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The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.
The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".
Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.
Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.
& Survival analysisi
Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.
METTL7A is not prognostic in Testicular Germ Cell Tumor (TCGA)
Stage:
Survival analysis
Current cut offi
Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.
:
Best expression cut offi
Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .
When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.
Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.
Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.
: N/A
P scorei
Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.
N/A
5-year survival highi
5-year survival for patients with higher expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
5-year survival lowi
5-year survival for patients with lower expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
TCGA RNA samplesi
RNA-seq data is reported as average FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.
Average TPM
20.5
Number of samples
133
Samples
Sample
Description
TPM
TCGA-XE-A9SE-01A
0 years, male, white, stage:Stage IA, alive, 708 days
66.4
TCGA-2G-AAGX-01A
0 years, male, white, stage:Stage IA, alive, 5514 days
55.8
TCGA-2G-AAG5-01A
0 years, male, white, stage:Stage IS, alive, 2299 days
54.8
TCGA-S6-A8JX-01A
0 years, male, white, stage:Stage IB, alive, 552 days
54.5
TCGA-SN-A84W-01A
0 years, male, white, stage:Stage IS, alive, 293 days
52.5
TCGA-SB-A76C-01A
0 years, male, white, stage:'--, alive, 42 days
49.6
TCGA-2G-AAGA-01A
0 years, male, white, stage:Stage IIA, alive, 2439 days
49.3
TCGA-YU-AA61-01A
0 years, male, white, stage:Stage IS, alive, 864 days
47.7
TCGA-VF-A8AB-01A
0 years, male, black or african american, stage:Stage IA, alive, 760 days
47.6
TCGA-2G-AAGW-01A
0 years, male, white, stage:Stage IS, alive, 4899 days
46.3
TCGA-XY-A8S2-01A
0 years, male, white, stage:Stage I, alive, 672 days
46.1
TCGA-2G-AAG6-01A
0 years, male, white, stage:Stage IS, alive, 2231 days
45.4
TCGA-2G-AAHC-01A
0 years, male, white, stage:Stage IS, alive, 5539 days
44.0
TCGA-2G-AAKM-01A
0 years, male, white, stage:Stage II, dead, 6972 days
39.8
TCGA-XE-AAOF-01A
0 years, male, asian, stage:Stage IA, alive, 1268 days
39.4
TCGA-XE-A8H1-01A
0 years, male, white, stage:Stage IS, alive, 209 days
38.0
TCGA-2G-AAGV-01A
0 years, male, white, stage:'--, alive, 4527 days
37.7
TCGA-2G-AAKL-01A
0 years, male, white, stage:Stage II, alive, 7023 days
37.3
TCGA-2G-AAFV-01A
0 years, male, white, stage:Stage IS, alive, 1389 days
36.5
TCGA-2G-AAH3-01A
0 years, male, white, stage:Stage I, alive, 1822 days
36.4
TCGA-2G-AAFZ-01A
0 years, male, white, stage:Stage III, alive, 1353 days
35.8
TCGA-2G-AAFL-01A
0 years, male, white, stage:Stage IB, alive, 750 days
