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The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.
The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".
Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.
Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.
& Survival analysisi
Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.
SERPINA1 is not prognostic in Pancreatic Adenocarcinoma (TCGA)
Stage:
Survival analysis
Current cut offi
Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.
:
Best expression cut offi
Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .
When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.
Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.
Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.
: N/A
P scorei
Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.
N/A
5-year survival highi
5-year survival for patients with higher expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
5-year survival lowi
5-year survival for patients with lower expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
TCGA RNA samplesi
RNA-seq data is reported as average FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.
Average TPM
1332.6
Number of samples
176
Samples
Sample
Description
TPM
TCGA-3A-A9IN-01A
0 years, female, white, stage:Stage IB, alive, 2084 days
16622.2
TCGA-3A-A9I5-01A
0 years, male, white, stage:'--, alive, 1794 days
12366.4
TCGA-LB-A8F3-01A
0 years, female, black or african american, stage:Stage IIA, alive, 379 days
12204.4
TCGA-2L-AAQM-01A
0 years, male, white, stage:Stage IIB, alive, 1383 days
11500.4
TCGA-3A-A9IO-01A
0 years, male, white, stage:'--, alive, 1942 days
9695.3
TCGA-HZ-7918-01A
0 years, male, white, stage:Stage IIB, alive, 969 days
8300.0
TCGA-3A-A9IS-01A
0 years, male, white, stage:Stage IB, alive, 998 days
6433.9
TCGA-3A-A9IZ-01A
0 years, male, white, stage:Stage IIB, dead, 308 days
5621.6
TCGA-3A-A9IV-01A
0 years, female, white, stage:Stage IB, alive, 1103 days
3771.0
TCGA-IB-A6UF-01A
0 years, male, white, stage:Stage IIB, alive, 666 days
3735.2
TCGA-FB-AAQ1-01A
0 years, male, white, stage:Stage IIB, dead, 123 days
2764.5
TCGA-Q3-AA2A-01A
0 years, female, white, stage:Stage IB, alive, 95 days
2755.6
TCGA-FB-AAPY-01A
0 years, male, white, stage:Stage IIB, dead, 1059 days
2740.3
TCGA-FB-AAQ6-01A
0 years, male, white, stage:Stage IA, dead, 244 days
2603.9
TCGA-HV-AA8V-01A
0 years, male, asian, stage:Stage IIB, alive, 920 days
2458.1
TCGA-HZ-7289-01A
0 years, male, white, stage:Stage IIB, dead, 661 days
2441.8
TCGA-HZ-7924-01A
0 years, female, white, stage:Stage IIA, alive, 840 days
2236.1
TCGA-HZ-A49I-01A
0 years, male, white, stage:Stage IIB, dead, 308 days
2180.0
TCGA-2J-AABR-01A
0 years, female, white, stage:Stage IIA, alive, 438 days
2095.3
TCGA-2J-AAB4-01A
0 years, male, white, stage:Stage IIB, alive, 729 days
2070.9
TCGA-HZ-A9TJ-01A
0 years, male, white, stage:Stage IV, alive, 603 days
2060.9
TCGA-2J-AABE-01A
0 years, male, white, stage:Stage IIA, alive, 676 days
1998.5
TCGA-F2-7276-01A
0 years, male, white, stage:Stage IIB, dead, 216 days
1933.1
TCGA-IB-7887-01A
0 years, female, white, stage:Stage IIB, dead, 110 days
1866.0
TCGA-3A-A9IU-01A
0 years, male, white, stage:Stage IIB, dead, 458 days
1863.2
TCGA-H6-8124-01A
0 years, female, white, stage:Stage IIB, alive, 392 days
1863.2
TCGA-XD-AAUL-01A
0 years, male, white, stage:Stage IIA, alive, 498 days
1832.2
