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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
22
Cytoband
q12.2
Chromosome location (bp)
29306618 - 29312787
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Involved in the cross-linking of microtubules and microfilaments 1,2. Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers 3....show less
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the growth arrest-specific 2 protein family. This protein binds components of the cytoskeleton and may be involved in mediating interactions between microtubules and microfilaments. This protein localizes to the proximal end of mature centrioles and links centrosomes to both microtubules and actin. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, May 2018]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
A0A5E8 [Direct mapping] GAS2-like protein 1; Growth arrest-specific 2 like 1, isoform CRA_a; cDNA FLJ16435 fis, clone BRACE3020671, highly similar to GAS2-like protein 1; cDNA FLJ36067 fis, clone TESTI2019308, highly similar to GAR22 PROTEIN
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
A0A5E8 [Direct mapping] GAS2-like protein 1; Growth arrest-specific 2 like 1, isoform CRA_a; cDNA FLJ16435 fis, clone BRACE3020671, highly similar to GAS2-like protein 1; cDNA FLJ36067 fis, clone TESTI2019308, highly similar to GAR22 PROTEIN
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
A0A5E8 [Direct mapping] GAS2-like protein 1; Growth arrest-specific 2 like 1, isoform CRA_a; cDNA FLJ16435 fis, clone BRACE3020671, highly similar to GAS2-like protein 1; cDNA FLJ36067 fis, clone TESTI2019308, highly similar to GAR22 PROTEIN
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
A0A5E8 [Direct mapping] GAS2-like protein 1; Growth arrest-specific 2 like 1, isoform CRA_a; cDNA FLJ16435 fis, clone BRACE3020671, highly similar to GAS2-like protein 1; cDNA FLJ36067 fis, clone TESTI2019308, highly similar to GAR22 PROTEIN
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