35.5
TCGA-W4-A7U3-01A
0 years, male, white, stage:'--, alive, 149 days
35.1
TCGA-2G-AAG7-01A
0 years, male, white, stage:Stage IS, alive, 2475 days
34.8
TCGA-XE-AAOC-01A
0 years, male, white, stage:Stage IA, alive, 270 days
34.7
TCGA-X3-A8G4-01A
0 years, male, white, stage:Stage IS, alive, 856 days
33.2
TCGA-2G-AAGN-01A
0 years, male, white, stage:Stage IIIB, alive, 3656 days
33.1
TCGA-2G-AAFJ-01A
0 years, male, asian, stage:'--, alive, 792 days
31.8
TCGA-2G-AAGM-01A
0 years, male, white, stage:Stage IS, alive, 3891 days
31.3
TCGA-2G-AAGY-01A
0 years, male, white, stage:Stage IS, alive, 5329 days
31.0
TCGA-XY-A9T9-01A
0 years, male, white, stage:Stage IS, alive, 281 days
30.6
TCGA-2G-AAGJ-01A
0 years, male, black or african american, stage:Stage IA, alive, 2938 days
30.4
TCGA-WZ-A8D5-01A
0 years, male, white, stage:'--, alive, 774 days
28.6
TCGA-2G-AAGZ-01A
0 years, male, white, stage:Stage IIIA, alive, 5233 days
27.9
TCGA-2G-AAEX-01A
0 years, male, white, stage:Stage IS, alive, 1259 days
26.1
TCGA-2G-AAF4-01A
0 years, male, white, stage:Stage I, alive, 2315 days
25.9
TCGA-2G-AAGI-01A
0 years, male, white, stage:Stage IS, alive, 3137 days
25.3
TCGA-2G-AAKD-01A
0 years, male, white, stage:Stage III, alive, 6340 days
25.3
TCGA-4K-AA1G-01A
0 years, male, white, stage:Stage IS, alive, 436 days
23.9
TCGA-2G-AAKH-01A
0 years, male, white, stage:Stage II, alive, 6862 days
23.5
TCGA-2G-AAGC-01A
0 years, male, white, stage:Stage IS, alive, 2585 days
23.2
TCGA-2G-AAHT-01A
0 years, male, white, stage:Stage IS, alive, 542 days
23.2
TCGA-4K-AAAL-01A
0 years, male, white, stage:Stage IS, alive, 483 days
23.1
TCGA-2G-AAGP-01A
0 years, male, white, stage:Stage IIA, alive, 4018 days
22.9
TCGA-XY-A89B-01A
0 years, male, white, stage:Stage IA, alive, 471 days
22.8
TCGA-4K-AA1H-01A
0 years, male, white, stage:Stage IA, alive, 518 days
22.8
TCGA-SN-A6IS-01A
0 years, male, white, stage:Stage IS, alive, 496 days
22.7
TCGA-2X-A9D5-01A
0 years, male, white, stage:Stage I, alive, 435 days
22.6
TCGA-YU-A90P-01A
0 years, male, white, stage:Stage IA, alive, 2069 days
22.4
TCGA-2G-AAGG-01A
0 years, male, white, stage:Stage IIIC, alive, 2611 days
21.6
TCGA-2G-AAG8-01A
0 years, male, white, stage:Stage IB, alive, 2289 days
21.6
TCGA-2G-AAH2-01A
0 years, male, white, stage:Stage IS, alive, 6060 days
21.4
TCGA-2G-AAL7-01A
0 years, male, white, stage:Stage IS, alive, 3991 days
20.8
TCGA-XE-AAOD-01A
0 years, male, white, stage:Stage IB, alive, 2058 days
20.7
TCGA-YU-A90Y-01A
0 years, male, black or african american, stage:Stage IIIC, dead, 17 days
20.5
TCGA-2G-AAFY-01A
0 years, male, white, stage:Stage IIA, alive, 1099 days
20.4
TCGA-YU-A912-01A
0 years, male, black or african american, stage:Stage IIIC, alive, 866 days
20.2
TCGA-XE-AAOJ-01A
0 years, male, white, stage:Stage IS, alive, 1550 days
20.1
TCGA-XE-AANI-01A
0 years, male, white, stage:Stage IS, alive, 1041 days
19.8
TCGA-2G-AAFE-01A