TCGA-RL-AAAS-01A
0 years, female, white, stage:Stage IB, alive, 9 days
1761.8
TCGA-IB-7649-01A
0 years, female, stage:Stage IIB, dead, 467 days
1691.8
TCGA-2L-AAQI-01A
0 years, male, white, stage:Stage IIB, dead, 103 days
1680.7
TCGA-IB-AAUQ-01A
0 years, male, white, stage:Stage IIB, dead, 183 days
1676.8
TCGA-S4-A8RP-01A
0 years, female, white, stage:Stage IIB, dead, 702 days
1630.2
TCGA-3A-A9IR-01A
0 years, female, white, stage:Stage IB, alive, 1542 days
1628.2
TCGA-S4-A8RO-01A
0 years, female, white, stage:Stage IIB, alive, 525 days
1612.9
TCGA-2J-AABF-01A
0 years, male, white, stage:Stage IIB, dead, 691 days
1592.9
TCGA-HZ-8638-01A
0 years, female, white, stage:Stage IA, dead, 151 days
1551.9
TCGA-HV-A5A6-01A
0 years, female, asian, stage:Stage IIB, dead, 2036 days
1540.7
TCGA-HZ-A77Q-01A
0 years, female, white, stage:Stage IIB, alive, 33 days
1467.1
TCGA-XN-A8T3-01A
0 years, male, white, stage:Stage IB, alive, 951 days
1451.8
TCGA-FB-A545-01A
0 years, female, white, stage:Stage IIB, dead, 732 days
1434.3
TCGA-US-A77J-01A
0 years, female, white, stage:Stage IIB, dead, 568 days
1432.9
TCGA-HZ-7920-01A
0 years, male, white, stage:Stage IB, dead, 236 days
1412.8
TCGA-2J-AAB9-01A
0 years, female, white, stage:Stage IIB, dead, 627 days
1342.3
TCGA-FB-AAPQ-01A
0 years, male, white, stage:Stage IIB, dead, 1130 days
1334.3
TCGA-RB-AA9M-01A
0 years, male, white, stage:Stage IIB, alive, 286 days
1333.9
TCGA-IB-7651-01A
0 years, female, white, stage:Stage IIB, dead, 603 days
1318.2
TCGA-HZ-A77O-01A
0 years, female, white, stage:Stage IIB, dead, 160 days
1309.8
TCGA-IB-AAUW-01A
0 years, female, white, stage:Stage IIB, dead, 230 days
1303.6
TCGA-IB-7885-01A
0 years, female, white, stage:Stage IIB, alive, 1257 days
1302.5
TCGA-IB-AAUT-01A
0 years, male, white, stage:Stage IIB, alive, 287 days
1294.8
TCGA-IB-A7LX-01A
0 years, male, white, stage:Stage IIB, dead, 250 days
1294.4
TCGA-HV-A5A5-01A
0 years, female, asian, stage:Stage IIB, alive, 289 days
1291.6
TCGA-HZ-8317-01A
0 years, female, white, stage:Stage IIB, dead, 378 days
1268.2
TCGA-HZ-8636-01A
0 years, female, white, stage:Stage IV, dead, 545 days
1259.2
TCGA-HZ-8002-01A
0 years, male, white, stage:Stage IIB, dead, 366 days
1228.7
TCGA-RB-A7B8-01A
0 years, female, white, stage:Stage IIB, dead, 466 days
1221.5
TCGA-F2-7273-01A
0 years, male, black or african american, stage:Stage IIB, dead, 592 days
1197.5
TCGA-HZ-7926-01A
0 years, male, black or african american, stage:Stage IIB, dead, 518 days
1148.3
TCGA-F2-A44G-01A
0 years, female, white, stage:Stage IIB, dead, 233 days
1105.0
TCGA-HZ-A4BK-01A
0 years, male, white, stage:Stage IIB, alive, 657 days
1104.2
TCGA-IB-AAUO-01A
0 years, female, white, stage:Stage IIB, dead, 239 days
1103.3
TCGA-2J-AABH-01A
0 years, male, white, stage:Stage IIA, alive, 1287 days
1045.7
TCGA-FB-A78T-01A
0 years, female, white, stage:Stage IIB, dead, 375 days
1030.2
TCGA-3A-A9IB-01A
0 years, female, white, stage:Stage IIB, dead, 224 days
1011.1
TCGA-YY-A8LH-01A
0 years, female, white, stage:Stage IIB, alive, 2016 days
989.1
TCGA-3A-A9I9-01A
0 years, male, white, stage:Stage IIA, dead, 634 days
983.7
TCGA-FB-AAPZ-01A
0 years, male, white, stage:Stage IIB, alive, 716 days
975.1
TCGA-HZ-7923-01A
0 years, male, white, stage:Stage IIA, alive, 314 days
969.8
TCGA-US-A774-01A
0 years, female, white, stage:Stage IIB, dead, 695 days
965.2
TCGA-IB-7652-01A
0 years, female, asian, stage:Stage IIB, alive, 1116 days
