
Normal
N/A
CPT0170240004
Tumor
N/A
CPT0247090003
Tumor
N/A
CPT0226610004
Normal
N/A
CPT0198420004
Tumor
N/A
CPT0209310004
Tumor
N/A
CPT0093860003
Tumor
N/A
CPT0083270003
Tumor
N/A
CPT0091680003
Normal
N/A
CPT0237920004
Normal
N/A
CPT0093880003
Normal
N/A
CPT0183750005
Tumor
N/A
CPT0246990003
Tumor
N/A
CPT0124530003
Normal
N/A
CPT0238710004
Tumor
N/A
CPT0091660003
Tumor
N/A
CPT0063970004
Tumor
N/A
CPT0108400003
Tumor
N/A
CPT0186050004
Normal
N/A
CPT0124610004
Tumor
N/A
CPT0237290004
Normal
N/A
KoreanReference1
Tumor
N/A
CPT0017040004
Tumor
N/A
CPT0248440003
Normal
N/A
CPT0198440004
Normal
N/A
CPT0123670003
Normal
N/A
CPT0077950003
Normal
N/A
CPT0248590004
Tumor
N/A
CPT0011520003
Tumor
N/A
CPT0226600004
Tumor
N/A
CPT0161770004
Tumor
N/A
CPT0264180003
Normal
N/A
CPT0065570003
Tumor
N/A
CPT0124980004
Tumor
N/A
CPT0238440005
Tumor
N/A
CPT0207780004
Tumor
N/A
CPT0246210004
Tumor
N/A
CPT0094180003
Tumor
N/A
CPT0221470005
Tumor
N/A
CPT0108930003
Tumor
N/A
CPT0207980005
Tumor
N/A
CPT0109200004
Tumor
N/A
C3L-00189-04
Normal
N/A
CPT0008750003
Tumor
N/A
CPT0078090004
Tumor
N/A
CPT0123440003
Tumor
N/A
CPT0238640004
Normal
N/A
CPT0237840004
Tumor
N/A
CPT0081470004
Tumor
N/A
CPT0127290003
Normal
N/A
CPT0264150003
Tumor
N/A
CPT0124500004
Tumor
N/A
CPT0187540004
Normal
N/A
CPT0209640005
Tumor
N/A
CPT0170260004
Normal
N/A
CPT0092630003
Tumor
N/A
CPT0063990003
Normal
N/A
CPT0124000003
Normal
N/A
CPT0208550005
Tumor
N/A
WU-PDA1
Tumor
N/A
CPT0138990003
Normal
N/A
CPT0183770004
Normal
N/A
CPT0127270003
Tumor
N/A
CPT0162660004
Tumor
N/A
CPT0094130004
Tumor
N/A
CPT0126200003
Normal
N/A
CPT0162760003
Tumor
N/A
CPT0246220004
Normal
N/A
CPT0001730017
Tumor
N/A
CPT0197420004
Tumor
N/A
C3L-03632-04
Normal
N/A
CPT0221240004
Tumor
N/A
CPT0347820002
Normal
N/A
CPT0226490004
Tumor
N/A
CPT0217700004
Tumor
N/A
CPT0174700004
Tumor
N/A
CPT0139000004
Tumor
N/A
CPT0126160004
Tumor
N/A
CPT0237910004
Tumor
N/A
CPT0025760003
Normal
N/A
CPT0198730004
Normal
N/A
CPT0355180003
Normal
N/A
CPT0224460004
Tumor
N/A
CPT0108960003
Normal
N/A
CPT0347790002
Normal
N/A
CPT0123750003
Tumor
N/A
CPT0236560004
Tumor
N/A
CPT0166760004
Tumor
N/A
CPT0276010003
Tumor
N/A
CPT0246810003
Tumor
N/A
CPT0238920004
Tumor
N/A
C3N-00709-06
Normal
N/A
CPT0077880003
Normal
N/A
CPT0078180003
Normal
N/A
CPT0088180004
Tumor
N/A
CPT0236360004
Normal
N/A
CPT0218220004
Normal
N/A
CPT0094940004
Tumor
N/A
CPT0078000003
Tumor
N/A
CPT0162780004
Normal
N/A
Show allShow less
PANCREATIC CANCER - Protein expressioni
A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here.
Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
Antibody stainingi
Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells.
Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.
The Human Protein Atlas project is funded