0 years, male, white, stage:Stage IIA, alive, 4702 days
19.6
TCGA-SN-A84Y-01A
0 years, male, white, stage:Stage IS, alive, 524 days
19.6
TCGA-XE-A8H5-01A
0 years, male, stage:Stage IS, alive, 1217 days
19.5
TCGA-WZ-A7V5-01A
0 years, male, white, stage:Stage I, alive, 1061 days
19.5
TCGA-2G-AAGK-01A
0 years, male, white, stage:Stage IS, alive, 3621 days
19.4
TCGA-2G-AAG3-01A
0 years, male, white, stage:Stage IS, alive, 1593 days
19.2
TCGA-2G-AAH0-01A
0 years, male, white, stage:Stage IS, alive, 5477 days
18.8
TCGA-2G-AAGE-01A
0 years, male, white, stage:Stage IS, alive, 2478 days
18.7
TCGA-2G-AAFH-01A
0 years, male, white, stage:Stage IIB, alive, 1375 days
18.6
TCGA-2G-AAFO-01A
0 years, male, white, stage:Stage IIA, alive, 685 days
18.4
TCGA-WZ-A7V3-01A
0 years, male, white, stage:Stage I, alive, 753 days
17.6
TCGA-2G-AAGS-01A
0 years, male, white, stage:Stage IIIB, alive, 4816 days
17.0
TCGA-2X-A9D6-01A
0 years, male, white, stage:Stage I, alive, 607 days
16.9
TCGA-2G-AAG9-01A
0 years, male, white, stage:Stage IIIB, alive, 2234 days
16.7
TCGA-VF-A8A8-01A
0 years, male, white, stage:Stage IA, alive, 1131 days
16.5
TCGA-W4-A7U2-01A
0 years, male, white, stage:'--, alive, 1263 days
16.5
TCGA-2G-AALP-01A
0 years, male, white, stage:Stage IIIB, alive, 2645 days
16.5
TCGA-YU-A90S-01A
0 years, male, white, stage:Stage IA, alive, 971 days
15.8
TCGA-2G-AAFI-01A
0 years, male, white, stage:Stage IB, alive, 675 days
15.7
TCGA-S6-A8JW-01A
0 years, male, white, stage:Stage IS, alive, 698 days
15.7
TCGA-XE-AAOB-01A
0 years, male, white, stage:Stage IS, dead, 513 days
15.6
TCGA-XE-A8H4-01A
0 years, male, white, stage:Stage IA, alive, 559 days
15.1
TCGA-VF-A8A9-01A
0 years, male, white, stage:Stage IA, alive, 1119 days
14.3
TCGA-2G-AAL5-01A
0 years, male, white, stage:Stage I, alive, 7437 days
14.3
TCGA-2G-AAGF-01A
0 years, male, white, stage:Stage IS, alive, 2734 days
13.4
TCGA-WZ-A7V4-01A
0 years, male, white, stage:Stage I, alive, 894 days
13.3
TCGA-2G-AAF1-01A
0 years, male, asian, stage:Stage IS, alive, 1403 days
13.1
TCGA-2G-AAG0-01A
0 years, male, white, stage:Stage IS, alive, 1529 days
13.0
TCGA-2G-AAEW-01A
0 years, male, white, stage:Stage IS, dead, 618 days
12.7
TCGA-2G-AAH4-01A
0 years, male, white, stage:Stage II, alive, 6210 days
12.4
TCGA-2G-AAHP-01A
0 years, male, white, stage:Stage IS, alive, 5667 days
12.2
TCGA-2G-AAF6-01A
0 years, male, white, stage:Stage IS, alive, 3491 days
12.2
TCGA-VF-A8AD-01A
0 years, male, white, stage:Stage IB, alive, 1006 days
12.0
TCGA-XE-AANR-01A
0 years, male, white, stage:Stage I, alive, 14 days
11.8
TCGA-YU-A94D-01A
0 years, male, stage:Stage IIIB, alive, 2167 days
11.5
TCGA-2G-AAGT-01A
0 years, male, white, stage:Stage IS, alive, 4406 days
10.9
TCGA-SN-A84X-01A
0 years, male, white, stage:Stage IS, alive, 312 days
10.6
TCGA-2G-AAF8-01A
0 years, male, white, stage:Stage IA, alive, 3911 days
10.5
TCGA-XE-AAO3-01A
0 years, male, asian, stage:Stage I, alive, 2857 days