948.8
TCGA-US-A77E-01A
0 years, male, white, stage:Stage IIB, dead, 430 days
944.2
TCGA-IB-8127-01A
0 years, male, white, stage:Stage IIB, alive, 522 days
941.4
TCGA-FB-A4P6-01A
0 years, male, white, stage:Stage IIB, alive, 767 days
935.1
TCGA-3A-A9IC-01A
0 years, female, white, stage:Stage IIB, dead, 738 days
907.5
TCGA-LB-A9Q5-01A
0 years, female, white, stage:Stage IIB, dead, 313 days
901.4
TCGA-IB-7897-01A
0 years, female, white, stage:Stage IIB, dead, 486 days
899.8
TCGA-HV-A5A3-01A
0 years, male, asian, stage:Stage IIA, dead, 128 days
883.7
TCGA-IB-AAUS-01A
0 years, female, white, stage:Stage IIB, alive, 225 days
873.8
TCGA-HZ-8001-01A
0 years, male, white, stage:Stage III, alive, 706 days
861.0
TCGA-F2-A8YN-01A
0 years, male, white, stage:Stage IIA, alive, 517 days
859.3
TCGA-IB-7889-01A
0 years, female, white, stage:Stage IIB, dead, 481 days
848.7
TCGA-OE-A75W-01A
0 years, male, white, stage:Stage IIA, dead, 267 days
837.6
TCGA-2L-AAQJ-01A
0 years, female, white, stage:Stage III, dead, 394 days
781.2
TCGA-F2-A44H-01A
0 years, male, white, stage:Stage IIA, alive, 586 days
758.8
TCGA-IB-7886-01A
0 years, male, white, stage:Stage IIB, dead, 123 days
751.8
TCGA-IB-7888-01A
0 years, female, black or african american, stage:Stage IIA, dead, 1332 days
745.9
TCGA-F2-A7TX-01A
0 years, male, white, stage:Stage IIB, dead, 95 days
742.7
TCGA-IB-A6UG-01A
0 years, male, white, stage:Stage IIB, dead, 41 days
735.0
TCGA-IB-7891-01A
0 years, female, white, stage:Stage IIB, dead, 913 days
718.2
TCGA-2J-AABA-01A
0 years, male, white, stage:Stage IIB, dead, 607 days
715.1
TCGA-XD-AAUI-01A
0 years, female, white, stage:Stage IIB, dead, 366 days
708.7
TCGA-HZ-7919-01A
0 years, female, white, stage:Stage IIB, dead, 593 days
705.8
TCGA-XD-AAUG-01A
0 years, female, white, stage:Stage IV, alive, 420 days
702.4
TCGA-IB-7645-01A
0 years, female, stage:Stage IIB, dead, 1502 days
695.2
TCGA-3A-A9I7-01A
0 years, male, black or african american, stage:Stage IIB, alive, 1323 days
692.5
TCGA-FB-A7DR-01A
0 years, male, asian, stage:Stage IIA, dead, 353 days
689.2
TCGA-M8-A5N4-01A
0 years, female, stage:Stage IIA, alive, 584 days
669.0
TCGA-YB-A89D-01A
0 years, male, white, stage:Stage IIB, alive, 350 days
664.3
TCGA-FB-AAQ3-01A
0 years, female, white, stage:Stage IIB, dead, 31 days
653.3
TCGA-HZ-8315-01A
0 years, female, white, stage:Stage IIA, dead, 299 days
631.3
TCGA-H6-A45N-01A
0 years, female, white, stage:Stage IIB, dead, 397 days
630.7
TCGA-H8-A6C1-01A
0 years, male, white, stage:Stage IIA, alive, 671 days
622.1
TCGA-US-A779-01A
0 years, female, white, stage:Stage IIB, dead, 511 days
615.9
TCGA-IB-AAUU-01A
0 years, male, white, stage:Stage IIB, alive, 245 days
602.6
TCGA-3A-A9J0-01A
0 years, male, white, stage:Stage IIB, alive, 743 days
599.6
TCGA-HV-A7OL-01A
0 years, male, asian, stage:Stage IIA, alive, 252 days
599.6
TCGA-HZ-A49G-01A
0 years, female, white, stage:Stage IIB, alive, 660 days
592.1
TCGA-2J-AABO-01A
0 years, male, white, stage:Stage IIB, alive, 440 days
561.1
TCGA-IB-AAUN-01A
0 years, female, white, stage:Stage IB, dead, 144 days
557.2
TCGA-HZ-A4BH-01A
0 years, male, white, stage:Stage IIB, alive, 194 days
554.6
TCGA-HZ-A77P-01A
0 years, male, white, stage:Stage IIB, alive, 330 days
548.3
TCGA-HV-A7OP-01A
0 years, male, asian, stage:Stage IIB, alive, 978 days
540.8
TCGA-PZ-A5RE-01A
0 years, female, white, stage:Stage IIB, dead, 470 days
538.7
TCGA-HZ-A49H-01A
0 years, female, white, stage:Stage IIB, alive, 491 days
530.1
TCGA-3E-AAAY-01A
0 years, male, white, stage:Stage IIB, alive, 2285 days
527.9
TCGA-IB-A5SS-01A
0 years, female, white, stage:Stage IIB, dead, 460 days
525.9
TCGA-HV-A5A4-01A
0 years, female, asian, stage:Stage IIA, alive, 232 days
525.1
TCGA-HZ-8637-01A
0 years, female, white, stage:Stage IIB, dead, 517 days
522.3
TCGA-IB-AAUV-01A
0 years, male, white, stage:Stage IIB, alive, 404 days
521.6
TCGA-FB-AAPP-01A
0 years, male, white, stage:Stage IIB, dead, 485 days
520.1
TCGA-FB-AAQ2-01A
0 years, female, white, stage:Stage IIB, dead, 153 days
516.8
TCGA-HZ-7922-01A
0 years, female, white, stage:Stage IIB, alive, 4 days
503.9
TCGA-US-A77G-01A
0 years, male, white, stage:Stage IIB, dead, 12 days
482.5
TCGA-2J-AABK-01A
0 years, male, white, stage:Stage IIB, alive, 484 days
472.5
TCGA-2J-AABT-01A
0 years, female, white, stage:Stage IIB, alive, 319 days
466.0
TCGA-FB-AAQ0-01A
0 years, male, white, stage:Stage IIA, dead, 473 days
435.1
TCGA-IB-A5SP-01A
0 years, male, white, stage:Stage IIA, alive, 482 days
411.7
TCGA-2L-AAQL-01A
0 years, male, white, stage:Stage IIB, dead, 292 days
407.4
TCGA-FB-A4P5-01A
0 years, female, white, stage:Stage IIB, dead, 179 days
398.8
TCGA-3A-A9IX-01A
0 years, male, white, stage:Stage IA, alive, 1037 days
392.3
TCGA-IB-AAUP-01A
0 years, male, white, stage:Stage IIB, alive, 431 days
389.7
TCGA-US-A776-01A
0 years, male, white, stage:Stage IIA, alive, 1216 days
381.0
TCGA-2J-AABU-01A
0 years, male, white, stage:Stage IIB, dead, 277 days
374.9
TCGA-2L-AAQA-01A
0 years, male, white, stage:Stage IIB, dead, 143 days
354.8
TCGA-HZ-8005-01A
0 years, male, white, stage:Stage IIB, dead, 120 days
352.2
TCGA-HZ-A8P1-01A
0 years, male, white, stage:Stage IB, alive, 7 days
348.0
TCGA-2J-AAB6-01A
0 years, male, white, stage:Stage IIA, dead, 293 days
346.5
TCGA-XD-AAUH-01A
0 years, female, white, stage:Stage IIB, alive, 395 days
344.0
TCGA-IB-AAUR-01A
0 years, male, white, stage:Stage IIB, alive, 338 days
334.2
TCGA-2J-AABV-01A
0 years, male, white, stage:Stage IIB, dead, 652 days
333.8
TCGA-3A-A9IH-01A
0 years, female, white, stage:Stage IA, alive, 1021 days
332.1
TCGA-IB-A5SO-01A
0 years, male, white, stage:Stage IIB, dead, 365 days
331.4
TCGA-XN-A8T5-01A
0 years, female, white, stage:Stage IB, alive, 720 days
327.4
TCGA-IB-A5SQ-01A
0 years, female, white, stage:Stage IB, dead, 219 days
327.2
TCGA-S4-A8RM-01A
0 years, male, white, stage:Stage IIB, alive, 737 days
326.3
TCGA-FB-AAPU-01A
0 years, female, asian, stage:Stage IIA, dead, 381 days
319.4
TCGA-3A-A9IL-01A
0 years, female, white, stage:Stage I, alive, 2741 days
303.0
TCGA-IB-7890-01A
0 years, male, stage:Stage IB, dead, 598 days
286.4
TCGA-IB-7893-01A
0 years, male, white, stage:Stage IIA, dead, 117 days
284.4
TCGA-F2-6879-01A
0 years, male, white, stage:Stage IIB, dead, 334 days
278.7
TCGA-2J-AAB1-01A
0 years, male, white, stage:Stage IIB, dead, 66 days
260.9
TCGA-HZ-8519-01A
0 years, male, white, stage:Stage IA, alive, 454 days
250.2
TCGA-HV-AA8X-01A
0 years, female, asian, stage:Stage IIB, dead, 532 days
247.6
TCGA-IB-7646-01A
0 years, male, white, stage:Stage IIB, dead, 145 days
238.3
TCGA-IB-AAUM-01A
0 years, male, white, stage:Stage IIB, alive, 8 days
237.3
TCGA-IB-A7M4-01A
0 years, male, white, stage:Stage IIB, alive, 483 days
232.3
TCGA-2J-AABI-01A
0 years, female, white, stage:Stage IIA, alive, 969 days