9.7
TCGA-2G-AAKG-01A
0 years, male, white, stage:Stage I, alive, 6598 days
9.6
TCGA-2G-AAHA-01A
0 years, male, white, stage:Stage IB, alive, 3349 days
9.0
TCGA-2G-AAHN-01A
0 years, male, white, stage:Stage I, alive, 6445 days
8.8
TCGA-YU-A90W-01A
0 years, male, white, stage:Stage IA, alive, 1113 days
8.5
TCGA-VF-A8AC-01A
0 years, male, white, stage:Stage IA, alive, 1083 days
8.5
TCGA-4K-AA1I-01A
0 years, male, white, stage:Stage IA, alive, 3 days
8.5
TCGA-W4-A7U4-01A
0 years, male, white, stage:'--, alive, 738 days
8.3
TCGA-XE-AANV-01A
0 years, male, stage:Stage IB, alive, 1701 days
8.2
TCGA-VF-A8AA-01A
0 years, male, white, stage:Stage I, alive, 1146 days
8.2
TCGA-XE-AANJ-01A
0 years, male, white, stage:Stage IS, alive, 2007 days
7.9
TCGA-VF-A8AE-01A
0 years, male, white, stage:Stage IA, alive, 727 days
7.6
TCGA-SO-A8JP-01A
0 years, male, white, stage:Stage I, alive, 540 days
7.2
TCGA-YU-A90Q-01A
0 years, male, stage:Stage IB, alive, 1964 days
7.2
TCGA-XE-AAO4-01A
0 years, male, white, stage:Stage IA, alive, 367 days
6.6
TCGA-SB-A6J6-01A
0 years, male, white, stage:Stage IA, alive, 413 days
6.6
TCGA-2G-AAFG-01A
0 years, male, white, stage:Stage IS, alive, 6183 days
6.4
TCGA-2G-AAFN-01A
0 years, male, white, stage:Stage IIIB, alive, 773 days
6.1
TCGA-ZM-AA0H-01A
0 years, male, white, stage:Stage IS, alive, 1736 days
6.0
TCGA-2G-AAGO-01A
0 years, male, white, stage:Stage IS, alive, 4026 days
5.6
TCGA-2G-AAHG-01A
0 years, male, white, stage:Stage I, alive, 1819 days
5.5
TCGA-ZM-AA0B-01A
0 years, male, white, stage:Stage IA, alive, 838 days
5.2
TCGA-2G-AAFM-01A
0 years, male, white, stage:Stage IIA, alive, 503 days
4.8
TCGA-2G-AAH8-01A
0 years, male, white, stage:Stage IIIC, alive, 2248 days
4.6
TCGA-S6-A8JY-01A
0 years, male, white, stage:Stage IS, alive, 278 days
4.2
TCGA-YU-A94I-01A
0 years, male, stage:Stage IA, alive, 536 days
3.7
TCGA-ZM-AA0D-01A
0 years, male, white, stage:Stage IA, alive, 848 days
3.4
TCGA-ZM-AA0F-01A
0 years, male, white, stage:Stage IA, alive, 681 days
3.3
TCGA-XE-AAO6-01A
0 years, male, white, stage:Stage IA, alive, 240 days
2.7
TCGA-ZM-AA0E-01A
0 years, male, white, stage:Stage IA, alive, 811 days
2.4
TCGA-2G-AAHL-01A
0 years, male, white, stage:Stage I, alive, 7081 days
2.1
TCGA-XE-AAOL-01A
0 years, male, black or african american, stage:Stage I, alive, 13 days
1.6
TCGA-ZM-AA0N-01A
0 years, male, white, stage:Stage IB, alive, 634 days
1.4
TCGA-ZM-AA06-01A
0 years, male, white, stage:Stage IB, alive, 1498 days
1.2
TCGA-YU-AA4L-01A
0 years, male, black or african american, stage:Stage IIIC, alive, 1573 days
0.0
TCGA-ZM-AA05-01A
0 years, male, white, stage:Stage IIC, alive, 1126 days
0.0
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TESTIS CANCER - Protein expressioni
A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here.
Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
The Human Protein Atlas project is funded