223.7
TCGA-IB-7654-01A
0 years, male, white, stage:Stage IIB, dead, 476 days
222.5
TCGA-IB-A5ST-01A
0 years, female, white, stage:Stage IIB, alive, 635 days
218.1
TCGA-IB-7644-01A
0 years, female, white, stage:Stage IV, dead, 394 days
205.0
TCGA-2L-AAQE-01A
0 years, male, white, stage:Stage IIB, dead, 684 days
201.2
TCGA-IB-8126-01A
0 years, female, white, stage:Stage III, alive, 462 days
193.0
TCGA-3E-AAAZ-01A
0 years, male, white, stage:Stage IIA, dead, 2182 days
191.6
TCGA-HZ-8003-01A
0 years, female, white, stage:Stage IIB, dead, 596 days
190.2
TCGA-FB-AAPS-01A
0 years, female, white, stage:Stage IIB, alive, 228 days
174.8
TCGA-YH-A8SY-01A
0 years, female, white, stage:'--, alive, 388 days
164.2
TCGA-2J-AABP-01A
0 years, female, white, stage:Stage IIB, alive, 463 days
162.8
TCGA-2J-AAB8-01A
0 years, male, white, stage:Stage IIB, alive, 80 days
134.7
TCGA-Z5-AAPL-01A
0 years, female, white, stage:Stage IIA, alive, 467 days
122.5
TCGA-L1-A7W4-01A
0 years, female, white, stage:Stage IIB, dead, 278 days
120.7
TCGA-FB-A5VM-01A
0 years, male, white, stage:Stage IB, dead, 498 days
97.6
TCGA-HZ-7925-01A
0 years, male, white, stage:Stage IIB, dead, 614 days
93.3
TCGA-LB-A7SX-01A
0 years, female, black or african american, stage:Stage IIB, dead, 393 days
93.3
TCGA-Q3-A5QY-01A
0 years, male, white, stage:Stage IIB, alive, 416 days
88.0
TCGA-F2-6880-01A
0 years, male, white, stage:Stage IIB, alive, 295 days
41.6
TCGA-3A-A9IJ-01A
0 years, male, white, stage:Stage IB, alive, 1854 days
The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.
The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".
Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.
Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.
& Survival analysisi
Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.
SERPINA1 is not prognostic in Pancreatic Adenocarcinoma (validation)
Stage:
Survival analysis
Current cut offi
Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.
:
Best expression cut offi
Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .
When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.
Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.
Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.
: N/A
P scorei
Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.
N/A
5-year survival highi
5-year survival for patients with higher expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
5-year survival lowi
5-year survival for patients with lower expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
TCGA RNA samplesi
RNA-seq data is reported as average FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.
Average TPM
363.0
Number of samples
80
Samples
Sample
Description
TPM
DO49113
0 years, female, NA, stage:, alive, 413 days
2841.5
DO49193
0 years, male, NA, stage:, dead, 1 days
2169.8
DO34504
0 years, male, NA, stage:, dead, 257 days
1599.0
DO32829
0 years, female, NA, stage:T2N0MX, dead, 1874 days
1598.0
DO34720
0 years, male, NA, stage:, alive, 555 days
1153.8
DO49166
0 years, female, NA, stage:, alive, 222 days
1034.6
DO34961
0 years, male, NA, stage:, dead, 632 days
903.5
DO49135
0 years, male, NA, stage:, alive, 270 days
825.3
DO34680
0 years, male, NA, stage:, dead, 99 days
722.0
DO34240
0 years, male, NA, stage:, dead, 236 days
561.3
DO49172
0 years, female, NA, stage:, dead, 1021 days
538.7
DO34640
0 years, female, NA, stage:, dead, 287 days
528.6
DO34849
0 years, female, NA, stage:, dead, 272 days
516.9
DO32875
0 years, male, NA, stage:, dead, 348 days
515.7
DO34736
0 years, female, NA, stage:, dead, 203 days
511.0
DO34312
0 years, female, NA, stage:, dead, 226 days
491.0
DO49076
0 years, male, NA, stage:, dead, 480 days
487.9
DO32863
0 years, male, NA, stage:, dead, 715 days
477.7
DO49080
0 years, male, NA, stage:, alive, 83 days
463.9
DO33488
0 years, male, NA, stage:, alive, 844 days
448.5
DO33344
0 years, male, NA, stage:, dead, 361 days
442.1
DO34793
0 years, male, NA, stage:, dead, 427 days
440.0
DO49090
0 years, female, NA, stage:, dead, 152 days
402.2
DO33376
0 years, female, NA, stage:, alive, 909 days
377.8
DO34696
0 years, male, NA, stage:, alive, 689 days
359.4
DO49074
0 years, male, NA, stage:, dead, 168 days
341.2
DO49185
0 years, male, NA, stage:, alive, 179 days
323.4
DO49130
0 years, female, NA, stage:, alive, 351 days
321.7
DO49164
0 years, male, NA, stage:, alive, 272 days
320.6
DO49170
0 years, male, NA, stage:, alive, 197 days
309.5
DO34432
0 years, female, NA, stage:, dead, 400 days
305.5
DO49087
0 years, female, NA, stage:, dead, 260 days
299.3
DO49138
0 years, male, NA, stage:, dead, 230 days
292.8
DO49198
0 years, female, NA, stage:, dead, 251 days
290.1
DO33472
0 years, female, NA, stage:, dead, 388 days
277.6
DO33400
0 years, female, NA, stage:, alive, 1043 days
271.9
DO49079
0 years, male, NA, stage:, dead, 332 days
239.7
DO32860
0 years, male, NA, stage:, dead, 1259 days
228.7
DO33128
0 years, male, NA, stage:, dead, 423 days
224.3
DO49129
0 years, male, NA, stage:, alive, 337 days
220.4
DO34809
0 years, female, NA, stage:, dead, 297 days
218.7
DO49184
0 years, male, NA, stage:, dead, 455 days
215.5
DO34785
0 years, female, NA, stage:, alive, 721 days
215.5
DO32878
0 years, female, NA, stage:, dead, 260 days
213.8
DO49183
0 years, female, NA, stage:, dead, 429 days
213.1
DO33600
0 years, female, NA, stage:, alive, 854 days
205.8
DO34600
0 years, male, NA, stage:, dead, 537 days
195.8
DO34288
0 years, female, NA, stage:, dead, 220 days
164.2
DO33984
0 years, male, NA, stage:, alive, 847 days
163.2
DO34264
0 years, female, NA, stage:, dead, 1144 days
148.6
DO32900
0 years, male, NA, stage:, dead, 768 days
143.9
DO33392
0 years, male, NA, stage:, alive, 1014 days
139.4
DO49078
0 years, male, NA, stage:, dead, 465 days
139.1
DO49181
0 years, male, NA, stage:, dead, 1534 days
131.1
DO49199
0 years, male, NA, stage:, dead, 1095 days
128.7
DO34608
0 years, female, NA, stage:, dead, 709 days
122.3
DO49178
0 years, male, NA, stage:, dead, 27 days
117.9
DO33544
0 years, female, NA, stage:, dead, 412 days
117.2
DO34368
0 years, female, NA, stage:, dead, 537 days
115.4
DO34905
0 years, male, NA, stage:, alive, 1142 days
111.6
DO49137
0 years, female, NA, stage:, alive, 232 days
110.3
DO49133
0 years, female, NA, stage:, alive, 188 days
105.7
DO33552
0 years, female, NA, stage:, alive, 873 days
86.2
DO49127
0 years, female, NA, stage:, alive, 392 days
84.3
DO34656
0 years, female, NA, stage:, alive, 834 days
80.2
DO34801
0 years, male, NA, stage:, alive, 626 days
73.1
DO49168
0 years, male, NA, stage:, alive, 149 days
72.9
DO33368
0 years, male, NA, stage:, dead, 98 days
69.8
DO33408
0 years, female, NA, stage:, alive, 909 days
60.6
DO33512
female, NA, stage:, dead, 499 days
59.5
DO34728
0 years, female, NA, stage:, alive, 508 days
57.0
DO49175
0 years, male, NA, stage:, dead, 414 days
49.5
DO33168
0 years, female, NA, stage:, dead, 8 days
49.0
DO34616
0 years, female, NA, stage:, alive, 666 days
47.9
DO34448
0 years, female, NA, stage:, dead, 719 days
37.3
DO33336
0 years, female, NA, stage:, dead, 451 days
33.4
DO34817
0 years, female, NA, stage:, alive, 540 days
28.2
DO33480
0 years, male, NA, stage:, alive, 1054 days
24.0
DO49204
0 years, male, NA, stage:, dead, 156 days
17.4
DO34336
0 years, female, NA, stage:, alive, 743 days
1.9
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PANCREATIC DUCTAL ADENOCARCINOMA - Protein relative expression (CPTAC)
Number of samples
235
Samples
Sample ID
Sample type
nRPX
CPT0088260004
Tumor
1.3
CPT0236340004
Tumor
1.1
CPT0197440004
Normal
1.0
CPT0011520003
Tumor
1.0
CPT0123750003
Tumor
0.9
WU-PDA1
Tumor
0.9
CPT0187930005
Tumor
0.9
CPT0247000003
Normal
0.9
CPT0226490004
Tumor
0.8
CPT0247040003
Tumor
0.8
CPT0161990005
Tumor
0.8
CPT0078030003
Normal
0.8
CPT0138990003
Normal
0.8
CPT0123650003
Tumor
0.8
CPT0226650004
Tumor
0.8
CPT0093980004
Tumor
0.7
CPT0123860003
Tumor
0.7
CPT0226610004
Normal
0.7
CPT0109010004
Tumor
0.6
CPT0001730017
Tumor
0.6
CPT0185920004
Tumor
0.6
CPT0246210004
Tumor
0.6
CPT0094230004
Tumor
0.5
CPT0174800003
Normal
0.5
CPT0238820005
Tumor
0.5
CPT0123990003
Tumor
0.5
CPT0008750003
Tumor
0.5
CPT0077880003
Normal
0.5
CPT0355200003
Normal
0.4
CPT0081060004
Tumor
0.4
CPT0088320003
Tumor
0.4
C3L-00401-04
Normal
0.4
CPT0187550004
Tumor
0.4
CPT0123770003
Normal
0.4
CPT0064570003
Normal
0.4
CPT0238610009
Tumor
0.4
CPT0226600004
Tumor
0.3
CPT0170240004
Tumor
0.3
CPT0065640003
Tumor
0.3
CPT0000250017
Tumor
0.3
CPT0109200004
Tumor
0.3
CPT0162660004
Tumor
0.3
CPT0108400003
Tumor
0.3
CPT0276030003
Normal
0.3
CPT0081470004
Tumor
0.3
CPT0186040004
Tumor
0.3
CPT0218200004
Tumor
0.3
CPT0237270005
Tumor
0.3
CPT0238710004
Tumor
0.3
CPT0019410004
Tumor
0.2
CPT0063970004
Tumor
0.2
CPT0183750005
Tumor
0.2
CPT0207990004
Normal
0.2
CPT0125010003
Normal
0.2
CPT0092630003
Tumor
0.2
CPT0221470005
Tumor
0.2
CPT0162760003
Tumor
0.2
CPT0001750003
Normal
0.2
CPT0355180003
Normal
0.2
CPT0124410004
Tumor
0.2
CPT0014040003
Tumor
0.2
CPT0236780005
Tumor
0.2
CPT0008800003
Tumor
0.2
CPT0066020003
Normal
0.2
CPT0238530005
Tumor
0.2
CPT0226570004
Tumor
0.2
CPT0078160004
Tumor
0.2
CPT0224460004
Tumor
0.2
CPT0162670004
Normal
0.2
CPT0238440005
Tumor
0.1
CPT0209640005
Tumor
0.1
CPT0197420004
Tumor
0.1
CPT0246840003
Tumor
0.1
CPT0246720003
Tumor
0.1
CPT0209310004
Tumor
0.1
CPT0239100009
Tumor
0.1
CPT0081260004
Tumor
0.1
CPT0237910004
Tumor
0.1
CPT0207980005
Tumor
0.1
CPT0248410004
Tumor
0.1
CPT0264150003
Tumor
0.1
CPT0208690004
Tumor
0.1
CPT0226530004
Tumor
0.0
CPT0174700004
Tumor
0.0
CPT0094630004
Tumor
0.0
CPT0017040004
Tumor
0.0
CPT0183450005
Tumor
0.0
CPT0124000003
Normal
0.0
CPT0078000003
Tumor
0.0
CPT0125090003
Tumor
0.0
CPT0124360003
Tumor
0.0
CPT0241510004
Normal
-0.1
CPT0218220004
Normal
-0.1
CPT0077860003
Tumor
-0.1
CPT0198420004
Tumor
-0.1
CPT0276010003
Tumor
-0.1
CPT0124530003
Normal
-0.1
CPT0124500004
Tumor
-0.1
CPT0125130003
Tumor
-0.1
CPT0064110003
Normal
-0.1
CPT0083270003
Tumor
-0.1
CPT0208550005
Tumor
-0.1
CPT0237840004
Tumor
-0.1
CPT0198700005
Tumor
-0.1
CPT0093860003
Tumor
-0.1
CPT0065570003
Tumor
-0.1
CPT0238040005
Tumor
-0.2
CPT0123890003
Normal
-0.2
CPT0088180004
Tumor
-0.2
CPT0093930004
Tumor
-0.2
CPT0246990003
Tumor
-0.2
CPT0025750003
Tumor
-0.2
CPT0238740004
Normal
-0.2
CPT0094940004
Tumor
-0.2
CPT0081360004
Tumor
-0.2
CPT0063570003
Tumor
-0.2
KoreanReference3
Tumor
-0.2
CPT0077930004
Tumor
-0.2
CPT0207780004
Tumor
-0.2
CPT0078250003
Tumor
-0.2
CPT0078090004
Tumor
-0.2
CPT0108930003
Tumor
-0.2
CPT0094180003
Tumor
-0.2
CPT0226760004
Tumor
-0.3
CPT0235230004
Tumor
-0.3
CPT0094130004
Tumor
-0.3
CPT0139000004
Tumor
-0.3
CPT0208840004
Tumor
-0.3
KoreanReference1
Tumor
-0.3
CPT0124980004
Tumor
-0.3
CPT0236360004
Normal
-0.3
CPT0236700005
Tumor
-0.3
CPT0203850004
Tumor
-0.3
CPT0238920004
Tumor
-0.3
CPT0347760002
Normal
-0.3
KoreanReference2
Tumor
-0.3
CPT0093880003
Normal
-0.3
CPT0077790004
Tumor
-0.3
CPT0227930004
Tumor
-0.3
CPT0248620003
Normal
-0.3
CPT0217700004
Tumor
-0.3
CPT0162780004
Normal
-0.4
CPT0019300004
Tumor
-0.4
CPT0248590004
Tumor
-0.4
CPT0246260004
Tumor
-0.4
CPT0161770004
Tumor
-0.4
CPT0246810003
Tumor
-0.4
CPT0123670003
Normal
-0.4
CPT0087890004
Tumor
-0.4
CPT0241320005
Tumor
-0.4
CPT0246940003
Tumor
-0.4
CPT0239910004
Tumor
-0.4
CPT0246220004
Normal
-0.4
CPT0086190004
Tumor
-0.4
CPT0089720003
Tumor
-0.5
C3L-03632-04
Normal
-0.5
CPT0094740004
Tumor
-0.5
CPT0221250004
Normal
-0.5
CPT0239140004
Normal
-0.5
CPT0064090003
Tumor
-0.5
CPT0254680003
Tumor
-0.5
CPT0064520004
Tumor
-0.5
CPT0091660003
Tumor
-0.5
CPT0123440003
Tumor
-0.5
CPT0198930003
Normal
-0.5
CPT0347790002
Normal
-0.5
CPT0198910005
Tumor
-0.5
CPT0198440004
Normal
-0.6
CPT0109300004
Tumor
-0.6
CPT0347850002
Normal
-0.6
CPT0011540003
Normal
-0.6
CPT0187540004
Normal
-0.6
CPT0126160004
Tumor
-0.6
CPT0077950003
Normal
-0.6
C3N-02573-03
Normal
-0.6
CPT0236560004
Tumor
-0.6
CPT0127290003
Normal
-0.7
CPT0108960003
Normal
-0.7
CPT0123460003
Normal
-0.7
CPT0086210003
Normal
-0.7
CPT0183770004
Normal
-0.7
CPT0166780004
Normal
-0.7
CPT0124610004
Tumor
-0.7
CPT0237850004
Normal
-0.7
CPT0127270003
Tumor
-0.7
CPT0094030003
Tumor
-0.8
CPT0241500004
Tumor
-0.8
CPT0236710004
Normal
-0.8
CPT0017130003
Normal
-0.8
CPT0238640004
Normal
-0.8
CPT0226680005
Tumor
-0.8
CPT0166760004
Tumor
-0.8
CPT0208850004
Normal
-0.8
CPT0248440003
Normal
-0.8
CPT0170260004
Normal
-0.9
CPT0221240004
Tumor
-0.9
CPT0246950003
Normal
-0.9
CPT0091680003
Normal
-0.9
CPT0078180003
Normal
-0.9
CPT0089750004
Normal
-0.9
CPT0025760003
Normal
-1.0
CPT0063580003
Normal
-1.0
CPT0239920004
Normal
-1.0
CPT0077810003
Normal
-1.0
CPT0247090003
Tumor
-1.0
CPT0209650004
Normal
-1.0
C3N-00709-06
Normal
-1.0
CPT0347880002
Normal
-1.1
CPT0238940004
Normal
-1.1
C3L-00189-04
Normal
-1.2
CPT0236800004
Normal
-1.2
CPT0208710004
Normal
-1.3
CPT0355190003
Normal
-1.3
CPT0237920004
Normal
-1.5
CPT0347820002
Normal
-1.6
CPT0247050003
Normal
N/A
CPT0108410003
Normal
N/A
CPT0248320003
Normal
N/A
CPT0166650006
Tumor
N/A
CPT0224470004
Normal
N/A
C3L-01687-04
Normal
N/A
CPT0138890003
Normal
N/A
CPT0109110004
Tumor
N/A
WU-pooled sample
Tumor
N/A
CPT0014060003
Normal
N/A
CPT0109130003
Normal
N/A
CPT0138900004
Tumor
N/A
CPT0166680004
Normal
N/A
CPT0094760003
Normal
N/A
CPT0186050004
Normal
N/A
CPT0237290004
Normal
N/A
CPT0264180003
Normal
N/A
CPT0063990003
Normal
N/A
CPT0126200003
Normal
N/A
CPT0198730004
Normal
N/A
Show allShow less
PANCREATIC CANCER - Protein expressioni
A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here.
Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
Antibody stainingi
Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells.
Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.
The Human Protein Atlas project is funded
